PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: leptin system pathway
Accession: PW:0000363
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Definition: Leptin acts on two populations of hypothalamic neurons that express orexigenic (feeding inducing) and anorexigenic genes, respectively. Leptin reduces the expression of genes from the former and enhances the expression of genes from the latter neurons. The leptin mediated response acts primarily via Jak-dependent activation of STAT.
Synonyms: related_synonym: Signaling by Leptin; leptin-mediated signaling pathway
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Irs1
insulin receptor substrate 1
ISO
RGD
PMID:15316008
RGD:2302071
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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Irs2
insulin receptor substrate 2
ISO
RGD
PMID:15316008
RGD:2302071
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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Jak2
Janus kinase 2
ISO
RGD
PMID:17010638 PMID:15316008
RGD:1625125 , RGD:2302071
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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Lep
leptin
TAS IDA ISO
RGD
PMID:11102451 PMID:9618284 PMID:9070213 PMID:17010638
RGD:61790 , RGD:2290294 , RGD:2290293 , RGD:1625125
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lepr
leptin receptor
TAS IDA ISO
RGD
PMID:11102451 PMID:9618284 PMID:9070213 PMID:17010638 PMID:17229951
RGD:61790 , RGD:2290294 , RGD:2290293 , RGD:1625125 , RGD:1600611
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Lepr_v1
leptin receptor, variant 1
IDA
RGD
PMID:9070213 PMID:9618284
RGD:2290293 , RGD:2290294
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Lepr_v2
leptin receptor, variant 2
ISO IDA
RGD
PMID:17578380 PMID:9618284 PMID:9070213
RGD:2290292 , RGD:2290294 , RGD:2290293
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Ptpn1
protein tyrosine phosphatase, non-receptor type 1
ISO
RGD
PMID:15821101
RGD:2289366
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
ISO
RGD
PMID:17872473
RGD:2289807
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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Sh2b1
SH2B adaptor protein 1
ISO
RGD
PMID:15316008
RGD:2302071
NCBI chr 1:181,048,622...181,057,036
Ensembl chr 1:181,048,623...181,056,579
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Socs3
suppressor of cytokine signaling 3
ISO
RGD
PMID:17010638
RGD:1625125
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Stat3
signal transducer and activator of transcription 3
ISO
RGD
PMID:17229951 PMID:17010638
RGD:1600611 , RGD:1625125
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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Insr
insulin receptor
IMP
increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down
RGD
PMID:17585961
RGD:2290473
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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Lep
leptin
TAS
RGD
PMID:11102451
RGD:61790
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lepr
leptin receptor
TAS ISO
RGD
PMID:11102451 PMID:17229951
RGD:61790 , RGD:1600611
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Lepr_v2
leptin receptor, variant 2
ISO
RGD
PMID:17578380
RGD:2290292
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