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chemosterilant - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chemosterilant
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Accession:CHEBI:23092 term browser browse the term
Definition:A substance intended to sterilize any organism.
Synonyms:related_synonym: chemosterilants
 xref: Wikipedia:Chemosterilant

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busulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 decreases response to substance ISO ADRB2 protein results in decreased susceptibility to Busulfan CTD PMID:7202579 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Busulfan results in increased expression of AHR mRNA CTD PMID:35641671 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of ANP32B protein CTD PMID:20933509 NCBI chr 5:65,538,872...65,561,305
Ensembl chr 5:60,743,443...60,765,717 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Busulfan CTD PMID:19470598 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Ar androgen receptor multiple interactions ISO Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions
affects response to substance 		ISO ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein]
ARHGDIA mRNA affects the susceptibility to Busulfan 		CTD PMID:17264767 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions 		ISO Busulfan results in increased expression of ATF4 mRNA
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of ATF4 protein] 		CTD PMID:35533795 PMID:35641671 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein CTD PMID:20933509 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions 		ISO Busulfan results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Busulfan results in increased expression of BECN1 protein] 		CTD PMID:38220133 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Busulfan results in decreased expression of BMP4 mRNA CTD PMID:15786497 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP3 protein; [decitabine co-treated with Busulfan] results in increased activity of CASP3 protein; ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] CTD PMID:17264767 PMID:18339423 PMID:19732952 PMID:20933509 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions 		ISO Busulfan results in increased activity of CASP8 protein
[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein] 		CTD PMID:18339423 PMID:19732952 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP9 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP9 protein] CTD PMID:19732952 PMID:20933509 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase decreases expression ISO Busulfan results in decreased expression of CAT protein CTD PMID:38123000 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein CTD PMID:20933509 NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Busulfan results in decreased expression of CDK2 mRNA CTD PMID:15388331 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Busulfan results in decreased expression of CDK4 mRNA CTD PMID:15388331 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions 		ISO Busulfan results in increased expression of CDKN1A protein
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of CDKN1A protein 		CTD PMID:16882877 PMID:20933509 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Busulfan results in increased expression of CDKN2A mRNA CTD PMID:14500376 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein CTD PMID:20933509 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cldn11 claudin 11 multiple interactions
decreases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of CLDN11 protein]
Busulfan results in decreased expression of CLDN11 mRNA; Busulfan results in decreased expression of CLDN11 protein 		CTD PMID:35533795 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Busulfan results in increased expression of COL1A1 mRNA CTD PMID:37597760 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Busulfan results in increased expression of COL3A1 mRNA CTD PMID:37597760 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO Busulfan affects the expression of COL4A1 mRNA CTD PMID:15941629 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Busulfan results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of DDIT3 protein] CTD PMID:35533795 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions 		ISO Busulfan results in increased phosphorylation of EIF2AK3 protein
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein] 		CTD PMID:35533795 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions 		ISO Busulfan results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2S1 protein] 		CTD PMID:35533795 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Faslg Fas ligand decreases expression ISO Busulfan results in decreased expression of FASL mRNA CTD PMID:15388331 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression EXP Busulfan results in decreased expression of FGF8 mRNA CTD PMID:15786497 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO Busulfan results in decreased expression of FSHB protein CTD PMID:38123000 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
decreases expression 		ISO 3-methyladenine inhibits the reaction [Busulfan results in decreased expression of FTH1 protein] CTD PMID:38220133 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gdnf glial cell derived neurotrophic factor affects expression
increases expression 		ISO Busulfan affects the expression of GDNF mRNA
Busulfan results in increased expression of GDNF mRNA 		CTD PMID:20684317 PMID:22082982 PMID:26524245 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
decreases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of GJA1 protein]
Busulfan results in decreased expression of GJA1 mRNA; Busulfan results in decreased expression of GJA1 protein 		CTD PMID:35533795 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions 		ISO Busulfan results in decreased expression of GPX4 mRNA; Busulfan results in decreased expression of GPX4 protein
