Myo1e (myosin IE) - Rat Genome Database

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Gene: Myo1e (myosin IE) Rattus norvegicus
Analyze
Symbol: Myo1e
Name: myosin IE
RGD ID: 3144
Description: Predicted to enable several functions, including ATP hydrolysis activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in several processes, including actin filament organization; glomerular filtration; and glomerulus development. Predicted to act upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; and vasculogenesis. Located in cuticular plate. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: myosin heavy chain myr 3; myosin I e; myosin-Ie; Myr3; MYR5; unconventional myosin 1E; Unconventional myosin from rat 5; unconventional myosin-Ie
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Vetf5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8879,768,828 - 79,961,048 (+)NCBIGRCr8
mRatBN7.2870,887,934 - 71,080,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,887,870 - 71,080,169 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,421,230 - 76,614,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0874,694,252 - 74,887,286 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,532,530 - 72,725,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0876,644,715 - 76,840,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl876,754,492 - 76,839,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0876,241,676 - 76,432,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4874,680,727 - 74,884,376 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1874,699,780 - 74,903,430 (+)NCBI
Celera870,648,832 - 70,842,630 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
glycidol  (EXP)
hydroxyurea  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lithium chloride  (ISO)
methotrexate  (ISO)
mifepristone  (EXP)
nickel sulfate  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
saccharin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, etal., J Assoc Res Otolaryngol 2002 Dec;3(4):375-89. Epub 2002 Feb 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. Krendel M, etal., FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. A novel mammalian myosin I from rat with an SH3 domain localizes to Con A-inducible, F-actin-rich structures at cell-cell contacts. Stoffler HE, etal., J Cell Biol 1995 May;129(3):819-30.
Additional References at PubMed
PMID:11208135   PMID:11940582   PMID:17143286   PMID:19005011   PMID:20089841   PMID:20458337   PMID:20860408   PMID:22114352  


Genomics

Comparative Map Data
Myo1e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8879,768,828 - 79,961,048 (+)NCBIGRCr8
mRatBN7.2870,887,934 - 71,080,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,887,870 - 71,080,169 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,421,230 - 76,614,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0874,694,252 - 74,887,286 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,532,530 - 72,725,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0876,644,715 - 76,840,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl876,754,492 - 76,839,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0876,241,676 - 76,432,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4874,680,727 - 74,884,376 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1874,699,780 - 74,903,430 (+)NCBI
Celera870,648,832 - 70,842,630 (-)NCBICelera
Cytogenetic Map8q24NCBI
MYO1E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381559,132,434 - 59,372,871 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1559,132,434 - 59,372,871 (-)EnsemblGRCh38hg38GRCh38
GRCh371559,424,633 - 59,665,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361557,215,855 - 57,452,363 (-)NCBINCBI36Build 36hg18NCBI36
Build 341557,215,855 - 57,452,363NCBI
Celera1536,316,513 - 36,553,029 (-)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1536,250,377 - 36,487,296 (-)NCBIHuRef
CHM1_11559,546,143 - 59,783,017 (-)NCBICHM1_1
T2T-CHM13v2.01556,934,526 - 57,174,966 (-)NCBIT2T-CHM13v2.0
Myo1e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,114,632 - 70,307,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,114,632 - 70,307,048 (+)EnsemblGRCm39 Ensembl
GRCm38970,207,350 - 70,400,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,207,350 - 70,399,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv37970,055,157 - 70,247,874 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,006,514 - 70,199,231 (+)NCBIMGSCv36mm8
Celera967,429,438 - 67,616,081 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.41NCBI
Myo1e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,456,580 - 15,551,584 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,421,843 - 15,551,680 (+)NCBIChiLan1.0ChiLan1.0
MYO1E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21648,401,647 - 48,638,895 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11552,584,087 - 52,820,740 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01538,106,599 - 38,343,040 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11556,413,570 - 56,649,683 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1556,413,570 - 56,649,722 (-)Ensemblpanpan1.1panPan2
MYO1E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13024,067,622 - 24,265,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3024,068,283 - 24,265,311 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3024,041,333 - 24,239,771 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03024,236,065 - 24,434,141 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3024,236,074 - 24,433,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13024,161,240 - 24,360,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03024,244,241 - 24,442,581 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03024,387,998 - 24,586,599 (-)NCBIUU_Cfam_GSD_1.0
Myo1e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640102,396,361 - 102,587,555 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647120,244,397 - 20,435,648 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647120,244,424 - 20,435,604 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO1E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,677,821 - 112,901,993 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11112,677,545 - 112,902,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21124,676,396 - 124,901,516 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO1E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,138,462 - 24,378,602 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,138,829 - 24,379,143 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,944,885 - 117,186,889 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo1e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478112,682,514 - 12,871,099 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478112,682,614 - 12,866,990 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo1e
844 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000016482
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat

