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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:granulocyte-macrophage colony-stimulating factor signaling pathway
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Accession:PW:0000970 term browser browse the term
Definition:GM-CSF signaling, like the other hemopoietic cytokines, is involved in the production and activation of hemopoietic cells. The GM-CSF pathway acts on monocytes, macrophages and granulocytes and is also involved in the regulation of T and dendritic cell functions.
Synonyms:exact_synonym: GM-CSF signaling pathway


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granulocyte-macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO PID PID:200019 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cish cytokine inducible SH2-containing protein ISO PID PID:200019 NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986 		JBrowse link
G Csf2 colony stimulating factor 2 ISO PID PID:200019 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha ISO PID PID:200019 NCBI chr14:113,219...118,808
Ensembl chr14:113,225...118,117 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta ISO PID PID:200019 NCBI chr 7:111,756,950...111,782,089
Ensembl chr 7:111,757,405...111,784,654 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200019 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gab2 GRB2-associated binding protein 2 ISO PID PID:200019 NCBI chr 1:160,841,066...161,036,940
Ensembl chr 1:160,841,066...161,036,940 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200019 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200019 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200019 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO PID PID:200019 NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589 		JBrowse link
G Irf8 interferon regulatory factor 8 ISO PID PID:200019 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062 		JBrowse link
G Jak2 Janus kinase 2 ISO PID PID:200019 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200019 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO PID PID:200019 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO PID PID:200019 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200019 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200019 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO PID PID:200019 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
G Osm oncostatin M ISO PID PID:200019 NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200019 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200019 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase ISO PID PID:200019 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200019 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO PID PID:200019 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200019 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200019 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200019 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200019 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200019 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO PID PID:200019 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO PID PID:200019 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO PID PID:200019 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200019 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta ISO PID PID:200019 NCBI chr 7:69,826,404...69,848,702
Ensembl chr 7:69,826,404...69,849,007 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway pertinent to immunity 793
        cytokine mediated signaling pathway 485
          Interleukin mediated signaling pathway 256
            interleukin-3/interleukin-5/GM-CSF mediated signaling pathway 47
              granulocyte-macrophage colony-stimulating factor signaling pathway 35
paths to the root