RGD Reference Report - Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma. - Rat Genome Database

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Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma.

Authors: Korwar, AM  Bhonsle, HS  Chougale, AD  Kote, SS  Gawai, KR  Ghole, VS  Koppikar, CB  Kulkarni, MJ 
Citation: Korwar AM, etal., Biochem Biophys Res Commun. 2012 Mar 16;419(3):490-4. doi: 10.1016/j.bbrc.2012.02.039. Epub 2012 Feb 14.
RGD ID: 8695990
Pubmed: PMID:22366088   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2012.02.039   (Journal Full-text)

Cancer is associated with increased glycolysis and carbonyl stress. In view of this, AGE modified proteins were identified from clinical breast cancer tissue using 2DE-immunoblot and mass-spectrometry. These proteins were identified to be serotransferrin, fibrinogen gamma chain, glycerol-3-phosphate dehydrogenase, lactate dehydrogenase, annexin II, prohibitin and peroxiredoxin 6, which have established role in cancer. Further, RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB were studied. Role of these AGE modified proteins and RAGE signaling in breast cancer is discussed.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
invasive ductal carcinoma  IEP 8695990protein:increased expression:breastRGD 
invasive ductal carcinoma  ISOAGER (Homo sapiens)8695990; 8695990protein:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ager  (advanced glycosylation end product-specific receptor)

Genes (Mus musculus)
Ager  (advanced glycosylation end product-specific receptor)

Genes (Homo sapiens)
AGER  (advanced glycosylation end-product specific receptor)


Additional Information