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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:11336 | 6480464 | Ethinyl Estradiol results in increased expression of SPARC mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:11336 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPARC mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of SPARC mRNA | CTD | PMID:17557909 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of SPARC mRNA | CTD | PMID:16079270 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731035 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPARC mRNA | CTD | PMID:11489354 PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:11336 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SPARC mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731035 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPARC mRNA | CTD | PMID:11489354 more ... | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731035 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPARC mRNA | CTD | PMID:20106945 PMID:11489354 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPARC mRNA | CTD | PMID:11752688 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:11336 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPARC mRNA | CTD | PMID:17942748 | 2,4,6-trinitrobenzenesulfonic acid | multiple interactions | ISO | RGD:11336 | 6480464 | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA] | CTD | PMID:18200517 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | ISO | RGD:11336 | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA | CTD | PMID:17994277 PMID:18200517 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | ISO | RGD:11336 | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA | CTD | PMID:18200517 PMID:17994277 | 2,4,6-trinitrobenzenesulfonic acid | multiple interactions | ISO | RGD:11336 | 6480464 | Tretinoin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]; more ... | CTD | PMID:17994277 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SPARC mRNA | CTD | PMID:20959002 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of SPARC mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:11336 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of SPARC mRNA | CTD | PMID:18648102 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:731035 | 6480464 | decitabine inhibits the reaction [DNMT3A protein binds to SPARC promoter] | CTD | PMID:19177197 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:731035 | 6480464 | [decitabine affects the methylation of SPARC promoter] which affects the expression of SPARC mRNA | CTD | PMID:18458674 PMID:18458674 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:731035 | 6480464 | decitabine results in increased expression of SPARC mRNA | CTD | PMID:17397030 PMID:19177197 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:731035 | 6480464 | decitabine results in increased expression of SPARC mRNA | CTD | PMID:19177197 PMID:17397030 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:731035 | 6480464 | decitabine results in increased expression of SPARC protein | CTD | PMID:19177197 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:731035 | 6480464 | [decitabine affects the methylation of SPARC promoter] which affects the susceptibility to Fluorouracil; more ... | CTD | PMID:18458674 | 5-fluorouracil | multiple interactions | ISO | RGD:731035 | 6480464 | [decitabine affects the methylation of SPARC promoter] which affects the susceptibility to Fluorouracil | CTD | PMID:18458674 | 5-fluorouracil | increases response to substance | ISO | RGD:731035 | 6480464 | SPARC protein results in increased susceptibility to Fluorouracil | CTD | PMID:15902309 | acetylsalicylic acid | multiple interactions | ISO | RGD:731035 | 6480464 | Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SPARC protein] | CTD | PMID:17303692 | alendronic acid | affects expression | EXP | | 6480464 | Alendronate affects the expression of SPARC mRNA | CTD | PMID:16079270 | all-trans-retinoic acid | multiple interactions | ISO | RGD:11336 | 6480464 | Tretinoin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA] | CTD | PMID:17994277 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SPARC mRNA | CTD | PMID:16483693 | arachidonic acid | decreases expression | ISO | RGD:731035 | 6480464 | Arachidonic Acid results in decreased expression of SPARC mRNA | CTD | PMID:16704987 | benzene | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SPARC mRNA | CTD | PMID:17905399 | benzo[a]pyrene | multiple interactions | ISO | RGD:11336 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of SPARC mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:11336 | 6480464 | Benzo(a)pyrene results in increased expression of SPARC mRNA | CTD | PMID:22610609 | cadmium atom | decreases expression | ISO | RGD:731035 | 6480464 | Cadmium results in decreased expression of SPARC mRNA | CTD | PMID:20570719 | cadmium dichloride | decreases expression | ISO | RGD:731035 | 6480464 | Cadmium Chloride results in decreased expression of SPARC mRNA; more ... | CTD | PMID:20837119 | calciol | multiple interactions | ISO | RGD:731035 | 6480464 | [Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPARC protein | CTD | PMID:17692823 | calcitriol | increases expression | EXP | | 6480464 | Calcitriol results in increased expression of SPARC protein | CTD | PMID:19092814 | carmustine | affects response to substance | ISO | RGD:731035 | 6480464 | SPARC mRNA affects the susceptibility to Carmustine | CTD | PMID:16365179 | chlorpyrifos | decreases expression | ISO | RGD:11336 | 6480464 | Chlorpyrifos results in decreased expression of SPARC mRNA | CTD | PMID:20350560 | choline | multiple interactions | ISO | RGD:11336 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARC mRNA | CTD | PMID:20938992 | copper atom | multiple