RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: disseminated intravascular coagulation
Accession: DOID:11247
browse the term
Definition: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Synonyms: exact_synonym: Consumption Coagulopathies; Consumption Coagulopathy; DIC; Defibrination syndrome; Diffuse or disseminated intravascular coagulation; Disseminated Intravascular Coagulations
narrow_synonym: DIC with the fibrinolytic phenotype
primary_id: MESH:D004211 ; RDO:0001199
xref: ICD9CM:286.6 ; NCI:C2992
For additional species annotation, visit the
Alliance of Genome Resources .
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Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
ISO
protein:decreased expression, decreased activity:plasma (human)
RGD
PMID:16189276
RGD:10449048
NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687
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Elane
elastase, neutrophil expressed
ISO
protein:increased expression:plasma: associated with Multiple Organ Failure, Craniocerebral Trauma;protein:increased expression:plasma:
RGD
PMID:20655560 PMID:10912863
RGD:10450544 , RGD:10450545
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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F13a1
coagulation factor XIII A1 chain
ISO
RGD
PMID:16642548
RGD:1581020
NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
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F2
coagulation factor II
IDA ISO
CTD Direct Evidence: marker/mechanism associated with Wounds and Injuries
CTD RGD
PMID:1894189 PMID:22229668 PMID:23737601 PMID:1336986 PMID:19682336
RGD:6893489 , RGD:10449432 , RGD:10449429 , RGD:10449422
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F3
coagulation factor III, tissue factor
ISO IEP
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:lung, plasma associated with Leukemia, Myeloid
CTD RGD
PMID:7740478 PMID:9134660 PMID:20642682 PMID:8914465 PMID:9426395 PMID:3802033 More...
RGD:11060253 , RGD:11060265 , RGD:11341675
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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F7
coagulation factor VII
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16159073
NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
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Fga
fibrinogen alpha chain
treatment
IEP IDA
protein:decreased expression:plasma (rat)
RGD
PMID:23538169 PMID:22800895
RGD:10755508 , RGD:10755509
NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
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Il10
interleukin 10
ISO
protein:increased expression:plasma
RGD
PMID:16613997
RGD:11049462
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il6
interleukin 6
severity treatment
ISO IEP IDA
associated with Hemorrhagic Fever, Crimean protein:increased expression:plasma (rat)
RGD
PMID:16518755 PMID:16932226 PMID:16810104 PMID:16613997
RGD:10450536 , RGD:11062099 , RGD:11060278 , RGD:11049462
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Oxt
oxytocin/neurophysin I prepropeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15547535
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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Plat
plasminogen activator, tissue type
treatment
ISO IDA
protein:increased expression:plasma (human) associated with Jaundice, Obstructive
RGD
PMID:23726093 PMID:1425827
RGD:11541052 , RGD:11541087
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18376272 PMID:9788960 PMID:10936861
RGD:11099993 , RGD:11100014
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Serpinc1
serpin family C member 1
treatment
ISO
associated with Endotoxemia CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:6233579 PMID:8810955 PMID:9637888 PMID:2679067
RGD:11035251
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpine1
serpin family E member 1
treatment
IDA IEP
associated with Endotoxemia protein:increased expression:blood (rat)
RGD
PMID:15869603 PMID:23737601
RGD:11080963 , RGD:10449432
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Tfpi
tissue factor pathway inhibitor
treatment
ISO IEP
mRNA, protein:increased expression:lung, plasma protein:increased expression:plasma:
RGD
PMID:11074537 PMID:8292719 PMID:8929465 PMID:9426395 PMID:8914465
RGD:11060128 , RGD:11341674 , RGD:11062067 , RGD:11060265 , RGD:11060253
NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
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Thbd
thrombomodulin
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:9134660 PMID:21569368 PMID:23952647
RGD:5685034 , RGD:11038686
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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Tnf
tumor necrosis factor
severity
ISO
associated with Hemorrhagic Fever, Crimean
RGD
PMID:16518755
RGD:10450536
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Plat
plasminogen activator, tissue type
treatment
IDA IEP
protein:increased expression:serum (rat)
RGD
PMID:25325345 PMID:25676919
RGD:11554179 , RGD:11554180
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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