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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,3-dinitrobenzene | increases expression | EXP | | 6480464 | 3-dinitrobenzene results in increased expression of SMAD7 mRNA | CTD | PMID:22841810 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:69141 | 6480464 | Ethinyl Estradiol affects the expression of SMAD7 mRNA | CTD | PMID:17555576 | 17beta-estradiol | affects expression | ISO | RGD:69141 | 6480464 | Estradiol affects the expression of SMAD7 mRNA | CTD | PMID:15598610 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1344957 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMAD7 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1344957 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMAD7 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMAD7 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:69141 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SMAD7 mRNA | CTD | PMID:19933214 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:69141 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of SMAD7 mRNA | CTD | PMID:18648102 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1344957 | 6480464 | decitabine results in increased expression of SMAD7 mRNA | CTD | PMID:19194470 | all-trans-retinoic acid | increases expression | ISO | RGD:69141 | 6480464 | Tretinoin results in increased expression of SMAD7 protein | CTD | PMID:16410076 | all-trans-retinoic acid | increases expression | ISO | RGD:1344957 | 6480464 | Tretinoin results in increased expression of SMAD7 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SMAD7 mRNA | CTD | PMID:16483693 | cadmium sulfate | multiple interactions | ISO | RGD:69141 | 6480464 | cadmium sulfate affects the reaction [MTF1 affects the expression of SMAD7 mRNA] | CTD | PMID:16221973 | calcitriol | increases expression | ISO | RGD:1344957 | 6480464 | Calcitriol results in increased expression of SMAD7 mRNA | CTD | PMID:16002434 | choline | multiple interactions | ISO | RGD:69141 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD7 gene | CTD | PMID:20938992 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of SMAD7 mRNA | CTD | PMID:22023808 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SMAD7 mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SMAD7 mRNA | CTD | PMID:22465980 | copper(2+) sulfate | increases expression | ISO | RGD:1344957 | 6480464 | Copper Sulfate results in increased expression of SMAD7 mRNA | CTD | PMID:19549813 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of SMAD7 mRNA | CTD | PMID:21266533 | doxorubicin | increases expression | ISO | RGD:1344957 | 6480464 | Doxorubicin results in increased expression of SMAD7 protein | CTD | PMID:18606404 | enalapril | increases expression | EXP | | 6480464 | Enalapril results in increased expression of SMAD7 mRNA | CTD | PMID:19197123 | enalapril | increases expression | EXP | | 6480464 | Enalapril results in increased expression of SMAD7 protein | CTD | PMID:19197123 PMID:19349682 | enalapril | increases expression | EXP | | 6480464 | Enalapril results in increased expression of SMAD7 protein | CTD | PMID:19349682 PMID:19197123 | folic acid | multiple interactions | ISO | RGD:69141 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD7 gene | CTD | PMID:20938992 | formaldehyde | decreases expression | ISO | RGD:1344957 | 6480464 | Formaldehyde results in decreased expression of SMAD7 mRNA | CTD | PMID:20655997 | indomethacin | increases expression | ISO | RGD:1344957 | 6480464 | Indomethacin results in increased expression of SMAD7 mRNA | CTD | PMID:16984733 | isobutyl nitrite | increases expression | ISO | RGD:69141 | 6480464 | isobutyl nitrite results in increased expression of SMAD7 mRNA | CTD | PMID:16288974 | L-methionine | multiple interactions | ISO | RGD:69141 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD7 gene | CTD | PMID:20938992 | methotrexate | affects expression | ISO | RGD:69141 | 6480464 | Methotrexate affects the expression of SMAD7 mRNA | CTD | PMID:18502557 | mono(2-ethylhexyl) phthalate | affects expression | ISO | RGD:69141 | 6480464 | mono-(2-ethylhexyl)phthalate affects the expression of SMAD7 mRNA | CTD | PMID:21195148 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of SMAD7 protein | CTD | PMID:18971187 | paracetamol | increases expression | ISO | RGD:1344957 | 6480464 | Acetaminophen results in increased expression of SMAD7 mRNA | CTD | PMID:22230336 | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SMAD7 mRNA | CTD | PMID:19162173 | perindopril | increases expression | EXP | | 6480464 | Perindopril results in increased expression of SMAD7 protein | CTD | PMID:15619341 | perindopril | multiple interactions | EXP | | 6480464 | Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein] | CTD | PMID:16872305 | pirinixic acid | decreases expression | ISO | RGD:69141 | 6480464 | pirinixic acid results in decreased expression of SMAD7 mRNA | CTD | PMID:20059764 | pirinixic acid | multiple interactions | ISO | RGD:69141 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SMAD7 mRNA] | CTD | PMID:20059764 | propiconazole | decreases expression | ISO | RGD:69141 | 6480464 | propiconazole results in decreased expression of SMAD7 mRNA | CTD | PMID:21278054 | quercetin | decreases expression | ISO | RGD:1344957 | 6480464 | Quercetin results in decreased expression of SMAD7 mRNA | CTD | PMID:21632981 | raloxifene | affects expression | ISO | RGD:1344957 | 6480464 | Raloxifene affects the expression of SMAD7 mRNA | CTD | PMID:14699072 | resveratrol | increases expression | ISO | RGD:1344957 | 6480464 | resveratrol results in increased expression of SMAD7 protein | CTD | PMID:20637737 | resveratrol | increases expression | ISO | RGD:1344957 | 6480464 | resveratrol results in increased expression of SMAD7 mRNA | CTD | PMID:18089832 | streptozocin | affects expression | EXP | | 6480464 | Streptozocin affects the expression of SMAD7 mRNA; more ... | CTD | PMID:17437042 | tacrolimus hydrate | multiple interactions | ISO | RGD:1344957 | 6480464 | Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]; more ... | CTD | PMID:16720724 | tamoxifen | affects expression | ISO | RGD:1344957 | 6480464 | Tamoxifen affects the expression of SMAD7 mRNA | CTD | PMID:14699072 | tamoxifen | affects expression | ISO | RGD:69141 | 6480464 | Tamoxifen affects the expression of SMAD7 mRNA | CTD | PMID:17555576 | tert-butyl hydroperoxide | increases expression | ISO | RGD:1344957 | 6480464 | tert-Butylhydroperoxide results in increased expression of SMAD7 mRNA | CTD | PMID:15336504 | testosterone | increases expression | ISO | RGD:69141 | 6480464 | Testosterone results in increased expression of SMAD7 mRNA | CTD | PMID:22138414 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SMAD7 protein | CTD | PMID:17163593 PMID:16872305 | tetrachloromethane | multiple interactions | EXP | | 6480464 | Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]; more ... | CTD | PMID:16872305 | tetrachloromethane | multiple interactions | EXP | | 6480464 | pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD7 mRNA] | CTD | PMID:12445421 | tetrachloromethane | multiple interactions | ISO | RGD:69141 | 6480464 | SMAD7 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of CTGF protein] | CTD | PMID:17657819 | tetrachloromethane | multiple interactions | EXP | | 6480464 | Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein] | CTD | PMID:17163593 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SMAD7 mRNA | CTD | PMID:12445421 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SMAD7 protein | CTD | PMID:16872305 PMID:17163593 | trans-resveratrol | increases expression | ISO | RGD:1344957 | 6480464 | resveratrol results in increased expression of SMAD7 protein | CTD | PMID:20637737 | trans-resveratrol | increases expression | ISO | RGD:1344957 | 6480464 | resveratrol results in increased expression of SMAD7 mRNA | CTD | PMID:18089832 | ursodeoxycholic acid | increases expression | EXP | | 6480464 | Ursodeoxycholic Acid results in increased expression of SMAD7 mRNA; more ... | CTD | PMID:19493473 | valsartan | multiple interactions | EXP | | 6480464 | valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein] | CTD | PMID:16872305 | valsartan | increases expression | EXP | | 6480464 | valsartan results in increased expression of SMAD7 protein | CTD | PMID:15619341 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Endocytosis |
| Hippo signaling pathway | |
| TGF-beta signaling pathway | |
| Pathway Interaction Database | ALK1 signaling events (PID:200148) |
| BMP receptor signaling (PID:200144) | |
| IFN-gamma pathway (PID:200129) | |
| Regulation of nuclear SMAD2/3 signaling (PID:200003) | |
| Signaling events mediated by HDAC Class I (PID:200084) | |
| TGF-beta receptor signaling (PID:200227) | |
References - curated| 1. |
Asano Y, etal., J Clin Invest. 2004 Jan;113(2):253-64. |
| 2. |
Dowdy SC, etal., Gynecol Oncol. 2005 Feb;96(2):368-73. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Kanamaru C, etal., J Biol Chem 2001 Dec 7;276(49):45636-41. |
| 5. |
Liu FY, etal., Am J Nephrol. 2007;27(2):176-83. Epub 2007 Mar 7. |
| 6. |
Liu X, etal., FEBS Lett 2002 May 22;519(1-3):93-8. |
| 7. |
Massague J Cell. 2008 Jul 25;134(2):215-30. |
| 8. |
MGD data from the GO Consortium |
| 9. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. |
Okado T, etal., Kidney Int 2002 Oct;62(4):1178-86. |
| 11. |
Park do Y, etal., J Korean Med Sci 2003 Aug;18(4):510-9. |
| 12. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 13. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 14. |
RGD automated data pipeline |
| 15. |
RGD automated import pipeline for gene-chemical interactions |
| 16. |
RGD Automated Pipelines |
| 17. |
Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700. |
| 18. |
Stopa M, etal., Mamm Genome 2000 Feb;11(2):169-76. |
| 19. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 20. |
Uchida K, etal., Mol Cell Biol Res Commun. 2000 Aug;4(2):98-105. |
| 21. |
Wang B, etal., Am J Physiol Heart Circ Physiol 2002 May;282(5):H1685-96. |
| 22. |
Wang D, etal., Int J Oncol. 2000 Dec;17(6):1087-91. |
References - uncurated| PubMed | 11181520 |
| 12668667 | |
| 15743788 | |
