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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | RGD:737117 | 6480464 | Catechin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species]; more ... | CTD | PMID:17103373 | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of S100B protein | CTD | PMID:18226170 | (R)-noradrenaline | increases expression | ISO | RGD:737117 | 6480464 | Norepinephrine results in increased expression of S100B protein; more ... | CTD | PMID:9788975 | (R)-noradrenaline | affects response to substance | ISO | RGD:737117 | 6480464 | S100B protein affects the susceptibility to Norepinephrine | CTD | PMID:9788975 | (S)-nicotine | decreases expression | ISO | RGD:11252 | 6480464 | Nicotine results in decreased expression of S100B mRNA | CTD | PMID:21955143 | 1-chloro-2,4-dinitrobenzene | decreases expression | ISO | RGD:737117 | 6480464 | Dinitrochlorobenzene results in decreased expression of S100B mRNA | CTD | PMID:17374397 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:737117 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of S100B mRNA | CTD | PMID:17101203 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of S100B mRNA | CTD | PMID:22808131 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:737117 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of S100B mRNA | CTD | PMID:21296121 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:11252 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to S100B promoter] | CTD | PMID:19654925 | 3,4-dihydroxybenzaldehyde | multiple interactions | ISO | RGD:737117 | 6480464 | protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; more ... | CTD | PMID:17597607 | 4-(ethoxymethylene)-2-phenyloxazol-5-one | decreases expression | ISO | RGD:737117 | 6480464 | Oxazolone results in decreased expression of S100B mRNA | CTD | PMID:17374397 | aluminium atom | increases expression | EXP | | 6480464 | Aluminum results in increased expression of S100B protein | CTD | PMID:16545059 | aluminium atom | multiple interactions | EXP | | 6480464 | Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein] | CTD | PMID:16545059 | aluminium(0) | increases expression | EXP | | 6480464 | Aluminum results in increased expression of S100B protein | CTD | PMID:16545059 | aluminium(0) | multiple interactions | EXP | | 6480464 | Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein] | CTD | PMID:16545059 | aminoguanidine | multiple interactions | EXP | | 6480464 | pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein]; more ... | CTD | PMID:19494442 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of S100B mRNA | CTD | PMID:16483693 | ammonium chloride | decreases expression | EXP | | 6480464 | Ammonium Chloride results in decreased expression of S100B protein | CTD | PMID:16483693 | astemizole | decreases expression | EXP | | 6480464 | Astemizole results in decreased expression of S100B mRNA | CTD | PMID:20221588 | buspirone | decreases response to substance | ISO | RGD:11252 | 6480464 | S100B results in decreased susceptibility to Buspirone | CTD | PMID:12888777 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of S100B mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of S100B promoter | CTD | PMID:22457795 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of S100B protein | CTD | PMID:17635592 | cobalt atom | multiple interactions | ISO | RGD:737117 | 6480464 | [tungsten carbide co-treated with Cobalt] results in decreased expression of S100B mRNA | CTD | PMID:18078969 | cocaine | multiple interactions | EXP | | 6480464 | ipsapirone inhibits the reaction [Cocaine affects the expression of S100B protein] | CTD | PMID:8041492 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of S100B protein | CTD | PMID:8041492 | cycloheximide | decreases expression | EXP | | 6480464 | Cycloheximide results in decreased expression of S100B mRNA | CTD | PMID:19146868 | Delta(9)-tetrahydrocannabinol | increases expression | ISO | RGD:11252 | 6480464 | Tetrahydrocannabinol results in increased expression of S100B mRNA | CTD | PMID:21955143 | diarsenic trioxide | increases expression | ISO | RGD:737117 | 6480464 | arsenic trioxide results in increased expression of S100B mRNA | CTD | PMID:20458559 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of S100B mRNA | CTD | PMID:21266533 | dimethoate | increases expression | EXP | | 6480464 | Dimethoate results in increased expression of S100B mRNA; more ... | CTD | PMID:21941777 | ethanol | increases expression | ISO | RGD:11252 | 6480464 | Ethanol results in increased expression of S100B mRNA | CTD | PMID:21955143 | fluoxetine | increases response to substance | ISO | RGD:11252 | 6480464 | S100B protein results in increased susceptibility to Fluoxetine | CTD | PMID:22113448 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of S100B protein | CTD | PMID:12960766 | fluoxetine | increases expression | ISO | RGD:11252 | 6480464 | Fluoxetine results in increased expression of S100B protein | CTD | PMID:12960766 | fluoxetine | increases expression | ISO | RGD:11252 | 6480464 | Fluoxetine results in increased expression of S100B mRNA | CTD | PMID:20857517 | heparin | affects expression | EXP | | 6480464 | Heparin affects the expression of S100B protein | CTD | PMID:12186470 | hydrogen peroxide | decreases secretion | EXP | | 6480464 | Hydrogen Peroxide results in decreased secretion of S100B protein | CTD | PMID:18835240 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of S100B mRNA | CTD | PMID:20080153 | L-ascorbic acid | increases expression | EXP | | 6480464 | Ascorbic Acid results in increased expression of S100B mRNA | CTD | PMID:15372504 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of S100B protein | CTD | PMID:17047031 | manganese(II) chloride | increases expression | ISO | RGD:11252 | 6480464 | manganese chloride results in increased expression of S100B mRNA; more ... | CTD | PMID:15295902 | mercaptopurine | increases expression | EXP | | 6480464 | 6-Mercaptopurine results in increased expression of S100B mRNA | CTD | PMID:23358152 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of S100B protein | CTD | PMID:21783483 | morphine | decreases expression | ISO | RGD:11252 | 6480464 | Morphine results in decreased expression of S100B mRNA | CTD | PMID:21955143 | nickel sulfate | decreases expression | ISO | RGD:737117 | 6480464 | nickel sulfate results in decreased expression of S100B mRNA | CTD | PMID:17374397 | nitric oxide | multiple interactions | ISO | RGD:11252 | 6480464 | [S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide | CTD | PMID:16376947 | nitric oxide | multiple interactions | EXP | | 6480464 | [S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide | CTD | PMID:16376947 | ouabain | increases expression | EXP | | 6480464 | Ouabain results in increased expression of S100B protein | CTD | PMID:15581912 | paraquat | affects expression | EXP | | 6480464 | Paraquat affects the expression of S100B mRNA | CTD | PMID:16854511 | perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of S100B protein | CTD | PMID:20937303 | phenylephrine | increases expression | EXP | | 6480464 | Phenylephrine results in increased expression of S100B mRNA | CTD | PMID:15652358 | phenylephrine | multiple interactions | EXP | | 6480464 | S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]; more ... | CTD | PMID:15652358 | pirinixic acid | multiple interactions | EXP | | 6480464 | L 663536 inhibits the reaction [pirinixic acid affects the expression of S100B protein] | CTD | PMID:16863991 | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of S100B protein | CTD | PMID:16863991 | purine-6-thiol | increases expression | EXP | | 6480464 | 6-Mercaptopurine results in increased expression of S100B mRNA | CTD | PMID:23358152 | quercetin | multiple interactions | ISO | RGD:737117 | 6480464 | Quercetin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species]; more ... | CTD | PMID:17103373 | resveratrol | increases secretion | EXP | | 6480464 | resveratrol results in increased secretion of S100B protein | CTD | PMID:17554623 | risperidone | increases secretion | EXP | | 6480464 | Risperidone results in increased secretion of S100B protein | CTD | PMID:18421423 | streptozocin | multiple interactions | EXP | | 6480464 | pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]; more ... | CTD | PMID:19494442 | streptozocin | decreases expression | EXP | | 6480464 | Streptozocin results in decreased expression of S100B protein | CTD | PMID:19494442 PMID:20953641 | streptozocin | decreases expression | EXP | | 6480464 | Streptozocin results in decreased expression of S100B protein | CTD | PMID:20953641 PMID:19494442 | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of S100B protein | CTD | PMID:19494442 | trans-resveratrol | increases secretion | EXP | | 6480464 | resveratrol results in increased secretion of S100B protein | CTD | PMID:17554623 | valproic acid | affects expression | ISO | RGD:11252 | 6480464 | Valproic Acid affects the expression of S100B mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| 8794737 | |
| 9485423 |
RGD Disease Portals| S100b has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| S100b (Rattus norvegicus) |
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| S100B (Homo sapiens) |
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| S100b (Mus musculus) |
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Position Markers| D20Wox6 |
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| RH94706 |
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| AA945753 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013191 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06100267 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06100268 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06100269 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01100158 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01100159 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC087026 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473988 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212122 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213381 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213618 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213687 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213774 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213840 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214218 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214292 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214554 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M15705 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M54919 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X01090 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013191 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037323 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037323 | (Get FASTA) |
| GenBank Protein | AAA42096 | (Get FASTA) |
| AAH87026 | (Get FASTA) | |
| CAA25567 | (Get FASTA) | |
| EDL97155 | (Get FASTA) | |
| EDL97156 | (Get FASTA) | |
| P04631 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001295 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000001743 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000001743 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25742 | ENTREZGENE |
| Gene3D-CATH | EF-Hand_type | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000001295 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 4567 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7193740 | IMAGE-MGC_LOAD |
| InterPro | EF-hand-like_dom | UniProtKB/Swiss-Prot |
| EF_Hand_1_Ca_BS | UniProtKB/Swiss-Prot | |
| EF_hand_Ca-bd | UniProtKB/Swiss-Prot | |
| S100/CaBP-9k_CS | UniProtKB/Swiss-Prot | |
| S100_Ca_bd_sub | UniProtKB/Swiss-Prot | |
| IPI | IPI00231771 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25742 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93559 | IMAGE-MGC_LOAD |
| Pfam | S_100 | UniProtKB/Swiss-Prot |
| PROSITE | EF_HAND_1 | UniProtKB/Swiss-Prot |
| EF_HAND_2 | UniProtKB/Swiss-Prot | |
| S100_CABP | UniProtKB/Swiss-Prot | |
| UniGene | Rn.8937 | ENTREZGENE |
| UniProt | S100B_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-18 | S100b | S100 calcium binding protein B | S100b | S100 protein, beta polypeptide, neural | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-18 | S100b | S100 protein, beta polypeptide, neural | S100b | S100 protein, beta polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | S100b | S100 calcium-binding protein, beta (neural) | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | colocalizes to membrane ruffles with GTPase activating protein IQGAP | 727451 |
| gene_expression | expressed in the brain astrocytes and mRNA was detected in the rat heart after coronary artery ligation | 628549 |
| gene_process | inhibits postinfarct myocardial hypertrophic response | 628549 |
| gene_protein | 20 kDa calcium binding homodimer | 628549 |
| gene_regulation | activation of the promoter is mediated through the PKC signalling pathway | 628549 |
| More on S100b | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3615 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