interactions | ISO | RGD:11336 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SPARC mRNA | CTD | PMID:15467011 | copper atom | decreases secretion | ISO | RGD:11336 | 6480464 | Copper results in decreased secretion of SPARC protein | CTD | PMID:19635393 | copper atom | increases expression | ISO | RGD:731035 | 6480464 | Copper results in increased expression of SPARC mRNA | CTD | PMID:16629173 | copper(0) | multiple interactions | ISO | RGD:11336 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SPARC mRNA | CTD | PMID:15467011 | copper(0) | decreases secretion | ISO | RGD:11336 | 6480464 | Copper results in decreased secretion of SPARC protein | CTD | PMID:19635393 | copper(0) | increases expression | ISO | RGD:731035 | 6480464 | Copper results in increased expression of SPARC mRNA | CTD | PMID:16629173 | curcumin | multiple interactions | ISO | RGD:11336 | 6480464 | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA] | CTD | PMID:18200517 | cyclophosphamide | decreases expression | ISO | RGD:11336 | 6480464 | Cyclophosphamide results in decreased expression of SPARC mRNA | CTD | PMID:15331540 | cyclophosphamide | increases expression | ISO | RGD:731035 | 6480464 | Cyclophosphamide results in increased expression of SPARC mRNA | CTD | PMID:17403535 | cyclosporin A | decreases expression | ISO | RGD:731035 | 6480464 | Cyclosporine results in decreased expression of SPARC mRNA | CTD | PMID:20106945 | cytarabine | decreases expression | ISO | RGD:731035 | 6480464 | Cytarabine results in decreased expression of SPARC mRNA | CTD | PMID:21198554 | D-glucose | decreases expression | ISO | RGD:731035 | 6480464 | Glucose results in decreased expression of SPARC mRNA | CTD | PMID:19924377 | D-glucose | multiple interactions | ISO | RGD:731035 | 6480464 | cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of SPARC mRNA] | CTD | PMID:19924377 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SPARC mRNA | CTD | PMID:21551480 | doxorubicin | increases expression | ISO | RGD:731035 | 6480464 | Doxorubicin results in increased expression of SPARC mRNA | CTD | PMID:15870702 | doxorubicin | increases expression | ISO | RGD:11336 | 6480464 | Doxorubicin results in increased expression of SPARC mRNA | CTD | PMID:15033991 | ethanol | increases expression | ISO | RGD:731035 | 6480464 | Ethanol results in increased expression of SPARC mRNA | CTD | PMID:15963989 | folic acid | multiple interactions | ISO | RGD:11336 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARC mRNA | CTD | PMID:20938992 | furosemide | increases expression | EXP | | 6480464 | Furosemide results in increased expression of SPARC mRNA | CTD | PMID:16526316 | glucose | decreases expression | ISO | RGD:731035 | 6480464 | Glucose results in decreased expression of SPARC mRNA | CTD | PMID:19924377 | glucose | multiple interactions | ISO | RGD:731035 | 6480464 | cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of SPARC mRNA] | CTD | PMID:19924377 | glycerol 2-phosphate | multiple interactions | ISO | RGD:731035 | 6480464 | [Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPARC protein | CTD | PMID:17692823 | indomethacin | multiple interactions | ISO | RGD:11336 | 6480464 | Indomethacin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA] | CTD | PMID:17994277 | L-ascorbic acid | multiple interactions | ISO | RGD:731035 | 6480464 | [Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPARC protein | CTD | PMID:17692823 | L-methionine | multiple interactions | ISO | RGD:11336 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARC mRNA | CTD | PMID:20938992 | losartan | decreases expression | EXP | | 6480464 | Losartan results in decreased expression of SPARC mRNA | CTD | PMID:15100363 | magnesium atom | increases expression | ISO | RGD:731035 | 6480464 | Magnesium results in increased expression of SPARC protein | CTD | PMID:10397942 | methylmercury(1+) | increases expression | EXP | | 6480464 | methylmercury II results in increased expression of SPARC mRNA | CTD | PMID:17905399 | methylmercury(1+) | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SPARC mRNA | CTD | PMID:17905399 | N-ethyl-N-nitrosourea | increases expression | EXP | | 6480464 | Ethylnitrosourea results in increased expression of SPARC mRNA | CTD | PMID:15954086 | N-methyl-N'-nitro-N-nitrosoguanidine | decreases expression | ISO | RGD:731035 | 6480464 | Methylnitronitrosoguanidine results in decreased expression of SPARC mRNA | CTD | PMID:12634122 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of SPARC mRNA | CTD | PMID:19638242 | paclitaxel | increases expression | ISO | RGD:731035 | 6480464 | Paclitaxel results in increased expression of SPARC mRNA | CTD | PMID:19682730 | paracetamol | affects expression | ISO | RGD:11336 | 6480464 | Acetaminophen affects the expression of SPARC mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | RGD:731035 | 6480464 | Phenobarbital affects the expression of SPARC mRNA | CTD | PMID:19159669 | piroxicam | decreases expression | ISO | RGD:731035 | 6480464 | Piroxicam results in decreased expression of SPARC mRNA | CTD | PMID:21858171 | raloxifene | affects expression | EXP | | 6480464 | Raloxifene affects the expression of SPARC mRNA | CTD | PMID:16079270 | resveratrol | decreases expression | ISO | RGD:731035 | 6480464 | resveratrol results in decreased expression of SPARC mRNA; more ... | CTD | PMID:16084059 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SPARC mRNA | CTD | PMID:19228061 | rosiglitazone | increases expression | EXP | | 6480464 | rosiglitazone results in increased expression of SPARC mRNA | CTD | PMID:21172411 | streptozocin | increases expression | ISO | RGD:11336 | 6480464 | Streptozocin results in increased expression of SPARC protein; more ... | CTD | PMID:12660331 | temozolomide | affects response to substance | ISO | RGD:731035 | 6480464 | SPARC mRNA affects the susceptibility to temozolomide | CTD | PMID:16365179 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:731035 | 6480464 | tert-Butylhydroperoxide results in decreased expression of SPARC mRNA | CTD | PMID:15336504 | tert-butyl hydroperoxide | increases expression | ISO | RGD:731035 | 6480464 | tert-Butylhydroperoxide results in increased expression of SPARC mRNA | CTD | PMID:15963989 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SPARC mRNA | CTD | PMID:17056239 PMID:16239168 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SPARC mRNA | CTD | PMID:16239168 PMID:17056239 | tetrachloromethane | affects expression | ISO | RGD:11336 | 6480464 | Carbon Tetrachloride affects the expression of SPARC mRNA | CTD | PMID:17484886 | trans-resveratrol | decreases expression | ISO | RGD:731035 | 6480464 | resveratrol results in decreased expression of SPARC mRNA; more ... | CTD | PMID:16084059 | trans-resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SPARC mRNA | CTD | PMID:19228061 | trichloroethene | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SPARC mRNA | CTD | PMID:17905399 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SPARC mRNA | CTD | PMID:19448997 | valproic acid | affects expression | ISO | RGD:11336 | 6480464 | Valproic Acid affects the expression of SPARC mRNA | CTD | PMID:17963808 | vancomycin | decreases expression | ISO | RGD:11336 | 6480464 | Vancomycin results in decreased expression of SPARC mRNA | CTD | PMID:18930951 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated| 1. |
Au E, etal., J Neurosci. 2007 Jul 4;27(27):7208-21. |
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Bagavandoss P, etal., J Histochem Cytochem. 1998 Sep;46(9):1043-49. |
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Brown TJ, etal., Gynecol Oncol. 1999 Oct;75(1):25-33. |
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Camino AM, etal., J Gene Med. 2008 Sep;10(9):993-1004. |
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Chang W, etal., Endocrinology. 2002 Apr;143(4):1467-74. |
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Cheng CY Biochem Biophys Res Commun. 1990 Mar 30;167(3):1393-9. |
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Engelmann GL Cardiovasc Res. 1993 Sep;27(9):1598-605. |
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Fujii M, etal., Kobe J Med Sci. 1997 Feb;43(1):13-23. |
| 9. |
Gilbert RE, etal., Kidney Int. 1995 Oct;48(4):1216-25. |
| 10. |
GOA data from the GO Consortium |
| 11. |
Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14. |
| 12. |
Inagaki H, etal., Life Sci. 1996;58(11):927-34. |
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Ishigaki R, etal., Histochem J. 2002 Jan-Feb;34(1-2):57-66. |
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Jandeleit-Dahm K, etal., Microvasc Res. 2000 Jan;59(1):61-71. |
| 15. |
Komatsubara I, etal., Cardiovasc Pathol. 2003 Jul-Aug;12(4):186-94. |
| 16. |
Kumei Y, etal., Ann N Y Acad Sci. 2006 Dec;1090:311-7. |
| 17. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 18. |
Lee MJ, etal., Arch Toxicol 1995;69(9):590-5. |
| 19. |
Li J, etal., Am J Physiol Endocrinol Metab 2002 Jun;282(6):E1334-41. |
| 20. |
Liao H, etal., Eur J Oral Sci 1998 Jan;106 Suppl 1:418-23. |
| 21. |
Maeng HY, etal., Jpn J Cancer Res. 2002 Sep;93(9):960-7. |
| 22. |
Mendis DB, etal., Neurochem Res. 1998 Aug;23(8):1117-23. |
| 23. |
MGD data from the GO Consortium |
| 24. |
Mothe AJ and Brown IR, Hear Res. 2001 May;155(1-2):161-74. |
| 25. |
Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30. |
| 26. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 27. |
Nimphius W, etal., Virchows Arch. 2007 Feb;450(2):179-85. |
| 28. |
Onyia JE, etal., J Cell Biochem. 2005 May 15;95(2):403-18. |
| 29. |
Pichler RH, etal., Am J Pathol. 1996 Apr;148(4):1153-67. |
| 30. |
Pichler RH, etal., Kidney Int. 1996 Dec;50(6):1978-89. |
| 31. |
Puolakkainen P, etal., Dig Dis Sci. 1999 Aug;44(8):1554-64. |
| 32. |
Reed MJ, etal., J Histochem Cytochem. 1993 Oct;41(10):1467-77. |
| 33. |
RGD automated data pipeline |
| 34. |
RGD automated import pipeline for gene-chemical interactions |
| 35. |
Rodriguez-Jimenez FJ, etal., Oncol Rep. 2007 Jun;17(6):1301-7. |
| 36. |
Said N, etal., Mol Cancer Res. 2007 Oct;5(10):1015-30. |
| 37. |
Sakai N, etal., Hum Pathol. 2001 Oct;32(10):1064-70. |
| 38. |
Sauk JJ, etal., Toxicol Appl Pharmacol. 1992 Oct;116(2):240-7. |
| 39. |
Socha MJ, etal., Am J Pathol. 2007 Oct;171(4):1104-12. Epub 2007 Aug 23. |
| 40. |
Sova P, etal., Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):114-23. |
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Strandjord TP, etal., Am J Respir Cell Mol Biol. 1995 Sep;13(3):279-87. |
| 42. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
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Sugimoto M, etal., J Bone Miner Res. 1998 Feb;13(2):271-8. |
| 44. |
Tartare-Deckert S, etal., J Biol Chem. 2001 Jun 22;276(25):22231-7. Epub 2001 Apr 9. |
| 45. |
Turner RT, etal., Alcohol Clin Exp Res. 2001 May;25(5):667-71. |
| 46. |
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| 47. |
Yamanaka M, etal., J Urol. 2001 Dec;166(6):2495-9. |
References - uncurated
RGD Disease Portals| Sparc has been annotated in the following RGD Disease Portals. |
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Candidate Gene Status
Comparative Map Data| Sparc (Rattus norvegicus) |
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| SPARC (Homo sapiens) |
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| Sparc (Mus musculus) |
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Position Markers| RH128632 |
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| RH94599 |
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| RH140308 |
