RGD Reference Report - Genotyping of -374A/T, -429A/G, and 63 bp Ins/del polymorphisms of RAGE by rapid one-step hexaprimer amplification refractory mutation system polymerase chain reaction in breast cancer patients. - Rat Genome Database

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Genotyping of -374A/T, -429A/G, and 63 bp Ins/del polymorphisms of RAGE by rapid one-step hexaprimer amplification refractory mutation system polymerase chain reaction in breast cancer patients.

Authors: Hashemi, M  Moazeni-Roodi, A  Arbabi, F  Fazaeli, A  Nasab, EE  Taheri, M  Kerkhoff, C  Ghavami, S 
Citation: Hashemi M, etal., Nucleosides Nucleotides Nucleic Acids. 2012 May;31(5):401-10. doi: 10.1080/15257770.2012.665545.
RGD ID: 8695989
Pubmed: PMID:22497255   (View Abstract at PubMed)
DOI: DOI:10.1080/15257770.2012.665545   (Journal Full-text)

Several studies have focused on the RAGE genetic background and have demonstrated that its polymorphisms affect the receptor's activity, expression, and downstream signaling. However, there is only little information regarding RAGE polymorphism in breast cancer. In the present study, the authors studied RAGE polymorphisms in 71 patients with breast cancer and 93 healthy women. RAGE -374T/A, -429T/C, and 63 bp Ins/del polymorphisms were analyzed using a hexaprimer amplification refractory mutation system PCR (H-ARMS-PCR). The results showed that RAGE polymorphisms are not associated with breast cancer in the current study population. Larger studies are required to confirm these data in other populations.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Breast Neoplasms no_associationIAGP 8695989DNA:SNPs more ...RGD 
Breast Neoplasms no_associationISOAGER (Homo sapiens)8695989; 8695989DNA:SNPs more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ager  (advanced glycosylation end product-specific receptor)

Genes (Mus musculus)
Ager  (advanced glycosylation end product-specific receptor)

Genes (Homo sapiens)
AGER  (advanced glycosylation end-product specific receptor)


Additional Information