Liph (lipase H) - Rat Genome Database

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Gene: Liph (lipase H) Rattus norvegicus
Analyze
Symbol: Liph
Name: lipase H
RGD ID: 1592849
Description: Predicted to enable heparin binding activity and phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H); INTERACTS WITH 17beta-estradiol; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lipase member H; lipase, member H; LOC681694; similar to lipase, member H
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,536,724 - 92,586,117 (+)NCBIGRCr8
mRatBN7.21179,032,229 - 79,081,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1179,033,312 - 79,081,625 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1187,767,801 - 87,815,562 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,421,447 - 80,469,206 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01179,482,142 - 79,529,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,680,167 - 82,732,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01185,808,222 - 85,815,457 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01185,770,270 - 85,788,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1177,895,628 - 77,940,437 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
lipid catabolic process  (IBA,IEA,ISO)

Cellular Component
extracellular space  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12963729   PMID:15489334  


Genomics

Comparative Map Data
Liph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,536,724 - 92,586,117 (+)NCBIGRCr8
mRatBN7.21179,032,229 - 79,081,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1179,033,312 - 79,081,625 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1187,767,801 - 87,815,562 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,421,447 - 80,469,206 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01179,482,142 - 79,529,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,680,167 - 82,732,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01185,808,222 - 85,815,457 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01185,770,270 - 85,788,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1177,895,628 - 77,940,437 (+)NCBICelera
Cytogenetic Map11q23NCBI
LIPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383185,506,262 - 185,552,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3185,506,262 - 185,552,588 (-)EnsemblGRCh38hg38GRCh38
GRCh373185,224,050 - 185,270,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363186,708,264 - 186,753,063 (-)NCBINCBI36Build 36hg18NCBI36
Build 343186,708,294 - 186,753,043NCBI
Celera3183,671,086 - 183,716,608 (-)NCBICelera
Cytogenetic Map3q27.2NCBI
HuRef3182,635,165 - 182,680,037 (-)NCBIHuRef
CHM1_13185,188,581 - 185,233,458 (-)NCBICHM1_1
T2T-CHM13v2.03188,322,024 - 188,368,409 (-)NCBIT2T-CHM13v2.0
Liph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391621,772,567 - 21,814,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1621,772,567 - 21,814,413 (-)EnsemblGRCm39 Ensembl
GRCm381621,953,817 - 21,995,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1621,953,817 - 21,995,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv371621,953,890 - 21,995,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361621,868,054 - 21,910,794 (-)NCBIMGSCv36mm8
Celera1622,520,630 - 22,562,761 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1612.95NCBI
Liph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542022,014,961 - 22,052,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542022,015,254 - 22,049,508 (+)NCBIChiLan1.0ChiLan1.0
LIPH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22183,383,292 - 183,426,940 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13183,388,009 - 183,431,657 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03182,541,666 - 182,586,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13191,018,172 - 191,062,502 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3191,018,178 - 191,062,502 (-)Ensemblpanpan1.1panPan2
LIPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13418,269,510 - 18,316,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3418,270,070 - 18,316,066 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3422,345,759 - 22,402,330 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03418,169,626 - 18,226,433 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3418,178,666 - 18,225,876 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13418,205,295 - 18,261,851 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03418,201,211 - 18,258,007 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03418,431,011 - 18,487,467 (-)NCBIUU_Cfam_GSD_1.0
Liph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602118,212,626 - 118,255,245 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365784,320,937 - 4,345,972 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365784,304,503 - 4,346,838 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13123,371,860 - 123,419,434 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113123,372,909 - 123,419,505 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213132,915,031 - 132,957,520 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1153,872,492 - 3,922,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl153,873,166 - 3,921,209 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606312,629,696 - 12,685,571 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Liph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473071,109,665 - 71,145,985 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473071,110,219 - 71,149,197 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Liph
279 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:196
Count of miRNA genes:134
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000075512
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

Markers in Region
BG378170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21179,076,168 - 79,076,347 (+)MAPPERmRatBN7.2
Rnor_6.01182,726,689 - 82,726,867NCBIRnor6.0
Rnor_5.01185,810,001 - 85,810,179UniSTSRnor5.0
Celera1177,934,981 - 77,935,159UniSTS
RH 3.4 Map11654.1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000075512   ⟹   ENSRNOP00000065168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1179,033,417 - 79,081,625 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077119   ⟹   ENSRNOP00000069088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1179,043,068 - 79,081,625 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094527   ⟹   ENSRNOP00000080503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1179,033,312 - 79,081,625 (+)Ensembl
RefSeq Acc Id: NM_001044279   ⟹   NP_001037744
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,537,910 - 92,586,117 (+)NCBI
mRatBN7.21179,033,417 - 79,081,625 (+)NCBI
Rnor_6.01182,680,167 - 82,732,145 (+)NCBI
Rnor_5.01185,770,270 - 85,788,987 (+)NCBI
Rnor_5.01185,808,222 - 85,815,457 (+)NCBI
Celera1177,895,628 - 77,940,437 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088624   ⟹   XP_038944552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,536,729 - 92,584,627 (+)NCBI
mRatBN7.21179,032,234 - 79,080,068 (+)NCBI
RefSeq Acc Id: XM_039088625   ⟹   XP_038944553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,536,724 - 92,580,999 (+)NCBI
mRatBN7.21179,032,229 - 79,078,387 (+)NCBI
RefSeq Acc Id: NP_001037744   ⟸   NM_001044279
- Peptide Label: precursor
- UniProtKB: Q6P6S8 (UniProtKB/Swiss-Prot),   Q32PY2 (UniProtKB/Swiss-Prot),   A0A0G2JUG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038944553   ⟸   XM_039088625
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G4M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944552   ⟸   XM_039088624
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G4M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000065168   ⟸   ENSRNOT00000075512
RefSeq Acc Id: ENSRNOP00000069088   ⟸   ENSRNOT00000077119
RefSeq Acc Id: ENSRNOP00000080503   ⟸   ENSRNOT00000094527
Protein Domains
Lipase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUG3-F1-model_v2 AlphaFold A0A0G2JUG3 1-451 view protein structure
AF-Q32PY2-F1-model_v2 AlphaFold Q32PY2 1-451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592849 AgrOrtholog
BioCyc Gene G2FUF-20794 BioCyc
Ensembl Genes ENSRNOG00000047894 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075512.3 UniProtKB/TrEMBL
  ENSRNOT00000077119.2 UniProtKB/TrEMBL
  ENSRNOT00000094527 ENTREZGENE
  ENSRNOT00000094527.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5597973 IMAGE-MGC_LOAD
  IMAGE:7124552 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAG_lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:681694 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124979 IMAGE-MGC_LOAD
  MGC:72573 IMAGE-MGC_LOAD
NCBI Gene 681694 ENTREZGENE
PANTHER LIPASE MEMBER H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Liph PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TAGLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047894 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JUG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G4M3 ENTREZGENE, UniProtKB/TrEMBL
  LIPH_RAT UniProtKB/Swiss-Prot
  M0R6V9_RAT UniProtKB/TrEMBL
  Q32PY2 ENTREZGENE
  Q6P6S8 ENTREZGENE
UniProt Secondary Q6P6S8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Liph  lipase H  Liph  lipase, member H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-12-01 Liph  lipase, member H  LOC681694  similar to lipase, member H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681694  similar to lipase, member H      Symbol and Name status set to provisional 70820 PROVISIONAL