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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pleurisy
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Accession:DOID:10247 term browser browse the term
Definition:INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.
Synonyms:exact_synonym: Pleurisies;   Pleuritides;   Pleuritis
 primary_id: MESH:D010998;   RDO:0006360
 xref: ICD9CM:511.8;   NCI:C26860
For additional species annotation, visit the Alliance of Genome Resources.


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pleurisy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO RGD PMID:16860713 RGD:5128847 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Alox5 arachidonate 5-lipoxygenase IMP RGD PMID:9109363 RGD:4890429 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Anxa1 annexin A1 IDA RGD PMID:15784654 RGD:2306907 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:11853231 RGD:5129218 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO
IMP
RGD PMID:15316088, PMID:9208140 RGD:4891029, RGD:4891041 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G C3 complement C3 ISO protein:increased activity:pleural cavity RGD PMID:18256172 RGD:5129520 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cat catalase ISO RGD PMID:19778612 RGD:5130749 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO
IMP
protein:increased expression:pleural fluid RGD PMID:11877329, PMID:11564646 RGD:4145443, RGD:4145479 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 ISO protein:increased expression:pleural fluid RGD PMID:18056919 RGD:5130924 NCBI chr12:2,429,492...2,438,928
Ensembl chr12:2,429,509...2,438,817
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung (mouse) RGD PMID:18672096 RGD:4890016 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO associated with Mycobacterium Infections RGD PMID:17158890 RGD:4145643 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Csf3 colony stimulating factor 3 ISO RGD PMID:8841835 RGD:11039424 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO RGD PMID:14527170 RGD:5135449 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:14527170 RGD:5135449 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 IEP
ISO
RGD PMID:21549112, PMID:14527170 RGD:5135064, RGD:5135449 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:14527170 RGD:5135449 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Ednra endothelin receptor type A ISO RGD PMID:15107459 RGD:4892325 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Elane elastase, neutrophil expressed IMP RGD PMID:20860667 RGD:10450565 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:17035596 RGD:4892303 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:bronchial epithelium (mouse)
CTD PMID:11181422, PMID:19714575, PMID:19056932 RGD:4145510, RGD:4145519 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:10823416 RGD:4990464 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il17a interleukin 17A treatment IDA RGD PMID:21898269 RGD:7175307 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:increased expression:pleural cavity, exudate (rat)
protein:increased expression:lung
CTD PMID:11181422, PMID:20141620, PMID:21898269, PMID:20175894 RGD:4142808, RGD:7175307, RGD:4142826 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:8491511 RGD:4143233 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:lung RGD PMID:11577999 RGD:5130991 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO RGD PMID:14673141 RGD:6893408 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 IEP
IDA
protein:increased expression:pleural cavity (rat) RGD PMID:21898269, PMID:20141620 RGD:7175307, RGD:4142808 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pla2g6 phospholipase A2 group VI IEP RGD PMID:15003994 RGD:6482741 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:8395390 RGD:10043147 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IDA
IEP
RGD PMID:20141620, PMID:15740981 RGD:4142808, RGD:5143929 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Selp selectin P ISO protein:increased expression:lung
CTD Direct Evidence: marker/mechanism
CTD PMID:11181422, PMID:21147071 RGD:6219005 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Serpine1 serpin family E member 1 susceptibility ISO associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human): RGD PMID:23052617 RGD:13207414 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tnf tumor necrosis factor ISO
IDA
CTD Direct Evidence: marker/mechanism CTD PMID:11181422 PMID:15380531, PMID:11161459, PMID:20141620 RGD:4143474, RGD:4142808 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15380531 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
pleuropneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:12773506 RGD:4890419 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17126
    disease of anatomical entity 16474
      respiratory system disease 2863
        Respiratory Tract Infections 509
          pleurisy 36
            pleuropneumonia 1
Path 2
Term Annotations click to browse term
  disease 17126
    disease of anatomical entity 16474
      respiratory system disease 2863
        lower respiratory tract disease 1757
          pleural disease 75
            pleurisy 36
              pleuropneumonia 1
paths to the root