Mir222 (microRNA 222) - Rat Genome Database

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Gene: Mir222 (microRNA 222) Rattus norvegicus
Analyze
Symbol: Mir222
Name: microRNA 222
RGD ID: 2325544
Description: Predicted to enable mRNA base-pairing translational repressor activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of apoptotic process; and regulation of hormone secretion. Located in extracellular space. Used to study polycystic ovary syndrome. Biomarker of breast cancer; diabetes mellitus (multiple); ileus; sciatic neuropathy; and skeletal muscle cancer. Human ortholog(s) of this gene implicated in colorectal cancer; gastrointestinal stromal tumor; lung cancer; and oral squamous cell carcinoma. Orthologous to human MIR222 (microRNA 222); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH aflatoxin B1; bleomycin A2; cadmium dichloride.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-222; rno-mir-222
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,022,621 - 6,022,723 (+)NCBIGRCr8
mRatBN7.2X3,428,904 - 3,429,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX3,428,904 - 3,429,006 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX3,494,603 - 3,494,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X6,970,399 - 6,970,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X3,287,490 - 3,287,592 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X3,683,919 - 3,684,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX3,683,919 - 3,684,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X4,474,734 - 4,474,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX3,968,681 - 3,968,783 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (IMP)
cellular response to amino acid stimulus  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to forskolin  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to inorganic substance  (ISO)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to polyamine macromolecule  (IEP)
cellular response to tumor necrosis factor  (ISO)
lactation  (IEP)
long-term synaptic potentiation  (ISO)
mesenchymal cell differentiation involved in bone development  (IMP)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of epithelial cell migration  (IMP)
negative regulation of epithelial cell proliferation  (IDA)
negative regulation of gene expression  (IMP)
negative regulation of hematopoietic stem cell proliferation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-21 production  (ISO)
negative regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of ossification  (IMP)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of progesterone secretion  (IMP)
negative regulation of TRAIL-activated apoptotic signaling pathway  (ISO)
positive regulation of autophagy  (IMP)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cell size  (IMP)
positive regulation of dendrite extension  (IMP)
positive regulation of epithelial cell apoptotic process  (IMP)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of estradiol secretion  (IMP)
positive regulation of follicle-stimulating hormone secretion  (IMP)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of luteinizing hormone secretion  (IMP)
positive regulation of prolactin secretion  (IMP)
positive regulation of Schwann cell migration  (IMP)
positive regulation of Schwann cell proliferation  (IMP)
positive regulation of testosterone secretion  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
response to ischemia  (IEP)
response to nutrient levels  (IEP)
response to oxygen levels  (ISO)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus. Deng JJ, etal., Acupunct Med. 2019 Apr;37(2):125-132. doi: 10.1177/0964528419829755. Epub 2019 Mar 11.
2. Evaluation of circulating miR-21 and miR-222 as diagnostic biomarkers for gastric cancer. Emami SS, etal., J Cancer Res Ther. 2019 Jan-Mar;15(1):115-119. doi: 10.4103/jcrt.JCRT_592_17.
3. miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition. Gan K, etal., Diabetes Res Clin Pract. 2020 Sep;167:108121. doi: 10.1016/j.diabres.2020.108121. Epub 2020 Mar 16.
4. Inhibition of microRNA-222 up-regulates TIMP3 to promotes osteogenic differentiation of MSCs from fracture rats with type 2 diabetes mellitus. Jiang C, etal., J Cell Mol Med. 2020 Jan;24(1):686-694. doi: 10.1111/jcmm.14777. Epub 2019 Nov 6.
5. Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer. Kabakov AV, etal., Bull Exp Biol Med. 2020 Feb;168(4):500-502. doi: 10.1007/s10517-020-04740-w. Epub 2020 Mar 10.
6. Expression of Hormonal Carcinogenesis Genes and Related Regulatory microRNAs in Uterus and Ovaries of DDT-Treated Female Rats. Kalinina TS, etal., Biochemistry (Mosc). 2017 Oct;82(10):1118-1128. doi: 10.1134/S0006297917100042.
7. Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors. Koelz M, etal., Int J Oncol. 2011 Feb;38(2):503-11. doi: 10.3892/ijo.2010.857. Epub 2010 Dec 3.
8. Altered microRNA regulation in Huntington's disease models. Lee ST, etal., Exp Neurol. 2011 Jan;227(1):172-9. doi: 10.1016/j.expneurol.2010.10.012. Epub 2010 Oct 28.
9. Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC. Lei Y, etal., Onco Targets Ther. 2018 Sep 6;11:5551-5557. doi: 10.2147/OTT.S172522. eCollection 2018.
10. lncRNA GAS5 Inhibits Cell Migration and Invasion and Promotes Autophagy by Targeting miR-222-3p via the GAS5/PTEN-Signaling Pathway in CRC. Liu L, etal., Mol Ther Nucleic Acids. 2019 Sep 6;17:644-656. doi: 10.1016/j.omtn.2019.06.009. Epub 2019 Jun 27.
11. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Liu S, etal., Gastroenterology. 2014 Oct;147(4):847-859.e11. doi: 10.1053/j.gastro.2014.06.006. Epub 2014 Jun 12.
12. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Liu X, etal., Cell Metab. 2015 Apr 7;21(4):584-95. doi: 10.1016/j.cmet.2015.02.014.
13. MicroRNA-222 expression and its prognostic potential in non-small cell lung cancer. Mao KP, etal., ScientificWorldJournal. 2014;2014:908326. doi: 10.1155/2014/908326. Epub 2014 Apr 13.
14. Upregulation of miR-222 in both Helicobacter pylori- infected and noninfected gastric cancer patients. Noormohammad M, etal., J Genet. 2016 Dec;95(4):991-995. doi: 10.1007/s12041-016-0728-9.
15. Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Odenthal M, etal., Int J Cancer. 2015 Jul 1;137(1):230-7. doi: 10.1002/ijc.29363. Epub 2014 Dec 3.
16. MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. Ogawa T, etal., Gut. 2012 Nov;61(11):1600-9. doi: 10.1136/gutjnl-2011-300717. Epub 2012 Jan 20.
17. MicroRNA deregulation in human thyroid papillary carcinomas. Pallante P, etal., Endocr Relat Cancer. 2006 Jun;13(2):497-508. doi: 10.1677/erc.1.01209.
18. Cafeteria Diet Consumption during Lactation in Rats, Rather than Obesity Per Se, alters miR-222, miR-200a, and miR-26a Levels in Milk. Pomar CA, etal., Mol Nutr Food Res. 2019 Apr;63(8):e1800928. doi: 10.1002/mnfr.201800928. Epub 2019 Feb 7.
19. The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility. Ravegnini G, etal., Epigenetics. 2019 Jun;14(6):545-557. doi: 10.1080/15592294.2019.1595997. Epub 2019 Apr 13.
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. Ribeiro-Rodrigues TM, etal., Cardiovasc Res. 2017 Sep 1;113(11):1338-1350. doi: 10.1093/cvr/cvx118.
23. Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice. Su M, etal., Cell Physiol Biochem. 2016;39(4):1503-11. doi: 10.1159/000447853. Epub 2016 Sep 12.
24. MicroRNA-222-3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation, invasion, and inhibits apoptosis in gastric cancer. Tan X, etal., J Cell Biochem. 2018 Jul;119(7):5153-5162. doi: 10.1002/jcb.26542. Epub 2018 Mar 25.
25. Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells. Terasawa K, etal., FEBS J. 2009 Jun;276(12):3269-76. doi: 10.1111/j.1742-4658.2009.07041.x. Epub 2009 Apr 25.
26. MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure. Verjans R, etal., Hypertension. 2018 Feb;71(2):280-288. doi: 10.1161/HYPERTENSIONAHA.117.10094. Epub 2017 Dec 18.
