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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:boric acids
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Accession:CHEBI:59765 term browser browse the term
Definition:Hydroxy boron compounds of general formula BxOyHz.
Synonyms:xref_mesh: MESH:D001888


show annotations for term's descendants           Sort by:
boric acids term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 decreases activity EXP Boric Acids analog results in decreased activity of GGT1 protein CTD PMID:6149445 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Muc1 mucin 1, cell surface associated decreases expression ISO Boric Acids results in decreased expression of MUC1 mRNA CTD PMID:21060261 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491 		JBrowse link
G Muc16 mucin 16, cell surface associated decreases expression ISO Boric Acids results in decreased expression of MUC16 mRNA CTD PMID:21060261 NCBI chr 8:24,440,840...24,644,494 JBrowse link
boric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO boric acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein] CTD PMID:28544013 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions EXP boric acid inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of ACSL4 mRNA]; boric acid inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of ACSL4 protein] CTD PMID:38108610 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO boric acid results in decreased expression of ACTA2 protein CTD PMID:25637568 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:28285642 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Agt angiotensinogen multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of AGT mRNA] CTD PMID:28285642 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO boric acid results in increased expression of AKT1 mRNA CTD PMID:31368021 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP boric acid results in increased expression of ALPL protein CTD PMID:37045926 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Arg1 arginase 1 decreases activity ISO boric acid results in decreased activity of ARG1 protein CTD PMID:21232540 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO boric acid results in increased expression of ATF4 mRNA; boric acid results in increased expression of ATF4 protein CTD PMID:25425213 PMID:27587023 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO boric acid results in increased cleavage of and affects the localization of ATF6 protein CTD PMID:27587023 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
increases expression 		ISO
EXP 		boric acid results in decreased expression of BAX mRNA
[boric acid results in increased abundance of Boron] which affects the expression of BAX mRNA; [boric acid results in increased abundance of Boron] which affects the expression of BAX protein
boric acid results in increased expression of BAX mRNA 		CTD PMID:31368021 PMID:33137424 PMID:34175401 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression 		ISO
EXP 		boric acid results in increased expression of BCL2 mRNA
[boric acid results in increased abundance of Boron] which results in decreased expression of BCL2 mRNA; [boric acid results in increased abundance of Boron] which results in decreased expression of BCL2 protein
boric acid results in decreased expression of BCL2 mRNA 		CTD PMID:31368021 PMID:33137424 PMID:34175401 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO boric acid results in decreased expression of BCL2L1 mRNA CTD PMID:34175401 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO boric acid results in increased expression of BID mRNA CTD PMID:34175401 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Calr calreticulin increases expression ISO boric acid results in increased expression of CALR mRNA CTD PMID:27587023 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases expression 		ISO boric acid results in decreased expression of CASP3 mRNA
boric acid inhibits the reaction [Formaldehyde results in increased expression of CASP3 mRNA]
boric acid results in increased expression of CASP3 mRNA 		CTD PMID:31368021 PMID:31823256 PMID:34175401 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 increases expression ISO boric acid results in increased expression of CASP9 mRNA CTD PMID:34175401 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression 		EXP
ISO 		[boric acid co-treated with Arsenic Trioxide] affects the activity of CAT protein; [boric acid results in increased abundance of Boron] inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; boric acid inhibits the reaction [Acrylamide results in increased activity of CAT protein]
boric acid affects the reaction [Formaldehyde results in decreased activity of CAT protein]
boric acid results in decreased activity of CAT protein
boric acid results in decreased expression of CAT protein 		CTD PMID:26184899 PMID:29913234 PMID:30997025 PMID:31823256 PMID:37045926 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of CCND1 protein]
