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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:737313 | 6480464 | epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of AGER protein] | CTD | PMID:22101032 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:737312 | 6480464 | Ethinyl Estradiol results in increased expression of AGER mRNA; more ... | CTD | PMID:15878629 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:737312 | 6480464 | SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA] | CTD | PMID:15878629 | 17beta-estradiol | multiple interactions | ISO | RGD:737312 | 6480464 | ESR1 protein promotes the reaction [Estradiol results in increased expression of AGER protein]; more ... | CTD | PMID:15878629 | 17beta-estradiol | increases expression | ISO | RGD:737312 | 6480464 | Estradiol results in increased expression of AGER mRNA; more ... | CTD | PMID:15878629 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:737313 | 6480464 | Tetrachlorodibenzodioxin affects the expression of AGER mRNA | CTD | PMID:21570461 | 3,4-dihydroxybenzaldehyde | multiple interactions | ISO | RGD:737312 | 6480464 | protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; more ... | CTD | PMID:17597607 | all-trans-retinol | multiple interactions | EXP | | 6480464 | [Vitamin A results in increased abundance of Reactive Oxygen Species] which results in increased expression of AGER protein | CTD | PMID:18396385 | all-trans-retinol | increases expression | EXP | | 6480464 | Vitamin A results in increased expression of AGER protein | CTD | PMID:18396385 PMID:21807062 | all-trans-retinol | increases expression | EXP | | 6480464 | Vitamin A results in increased expression of AGER protein | CTD | PMID:21807062 PMID:18396385 | all-trans-retinol | multiple interactions | EXP | | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein]; more ... | CTD | PMID:21807062 | all-trans-retinol | increases expression | EXP | | 6480464 | Vitamin A results in increased expression of AGER protein | CTD | PMID:18396385 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of AGER mRNA | CTD | PMID:16483693 | benazepril | decreases expression | EXP | | 6480464 | benazepril results in decreased expression of AGER mRNA; more ... | CTD | PMID:19018797 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of AGER promoter | CTD | PMID:22457795 | carbamazepine | increases expression | ISO | RGD:737313 | 6480464 | Carbamazepine results in increased expression of AGER mRNA | CTD | PMID:22790970 | cholesterol | affects abundance | ISO | RGD:737312 | 6480464 | AGER protein affects the abundance of Cholesterol | CTD | PMID:20372816 | D-glucose | increases expression | ISO | RGD:737312 | 6480464 | Glucose results in increased expression of AGER mRNA | CTD | PMID:19557821 | D-glucose | increases expression | EXP | | 6480464 | Glucose results in increased expression of AGER protein | CTD | PMID:19759273 | D-glucose | multiple interactions | ISO | RGD:737312 | 6480464 | Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA]; more ... | CTD | PMID:19557821 | dichlorine | decreases expression | EXP | | 6480464 | Chlorine results in decreased expression of AGER mRNA | CTD | PMID:18636392 | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in increased expression of AGER mRNA | CTD | PMID:18636392 | estriol | increases expression | ISO | RGD:737312 | 6480464 | Estriol results in increased expression of AGER protein | CTD | PMID:15878629 | fulvestrant | multiple interactions | ISO | RGD:737312 | 6480464 | fulvestrant inhibits the reaction [Estradiol results in increased expression of AGER protein] | CTD | PMID:15878629 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of AGER gene | CTD | PMID:22079235 | galactose | increases expression | ISO | RGD:737313 | 6480464 | Galactose results in increased expression of AGER mRNA; more ... | CTD | PMID:22687555 | glucose | increases expression | ISO | RGD:737312 | 6480464 | Glucose results in increased expression of AGER mRNA | CTD | PMID:19557821 | glucose | increases expression | EXP | | 6480464 | Glucose results in increased expression of AGER protein | CTD | PMID:19759273 | glucose | multiple interactions | ISO | RGD:737312 | 6480464 | Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA]; more ... | CTD | PMID:19557821 | leflunomide | decreases expression | ISO | RGD:737313 | 6480464 | leflunomide results in decreased expression of AGER mRNA | CTD | PMID:19751817 | luteolin | multiple interactions | ISO | RGD:737312 | 6480464 | Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA] | CTD | PMID:19557821 | LY294002 | multiple interactions | EXP | | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein] | CTD | PMID:21807062 | lycopene | multiple interactions | ISO | RGD:737312 | 6480464 | lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; more ... | CTD | PMID:22429818 | methylglyoxal | multiple interactions | ISO | RGD:737313 | 6480464 | epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of AGER protein] | CTD | PMID:22101032 | methylglyoxal | increases expression | ISO | RGD:737313 | 6480464 | Pyruvaldehyde results in increased expression of AGER protein | CTD | PMID:22101032 | N-acetyl-L-cysteine | multiple interactions | ISO | RGD:737312 | 6480464 | Acetylcysteine inhibits the reaction [advanced glycation end products-bovine serum albumin results in increased expression of AGER protein]; more ... | CTD | PMID:19553346 | naphthalene | affects binding | ISO | RGD:737313 | 6480464 | naphthalene metabolite binds to AGER protein | CTD | PMID:15892573 | nitroprusside | multiple interactions | ISO | RGD:737312 | 6480464 | Nitroprusside inhibits the reaction [advanced glycation end products-bovine serum albumin results in increased expression of AGER protein]; more ... | CTD | PMID:19553346 | oleanolic acid | multiple interactions | ISO | RGD:737312 | 6480464 | Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] | CTD | PMID:22386814 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in increased expression of AGER mRNA | CTD | PMID:18636392 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Vehicle Emissions] results in increased expression of AGER mRNA | CTD | PMID:20980218 | paracetamol | affects expression | ISO | RGD:737313 | 6480464 | Acetaminophen affects the expression of AGER mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:737312 | 6480464 | Acetaminophen results in decreased expression of AGER mRNA | CTD | PMID:22230336 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of AGER mRNA | CTD | PMID:19162173 | quercetin | multiple interactions | ISO | RGD:737312 | 6480464 | Quercetin inhibits the reaction [Glucose results in increased expression of AGER mRNA] | CTD | PMID:19557821 | resveratrol | multiple