Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Rattus norvegicus
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Description: ENCODES a protein that exhibits double-stranded DNA binding; hormone binding; mineralocorticoid receptor activity; INVOLVED IN mineralocorticoid receptor signaling pathway; regulation of cell proliferation; cellular sodium ion homeostasis (ortholog); PARTICIPATES IN aldosterone signaling pathway; ASSOCIATED WITH Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (ortholog); Pseudohypoaldosteronism (ortholog); FOUND IN cytoplasm; nucleus; cell (ortholog); INTERACTS WITH (S)-nicotine; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
Also known as: MCR; mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); Mlr; MR
Is Marker For: QTLs:   Salc2   Gmadr1   Bw28  
Latest Assembly: RGSC Genome Assembly v5.0
NCBI Annotation Information: Annotation category: partial on reference assembly
RGSC Genome Assembly v6.01934,408,275 - 34,761,003-NCBI
Rat Cytogenetic Map19q11 NCBI
RGSC Genome Assembly v5.01945,287,442 - 45,639,834-NCBI
RGSC Genome Assembly v3.41932,527,752 - 32,875,369-NCBI
Rat Celera Assembly1930,192,512 - 30,534,995-NCBI
Genome Assembly 3.11932,532,632 - 32,880,250-NCBI

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Candidate Gene Status
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Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

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Nomenclature History
RGD Curation Notes
More on Nr3c2
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RGD Object Information
RGD ID: 3094
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2015-05-12
Status: ACTIVE