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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:disseminated intravascular coagulation
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Accession:DOID:11247 term browser browse the term
Definition:A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Synonyms:exact_synonym: Consumption Coagulopathies;   Consumption Coagulopathy;   DIC;   Defibrination syndrome;   Diffuse or disseminated intravascular coagulation;   Disseminated Intravascular Coagulations
 narrow_synonym: DIC with the fibrinolytic phenotype
 primary_id: MESH:D004211;   RDO:0001199
 xref: ICD9CM:286.6;   NCI:C2992
For additional species annotation, visit the Alliance of Genome Resources.


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disseminated intravascular coagulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 ISO protein:decreased expression, decreased activity:plasma (human) RGD PMID:16189276 RGD:10449048 NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687 		JBrowse link
G Elane elastase, neutrophil expressed ISO protein:increased expression:plasma:
associated with Multiple Organ Failure, Craniocerebral Trauma;protein:increased expression:plasma:		 RGD PMID:20655560 PMID:10912863 RGD:10450544, RGD:10450545 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO RGD PMID:16642548 RGD:1581020 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F2 coagulation factor II IDA
ISO		 CTD Direct Evidence: marker/mechanism
associated with Wounds and Injuries		 CTD
RGD		 PMID:1894189 PMID:22229668 PMID:23737601 PMID:1336986 PMID:19682336 RGD:6893489, RGD:10449432, RGD:10449429, RGD:10449422 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor ISO
IEP		 protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:lung, plasma
associated with Leukemia, Myeloid		 CTD
RGD		 PMID:7740478 PMID:9134660 PMID:20642682 PMID:8914465 PMID:9426395 More... RGD:11060253, RGD:11060265, RGD:11341675 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G F7 coagulation factor VII ISO CTD Direct Evidence: marker/mechanism CTD PMID:16159073 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Fga fibrinogen alpha chain treatment IEP
IDA		 protein:decreased expression:plasma (rat) RGD PMID:23538169 PMID:22800895 RGD:10755508, RGD:10755509 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Il10 interleukin 10 ISO protein:increased expression:plasma RGD PMID:16613997 RGD:11049462 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 severity
treatment		 ISO
IEP
IDA		 associated with Hemorrhagic Fever, Crimean
protein:increased expression:plasma (rat)		 RGD PMID:16518755 PMID:16932226 PMID:16810104 PMID:16613997 RGD:10450536, RGD:11062099, RGD:11060278, RGD:11049462 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:15547535 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Plat plasminogen activator, tissue type treatment ISO
IDA		 protein:increased expression:plasma (human)
associated with Jaundice, Obstructive		 RGD PMID:23726093 PMID:1425827 RGD:11541052, RGD:11541087 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18376272 PMID:9788960 PMID:10936861 RGD:11099993, RGD:11100014 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO associated with Endotoxemia
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:6233579 PMID:8810955 PMID:9637888 PMID:2679067 RGD:11035251 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpine1 serpin family E member 1 treatment IDA
IEP		 associated with Endotoxemia
protein:increased expression:blood (rat)		 RGD PMID:15869603 PMID:23737601 RGD:11080963, RGD:10449432 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO
IEP		 mRNA, protein:increased expression:lung, plasma
protein:increased expression:plasma:		 RGD PMID:11074537 PMID:8292719 PMID:8929465 PMID:9426395 PMID:8914465 RGD:11060128, RGD:11341674, RGD:11062067, RGD:11060265, RGD:11060253 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Thbd thrombomodulin treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:9134660 PMID:21569368 PMID:23952647 RGD:5685034, RGD:11038686 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Tnf tumor necrosis factor severity ISO associated with Hemorrhagic Fever, Crimean RGD PMID:16518755 RGD:10450536 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Acute Traumatic Coagulopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plat plasminogen activator, tissue type treatment IDA
IEP		 protein:increased expression:serum (rat) RGD PMID:25325345 PMID:25676919 RGD:11554179, RGD:11554180 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18032
    disease of anatomical entity 17412
      hematopoietic system disease 2693
        blood coagulation disease 831
          disseminated intravascular coagulation 17
            Acute Traumatic Coagulopathy 1
            DIC in newborn 0
Path 2
Term Annotations click to browse term
  disease 18032
    disease of anatomical entity 17412
      Hemic and Lymphatic Diseases 3149
        hematopoietic system disease 2693
          blood coagulation disease 831
            thrombophilia 60
              disseminated intravascular coagulation 17
                Acute Traumatic Coagulopathy 1
                DIC in newborn 0
paths to the root