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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:lymphoplasmacytic lymphoma
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Accession:DOID:0060901 term browser browse the term
Definition:A B-cell lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein. (DO)
Synonyms:exact_synonym: Waldenstroem's macroglobulinemia;   Waldenstrom Macroglobulinaemia;   Waldenstrom macroglobulinemia;   Waldenstrom's Macroglobulinaemia;   Waldenstrom's macroglobulinemia;   Waldenstroms macroglobulinaemia;   Waldenstroms macroglobulinemia;   familial Waldenstrom macroglobulinaemia;   familial Waldenstrom macroglobulinemia;   familial Waldenstrom's macroglobulinaemia;   familial Waldenstroms macroglobulinaemia;   immunocytoma;   lymphoplasmacytic lymphoma with IgM gammopathy
 related_synonym: WM1;   WM2;   Waldenstrom macroglobulinemia, somatic;   Waldenstrom macroglobulinemia, susceptibility to, 1;   Waldenstrom macroglobulinemia, susceptibility to, 2
 primary_id: MESH:D008258
 alt_id: DOID:0050747;   OMIM:153600;   OMIM:610430
 xref: EFO:0009441;   GARD:7872;   ICD10CM:C88.0;   ICD9CM:273.3;   NCI:C115212;   NCI:C3212;   NCI:C80307;   OMIM:PS153600;   ORDO:33226

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lymphoplasmacytic lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr4 C-X-C motif chemokine receptor 4 disease_progression ISO DNA:mutation:cds:1013C>G(p.S338X)(human) RGD PMID:24711662 RGD:11352304 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Fcgr3a Fc gamma receptor 3A disease_progression
ISO DNA:polymorphism: :
DNA:SNP:exon:p.F158V (rs396991) (human)
RGD PMID:21564078 PMID:15659493 RGD:11040774, RGD:11352262 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:bone marrow RGD PMID:32763516 RGD:401827827 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Il10 interleukin 10 ISO DNA:SNPs: :multiple RGD PMID:19573080 RGD:11049165 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 no_association ISO DNA:SNPs: :rs6952003, rs7801617, rs10156056 (human)
DNA:SNPs: :multiple
RGD PMID:19573080 PMID:19573080 RGD:11049165, RGD:11049165 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf4 interferon regulatory factor 4 ISO RGD PMID:23355206 RGD:11530052 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Macroglobulinemia, Waldenstrom, somatic
PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More... NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    syndrome 10832
      primary immunodeficiency disease 4144
        lymphoproliferative syndrome 1054
          lymphoplasmacytic lymphoma 7
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18212
      Hemic and Lymphatic Diseases 3854
        hematopoietic system disease 3344
          Hematologic Neoplasms 1044
            hematologic cancer 1044
              lymphoma 575
                non-Hodgkin lymphoma 486
                  B-cell lymphoma 347
                    mature B-cell neoplasm 198
                      plasma cell neoplasm 176
                        lymphoplasmacytic lymphoma 7
paths to the root