Mir30a (microRNA 30a) - Rat Genome Database

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Gene: Mir30a (microRNA 30a) Rattus norvegicus
Analyze
Symbol: Mir30a
Name: microRNA 30a
RGD ID: 2325588
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in negative regulation of hepatic stellate cell activation and negative regulation of hepatic stellate cell proliferation. Predicted to be part of RISC complex. Used to study myocardial infarction. Biomarker of alcohol use disorder; cerebral infarction; and pulmonary fibrosis. Orthologous to human MIR30A (microRNA 30a); INTERACTS WITH 2,5-hexanedione; aflatoxin B1; bis(2-ethylhexyl) phthalate.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-30a; rno-mir-30a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8933,233,941 - 33,234,011 (+)NCBIGRCr8
mRatBN7.2925,737,600 - 25,737,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl925,737,600 - 25,737,670 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx934,240,501 - 34,240,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0939,363,811 - 39,363,881 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0937,668,558 - 37,668,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0929,542,635 - 29,542,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl929,542,635 - 29,542,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0928,377,823 - 28,377,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera923,285,608 - 23,285,678 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. miR-30a attenuates cardiac fibrosis in rats with myocardial infarction by inhibiting CTGF. Chen L, etal., Exp Ther Med. 2018 May;15(5):4318-4324. doi: 10.3892/etm.2018.5952. Epub 2018 Mar 13.
3. Inhibition of Autophagy by MiR-30A Induced by Mycobacteria tuberculosis as a Possible Mechanism of Immune Escape in Human Macrophages. Chen Z, etal., Jpn J Infect Dis. 2015;68(5):420-4. doi: 10.7883/yoken.JJID.2014.466. Epub 2015 Apr 10.
4. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Ehinger Y, etal., Addict Biol. 2020 Mar 5:e12890. doi: 10.1111/adb.12890.
5. Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis. Forini F, etal., Endocrinology. 2014 Nov;155(11):4581-90. doi: 10.1210/en.2014-1106. Epub 2014 Aug 19.
6. MiRNA-30a inhibits AECs-II apoptosis by blocking mitochondrial fission dependent on Drp-1. Mao C, etal., J Cell Mol Med. 2014 Dec;18(12):2404-16. doi: 10.1111/jcmm.12420. Epub 2014 Oct 6.
7. MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. Pan W, etal., PLoS One. 2013;8(1):e53950. doi: 10.1371/journal.pone.0053950. Epub 2013 Jan 9.
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Circulating MicroRNA-188, -30a, and -30e as Early Biomarkers for Contrast-Induced Acute Kidney Injury. Sun SQ, etal., J Am Heart Assoc. 2016 Aug 15;5(8). pii: JAHA.116.004138. doi: 10.1161/JAHA.116.004138.
10. MiR-30a suppresses metastasis of gastric adenocarcinoma via targeting FAPα. Yu T, etal., Cancer Biomark. 2020;27(4):471-484. doi: 10.3233/CBM-190314.
11. EPO-cyclosporine combination therapy reduced brain infarct area in rat after acute ischemic stroke: role of innate immune-inflammatory response, micro-RNAs and MAPK family signaling pathway. Yuen CM, etal., Am J Transl Res. 2017 Apr 15;9(4):1651-1666. eCollection 2017.
12. MicroRNA-30a Suppresses the Activation of Hepatic Stellate Cells by Inhibiting Epithelial-to-Mesenchymal Transition. Zheng J, etal., Cell Physiol Biochem. 2018;46(1):82-92. doi: 10.1159/000488411. Epub 2018 Mar 20.
13. miR-30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma. Zhong M, etal., Cell Physiol Biochem. 2013;31(2-3):209-18. doi: 10.1159/000343362. Epub 2013 Feb 8.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:19091803   PMID:19185580   PMID:20403161   PMID:20548288   PMID:20805985   PMID:21993888   PMID:23185045   PMID:23831330  
PMID:24205035   PMID:24612558   PMID:25751060   PMID:25766280   PMID:25858512   PMID:26872979   PMID:26884822   PMID:28711328   PMID:31115541   PMID:31199706   PMID:31486507   PMID:31799642  
PMID:32016995   PMID:32115441   PMID:33058540   PMID:33450324   PMID:33880587   PMID:35025607   PMID:35488974   PMID:35927903  