interactions | ISO | RGD:737312 | 6480464 | [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [resveratrol results in increased expression of AGER protein]; more ... | CTD | PMID:20372816 | resveratrol | decreases expression | ISO | RGD:737312 | 6480464 | resveratrol results in decreased expression of AGER protein | CTD | PMID:20372816 | rutin | multiple interactions | ISO | RGD:737312 | 6480464 | Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA] | CTD | PMID:19557821 | simvastatin | multiple interactions | ISO | RGD:737312 | 6480464 | Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] | CTD | PMID:17038636 | simvastatin | decreases expression | ISO | RGD:737312 | 6480464 | Simvastatin results in decreased expression of AGER protein | CTD | PMID:17038636 | taurine | multiple interactions | ISO | RGD:737312 | 6480464 | Taurine inhibits the reaction [advanced glycation end products-bovine serum albumin results in increased expression of AGER protein]; more ... | CTD | PMID:19553346 | trans-resveratrol | decreases expression | ISO | RGD:737312 | 6480464 | resveratrol results in decreased expression of AGER protein | CTD | PMID:20372816 | trans-resveratrol | multiple interactions | ISO | RGD:737312 | 6480464 | [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [resveratrol results in increased expression of AGER protein]; more ... | CTD | PMID:20372816 | zinc atom | multiple interactions | ISO | RGD:737313 | 6480464 | Zinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of AGER protein] | CTD | PMID:20857495 | zinc atom | multiple interactions | EXP | | 6480464 | Zinc inhibits the reaction [Zinc deficiency results in increased expression of AGER protein] | CTD | PMID:19111725 | zinc atom | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of AGER protein | CTD | PMID:19111725 | zinc(0) | multiple interactions | ISO | RGD:737313 | 6480464 | Zinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of AGER protein] | CTD | PMID:20857495 | zinc(0) | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of AGER protein | CTD | PMID:19111725 | zinc(0) | multiple interactions | EXP | | 6480464 | Zinc inhibits the reaction [Zinc deficiency results in increased expression of AGER protein] | CTD | PMID:19111725 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | amb2 Integrin signaling (PID:200127) |
Disease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| Pathway Interaction Database | amb2 Integrin signaling (PID:200127) |
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MGD data from the GO Consortium |
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RGD automated import pipeline for gene-chemical interactions |
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References - uncurated| PubMed | 12477932 |
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RGD Disease Portals| Ager has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ager (Rattus norvegicus) |
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| AGER (Homo sapiens) |
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| Ager (Mus musculus) |
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Position Markers| RH133750 |
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| PMC162222P1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053336 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06099863 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01099582 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC084697 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BX883044 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474121 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR475487 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164715 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164716 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164717 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164718 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164719 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164720 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164721 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164723 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164724 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU164725 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L33413 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053336 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_445788 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_445788 | (Get FASTA) |
| GenBank Protein | AAA42027 | (Get FASTA) |
| AAH84697 | (Get FASTA) | |
| ADX07273 | (Get FASTA) | |
| ADX07274 | (Get FASTA) | |
| ADX07275 | (Get FASTA) | |
| ADX07276 | (Get FASTA) | |
| CAE83960 | (Get FASTA) | |
| EDL83392 | (Get FASTA) | |
| EDL83393 | (Get FASTA) | |
| EDL83394 | (Get FASTA) | |
| Q63495 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000000439 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000000508 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000066649 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000000508 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000072848 | UniProtKB/TrEMBL | |
| Entrez Gene | 81722 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000000439 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 883 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7121345 | IMAGE-MGC_LOAD |
| InterPro | CD80_C2-set | UniProtKB/Swiss-Prot |
| Ig-like | UniProtKB/Swiss-Prot | |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig/MHC_CS | UniProtKB/Swiss-Prot | |
| Ig_sub | UniProtKB/Swiss-Prot | |
| Ig_sub2 | UniProtKB/Swiss-Prot | |
| IPI | IPI00209188 | UniProtKB/Swiss-Prot |
| IPI00951462 | UniProtKB/TrEMBL | |
| KEGG Report | rno:81722 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:105376 | IMAGE-MGC_LOAD |
| Pfam | C2-set_2 | UniProtKB/Swiss-Prot |
| PROSITE | IG_LIKE | UniProtKB/Swiss-Prot |
| IG_MHC | UniProtKB/Swiss-Prot | |
| SMART | IGc2 | UniProtKB/Swiss-Prot |
| SM00409 | UniProtKB/Swiss-Prot | |
| TIGR | TC208219 | |
| UniGene | Rn.9829 | ENTREZGENE |
| UniProt | M0RAU0_RAT | UniProtKB/TrEMBL |
| Q6MG86_RAT | UniProtKB/TrEMBL | |
| RAGE_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Ager | advanced glycosylation end product-specific receptor | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_mapping | is found within the rat major histocompatibility RT1 complex. | 1300431 |
| gene_process | mediates interactions of advanced glycosylation end products (age), which accumulate in vascular tissue in aging and at an accelerated rate in diabetes | 724707 |
| More on Ager | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 69258 |
| Created: | 2001-11-14 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.