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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | decreases expression | ISO | RGD:732783 | 6480464 | epigallocatechin gallate results in decreased expression of KL mRNA | CTD | PMID:20706672 | 17beta-estradiol 3-glucosiduronic acid | multiple interactions | ISO | RGD:732784 | 6480464 | estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] | CTD | PMID:14701853 | 17beta-estradiol 3-glucosiduronic acid | increases hydrolysis | ISO | RGD:732784 | 6480464 | KL protein results in increased hydrolysis of estradiol-3-glucuronide | CTD | PMID:14701853 | 4-hydroperoxycyclophosphamide | decreases expression | ISO | RGD:732784 | 6480464 | perfosfamide results in decreased expression of KL mRNA | CTD | PMID:19429390 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KL mRNA | CTD | PMID:16483693 | androsterone 3-glucosiduronic acid | multiple interactions | ISO | RGD:732784 | 6480464 | androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] | CTD | PMID:14701853 | benzo[a]pyrene | increases expression | ISO | RGD:732783 | 6480464 | Benzo(a)pyrene results in increased expression of KL mRNA | CTD | PMID:19152381 | benzo[a]pyrene | multiple interactions | ISO | RGD:732783 | 6480464 | chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of KL mRNA] | CTD | PMID:19152381 | benzo[a]pyrene | multiple interactions | ISO | RGD:732784 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of KL mRNA | CTD | PMID:21715664 | bis(2-chloroethyl) sulfide | decreases expression | ISO | RGD:732784 | 6480464 | Mustard Gas results in decreased expression of KL mRNA | CTD | PMID:15674843 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of KL promoter | CTD | PMID:22457795 | calcium atom | affects abundance | ISO | RGD:732784 | 6480464 | KL protein affects the abundance of Calcium | CTD | PMID:11796525 | calcium(0) | affects abundance | ISO | RGD:732784 | 6480464 | KL protein affects the abundance of Calcium | CTD | PMID:11796525 | cocaine | increases expression | ISO | RGD:732783 | 6480464 | Cocaine results in increased expression of KL mRNA | CTD | PMID:15009677 | dehydroepiandrosterone | multiple interactions | ISO | RGD:732784 | 6480464 | Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] | CTD | PMID:14701853 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of KL mRNA; more ... | CTD | PMID:20606417 | doxorubicin | multiple interactions | EXP | | 6480464 | EPO protein inhibits the reaction [Doxorubicin results in decreased expression of KL mRNA]; more ... | CTD | PMID:20606417 | elemental selenium | multiple interactions | ISO | RGD:732783 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of KL mRNA | CTD | PMID:19244175 | estriol 3-O-(beta-D-glucuronide) | increases hydrolysis | ISO | RGD:732784 | 6480464 | KL protein results in increased hydrolysis of estriol 3-glucuronide | CTD | PMID:14701853 | estriol 3-O-(beta-D-glucuronide) | multiple interactions | ISO | RGD:732784 | 6480464 | estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] | CTD | PMID:14701853 | estrone 3-O-(beta-D-glucuronide) | increases hydrolysis | ISO | RGD:732784 | 6480464 | KL protein results in increased hydrolysis of estrone-3-glucuronide | CTD | PMID:14701853 | estrone 3-O-(beta-D-glucuronide) | multiple interactions | ISO | RGD:732784 | 6480464 | estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] | CTD | PMID:14701853 | genistein | decreases expression | ISO | RGD:732783 | 6480464 | Genistein results in decreased expression of KL mRNA | CTD | PMID:20706672 | lead diacetate | affects expression | EXP | | 6480464 | lead acetate affects the expression of KL mRNA | CTD | PMID:21864555 | lead diacetate | decreases expression | ISO | RGD:732784 | 6480464 | lead acetate results in decreased expression of KL mRNA | CTD | PMID:22609695 | mono(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:732784 | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of KL mRNA | CTD | PMID:22401849 | paraquat | decreases response to substance | ISO | RGD:732784 | 6480464 | KL protein results in decreased susceptibility to Paraquat | CTD | PMID:16186101 | phenobarbital | decreases expression | ISO | RGD:732783 | 6480464 | Phenobarbital results in decreased expression of KL mRNA | CTD | PMID:19084549 | phosphorus atom | affects abundance | ISO | RGD:732784 | 6480464 | KL protein affects the abundance of Phosphorus | CTD | PMID:11796525 | phosphorus(.) | affects abundance | ISO | RGD:732784 | 6480464 | KL protein affects the abundance of Phosphorus | CTD | PMID:11796525 | resveratrol | decreases expression | ISO | RGD:732783 | 6480464 | resveratrol results in decreased expression of KL mRNA | CTD | PMID:20706672 | retinyl acetate | increases expression | ISO | RGD:732784 | 6480464 | retinol acetate results in increased expression of KL mRNA | CTD | PMID:16772331 | selenium atom | multiple interactions | ISO | RGD:732783 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of KL mRNA | CTD | PMID:19244175 | taurocholic acid | multiple interactions | ISO | RGD:732784 | 6480464 | Taurocholic Acid inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] | CTD | PMID:14701853 | testosterone 17-glucosiduronic acid | multiple interactions | ISO | RGD:732784 | 6480464 | testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] | CTD | PMID:14701853 | trans-resveratrol | decreases expression | ISO | RGD:732783 | 6480464 | resveratrol results in decreased expression of KL mRNA | CTD | PMID:20706672 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of KL mRNA | CTD | PMID:11768731 | vancomycin | increases expression | ISO | RGD:732784 | 6480464 | Vancomycin results in increased expression of KL mRNA | CTD | PMID:18930951 | zinc atom | decreases expression | ISO | RGD:732783 | 6480464 | Zinc deficiency results in decreased expression of KL mRNA | CTD | PMID:18356318 | zinc(0) | decreases expression | ISO | RGD:732783 | 6480464 | Zinc deficiency results in decreased expression of KL mRNA | CTD | PMID:18356318 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Endocrine and other factor-regulated calcium reabsorption |
| Metabolic pathways | |
| Pentose and glucuronate interconversions | |
| Starch and sucrose metabolism | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway AnnotationsReferences - curated| 1. |
Arking DE, etal., Circ Res. 2005 Mar 4;96(4):412-8. Epub 2005 Jan 27. |
| 2. |
GOA data from the GO Consortium |
| 3. |
Imamura A, etal., Clin Chim Acta. 2006 Sep;371(1-2):66-70. Epub 2006 Mar 6. |
| 4. |
Kurosu H, etal., J Biol Chem. 2006 Mar 10;281(10):6120-3. Epub 2006 Jan 25. |
| 5. |
MGD data from the GO Consortium |
| 6. |
Mitani H, etal., Hypertension 2002 Apr;39(4):838-43. |
| 7. |
Nagai R, etal., Cell Mol Life Sci. 2000 May;57(5):738-46. |
| 8. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 9. |
Ohyama Y, etal., Biochem Biophys Res Commun 1998 Oct 29;251(3):920-5. |
| 10. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 11. |
RGD automated data pipeline |
| 12. |
RGD automated import pipeline for gene-chemical interactions |
| 13. |
RGD Automated Pipelines |
| 14. |
Rhee EJ, etal., Metabolism. 2006 Oct;55(10):1344-51. |
| 15. |
Takeshita K, etal., Circulation. 2004 Apr 13;109(14):1776-82. Epub 2004 Mar 22. |
References - uncurated| PubMed | 10631108 |
| 12965205 | |
| 15135068 | |
| 18056631 | |
| 19349416 | |
| 19367378 | |
| 19756714 | |
| 19955715 | |
| 20360647 | |
| 20625492 | |
| 20631679 | |
| 20830528 | |
| 21038689 | |
| 21209102 | |
| 21276773 | |
| 21311136 | |
| 21389697 | |
| 21646815 | |
| 23225045 | |
| 23365232 | |
| 9731228 |
RGD Disease Portals| Kl has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Kl (Rattus norvegicus) |
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| KL (Homo sapiens) |
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| Kl (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031336 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06069807 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06069808 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06069809 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06069810 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06069811 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070654 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070655 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB017820 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474108 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031336 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_112626 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_112626 | (Get FASTA) |
| GenBank Protein | BAA34740 | (Get FASTA) |
| EDL74914 | (Get FASTA) | |
| Q9Z2Y9 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001092 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000001449 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000001449 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 83504 | ENTREZGENE |
| Gene3D-CATH | Glyco_hydro_cat | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000001092 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 68415 | ENTREZGENE |
| InterPro | Glyco_hydro_1 | UniProtKB/Swiss-Prot |
| Glyco_hydro_1_AS | UniProtKB/Swiss-Prot | |
| Glyco_hydro_catalytic_core | UniProtKB/Swiss-Prot | |
| Glyco_hydro_sg_catalytic | UniProtKB/Swiss-Prot | |
| IPI | IPI00210396 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:83504 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Glyco_hydro_1 | UniProtKB/Swiss-Prot |
| Pfam | Glyco_hydro_1 | UniProtKB/Swiss-Prot |
| PRINTS | GLHYDRLASE1 | UniProtKB/Swiss-Prot |
| PROSITE | GLYCOSYL_HYDROL_F1_1; FALSE_NEG | UniProtKB/Swiss-Prot |
| GLYCOSYL_HYDROL_F1_2 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Glyco_hydro_cat | UniProtKB/Swiss-Prot |
| UniGene | Rn.30061 | ENTREZGENE |
| UniProt | KLOT_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | Kl | Klotho | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Kl | Klotho | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | upregulated in arteriosclerosis, osteoporosis, infertility, pulmonary emphysema | 70544 |
| gene_expression | expressed in kidney | 70544 |
| gene_process | has a role in protection against Ang II-induced renal damage | 70544 |
| gene_regulation | downregulated by Ang II | 70544 |
| gene_regulation | expression decreased by lipopolysaccharide | 633145 |
| More on Kl | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620396 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.