boric acid results in increased expression of CCND1 mRNA 		CTD PMID:28285642 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA protein]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA protein]] CTD PMID:28285642 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA] CTD PMID:28285642 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Col1a2 collagen type I alpha 2 chain affects expression ISO boric acid affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO boric acid results in increased expression of CSF2 protein CTD PMID:27206737 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Csf3 colony stimulating factor 3 increases expression ISO boric acid results in increased expression of CSF3 protein CTD PMID:27206737 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Cst3 cystatin C multiple interactions EXP [boric acid results in increased abundance of Boron] inhibits the reaction [Acetaminophen results in increased expression of CST3 protein] CTD PMID:35020164 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of CTNNB1 protein]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA protein]]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG protein]] CTD PMID:28285642 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression ISO boric acid results in decreased expression of DDIT3 mRNA; boric acid results in decreased expression of DDIT3 protein CTD PMID:27587023 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Des desmin affects expression ISO boric acid affects the expression of DES mRNA CTD PMID:25637568 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA] CTD PMID:28285642 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:55,222,056...55,231,506 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO boric acid results in increased expression of EDEM1 mRNA CTD PMID:27587023 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO EIF2AK3 protein affects the reaction [boric acid affects the localization of NFE2L2 protein]; EIF2AK3 protein affects the reaction [boric acid results in increased expression of GCLC mRNA]; EIF2AK3 protein affects the reaction [boric acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:30196486 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions 		ISO boric acid results in increased phosphorylation of EIF2S1 protein
EIF2AK3 protein affects the reaction [boric acid results in increased phosphorylation of EIF2S1 protein] 		CTD PMID:25425213 PMID:27587023 PMID:30196486 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]] CTD PMID:28285642 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FASN mRNA] CTD PMID:28285642 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO boric acid promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FGF2 protein] CTD PMID:28285642 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fgf7 fibroblast growth factor 7 increases expression ISO boric acid results in increased expression of FGF7 protein CTD PMID:27206737 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328 		JBrowse link
G Fn1 fibronectin 1 increases expression
affects expression 		ISO boric acid results in increased expression of FN1 mRNA
boric acid affects the expression of FN1 mRNA 		CTD PMID:27206737 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression ISO boric acid results in decreased expression of GAPDH protein CTD PMID:28285642 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377 		JBrowse link
G Gas6 growth arrest specific 6 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein] CTD PMID:28285642 NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088 		JBrowse link
G Gck glucokinase increases expression ISO boric acid results in increased expression of GCK mRNA CTD PMID:31368021 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression 		ISO EIF2AK3 protein affects the reaction [boric acid results in increased expression of GCLC mRNA] CTD PMID:30196486 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression EXP boric acid results in increased expression of GOT1 protein CTD PMID:37045926 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression 		EXP [boric acid results in increased abundance of Boron] inhibits the reaction [bisphenol A results in increased expression of GPT protein]
boric acid results in increased expression of GPT protein 		CTD PMID:30997025 PMID:37045926 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP boric acid inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of GPX4 mRNA]; boric acid inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of GPX4 protein] CTD PMID:38108610 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [boric acid results in increased abundance of Boron] inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] CTD PMID:35020164 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO boric acid results in increased expression of HERPUD1 mRNA CTD PMID:27587023 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO boric acid results in increased expression of HMOX1 mRNA CTD PMID:30196486 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hoxa6 homeobox A6 affects expression EXP boric acid affects the expression of HOXA6 mRNA CTD PMID:12749385 NCBI chr 4:82,637,024...82,639,463 JBrowse link
G Hoxc6 homeo box C6 affects expression EXP boric acid affects the expression of HOXC6 mRNA CTD PMID:12749385 NCBI chr 7:136,013,679...136,051,601
Ensembl chr 7:136,024,961...136,027,365 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO boric acid results in increased expression of HSPA5 mRNA; boric acid results in increased expression of HSPA5 protein CTD PMID:25425213 PMID:27587023 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [boric acid results in increased abundance of Boron] promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased secretion of IFNG protein]; [boric acid results in increased abundance of Boron] which affects the secretion of IFNG protein; [Food Preservatives results in increased abundance of boric acid] which results in increased expression of IFNG mRNA; boric acid inhibits the reaction [Acrylamide results in increased expression of IFNG mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IFNG mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IFNG protein] CTD PMID:29913234 PMID:30368975 PMID:32179172 PMID:33137424 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [boric acid results in increased abundance of Boron] inhibits the reaction [bisphenol A results in decreased expression of IL10 mRNA]; [Food Preservatives results in increased abundance of boric