27. Role and mechanism of miR-222 in arsenic-transformed cells for inducing tumor growth. Wang M, etal., Oncotarget. 2016 Apr 5;7(14):17805-14. doi: 10.18632/oncotarget.7525.
28. MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling. Wong QW, etal., Clin Cancer Res. 2010 Feb 1;16(3):867-75. doi: 10.1158/1078-0432.CCR-09-1840. Epub 2010 Jan 26.
29. microRNA-222 promotes tumor growth and confers radioresistance in nasopharyngeal carcinoma by targeting PTEN. Wu W, etal., Mol Med Rep. 2018 Jan;17(1):1305-1310. doi: 10.3892/mmr.2017.7931. Epub 2017 Oct 31.
30. Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines. Xiao L, etal., Mol Biol Cell. 2011 Sep;22(17):3055-69. doi: 10.1091/mbc.E11-01-0069. Epub 2011 Jul 7.
31. MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3. Xu Y, etal., Cell Physiol Biochem. 2017;43(1):282-292. doi: 10.1159/000480371. Epub 2017 Aug 30.
32. miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. Yang CJ, etal., J Oral Pathol Med. 2011 Aug;40(7):560-6. doi: 10.1111/j.1600-0714.2010.01005.x. Epub 2011 Jan 13.
33. MicroRNA-222-3p participates in the development of oral squamous cell carcinoma by targeting CDKN1B. Yang K, etal., J Oral Pathol Med. 2020 Aug;49(7):621-629. doi: 10.1111/jop.12986. Epub 2020 Mar 1.
34. Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis. Yang Q, etal., J Ethnopharmacol. 2016 Dec 4;193:255-265. doi: 10.1016/j.jep.2016.08.040. Epub 2016 Aug 24.
35. Downregulation of MicroRNA-222 Reduces Insulin Resistance in Rats with PCOS by Inhibiting Activation of the MAPK/ERK Pathway via Pten. Ye H, etal., Mol Ther Nucleic Acids. 2020 Jul 10;22:733-741. doi: 10.1016/j.omtn.2020.07.014. eCollection 2020 Dec 4.
36. Inhibition of microRNA-222 expression accelerates bone healing with enhancement of osteogenesis, chondrogenesis, and angiogenesis in a rat refractory fracture model. Yoshizuka M, etal., J Orthop Sci. 2016 Nov;21(6):852-858. doi: 10.1016/j.jos.2016.07.021. Epub 2016 Aug 18.
37. miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury. Yu B, etal., J Cell Sci. 2012 Jun 1;125(Pt 11):2675-83. doi: 10.1242/jcs.098996. Epub 2012 Mar 5.
38. [Expression of serum microRNAs (miR-222, miR-181, miR-216) in human hepatocellular carcinoma and its clinical significance]. Zhan MX, etal., Zhonghua Yi Xue Za Zhi. 2013 Jun 18;93(23):1830-2.
39. The alteration of miR-222 and its target genes in nickel-induced tumor. Zhang J, etal., Biol Trace Elem Res. 2013 May;152(2):267-74. doi: 10.1007/s12011-013-9619-6. Epub 2013 Feb 28.
40. Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1. Zhao H, etal., J Neuroinflammation. 2011 Nov 14;8:159. doi: 10.1186/1742-2094-8-159.
41. miR-222 regulates cell growth, apoptosis, and autophagy of interstitial cells of Cajal isolated from slow transit constipation rats by targeting c-kit. Zheng H, etal., Indian J Gastroenterol. 2021 Apr;40(2):198-208. doi: 10.1007/s12664-020-01143-7. Epub 2021 Apr 1.
42. MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury. Zhou S, etal., Neurosci Lett. 2015 Jan 23;586:43-9. doi: 10.1016/j.neulet.2014.12.006. Epub 2014 Dec 4.
43. microRNA-222 targeting PTEN promotes neurite outgrowth from adult dorsal root ganglion neurons following sciatic nerve transection. Zhou S, etal., PLoS One. 2012;7(9):e44768. doi: 10.1371/journal.pone.0044768. Epub 2012 Sep 13.
