bleomycin A2 - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	bleomycin A2	go back to main search page
Accession:	CHEBI:3139	browse the term
Definition:	A bleomycin that has formula C55H84N17O21S3.
Synonyms:	exact_synonym:	(betaR)-N(alpha)-{[6-amino-2-((1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl)-5-methylpyrimidin-4-yl]carbonyl}-beta-{2-O-[3-O-(aminocarbonyl)-alpha-D-mannopyranosyl]-alpha-L-gulopyranosyloxy}-N-[(1R,2S,3S)-5-({(1S,2R)-1-[({2-[4-({[3-(dimethylsulfonio)propyl]amino}carbonyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}amino)carbonyl]-2-hydroxypropyl}amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl]-L-histidinamide
	related_synonym:	Bleomycin; C55H84N17O21S3; InChI=1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29-,30+,34-,35-,36-,37+,38+,39-,40-,41-,42-,43-,53+,54-/m0/s1; InChIKey=OYVAGSVQBOHSSS-UAPAGMARSA-O; N(1)-[3-(dimethylsulfonio)propyl]bleomycinamide; [H][C@](C)(NC(=O)[C@@]([H])(NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@]([H])(O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)c1c[nH]cn1)[C@@H](O)[C@H](C)C(=O)N[C@]([H])(C(=O)NCCc1nc(cs1)-c1nc(cs1)C(=O)NCCC[S+](C)C)[C@@]([H])(C)O
	alt_id:	CHEBI:165316; CHEBI:357107; CHEBI:41102; CHEBI:653800
	xref_casrn:	11056-06-7; 11116-31-7
	xref:	Beilstein:4379083 "Beilstein Registry Number"; ChEMBL:12477361 "PubMed citation"; ChEMBL:165316 "ChEMBL COMPOUND"; ChEMBL:357107 "ChEMBL COMPOUND"; ChEMBL:527010 "ChEMBL COMPOUND"; ChEMBL:653800 "ChEMBL COMPOUND"; ChemIDplus:11116-31-7 "CAS Registry Number"; Gmelin:1667354 "Gmelin Registry Number"; KEGG COMPOUND:11056-06-7 "CAS Registry Number"; KEGG COMPOUND:C06854 "KEGG COMPOUND"
	xref_mesh:	MESH:D001761
	xref:	PDBeChem:BLM "PDBeChem"; Wikipedia:Bleomycin "Wikipedia"

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bleomycin A2
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Adam17	ADAM metallopeptidase domain 17		multiple interactions	ISO	6	41,882,432	41,930,755	RGD:6480464	CTD
G	Adra1b	adrenoceptor alpha 1B		decreases expression	EXP	10	28,889,092	28,946,889	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		increases phosphorylation	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Aqp1	aquaporin 1		decreases expression	EXP	4	84,098,346	84,110,524	RGD:6480464	CTD
G	Avpr1a	arginine vasopressin receptor 1A		decreases expression	EXP	7	62,225,537	62,229,461	RGD:6480464	CTD
G	Birc2	baculoviral IAP repeat-containing 2		decreases response to substance	ISO	8	4,649,559	4,667,733	RGD:6480464	CTD
G	Birc2	baculoviral IAP repeat-containing 2		increases expression	EXP	8	4,649,559	4,667,733	RGD:6480464	CTD
G	Blmh	bleomycin hydrolase		affects response to substance	ISO	10	67,195,276	67,238,359	RGD:6480464	CTD
G	Bscl2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)		increases expression	ISO	1	211,509,675	211,518,963	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	EXP	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases activity	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp9	caspase 9, apoptosis-related cysteine peptidase		multiple interactions	EXP	5	160,704,234	160,721,796	RGD:6480464	CTD
G	Casp9	caspase 9, apoptosis-related cysteine peptidase		increases activity	ISO	5	160,704,234	160,721,796	RGD:6480464	CTD
G	Cat	catalase		increases response to substance	ISO	3	88,654,077	88,686,212	RGD:6480464	CTD
G	Cckar	cholecystokinin A receptor		decreases expression	EXP	14	62,052,510	62,057,201	RGD:6480464	CTD
G	Ccl11	chemokine (C-C motif) ligand 11		increases expression	ISO	10	70,279,161	70,283,762	RGD:6480464	CTD
G	Ccl11	chemokine (C-C motif) ligand 11		decreases response to substance	ISO	10	70,279,161	70,283,762	RGD:6480464	CTD
G	Ccl11	chemokine (C-C motif) ligand 11		multiple interactions	ISO	10	70,279,161	70,283,762	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccr2	chemokine (C-C motif) receptor 2		multiple interactions	ISO	8	128,892,784	128,893,905	RGD:6480464	CTD