acid] which results in increased expression of IL10 mRNA CTD PMID:30997025 PMID:32179172 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP [boric acid results in increased abundance of Boron] inhibits the reaction [Acetaminophen results in increased expression of IL18 protein] CTD PMID:35020164 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [boric acid results in increased abundance of Boron] inhibits the reaction [bisphenol A results in increased expression of IL1B mRNA]; [Food Preservatives results in increased abundance of boric acid] which results in increased expression of IL1B mRNA; boric acid inhibits the reaction [Acrylamide results in increased expression of IL1B mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein] CTD PMID:29913234 PMID:30368975 PMID:30997025 PMID:32179172 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP [boric acid results in increased abundance of Boron] promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased secretion of IL2 protein]; [boric acid results in increased abundance of Boron] which results in decreased secretion of IL2 protein CTD PMID:33137424 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions 		ISO
EXP 		boric acid results in increased expression of IL4 mRNA
[boric acid results in increased abundance of Boron] which affects the secretion of IL4 protein 		CTD PMID:31368021 PMID:33137424 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		boric acid promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of IL6 mRNA]
[boric acid results in increased abundance of Boron] inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; [Food Preservatives results in increased abundance of boric acid] which results in increased expression of IL6 mRNA 		CTD PMID:28285642 PMID:30997025 PMID:32179172 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 increases expression ISO boric acid results in increased expression of INS1 mRNA CTD PMID:31368021 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression 		ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of CCND1 protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of CTNNB1 protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of AGT mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FASN mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SLC2A4 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SLC2A4 protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; boric acid promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FGF2 protein]; boric acid promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of IL6 mRNA]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA protein]]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG protein]]
boric acid results in increased expression of INS2 mRNA 		CTD PMID:28285642 PMID:31368021 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Klf5 KLF transcription factor 5 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA] CTD PMID:28285642 NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262 		JBrowse link
G Lama5 laminin subunit alpha 5 increases expression ISO boric acid results in increased expression of LAMA5 mRNA CTD PMID:27206737 NCBI chr 3:187,647,904...187,695,974
Ensembl chr 3:187,647,904...187,696,173 		JBrowse link
G Lep leptin multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA]; boric acid results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:28285642 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LIPE mRNA] CTD PMID:28285642 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:28285642 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:28285642 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mir130a microRNA 130a decreases expression ISO boric acid results in decreased expression of MIR130A mRNA CTD PMID:34175401 NCBI chr 3:90,229,228...90,229,315 JBrowse link
G Mir200a microRNA 200a decreases expression ISO boric acid results in decreased expression of MIR200A mRNA CTD PMID:34175401 NCBI chr 5:171,930,717...171,930,805 JBrowse link
G Mir21 microRNA 21 decreases expression ISO boric acid results in decreased expression of MIR21 mRNA CTD PMID:34175401 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir224 microRNA 224 decreases expression ISO boric acid results in decreased expression of MIR224 mRNA CTD PMID:34175401 NCBI chr  X:155,107,130...155,107,211 JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO boric acid results in decreased expression of MMP2 protein CTD PMID:28285642 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Myh1 myosin heavy chain 1 affects expression ISO boric acid affects the expression of MYH1 mRNA CTD PMID:25637568 NCBI chr10:52,384,810...52,408,698
Ensembl chr10:52,384,908...52,409,047 		JBrowse link
G Myod1 myogenic differentiation 1 affects expression
decreases expression 		ISO boric acid affects the expression of MYOD1 mRNA
boric acid results in decreased expression of MYOD1 protein 		CTD PMID:25637568 NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871 		JBrowse link
G Myog myogenin affects expression ISO boric acid affects the expression of MYOG mRNA CTD PMID:25637568 NCBI chr13:48,297,476...48,300,065
Ensembl chr13:48,297,235...48,300,065 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions 		ISO boric acid affects the localization of NFE2L2 protein
EIF2AK3 protein affects the reaction [boric acid affects the localization of NFE2L2 protein] 		CTD PMID:30196486 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
affects expression 		ISO
EXP 		boric acid affects the reaction [Formaldehyde results in increased expression of NFKB1 mRNA]
boric acid results in increased expression of NFKB1 mRNA
