Cldn11 (claudin 11) - Rat Genome Database

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Gene: Cldn11 (claudin 11) Rattus norvegicus
Analyze
Symbol: Cldn11
Name: claudin 11
RGD ID: 71081
Description: Predicted to enable identical protein binding activity. Predicted to be involved in bicellular tight junction assembly and calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules. Predicted to act upstream of or within axon ensheathment and spermatogenesis. Predicted to be located in several cellular components, including lipid droplet; neurofilament; and tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 22. Orthologous to human CLDN11 (claudin 11); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: claudin-11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,136,234 - 114,149,539 (-)NCBIGRCr8
mRatBN7.22112,207,745 - 112,221,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,207,745 - 112,221,050 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,854,213 - 118,867,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02116,966,771 - 116,980,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,676,502 - 111,689,756 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,823,541 - 115,836,846 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,823,538 - 115,836,846 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02135,520,050 - 135,533,355 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,626,427 - 116,639,732 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12116,571,388 - 116,584,694 (-)NCBI
Celera2107,394,882 - 107,408,187 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,4-dichloroaniline  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
busulfan  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbendazim  (EXP)
CGP 52608  (ISO)
chromium(6+)  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
flavonoids  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
haloperidol  (ISO)
hydrogen sulfide  (ISO)
iprodione  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
Salidroside  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium sulfide (anhydrous)  (ISO)
stigmasterol  (ISO)
streptozocin  (ISO)
sulfur dioxide  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IEA,ISO)
basal part of cell  (IEA,ISO)
bicellular tight junction  (IBA,IEA,ISO,ISS,TAS)
cell junction  (ISO)
lipid droplet  (IEA,ISO)
neurofilament  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
tight junction  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11. Lui WY, etal., Endocrinology 2001 May;142(5):1865-77.
3. Gene Data Set MGD Curation, June 12, 2002
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10612400   PMID:12477932   PMID:15591150   PMID:17634366   PMID:18036336   PMID:18308723   PMID:20375010   PMID:22871113   PMID:23376485   PMID:23789093   PMID:25666991   PMID:26060893  
PMID:26585695   PMID:27164517   PMID:29476059   PMID:30734065   PMID:32196966  


Genomics

Comparative Map Data
Cldn11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,136,234 - 114,149,539 (-)NCBIGRCr8
mRatBN7.22112,207,745 - 112,221,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,207,745 - 112,221,050 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,854,213 - 118,867,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02116,966,771 - 116,980,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,676,502 - 111,689,756 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,823,541 - 115,836,846 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,823,538 - 115,836,846 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02135,520,050 - 135,533,355 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,626,427 - 116,639,732 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12116,571,388 - 116,584,694 (-)NCBI
Celera2107,394,882 - 107,408,187 (-)NCBICelera
Cytogenetic Map2q24NCBI
CLDN11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383170,418,868 - 170,434,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3170,418,868 - 170,454,733 (+)EnsemblGRCh38hg38GRCh38
GRCh373170,136,656 - 170,152,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363171,619,359 - 171,634,581 (+)NCBINCBI36Build 36hg18NCBI36
Build 343171,619,366 - 171,634,585NCBI
Celera3168,535,836 - 168,551,662 (+)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3167,506,076 - 167,521,977 (+)NCBIHuRef
CHM1_13170,099,809 - 170,115,631 (+)NCBICHM1_1
T2T-CHM13v2.03173,203,212 - 173,219,032 (+)NCBIT2T-CHM13v2.0
Cldn11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39331,204,069 - 31,218,475 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl331,204,069 - 31,218,473 (+)EnsemblGRCm39 Ensembl
GRCm38331,149,920 - 31,164,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl331,149,920 - 31,164,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv37331,048,913 - 31,063,240 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36331,340,869 - 31,355,196 (+)NCBIMGSCv36mm8
Celera331,063,978 - 31,078,367 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.14NCBI
Cldn11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955420580,588 - 595,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955420580,588 - 595,052 (+)NCBIChiLan1.0ChiLan1.0
CLDN11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,313,680 - 168,328,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13168,318,403 - 168,333,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03167,432,856 - 167,448,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13175,621,472 - 175,636,782 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3175,621,472 - 175,908,350 (+)Ensemblpanpan1.1panPan2
CLDN11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13434,912,903 - 34,929,441 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3434,912,449 - 34,928,433 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3443,924,891 - 43,941,855 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03434,994,383 - 35,011,477 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3434,994,046 - 35,011,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13434,937,785 - 34,954,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03434,907,493 - 34,924,620 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,171,151 - 35,187,831 (+)NCBIUU_Cfam_GSD_1.0
Cldn11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602101,534,109 - 101,549,597 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365932,071,882 - 2,087,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365932,072,368 - 2,087,820 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13109,075,452 - 109,090,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113109,075,672 - 109,089,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213117,956,912 - 117,970,337 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11518,991,734 - 19,006,902 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1518,991,042 - 19,006,866 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606327,767,141 - 27,782,304 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473048,458,512 - 48,474,734 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473048,458,593 - 48,473,463 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cldn11
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:397
Count of miRNA genes:226
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000014359
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat

Markers in Region
RH128644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,207,883 - 112,208,091 (+)MAPPERmRatBN7.2
Rnor_6.02115,823,680 - 115,823,887NCBIRnor6.0
Rnor_5.02135,520,189 - 135,520,396UniSTSRnor5.0
RGSC_v3.42116,626,566 - 116,626,773UniSTSRGSC3.4
Celera2107,395,021 - 107,395,228UniSTS
RH 3.4 Map2718.1UniSTS
Cytogenetic Map2q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 58 20 32 6
Low 2 39 19 5 15 5 7 7 16 15 9 5 7
Below cutoff 1 3 22 22 4 22 1 2 1

Sequence


RefSeq Acc Id: ENSRNOT00000014359   ⟹   ENSRNOP00000014359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2112,207,745 - 112,221,050 (-)Ensembl
Rnor_6.0 Ensembl2115,823,538 - 115,836,846 (-)Ensembl
RefSeq Acc Id: NM_053457   ⟹   NP_445909
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,136,234 - 114,149,539 (-)NCBI
mRatBN7.22112,207,745 - 112,221,050 (-)NCBI
Rnor_6.02115,823,541 - 115,836,846 (-)NCBI
Rnor_5.02135,520,050 - 135,533,355 (-)NCBI
RGSC_v3.42116,626,427 - 116,639,732 (-)RGD
Celera2107,394,882 - 107,408,187 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445909 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG50277 (Get FASTA)   NCBI Sequence Viewer  
  AAH70927 (Get FASTA)   NCBI Sequence Viewer  
  AAK52076 (Get FASTA)   NCBI Sequence Viewer  
  EDM01147 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014359
  ENSRNOP00000014359.3
GenBank Protein Q99P82 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445909   ⟸   NM_053457
- UniProtKB: Q99P82 (UniProtKB/Swiss-Prot),   Q6IRG7 (UniProtKB/TrEMBL),   F7FQF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014359   ⟸   ENSRNOT00000014359

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99P82-F1-model_v2 AlphaFold Q99P82 1-207 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691271
Promoter ID:EPDNEW_R1796
Type:initiation region
Name:Cldn11_1
Description:claudin 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02115,836,855 - 115,836,915EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71081 AgrOrtholog
BioCyc Gene G2FUF-53478 BioCyc
Ensembl Genes ENSRNOG00000010263 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014359 ENTREZGENE
  ENSRNOT00000014359.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096642 IMAGE-MGC_LOAD
InterPro Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Claudin11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Claudin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84588 UniProtKB/TrEMBL
MGC_CLONE MGC:91580 IMAGE-MGC_LOAD
NCBI Gene 84588 ENTREZGENE
PANTHER PTHR12002 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12002:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cldn11 PhenoGen
PRINTS CLAUDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLAUDIN11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010263 RatGTEx
UniProt CLD11_RAT UniProtKB/Swiss-Prot
  F7FQF2 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRG7 ENTREZGENE, UniProtKB/TrEMBL
  Q99P82 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Cldn11  claudin 11      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression decreases in response to TGF-beta3 70685