Additional References at PubMed
PMID:16381832   PMID:16682203   PMID:17604727   PMID:18723672   PMID:19147652   PMID:19150885   PMID:19188425   PMID:20403161   PMID:20548288   PMID:21993888   PMID:23185045   PMID:23646144  
PMID:24604335   PMID:25858512   PMID:30463111   PMID:31432092   PMID:31894320   PMID:32396526   PMID:34450404   PMID:34687039   PMID:34796469   PMID:36310379   PMID:36328305  


Genomics

Comparative Map Data
Mir222
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,022,621 - 6,022,723 (+)NCBIGRCr8
mRatBN7.2X3,428,904 - 3,429,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX3,428,904 - 3,429,006 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX3,494,603 - 3,494,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X6,970,399 - 6,970,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X3,287,490 - 3,287,592 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X3,683,919 - 3,684,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX3,683,919 - 3,684,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X4,474,734 - 4,474,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX3,968,681 - 3,968,783 (+)NCBICelera
Cytogenetic MapXq11NCBI
MIR222
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X45,747,015 - 45,747,124 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX45,747,015 - 45,747,124 (-)EnsemblGRCh38hg38GRCh38
GRCh37X45,606,421 - 45,606,530 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X45,491,364 - 45,491,473 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX49,798,348 - 49,798,457 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX43,321,845 - 43,321,954 (-)NCBIHuRef
CHM1_1X45,638,880 - 45,638,989 (-)NCBICHM1_1
T2T-CHM13v2.0X45,156,474 - 45,156,583 (-)NCBIT2T-CHM13v2.0
Mir222
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,013,132 - 19,013,210 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX19,013,132 - 19,013,210 (-)EnsemblGRCm39 Ensembl
GRCm38X19,146,893 - 19,146,971 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX19,146,893 - 19,146,971 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X18,724,019 - 18,724,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX16,723,051 - 16,723,129 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX14.52NCBI
MIR222
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X39,524,519 - 39,524,608 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX39,524,519 - 39,524,608 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX26,757,541 - 26,757,630 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X39,656,443 - 39,656,532 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X39,646,830 - 39,646,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X39,633,847 - 39,633,936 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X39,726,166 - 39,726,255 (-)NCBIUU_Cfam_GSD_1.0
MIR222
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX40,571,808 - 40,571,887 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X40,571,808 - 40,571,887 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X45,275,613 - 45,275,692 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Cdkn1brno-miR-222-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19150885
Bcl2l11rno-miR-222-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//ReFunctional MTI19438724

Predicted Targets
Summary Value
Count of predictions:9689
Count of gene targets:5896
Count of transcripts:6320
Interacting mature miRNAs:rno-miR-222-3p, rno-miR-222-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 7 16 2 14 2 1 1 17 8 12 8 1
Below cutoff 1 1 1 2 3 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX3,428,904 - 3,429,006 (+)Ensembl
Rnor_6.0 EnsemblX3,683,919 - 3,684,021 (+)Ensembl
RefSeq Acc Id: NR_031935
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,022,621 - 6,022,723 (+)NCBI
mRatBN7.2X3,428,904 - 3,429,006 (+)NCBI
Rnor_6.0X3,683,919 - 3,684,021 (+)NCBI
Rnor_5.0X4,474,734 - 4,474,836 (+)NCBI
CeleraX3,968,681 - 3,968,783 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325544 AgrOrtholog
BioCyc Gene G2FUF-3143 BioCyc
Ensembl Genes ENSRNOG00000035581 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053704 ENTREZGENE
miRBase MI0000962 ENTREZGENE
NCBI Gene 100314059 ENTREZGENE
PhenoGen Mir222 PhenoGen
RatGTEx ENSRNOG00000035581 RatGTEx
RNAcentral URS00002C6949 RNACentral
  URS000075C937 RNACentral
  URS000075D93A RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir222  microRNA 222  Mir222  microRNA mir-222  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir222  microRNA mir-222      Symbol and Name status set to provisional 70820 PROVISIONAL