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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ager
Name: advanced glycosylation end product-specific receptor
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agerincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of AGER proteinPMID:29480285
Agermultiple interactionsEXP 6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]PMID:29480285
Ageraffects expressionISOAger (Mus musculus)6480464CTDLipopolysaccharides affects the expression of AGER mRNAPMID:22169119
Agerincreases expressionISOAGER (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of AGER mRNA; Lipopolysaccharides results in increased expression of AGER proteinPMID:17038636 PMID:22429818 PMID:24747151
Agermultiple interactionsISOAGER (Homo sapiens)6480464CTDlycopene inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]PMID:17038636 PMID:22429818
Agermultiple interactionsISOAger (Mus musculus)6480464CTD[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNAPMID:22169119
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