boric acid affects the expression of NFKB1 mRNA 		CTD PMID:31823256 PMID:37045926 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO boric acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:27206737 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO boric acid results in increased expression of NQO1 mRNA CTD PMID:30196486 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions 		EXP boric acid results in increased expression of PCNA protein
[boric acid results in increased abundance of Boron] promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of PCNA protein]; [boric acid results in increased abundance of Boron] which affects the expression of PCNA protein; [boric acid results in increased abundance of Boron] which results in decreased expression of PCNA mRNA 		CTD PMID:17943231 PMID:33137424 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO boric acid results in increased expression of PDX1 mRNA CTD PMID:31368021 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG protein]; CTNNB1 protein promotes the reaction [boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG protein]] CTD PMID:28285642 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO boric acid results in increased expression of PPP1R15A mRNA; boric acid results in increased expression of PPP1R15A protein CTD PMID:27587023 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO boric acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27206737 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP boric acid inhibits the reaction [Acrylamide results in increased expression of RELA mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of RELA mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein] CTD PMID:29913234 PMID:30368975 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO boric acid affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO boric acid results in increased expression of SLC2A2 mRNA CTD PMID:31368021 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SLC2A4 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SLC2A4 protein] CTD PMID:28285642 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Slc4a2 solute carrier family 4 member 2 increases expression ISO boric acid results in increased expression of SLC4A2 mRNA CTD PMID:22576912 NCBI chr 4:11,628,860...11,646,961
Ensembl chr 4:11,628,862...11,645,402 		JBrowse link
G Slc4a3 solute carrier family 4 member 3 increases expression ISO boric acid results in increased expression of SLC4A3 mRNA CTD PMID:22576912 NCBI chr 9:84,484,749...84,497,746
Ensembl chr 9:84,485,085...84,497,738 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP boric acid results in decreased expression of SOD1 protein CTD PMID:37045926 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression ISO boric acid affects the expression of SPARC mRNA CTD PMID:24704097 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of SREBF1 mRNA] CTD PMID:28285642 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Syvn1 synoviolin 1 decreases expression ISO boric acid results in decreased expression of SYVN1 mRNA CTD PMID:27587023 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457 		JBrowse link
G Tfrc transferrin receptor multiple interactions EXP boric acid inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of TFRC mRNA]; boric acid inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of TFRC protein] CTD PMID:38108610 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO boric acid results in increased expression of TGFB1 protein
boric acid results in increased expression of TGFB1 mRNA 		CTD PMID:27206737 PMID:31368021 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP boric acid results in increased expression of TLR2 mRNA CTD PMID:37045926 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression EXP boric acid results in increased expression of TLR4 mRNA CTD PMID:37045926 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
increases secretion 		ISO
EXP 		boric acid inhibits the reaction [Formaldehyde results in increased expression of TNF mRNA]; boric acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; boric acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
boric acid results in increased expression of TNF mRNA
boric acid results in decreased expression of TNF mRNA
[boric acid results in increased abundance of Boron] inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; [Food Preservatives results in increased abundance of boric acid] which results in increased expression of TNF mRNA; boric acid inhibits the reaction [Acrylamide results in increased expression of TNF mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]
boric acid results in increased secretion of TNF protein 		CTD PMID:9618283 PMID:18755394 PMID:29913234 PMID:30368975 PMID:30997025 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein] CTD PMID:28285642 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO boric acid results in decreased expression of TRP53 mRNA CTD PMID:31368021 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO boric acid results in increased expression of XBP1 mRNA CTD PMID:27587023 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        acid 19329
          Bronsted acid 19319
            inorganic acid 16578
              boric acids 103
                boric acid + 100
                metaboric acid 0
                perboric acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      chalcogen 20491
                        oxygen atom 20457
                          oxygen molecular entity 20457
                            hydroxides 20230
                              oxoacid 19289
                                boron oxoacid 909
                                  boric acids 103
                                    boric acid + 100
                                    metaboric acid 0
                                    perboric acid 0
paths to the root