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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pleurisy
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Accession:DOID:10247 term browser browse the term
Definition:A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. (DO)
Synonyms:exact_synonym: pleurisies;   pleuritides;   pleuritis
 primary_id: MESH:D010998
 xref: ICD9CM:511.8;   NCI:C26860
For additional species annotation, visit the Alliance of Genome Resources.



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pleurisy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO RGD PMID:16860713 RGD:5128847 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Alox5 arachidonate 5-lipoxygenase IMP RGD PMID:9109363 RGD:4890429 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Anxa1 annexin A1 IDA RGD PMID:15784654 RGD:2306907 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:11853231 RGD:5129218 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO
IMP
RGD PMID:15316088 PMID:9208140 RGD:4891029, RGD:4891041 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G C3 complement C3 ISO protein:increased activity:pleural cavity RGD PMID:18256172 RGD:5129520 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cat catalase ISO RGD PMID:19778612 RGD:5130749 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO
IMP
protein:increased expression:pleural fluid RGD PMID:11877329 PMID:11564646 RGD:4145443, RGD:4145479 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 ISO protein:increased expression:pleural fluid RGD PMID:18056919 RGD:5130924 NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung (mouse) RGD PMID:18672096 RGD:4890016 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO associated with Mycobacterium Infections RGD PMID:17158890 RGD:4145643 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
JBrowse link
G Csf3 colony stimulating factor 3 ISO RGD PMID:8841835 RGD:11039424 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO RGD PMID:14527170 RGD:5135449 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:14527170 RGD:5135449 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 IEP
ISO
RGD PMID:21549112 PMID:14527170 RGD:5135064, RGD:5135449 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:14527170 RGD:5135449 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Ednra endothelin receptor type A ISO RGD PMID:15107459 RGD:4892325 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Elane elastase, neutrophil expressed IMP RGD PMID:20860667 RGD:10450565 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:17035596 RGD:4892303 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:bronchial epithelium (mouse)
CTD
RGD
PMID:11181422 PMID:19714575 PMID:19056932 RGD:4145510, RGD:4145519 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:10823416 RGD:4990464 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il17a interleukin 17A treatment IDA RGD PMID:21898269 RGD:7175307 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:increased expression:pleural cavity, exudate (rat)
protein:increased expression:lung
CTD
RGD
PMID:11181422 PMID:20141620 PMID:21898269 PMID:20175894 RGD:4142808, RGD:7175307, RGD:4142826 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:8491511 RGD:4143233 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:lung RGD PMID:11577999 RGD:5130991 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO RGD PMID:14673141 RGD:6893408 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 IEP
IDA
protein:increased expression:pleural cavity (rat) RGD PMID:21898269 PMID:20141620 RGD:7175307, RGD:4142808 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pla2g6 phospholipase A2 group VI IEP RGD PMID:15003994 RGD:6482741 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:8395390 RGD:10043147 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IDA
IEP
RGD PMID:20141620 PMID:15740981 RGD:4142808, RGD:5143929 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Selp selectin P ISO protein:increased expression:lung
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:11181422 PMID:21147071 RGD:6219005 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Serpine1 serpin family E member 1 susceptibility ISO associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human): RGD PMID:23052617 RGD:13207414 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Tnf tumor necrosis factor ISO
IDA
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11181422 PMID:15380531 PMID:11161459 PMID:20141620 RGD:4143474, RGD:4142808 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15380531 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421
JBrowse link
pleuropneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:12773506 RGD:4890419 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18154
    disease of anatomical entity 17529
      respiratory system disease 3396
        Respiratory Tract Infections 538
          pleurisy 36
            pleuropneumonia 1
Path 2
Term Annotations click to browse term
  disease 18154
    disease of anatomical entity 17529
      respiratory system disease 3396
        lower respiratory tract disease 2238
          pleural disease 114
            pleurisy 36
              pleuropneumonia 1
paths to the root