Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:732281 | 6480464 | Ethinyl Estradiol results in increased expression of SLC9A3R1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1342625 | 6480464 | Ethinyl Estradiol results in increased expression of SLC9A3R1 mRNA | CTD | PMID:18936297 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of SLC9A3R1 mRNA | CTD | PMID:15834898 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:732281 | 6480464 | Ethinyl Estradiol affects the expression of SLC9A3R1 mRNA | CTD | PMID:17555576 | 17beta-estradiol | increases expression | ISO | RGD:732281 | 6480464 | Estradiol results in increased expression of SLC9A3R1 mRNA | CTD | PMID:15289156 | 17beta-estradiol | multiple interactions | ISO | RGD:1342625 | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of SLC9A3R1 mRNA | CTD | PMID:20404318 | 17beta-estradiol | increases expression | ISO | RGD:1342625 | 6480464 | Estradiol results in increased expression of SLC9A3R1 mRNA | CTD | PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732281 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SLC9A3R1 mRNA | CTD | PMID:21570461 | 2-methylcholine | affects expression | ISO | RGD:1342625 | 6480464 | beta-methylcholine affects the expression of SLC9A3R1 mRNA | CTD | PMID:21179406 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:732281 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC9A3R1 mRNA] | CTD | PMID:19467301 | all-trans-retinoic acid | increases expression | ISO | RGD:1342625 | 6480464 | Tretinoin results in increased expression of SLC9A3R1 mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SLC9A3R1 mRNA | CTD | PMID:16483693 | arsenic atom | affects expression | ISO | RGD:1342625 | 6480464 | Arsenic affects the expression of SLC9A3R1 mRNA | CTD | PMID:18414638 | benzene | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:17905399 | benzo[a]pyrene | multiple interactions | ISO | RGD:732281 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of SLC9A3R1 mRNA | CTD | PMID:21715664 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:19167457 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC9A3R1 mRNA | CTD | PMID:17602206 | copper atom | multiple interactions | ISO | RGD:1342625 | 6480464 | [Thiosemicarbazones binds to Copper] which results in increased expression of SLC9A3R1 protein | CTD | PMID:20931265 | copper(0) | multiple interactions | ISO | RGD:1342625 | 6480464 | [Thiosemicarbazones binds to Copper] which results in increased expression of SLC9A3R1 protein | CTD | PMID:20931265 | copper(2+) sulfate | decreases expression | ISO | RGD:1342625 | 6480464 | Copper Sulfate results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1342625 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SLC9A3R1 mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | RGD:1342625 | 6480464 | Cyclosporine results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:20106945 | cytarabine | decreases expression | ISO | RGD:1342625 | 6480464 | Cytarabine results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:21198554 | diethyl maleate | decreases expression | EXP | | 6480464 | diethyl maleate results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:21161181 | diethylstilbestrol | increases expression | ISO | RGD:732281 | 6480464 | Diethylstilbestrol results in increased expression of SLC9A3R1 mRNA | CTD | PMID:15289156 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:21551480 | furan | affects binding | EXP | | 6480464 | furan binds to SLC9A3R1 protein | CTD | PMID:22240984 | genistein | increases expression | ISO | RGD:732281 | 6480464 | Genistein results in increased expression of SLC9A3R1 mRNA | CTD | PMID:15289156 | genistein | increases expression | ISO | RGD:1342625 | 6480464 | Genistein results in increased expression of SLC9A3R1 mRNA | CTD | PMID:23019147 | genistein | increases expression | ISO | RGD:1342625 | 6480464 | Genistein results in increased expression of SLC9A3R1 protein | CTD | PMID:20884965 | genistein | multiple interactions | ISO | RGD:1342625 | 6480464 | ESR2 promotes the reaction [Genistein results in increased expression of SLC9A3R1 protein] | CTD | PMID:20884965 | hydrogen peroxide | affects expression | ISO | RGD:1342625 | 6480464 | Hydrogen Peroxide affects the expression of SLC9A3R1 mRNA | CTD | PMID:20044591 | methamphetamine | decreases expression | ISO | RGD:732281 | 6480464 | Methamphetamine results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:11756511 | methamphetamine | multiple interactions | ISO | RGD:732281 | 6480464 | (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of SLC9A3R1 mRNA] | CTD | PMID:11756511 | methylmercury(1+) | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:17905399 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC9A3R1 mRNA | CTD | PMID:17602206 | paracetamol | affects expression | ISO | RGD:732281 | 6480464 | Acetaminophen affects the expression of SLC9A3R1 mRNA | CTD | PMID:17562736 | pirinixic acid | multiple interactions | ISO | RGD:732281 | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:732281 | 6480464 | pirinixic acid results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:20813756 | progesterone | decreases expression | ISO | RGD:1342625 | 6480464 | Progesterone results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:18037150 | quercetin | decreases expression | ISO | RGD:1342625 | 6480464 | Quercetin