G	Ccr2	chemokine (C-C motif) receptor 2		decreases response to substance	ISO	8	128,892,784	128,893,905	RGD:6480464	CTD
G	Ccr3	chemokine (C-C motif) receptor 3		increases expression	ISO	8	128,759,943	128,769,341	RGD:6480464	CTD
G	Cebpb	CCAAT/enhancer binding protein (C/EBP), beta		increases expression	ISO	3	158,826,021	158,827,848	RGD:6480464	CTD
G	Cebpb	CCAAT/enhancer binding protein (C/EBP), beta		decreases response to substance	ISO	3	158,826,021	158,827,848	RGD:6480464	CTD
G	Cebpb	CCAAT/enhancer binding protein (C/EBP), beta		multiple interactions	ISO	3	158,826,021	158,827,848	RGD:6480464	CTD
G	Cebpb	CCAAT/enhancer binding protein (C/EBP), beta		increases response to substance	ISO	3	158,826,021	158,827,848	RGD:6480464	CTD
G	Chrnb2	cholinergic receptor, nicotinic, beta 2 (neuronal)		decreases expression	EXP	2	181,961,373	181,969,581	RGD:6480464	CTD
G	Clcn5	chloride channel, voltage-sensitive 5		increases expression	EXP	X	27,383,769	27,409,877	RGD:6480464	CTD
G	Cnr1	cannabinoid receptor 1 (brain)		decreases expression	EXP	5	50,427,173	50,445,471	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		increases expression	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		increases expression	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		multiple interactions	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		increases expression	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		increases expression	EXP	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		multiple interactions	EXP	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		multiple interactions	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		increases expression	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		multiple interactions	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		increases expression	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a2	collagen, type I, alpha 2		increases expression	ISO	4	29,393,645	29,428,572	RGD:6480464	CTD
G	Col1a2	collagen, type I, alpha 2		multiple interactions	ISO	4	29,393,645	29,428,572	RGD:6480464	CTD
G	Cp	ceruloplasmin (ferroxidase)		multiple interactions	ISO	2	105,086,278	105,135,367	RGD:6480464	CTD
G	Cp	ceruloplasmin (ferroxidase)		increases expression	ISO	2	105,086,278	105,135,367	RGD:6480464	CTD
G	Csf2	colony stimulating factor 2 (granulocyte-macrophage)		increases expression	ISO	10	39,665,850	39,667,831	RGD:6480464	CTD
G	Csf3	colony stimulating factor 3 (granulocyte)		decreases expression	EXP	10	87,473,990	87,476,365	RGD:6480464	CTD
G	Ctgf	connective tissue growth factor		increases expression	ISO	1	21,327,099	21,330,215	RGD:6480464	CTD
G	Ctgf	connective tissue growth factor		multiple interactions	ISO	1	21,327,099	21,330,215	RGD:6480464	CTD
G	Ctss	cathepsin S		increases expression	ISO	2	190,425,290	190,466,877	RGD:6480464	CTD
G	Cxcl2	chemokine (C-X-C motif) ligand 2		increases expression	ISO	14	18,677,129	18,679,175	RGD:6480464	CTD
G	Cxcl2	chemokine (C-X-C motif) ligand 2		increases expression	ISO	14	18,677,129	18,679,175	RGD:6480464	CTD
G	Cxcl2	chemokine (C-X-C motif) ligand 2		increases secretion	ISO	14	18,677,129	18,679,175	RGD:6480464	CTD
G	Cycs	cytochrome c, somatic		affects localization	EXP	4	78,825,878	78,827,978	RGD:6480464	CTD
G	Dnmt1	DNA (cytosine-5-)-methyltransferase 1		affects response to substance	ISO	8	19,926,995	19,973,256	RGD:6480464	CTD
G	Egr1	early growth response 1		increases expression	ISO	18	27,343,919	27,346,117	RGD:6480464	CTD
G	Egr1	early growth response 1		multiple interactions	ISO	18	27,343,919	27,346,117	RGD:6480464	CTD
G	Faslg	Fas ligand (TNF superfamily, member 6)		increases expression	ISO	13	77,472,950	77,480,210	RGD:6480464	CTD
G	Fos	FBJ osteosarcoma oncogene		increases activity	ISO	6	109,559,135	109,562,001	RGD:6480464	CTD