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| PMC151926P2 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012656 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06063871 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01063974 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC061777 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D28875 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212364 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212499 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212746 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213815 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213945 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214222 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214492 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214649 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214673 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215195 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215581 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215622 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215818 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215935 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ216823 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ217546 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219866 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219932 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219983 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220003 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220043 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220046 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220186 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220279 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220287 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220443 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220507 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220547 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220572 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220644 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220827 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220880 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220901 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222209 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222224 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ223025 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ223521 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ224996 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225033 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225092 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225200 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225220 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225486 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225609 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225618 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225644 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225678 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225688 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225694 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225722 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225884 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225913 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225914 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225965 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226299 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226354 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226360 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226584 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226599 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226651 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226673 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226731 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226746 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227279 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227628 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227644 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227708 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227725 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227727 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227749 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228032 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228597 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229172 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229199 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229230 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229283 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229299 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229315 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229316 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229384 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229936 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230029 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230086 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230210 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230381 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230595 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230619 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230667 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230705 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230778 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230864 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230993 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231067 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231166 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231444 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231523 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231543 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231632 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231753 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231815 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231918 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231975 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232042 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232191 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232201 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232223 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232271 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232364 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232445 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232464 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232710 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232838 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232847 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232862 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232869 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232965 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232977 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232986 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233178 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233283 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233669 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233698 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233777 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233810 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233845 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233850 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233926 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234037 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234069 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234108 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234199 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234410 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234418 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234523 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234589 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234657 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234685 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234766 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ235008 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ235038 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ235049 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U75928 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y13714 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012656 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036788 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_036788 | (Get FASTA) |
| GenBank Protein | AAH61777 | (Get FASTA) |
| BAA06029 | (Get FASTA) | |
| CAA74042 | (Get FASTA) | |
| EDM04474 | (Get FASTA) | |
| EDM04475 | (Get FASTA) | |
| EDM04476 | (Get FASTA) | |
| EDM04477 | (Get FASTA) | |
| EDM04478 | (Get FASTA) | |
| EDM04479 | (Get FASTA) | |
| EDM04480 | (Get FASTA) | |
| EDM04481 | (Get FASTA) | |
| EDM04482 | (Get FASTA) | |
| EDM04483 | (Get FASTA) | |
| P16975 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000012840 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000017486 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000017486 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 24791 | ENTREZGENE |
| Gene3D-CATH | EF-Hand_type | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000012840 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 31132 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:5621666 | IMAGE-MGC_LOAD |
| InterPro | EF-hand-like_dom | UniProtKB/Swiss-Prot |
| EF_Hand_1_Ca_BS | UniProtKB/Swiss-Prot | |
| Fol_N | UniProtKB/Swiss-Prot | |
| Follistatin/Osteonectin_EGF | UniProtKB/Swiss-Prot | |
| Osteonectin_CS | UniProtKB/Swiss-Prot | |
| Prot_inh_Kazal | UniProtKB/Swiss-Prot | |
| SPARC/Testican_Ca-bd-dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00189424 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24791 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72514 | IMAGE-MGC_LOAD |
| Pfam | FOLN | UniProtKB/Swiss-Prot |
| Kazal_1 | UniProtKB/Swiss-Prot | |
| SPARC_Ca_bdg | UniProtKB/Swiss-Prot | |
| PROSITE | EF_HAND_1 | UniProtKB/Swiss-Prot |
| EF_HAND_2; FALSE_NEG | UniProtKB/Swiss-Prot | |
| KAZAL_2 | UniProtKB/Swiss-Prot | |
| OSTEONECTIN_1 | UniProtKB/Swiss-Prot | |
| OSTEONECTIN_2 | UniProtKB/Swiss-Prot | |
| SMART | FOLN | UniProtKB/Swiss-Prot |
| KAZAL | UniProtKB/Swiss-Prot | |
| UniGene | Rn.98989 | ENTREZGENE |
| UniProt | SPRC_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-18 | Sparc | secreted protein, acidic, cysteine-rich (osteonectin) | Sparc | secreted acidic cysteine rich glycoprotein | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Sparc | Secreted acidic cystein-rich glycoprotein (osteonectin) | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | mRNA expressed in osteoblasts, odontoblasts, and fibroblasts during development | 730043 |
| gene_expression | expression is increased 2.2 fold in SHR compared with WKY rats | 1357414 |
| gene_regulation | expression increases at the onset of high-fat-diet obesity | 625747 |
| More on Sparc | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3742 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