results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:21632981 | raloxifene | affects expression | ISO | RGD:1342625 | 6480464 | Raloxifene affects the expression of SLC9A3R1 mRNA | CTD | PMID:14699072 | salmeterol | multiple interactions | ISO | RGD:1342625 | 6480464 | salmeterol promotes the reaction [CFTR protein binds to SLC9A3R1 protein] | CTD | PMID:12621035 | tamibarotene | increases expression | ISO | RGD:1342625 | 6480464 | Am 80 results in increased expression of SLC9A3R1 mRNA; more ... | CTD | PMID:15498508 | tamoxifen | affects expression | ISO | RGD:732281 | 6480464 | Tamoxifen affects the expression of SLC9A3R1 mRNA | CTD | PMID:17555576 | tetrachloromethane | affects expression | ISO | RGD:732281 | 6480464 | Carbon Tetrachloride affects the expression of SLC9A3R1 mRNA | CTD | PMID:17484886 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of SLC9A3R1 mRNA | CTD | PMID:18653662 | trichloroethene | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SLC9A3R1 mRNA | CTD | PMID:17905399 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | PDGFR-beta signaling pathway (PID:200149) |
| Thromboxane A2 receptor signaling (PID:200082) | |
Disease Annotations
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| Pathway Interaction Database | PDGFR-beta signaling pathway (PID:200149) |
| Thromboxane A2 receptor signaling (PID:200082) | |
References - curated| 1. |
Fouassier L, etal., J Biol Chem 2000 Aug 11;275(32):25039-45. |
| 2. |
Giral H, etal., J Biol Chem. 2012 Oct 12;287(42):35047-56. doi: 10.1074/jbc.M112.392415. Epub 2012 Aug 17. |
| 3. |
Kreimann EL and Cabrini RL, Reprod Sci. 2013 Jan;20(1):103-11. doi: 10.1177/1933719112451148. Epub 2012 Aug 7. |
| 4. |
Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28. |
| 5. |
MGD data from the GO Consortium |
| 6. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 7. |
RGD automated data pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD Automated Pipelines |
| 10. |
Slattery C, etal., Cell Physiol Biochem. 2011;27(2):171-8. doi: 10.1159/000325219. Epub 2011 Feb 11. |
| 11. |
Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7. |
References - uncurated| PubMed | 11726633 |
| 15878350 | |
| 16160858 | |
| 16234233 | |
| 16641100 | |
| 17110338 | |
| 18055461 | |
| 19188335 | |
| 20124415 | |
| 20404332 | |
| 20843475 | |
| 20926777 | |
| 21079987 | |
| 21120533 | |
| 21598299 | |
| 21832055 |
RGD Disease Portals| Slc9a3r1 has been annotated in the following RGD Disease Portals. |
|||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
Comparative Map Data| Slc9a3r1 (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| SLC9A3R1 (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Slc9a3r1 (Mus musculus) |
|
Position Markers| RH132852 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_021594 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06066203 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06066204 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06066205 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01066708 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01066709 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01066710 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF154336 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213792 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228926 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_021594 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_067605 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_067605 | (Get FASTA) |
| GenBank Protein | AAF73258 | (Get FASTA) |
| EDM06563 | (Get FASTA) | |
| Q9JJ19 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003232 | UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000004351 | UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000004351 | UniProtKB/Swiss-Prot |
| Entrez Gene | 59114 | ENTREZGENE |
| Germonline | ENSRNOG00000003232 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 3137 | ENTREZGENE |
| InterPro | EBP50_C-term | UniProtKB/Swiss-Prot |
| NaH_exchngr_reg_CF_NHE-RF | UniProtKB/Swiss-Prot | |
| PDZ/DHR/GLGF | UniProtKB/Swiss-Prot | |
| IPI | IPI00200898 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:59114 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | EBP50_C-term | UniProtKB/Swiss-Prot |
| PDZ | UniProtKB/Swiss-Prot | |
| PIRSF | EBP50 | UniProtKB/Swiss-Prot |
| ProDom | EBP50_C-term | UniProtKB/Swiss-Prot |
| PROSITE | PDZ | UniProtKB/Swiss-Prot |
| SMART | PDZ | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | PDZ | UniProtKB/Swiss-Prot |
| UniGene | Rn.35142 | ENTREZGENE |
| UniProt | NHRF1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-10-16 | Slc9a3r1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | Slc9a3r1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-03-31 | Slc9a3r1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | Slc9a3r1 | solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Slc9a3r1 | solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 | ERM-binding phosphoprotein | Name updated | 10779 | APPROVED | |
| 2004-09-10 | Slc9a3r1 | ERM-binding phosphoprotein | LOC59114 | Symbol and Name updated | 10779 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|
| More on Slc9a3r1 | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 708538 |
| Created: | 2003-09-23 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




