Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Rattus norvegicus
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Description: ENCODES a protein that exhibits double-stranded DNA binding; hormone binding; mineralocorticoid receptor activity; INVOLVED IN mineralocorticoid receptor signaling pathway; regulation of cell proliferation; cellular sodium ion homeostasis (ortholog); PARTICIPATES IN aldosterone signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; ASSOCIATED WITH Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (ortholog); Pseudohypoaldosteronism (ortholog); FOUND IN cytoplasm; nucleus; receptor complex (ortholog); INTERACTS WITH 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene
Type: protein-coding
Also known as: MCR; mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); Mlr; MR; nuclear receptor subfamily 3 group C member 2
Is Marker For: QTLs:   Salc2   Gmadr1   Bw28  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Celera1930,192,512 - 30,534,995 (-)NCBI
Cytogenetic Map19q11NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nr3c2
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 3094
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-09-13
Status: ACTIVE