Genomics

Comparative Map Data
Mir30a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8933,233,941 - 33,234,011 (+)NCBIGRCr8
mRatBN7.2925,737,600 - 25,737,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl925,737,600 - 25,737,670 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx934,240,501 - 34,240,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0939,363,811 - 39,363,881 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0937,668,558 - 37,668,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0929,542,635 - 29,542,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl929,542,635 - 29,542,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0928,377,823 - 28,377,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera923,285,608 - 23,285,678 (+)NCBICelera
Cytogenetic Map9q13NCBI
MIR30A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38671,403,551 - 71,403,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl671,403,551 - 71,403,621 (-)EnsemblGRCh38hg38GRCh38
GRCh37672,113,254 - 72,113,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36672,169,974 - 72,170,044 (-)NCBINCBI36Build 36hg18NCBI36
Celera672,501,691 - 72,501,761 (-)NCBICelera
Cytogenetic Map6q13NCBI
HuRef669,311,486 - 69,311,556 (-)NCBIHuRef
CHM1_1672,279,288 - 72,279,358 (-)NCBICHM1_1
T2T-CHM13v2.0672,584,045 - 72,584,115 (-)NCBIT2T-CHM13v2.0
Mir30a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,311,350 - 23,311,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,311,350 - 23,311,420 (+)EnsemblGRCm39 Ensembl
GRCm38123,272,269 - 23,272,339 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,272,269 - 23,272,339 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,279,108 - 23,279,178 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera123,119,251 - 23,119,321 (+)NCBICelera
Cytogenetic Map1A5NCBI
cM Map19.53NCBI
MIR30A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11233,783,894 - 33,783,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1233,783,891 - 33,783,961 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1233,642,836 - 33,642,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01234,324,114 - 34,324,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1234,324,111 - 34,324,181 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11233,859,545 - 33,859,607 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01233,897,604 - 33,897,666 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01234,008,413 - 34,008,475 (-)NCBIUU_Cfam_GSD_1.0
MIR30A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl151,412,827 - 51,412,933 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1151,412,827 - 51,412,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2157,750,736 - 57,750,842 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Syt4rno-miR-30a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Tp53rno-miR-30a-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI20062521
Aqp4rno-miR-30a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:13128
Count of gene targets:7258
Count of transcripts:7783
Interacting mature miRNAs:rno-miR-30a-3p, rno-miR-30a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 8
Low 8 20 7 13 7 8 8 8 9 8 8
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl925,737,600 - 25,737,670 (+)Ensembl
Rnor_6.0 Ensembl929,542,635 - 29,542,705 (+)Ensembl
RefSeq Acc Id: NR_031843
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8933,233,941 - 33,234,011 (+)NCBI
mRatBN7.2925,737,600 - 25,737,670 (+)NCBI
Rnor_6.0929,542,635 - 29,542,705 (+)NCBI
Rnor_5.0928,377,823 - 28,377,893 (+)NCBI
Celera923,285,608 - 23,285,678 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325588 AgrOrtholog
BioCyc Gene G2FUF-27978 BioCyc
Ensembl Genes ENSRNOG00000035646 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053769 ENTREZGENE
miRBase MI0000870 ENTREZGENE
NCBI Gene 100314011 ENTREZGENE
PhenoGen Mir30a PhenoGen
RatGTEx ENSRNOG00000035646 RatGTEx
RNAcentral URS0000065D58 RNACentral
  URS000043D1A9 RNACentral
  URS000075E601 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir30a  microRNA 30a  Mir30a  microRNA mir-30a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir30a  microRNA mir-30a      Symbol and Name status set to provisional 70820 PROVISIONAL