G	Fshr	follicle stimulating hormone receptor		decreases expression	EXP	6	12,925,894	13,161,215	RGD:6480464	CTD
G	Gabra4	gamma-aminobutyric acid (GABA) A receptor, alpha 4		decreases expression	EXP	14	39,047,461	39,122,531	RGD:6480464	CTD
G	Gabrb2	gamma-aminobutyric acid (GABA) A receptor, beta 2		decreases expression	EXP	10	27,602,085	27,819,145	RGD:6480464	CTD
G	Gabrg2	gamma-aminobutyric acid (GABA) A receptor, gamma 2		decreases expression	EXP	10	27,037,561	27,126,074	RGD:6480464	CTD
G	Gabrr1	gamma-aminobutyric acid (GABA) A receptor, rho 1		decreases expression	EXP	5	49,421,463	49,458,535	RGD:6480464	CTD
G	Gria2	glutamate receptor, ionotropic, AMPA 2		decreases expression	EXP	2	172,265,155	172,385,285	RGD:6480464	CTD
G	Grik3	glutamate receptor, ionotropic, kainate 3		decreases expression	EXP	5	144,842,374	145,058,047	RGD:6480464	CTD
G	Grpr	gastrin releasing peptide receptor		decreases expression	EXP	X	51,743,248	51,783,255	RGD:6480464	CTD
G	Gsk3b	glycogen synthase kinase 3 beta		multiple interactions	ISO	11	64,284,731	64,428,698	RGD:6480464	CTD
G	Gsk3b	glycogen synthase kinase 3 beta		increases phosphorylation	ISO	11	64,284,731	64,428,698	RGD:6480464	CTD
G	Hbegf	heparin-binding EGF-like growth factor		increases expression	ISO	18	29,143,567	29,153,944	RGD:6480464	CTD
G	Hgf	hepatocyte growth factor		decreases expression	EXP	4	14,864,357	14,932,513	RGD:6480464	CTD
G	Hgf	hepatocyte growth factor		multiple interactions	EXP	4	14,864,357	14,932,513	RGD:6480464	CTD
G	Hgf	hepatocyte growth factor		increases secretion	ISO	4	14,864,357	14,932,513	RGD:6480464	CTD
G	Hgf	hepatocyte growth factor		increases expression	ISO	4	14,864,357	14,932,513	RGD:6480464	CTD
G	Hmox1	heme oxygenase (decycling) 1		increases expression	ISO	19	13,963,139	13,969,960	RGD:6480464	CTD
G	Hmox1	heme oxygenase (decycling) 1		multiple interactions	ISO	19	13,963,139	13,969,960	RGD:6480464	CTD
G	Htr1f	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled		decreases expression	EXP	11	2,260,587	2,261,687	RGD:6480464	CTD
G	Htr5a	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled		decreases expression	EXP	4	2,707,261	2,716,944	RGD:6480464	CTD
G	Htr5b	5-hydroxytryptamine (serotonin) receptor 5B		decreases expression	EXP	13	33,545,128	33,558,050	RGD:6480464	CTD
G	Ifng	interferon gamma		increases expression	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Il12b	interleukin 12B		increases expression	ISO	10	29,558,955	29,568,331	RGD:6480464	CTD
G	Il12rb2	interleukin 12 receptor, beta 2		increases expression	ISO	4	96,929,755	96,995,733	RGD:6480464	CTD
G	Il13	interleukin 13		decreases response to substance	ISO	10	39,093,512	39,096,069	RGD:6480464	CTD
G	Il13	interleukin 13		multiple interactions	ISO	10	39,093,512	39,096,069	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	EXP	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	EXP	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases secretion	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il4	interleukin 4		increases expression	ISO	10	39,074,582	39,080,134	RGD:6480464	CTD
G	Il4	interleukin 4		decreases response to substance	ISO	10	39,074,582	39,080,134	RGD:6480464	CTD
G	Il4	interleukin 4		multiple interactions	ISO	10	39,074,582	39,080,134	RGD:6480464	CTD
G	Il4	interleukin 4		affects response to substance	ISO	10	39,074,582	39,080,134	RGD:6480464	CTD
G	Il6	interleukin 6		increases expression	ISO	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		increases expression	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		multiple interactions	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Jun	jun proto-oncogene		increases activity	ISO	5	115,358,166	115,361,259	RGD:6480464	CTD
G	Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog		multiple interactions	ISO	4	182,869,242	182,895,106	RGD:6480464	CTD
G	Mecp2	methyl CpG binding protein 2		affects response to substance	ISO	X	159,980,599	160,035,260	RGD:6480464	CTD