3-methyladenine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; Busulfan results in decreased expression of and results in decreased activity of GPX4 protein; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 mRNA]; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] 		CTD PMID:32416107 PMID:38220133 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects response to substance
affects metabolic processing
affects abundance
decreases response to substance
multiple interactions 		ISO GSTA1 polymorphism affects the susceptibility to Busulfan
GSTA1 gene polymorphism affects the metabolism of Busulfan; GSTA1 protein affects the metabolism of Busulfan
GSTA1 gene polymorphism affects the abundance of Busulfan
GSTA1 protein results in decreased susceptibility to Busulfan
GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione] 		CTD PMID:8886613 PMID:10437668 PMID:10570028 PMID:12429583 PMID:20672371 More... NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
affects response to substance
affects metabolic processing
affects abundance 		ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan; [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]
GSTM1 gene polymorphism affects the susceptibility to Busulfan
GSTM1 protein affects the metabolism of Busulfan
GSTM1 gene polymorphism affects the abundance of Busulfan 		CTD PMID:8886613 PMID:15142875 PMID:19584821 PMID:20672371 PMID:21215809 More... NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
affects abundance 		ISO GSTP1 protein affects the metabolism of Busulfan
GSTP1 gene polymorphism affects the abundance of Busulfan 		CTD PMID:8886613 PMID:20672371 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan CTD PMID:21215809 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions 		ISO Busulfan results in increased phosphorylation of H2AX protein
[Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein 		CTD PMID:18339423 PMID:20933509 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Busulfan results in increased expression of HIF1A mRNA CTD PMID:35641671 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of HSPA5 protein] CTD PMID:35533795 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Inhba inhibin subunit beta A multiple interactions
increases expression 		ISO bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA mRNA]; bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA protein]
Busulfan results in increased expression of INHBA mRNA; Busulfan results in increased expression of INHBA protein 		CTD PMID:12966370 PMID:22286157 NCBI chr17:53,787,159...53,810,942
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Busulfan results in decreased expression of KIT mRNA CTD PMID:15388331 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO Busulfan affects the expression of LAMA1 mRNA CTD PMID:15941629 NCBI chr 9:115,139,548...115,263,620
Ensembl chr 9:107,692,770...107,817,478 		JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO Busulfan affects the expression of LAMA4 mRNA CTD PMID:15941629 NCBI chr20:43,946,898...44,087,972
Ensembl chr20:42,392,268...42,533,347 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO Busulfan results in decreased expression of LHB protein CTD PMID:38123000 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions 		ISO Busulfan results in increased expression of MAP1LC3B protein
3-methyladenine inhibits the reaction [Busulfan results in increased expression of MAP1LC3B protein] 		CTD PMID:38220133 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Busulfan results in increased activity of MAPK1 protein CTD PMID:16882877 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Busulfan results in increased activity of MAPK3 protein CTD PMID:16882877 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases response to substance ISO MGST2 protein results in decreased susceptibility to Busulfan CTD PMID:15779864 NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 decreases expression ISO Busulfan results in decreased expression of MTF1 mRNA CTD PMID:35641671 NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of MYC protein CTD PMID:20933509 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nanos2 nanos C2HC-type zinc finger 2 decreases expression ISO Busulfan results in decreased expression of NANOS2 mRNA; Busulfan results in decreased expression of NANOS2 protein CTD PMID:26524245 NCBI chr 1:87,763,716...87,765,176
Ensembl chr 1:78,635,668...78,637,128 		JBrowse link
G Nanos3 nanos C2HC-type zinc finger 3 decreases expression ISO Busulfan results in decreased expression of NANOS3 mRNA CTD PMID:26524245 NCBI chr19:23,978,465...23,988,933
Ensembl chr19:23,985,504...23,988,932 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 increases expression
multiple interactions 		ISO Busulfan results in increased expression of NCOA4 protein
3-methyladenine inhibits the reaction [Busulfan results in increased expression of NCOA4 protein] 		CTD PMID:38220133 NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
decreases expression 		ISO Deferoxamine inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]
Busulfan results in increased expression of NFE2L2 mRNA 		CTD PMID:32416107 PMID:35641671 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Busulfan results in increased expression of NFKB1 mRNA CTD PMID:35641671 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] CTD PMID:20172040 NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645
Ensembl chr  X:17,739,941...17,751,645 		JBrowse link
G Ocln occludin decreases expression
multiple interactions 		ISO Busulfan results in decreased expression of OCLN mRNA; Busulfan results in decreased expression of OCLN protein
4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of OCLN protein] 		CTD PMID:35533795 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage 		ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; [decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]
Busulfan results in increased cleavage of PARP1 protein 		CTD PMID:18339423 PMID:19732952 PMID:20933509 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Phb1 prohibitin 1 affects expression ISO Busulfan affects the expression of PHB1 mRNA CTD PMID:15388331 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Busulfan affects the expression of PPARG mRNA CTD PMID:35641671 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		ISO Busulfan results in increased expression of PTGS2 mRNA
ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA] 		CTD PMID:12966370 PMID:32416107 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pus7 pseudouridine synthase 7 increases expression ISO Busulfan results in increased expression of PUS7 mRNA CTD PMID:34097952 NCBI chr 4:11,360,169...11,401,139
Ensembl chr 4:11,360,188...11,401,172 		JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Busulfan results in decreased expression of RAD51 mRNA CTD PMID:15388331 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Busulfan results in decreased phosphorylation of RB1 protein CTD PMID:15388331 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 increases expression ISO Busulfan results in increased expression of SAT2 mRNA; Busulfan results in increased expression of SAT2 protein CTD PMID:28578006 NCBI chr10:54,839,531...54,841,651
Ensembl chr10:54,340,372...54,343,224 		JBrowse link
G Serpinc1 serpin family C member 1 affects expression ISO Busulfan affects the expression of SERPINC1 protein CTD PMID:15580502 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions 		ISO Busulfan results in increased expression of SERPINE1 mRNA; Busulfan results in increased expression of SERPINE1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA] 		CTD PMID:22286157 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions
decreases expression 		ISO Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein] CTD PMID:32416107 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
decreases expression 		ISO 3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein]; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC7A11 mRNA]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein]
Busulfan results in decreased expression of SLC7A11 mRNA; Busulfan results in decreased expression of SLC7A11 protein 		CTD PMID:38220133 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein CTD PMID:20933509 NCBI chr  X:24,582,732...24,627,462
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC3 protein CTD PMID:20933509 NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:252,601,753...252,644,522 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression 		ISO 3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SQSTM1 protein] CTD PMID:38220133 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO Busulfan affects the expression of STAT1 mRNA CTD PMID:35641671 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 decreases expression ISO Busulfan results in decreased expression of STAT2 mRNA CTD PMID:35641671 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967 		JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression ISO Busulfan results in decreased expression of STRA8 mRNA CTD PMID:15388331 NCBI chr 4:64,568,580...64,591,914
Ensembl chr 4:63,601,604...63,624,771 		JBrowse link
G Tf transferrin increases expression
multiple interactions 		ISO Busulfan results in increased expression of TF mRNA; Busulfan results in increased expression of TF protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of TF mRNA] 		CTD PMID:12966370 PMID:22286157 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Busulfan results in decreased expression of TFPI mRNA CTD PMID:22286157 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Tfrc transferrin receptor multiple interactions
decreases expression 		ISO Deferoxamine promotes the reaction [Busulfan results in decreased expression of TFRC protein] CTD PMID:32416107 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions 		ISO Busulfan results in increased expression of TGFB1 mRNA
pirfenidone inhibits the reaction [Busulfan results in increased expression of TGFB1 mRNA] 		CTD PMID:22286157 PMID:37597760 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Busulfan results in increased expression of THBS1 mRNA CTD PMID:22286157 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Busulfan results in increased expression of TIMP1 mRNA CTD PMID:37597760 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Busulfan results in increased expression of TNF mRNA CTD PMID:22286157 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO Busulfan affects the phosphorylation of and affects the activity of TP53 protein
Busulfan results in increased expression of TP53 mRNA 		CTD PMID:16882877 PMID:35641671 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP Busulfan results in decreased activity of TXNRD1 protein CTD PMID:16085187 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Xbp1 X-box binding protein 1 affects expression ISO Busulfan affects the expression of XBP1 mRNA CTD PMID:35641671 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein CTD PMID:20933509 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 increases expression ISO Busulfan results in increased expression of ZBTB16 mRNA CTD PMID:26524245 NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:48,994,566...49,177,011 		JBrowse link
diflubenzuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Diflubenzuron results in increased expression of CYP1A1 protein CTD PMID:8812189 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO Diflubenzuron binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects binding ISO Diflubenzuron binds to CYP3A4 protein CTD PMID:32278787 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diflubenzuron results in increased expression of CYP3A23-3A1 protein CTD PMID:8812189 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Diflubenzuron results in increased activity of NR1I2 protein CTD PMID:16565514 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
hexamethylphosphoric triamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions 		ISO CYP2A13 protein results in increased metabolism of Hempa
CYP2A13 gene polymorphism inhibits the reaction [CYP2A13 protein results in increased metabolism of Hempa] 		CTD PMID:18669584 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
Term paths to the root
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  CHEBI ontology 19887
    role 19858
      application 19697
        pesticide 18082
          chemosterilant 96
            insect sterilant + 96
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