Markers in Region
D8Rat195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,035,636 - 71,035,802 (+)MAPPERmRatBN7.2
Rnor_6.0876,792,194 - 76,792,361NCBIRnor6.0
Rnor_5.0876,285,024 - 76,285,191UniSTSRnor5.0
RGSC_v3.4874,831,544 - 74,831,712RGDRGSC3.4
RGSC_v3.4874,831,545 - 74,831,712UniSTSRGSC3.4
RGSC_v3.1874,850,457 - 74,850,839RGD
Celera870,694,432 - 70,694,597UniSTS
FHH x ACI Map851.31RGD
FHH x ACI Map851.31UniSTS
Cytogenetic Map8q24UniSTS
D8Got203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,051,708 - 71,051,915 (+)MAPPERmRatBN7.2
Rnor_6.0876,808,267 - 76,808,469NCBIRnor6.0
Rnor_5.0876,268,916 - 76,269,118UniSTSRnor5.0
RGSC_v3.4874,847,618 - 74,847,821RGDRGSC3.4
RGSC_v3.4874,847,619 - 74,847,821UniSTSRGSC3.4
RGSC_v3.1874,866,672 - 74,866,875RGD
Celera870,678,340 - 70,678,554UniSTS
RH 2.0 Map8677.0RGD
Cytogenetic Map8q24UniSTS
D8Got307  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,051,711 - 71,051,959 (+)MAPPERmRatBN7.2
Rnor_6.0876,808,270 - 76,808,513NCBIRnor6.0
Rnor_5.0876,268,872 - 76,269,115UniSTSRnor5.0
RGSC_v3.4874,847,622 - 74,847,865UniSTSRGSC3.4
Celera870,678,296 - 70,678,551UniSTS
Cytogenetic Map8q24UniSTS
RH132530  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,079,970 - 71,080,185 (+)MAPPERmRatBN7.2
Rnor_6.0876,840,352 - 76,840,566NCBIRnor6.0
Rnor_5.0876,241,350 - 76,241,564UniSTSRnor5.0
RGSC_v3.4874,884,488 - 74,884,702UniSTSRGSC3.4
Celera870,648,506 - 70,648,720UniSTS
Cytogenetic Map8q24UniSTS
AU049451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,059,769 - 71,059,909 (+)MAPPERmRatBN7.2
Rnor_6.0876,816,488 - 76,816,627NCBIRnor6.0
Rnor_5.0876,260,971 - 76,261,110UniSTSRnor5.0
RGSC_v3.4874,856,251 - 74,856,390UniSTSRGSC3.4
Cytogenetic Map8q24UniSTS
STS-Z41090  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,068,063 - 71,068,716 (+)MAPPERmRatBN7.2
Rnor_6.0876,828,445 - 76,829,097NCBIRnor6.0
Rnor_5.0876,252,819 - 76,253,471UniSTSRnor5.0
Celera870,659,983 - 70,660,635UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 13 16 12 13 12 1 1 17 35 25 11 1
Low 30 41 29 6 29 7 10 57 16 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000085727   ⟹   ENSRNOP00000074970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,997,105 - 71,080,169 (+)Ensembl
Rnor_6.0 Ensembl876,754,492 - 76,839,593 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104863   ⟹   ENSRNOP00000083425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,887,870 - 71,080,169 (+)Ensembl
RefSeq Acc Id: NM_173101   ⟹   NP_775124
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8879,768,828 - 79,960,727 (+)NCBI
mRatBN7.2870,887,934 - 71,079,859 (+)NCBI
Rnor_6.0876,644,715 - 76,840,240 (+)NCBI
Rnor_5.0876,241,676 - 76,432,611 (-)NCBI
RGSC_v3.4874,680,727 - 74,884,376 (+)RGD
Celera870,648,832 - 70,842,630 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080888   ⟹   XP_038936816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8879,848,450 - 79,961,048 (+)NCBI
mRatBN7.2870,967,578 - 71,080,180 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_775124   ⟸   NM_173101
- UniProtKB: Q63356 (UniProtKB/Swiss-Prot),   A0A0G2K9E8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074970   ⟸   ENSRNOT00000085727
RefSeq Acc Id: XP_038936816   ⟸   XM_039080888
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9E8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083425   ⟸   ENSRNOT00000104863
Protein Domains
IQ   Myosin motor   SH3   TH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63356-F1-model_v2 AlphaFold Q63356 1-1107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3144 AgrOrtholog
BioCyc Gene G2FUF-29937 BioCyc
Ensembl Genes ENSRNOG00000061928 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007084 UniProtKB/Swiss-Prot
  ENSRNOG00060017424 UniProtKB/Swiss-Prot
  ENSRNOG00065016265 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085727.2 UniProtKB/TrEMBL
  ENSRNOT00000104863 ENTREZGENE
  ENSRNOT00000104863.1 UniProtKB/Swiss-Prot
  ENSRNOT00055011767 UniProtKB/Swiss-Prot
  ENSRNOT00060030120 UniProtKB/Swiss-Prot
  ENSRNOT00065027124 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.4820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ie/If_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYSc_Myo1 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25484 UniProtKB/Swiss-Prot
NCBI Gene 25484 ENTREZGENE
PANTHER MYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UNCONVENTIONAL MYOSIN-IE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myo1e PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061928 RatGTEx
  ENSRNOG00055007084 RatGTEx
  ENSRNOG00060017424 RatGTEx
  ENSRNOG00065016265 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9E8 ENTREZGENE, UniProtKB/TrEMBL
  A6KET8_RAT UniProtKB/TrEMBL
  A6KET9_RAT UniProtKB/TrEMBL
  MYO1E_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Myo1e  myosin IE  Myr3  Unconventional myosin from rat 5  Symbol and Name updated 625702 APPROVED
2002-06-10 Myr3  Unconventional myosin from rat 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in hair cells of the auditory and vestibular epithelia 1298992
gene_expression localized in cytoplasm and in elongated structures to F-actin-rich structures at regions of cell-cell contact 1298993
gene_function function may be mediated by cell-cell contact 1298993