G	Mertk	c-mer proto-oncogene tyrosine kinase		multiple interactions	ISO	3	116,308,387	116,416,414	RGD:6480464	CTD
G	Mertk	c-mer proto-oncogene tyrosine kinase		increases phosphorylation	ISO	3	116,308,387	116,416,414	RGD:6480464	CTD
G	Mmp1	matrix metallopeptidase 1 (interstitial collagenase)		increases expression	ISO	8	4,333,773	4,354,284	RGD:6480464	CTD
G	Mpo	myeloperoxidase		increases activity	ISO	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		multiple interactions	ISO	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		multiple interactions	ISO	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		increases activity	ISO	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		increases activity	EXP	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		multiple interactions	EXP	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Muc5ac	mucin 5AC, oligomeric mucus/gel-forming		increases expression	ISO				RGD:6480464	CTD
G	Myc	myelocytomatosis oncogene		increases response to substance	ISO	7	98,953,142	98,958,060	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		increases activity	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		multiple interactions	ISO	6	75,729,302	75,732,475	RGD:6480464	CTD
G	Nmbr	neuromedin B receptor		decreases expression	EXP				RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases expression	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases expression	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases expression	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases expression	ISO	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	ISO	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nr3c1	nuclear receptor subfamily 3, group C, member 1		decreases expression	EXP	18	32,371,496	32,459,145	RGD:6480464	CTD
G	Nr3c2	nuclear receptor subfamily 3, group C, member 2		decreases expression	EXP	19	32,527,752	32,875,369	RGD:6480464	CTD
G	Parp1	poly (ADP-ribose) polymerase 1		increases expression	ISO	13	96,309,670	96,341,486	RGD:6480464	CTD
G	Parp1	poly (ADP-ribose) polymerase 1		increases cleavage	EXP	13	96,309,670	96,341,486	RGD:6480464	CTD
G	Polb	polymerase (DNA directed), beta		decreases response to substance	ISO	16	73,864,702	73,888,011	RGD:6480464	CTD
G	Potef	POTE ankyrin domain family, member F		increases expression	ISO	18	24,420,779	24,422,284	RGD:6480464	CTD
G	Potef	POTE ankyrin domain family, member F		multiple interactions	ISO	18	24,420,779	24,422,284	RGD:6480464	CTD
G	Potef	POTE ankyrin domain family, member F		multiple interactions	ISO	18	24,420,779	24,422,284	RGD:6480464	CTD
G	Ppara	peroxisome proliferator activated receptor alpha		multiple interactions	ISO	7	123,729,774	123,807,090	RGD:6480464	CTD
G	Ppara	peroxisome proliferator activated receptor alpha		decreases response to substance	ISO	7	123,729,774	123,807,090	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		decreases expression	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Ptgdr	prostaglandin D2 receptor		increases expression	ISO	15	19,345,555	19,352,929	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		increases expression	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		increases expression	EXP	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	EXP	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Retnla	resistin like alpha		increases expression	ISO	11	53,205,246	53,206,745	RGD:6480464	CTD
G	Retnla	resistin like alpha		multiple interactions	ISO	11	53,205,246	53,206,745	RGD:6480464	CTD
G	Sftpa1	surfactant protein A1		multiple interactions	ISO	16	17,570,887	17,574,389	RGD:6480464	CTD
G	Sftpa1	surfactant protein A1		decreases expression	EXP	16	17,570,887	17,574,389	RGD:6480464	CTD
G	Sftpb	surfactant protein B		decreases expression	EXP	4	105,609,410	105,618,452	RGD:6480464	CTD
G	Sftpd	surfactant protein D		increases expression	EXP				RGD:6480464	CTD