| 16266486 | |
| 16278212 | |
| 16297324 | |
| 16380081 | |
| 16931807 | |
| 17437042 | |
| 17541159 | |
| 17634402 | |
| 17704451 | |
| 17723189 | |
| 17855642 | |
| 17928287 | |
| 18095586 | |
| 18395914 | |
| 18762808 | |
| 18988920 | |
| 19197123 | |
| 19349682 | |
| 20182310 | |
| 20386537 | |
| 20943464 | |
| 21049555 | |
| 21144460 | |
| 21429339 | |
| 21505983 | |
| 21718693 | |
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RGD Disease Portals| Smad7 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Smad7 (Rattus norvegicus) |
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| SMAD7 (Homo sapiens) |
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| Smad7 (Mus musculus) |
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Position Markers| Smad7 |
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| PMC193708P2 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_030858 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06095946 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06095947 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01096002 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01096003 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF042499 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF156727 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF156728 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF156729 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF156730 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF159626 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474095 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_030858 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_110485 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_110485 | (Get FASTA) |
| GenBank Protein | AAC25062 | (Get FASTA) |
| AAD41130 | (Get FASTA) | |
| AAF00608 | (Get FASTA) | |
| EDL82858 | (Get FASTA) | |
| EDL82859 | (Get FASTA) | |
| O88406 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018359 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000024831 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000024831 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 81516 | ENTREZGENE |
| Gene3D-CATH | MAD_MH1 | UniProtKB/Swiss-Prot |
| MH2_Dwarfin-type | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000018359 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 4314 | ENTREZGENE |
| InterPro | Dwarfin | UniProtKB/Swiss-Prot |
| MAD_homology1_Dwarfin-type | UniProtKB/Swiss-Prot | |
| MAD_homology_MH1 | UniProtKB/Swiss-Prot | |
| SMAD_dom-like | UniProtKB/Swiss-Prot | |
| SMAD_dom_Dwarfin-type | UniProtKB/Swiss-Prot | |
| SMAD_FHA_domain | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:81516 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Dwarfin | UniProtKB/Swiss-Prot |
| Pfam | MH1 | UniProtKB/Swiss-Prot |
| MH2 | UniProtKB/Swiss-Prot | |
| PROSITE | MH1 | UniProtKB/Swiss-Prot |
| MH2 | UniProtKB/Swiss-Prot | |
| SMART | DWA | UniProtKB/Swiss-Prot |
| DWB | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | MAD_MH1 | UniProtKB/Swiss-Prot |
| SMAD_FHA | UniProtKB/Swiss-Prot | |
| TIGR | TC218914 | |
| UniGene | Rn.29980 | ENTREZGENE |
| UniProt | SMAD7_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-10-23 | Smad7 | SMAD family member 7 | Smad7 | MAD homolog 7 (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-05-18 | Smad7 | Madh7 | MAD homolog 7 (Drosophila) | Symbol updated to reflect Human and Mouse nomenclature | 10779 | APPROVED | |
| 2002-06-10 | Madh7 | MAD homolog 7 (Drosophila) | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | mediates the pathogenesis of cardiac fibrosis in the post-postmyocardial infarct (MI) heart | 625758 |
| gene_expression | expressed in anterior pituitary cells | 70231 |
| gene_expression | expressed in anterior pituitary cells | 625758 |
| gene_function | forms protein complexes | 68665 |
| gene_function | activates caspase-3 to induce apoptosis | 727429 |
| gene_physical_interaction | directly associates with activin type I receptor (ALK-4) | 729221 |
| gene_process | negatively modulates activin/TGFb signaling pathway | 68665 |
| gene_process | inhibits expression of fibrillar collagen genes in cultured primary cardiac fibroblasts | 625758 |
| gene_regulation | can be induced by TGF-beta and activin A | 70231 |
| gene_regulation | can be induced by TGF-beta and activin A | 625758 |
| gene_regulation | additive increase in expression caused by activin A and TGFb1 in anterior pituitary whereas inhibition occurs with follistatin | 70231 |
| gene_regulation | additive increase in expression caused by activin A and TGFb1 in anterior pituitary whereas inhibition occurs with follistatin | 625758 |
| gene_regulation | expression rapidly increased by norepinephrine (NE) through NF-kB activation | 70231 |
| gene_regulation | expression is induced by TGF-b1 in several cell types, including primary cardiac fibroblasts | 625758 |
| More on Smad7 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 69314 |
| Created: | 2001-11-14 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