G	Slc12a1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1		increases expression	EXP	3	112,455,897	112,534,752	RGD:6480464	CTD
G	Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2		increases expression	EXP	3	87,870,558	87,992,401	RGD:6480464	CTD
G	Slc6a12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12		increases expression	EXP	4	157,781,178	157,800,038	RGD:6480464	CTD
G	Socs1	suppressor of cytokine signaling 1		decreases expression	ISO	10	4,819,971	4,820,609	RGD:6480464	CTD
G	Srxn1	sulfiredoxin 1		increases expression	ISO	3	142,457,352	142,462,725	RGD:6480464	CTD
G	Sstr1	somatostatin receptor 1		decreases expression	EXP	6	78,803,393	78,806,978	RGD:6480464	CTD
G	Sstr2	somatostatin receptor 2		decreases expression	EXP	10	103,246,880	103,254,444	RGD:6480464	CTD
G	Sstr3	somatostatin receptor 3		decreases expression	EXP	7	116,495,750	116,502,948	RGD:6480464	CTD
G	Stat6	signal transducer and activator of transcription 6, interleukin-4 induced		multiple interactions	ISO	7	67,623,534	67,642,283	RGD:6480464	CTD
G	Stat6	signal transducer and activator of transcription 6, interleukin-4 induced		decreases response to substance	ISO	7	67,623,534	67,642,283	RGD:6480464	CTD
G	Sv2b	synaptic vesicle glycoprotein 2b		increases expression	EXP	1	130,683,155	130,884,752	RGD:6480464	CTD
G	Tacr2	tachykinin receptor 2		decreases expression	EXP				RGD:6480464	CTD
G	Tert	telomerase reverse transcriptase		decreases response to substance	ISO	1	30,445,180	30,465,942	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases expression	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		increases secretion	ISO	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Thrb	thyroid hormone receptor beta		decreases expression	EXP	15	9,282,845	9,345,506	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases secretion	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a		increases response to substance	ISO	4	162,172,563	162,185,252	RGD:6480464	CTD
G	Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b		increases expression	EXP	5	163,666,541	163,697,484	RGD:6480464	CTD
G	Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b		increases response to substance	ISO	5	163,666,541	163,697,484	RGD:6480464	CTD
G	Tp53	tumor protein p53		increases expression	ISO	10	56,399,721	56,411,150	RGD:6480464	CTD
G	Tp53	tumor protein p53		increases response to substance	ISO	10	56,399,721	56,411,150	RGD:6480464	CTD
G	Traf2	Tnf receptor-associated factor 2		decreases expression	EXP	3	3,692,740	3,717,332	RGD:6480464	CTD
G	Tshr	thyroid stimulating hormone receptor		decreases expression	EXP	6	115,024,999	115,162,531	RGD:6480464	CTD
G	Xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1		decreases response to substance	ISO	1	79,834,167	79,860,300	RGD:6480464	CTD
G	Xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1		affects response to substance	ISO	1	79,834,167	79,860,300	RGD:6480464	CTD
G	Xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5		affects response to substance	ISO	9	71,472,459	71,581,936	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	492574
role	482262
biological role	480454
biochemical role	193861
metabolite	175191
secondary metabolite	170532
bleomycin A2	237
Path 2
Term	Annotations
CHEBI ontology	492574
subatomic particle	491537
composite particle	491537
hadron	491537
baryon	491537
nucleon	491537
atomic nucleus	491537
atom	491537
main group element atom	461203
p-block element atom	458699
carbon group element atom	410677
carbon atom	407233
organic molecular entity	407226
organic group	167766
organic divalent group	166601
organodiyl group	166601
carbonyl group	166291
carbonyl compound	166291
carboxylic acid	121484
carboacyl group	40976
univalent carboacyl group	40976
carbamoyl group	37195
carboxamide	37186
peptide	10075
peptide antibiotic	1560
chelate-forming peptide	237
bleomycin	237
bleomycin A2	237