RGD Reference Report - The relationship between RAGE gene four common polymorphisms and breast cancer risk in northeastern Han Chinese. - Rat Genome Database

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The relationship between RAGE gene four common polymorphisms and breast cancer risk in northeastern Han Chinese.

Authors: Pan, H  He, L  Wang, B  Niu, W 
Citation: Pan H, etal., Sci Rep. 2014 Mar 12;4:4355. doi: 10.1038/srep04355.
RGD ID: 8695984
Pubmed: PMID:24619131   (View Abstract at PubMed)
PMCID: PMC5394748   (View Article at PubMed Central)
DOI: DOI:10.1038/srep04355   (Journal Full-text)

We aimed to evaluate the association of four common polymorphisms (rs1800625, rs1800624, rs2070600, and rs184003) in receptor for advanced glycation end products (RAGE) gene to evaluate their epistatic influence on breast cancer risk in northeastern Han Chinese. This is a hospital-based case-control study involving 509 histologically-proven breast cancer patients and 504 cancer-free controls. The genotype and allele distributions of rs184003 differed significantly between patients and controls, even after the Bonferroni correction. Individuals carrying the rs184003 T allele exhibited 1.62-fold increased risk of breast cancer (odds ratio (OR) = 1.62; 95% confidence interval (95% CI): 1.26-2.08; P < 0.001) after adjusting for confounders. The frequency of haplotype T-T-G-T (alleles in order of rs1800625, rs1800624, rs2070600, and rs184003) was remarkably higher in patients than in controls (Simulated P = 0.001), and this haplotype was significantly associated with a 1.43-fold (95% CI: 1.01-2.01; P = 0.041) increase in adjusted risk of breast cancer. Further analysis indicated that there was synergistic interaction between rs184003 and rs2070600, whereas their joint information gain value was relatively small (0.27%). Taken together, although there was no suggestive evidence for the presence of epistasis in RAGE gene, our findings clearly demonstrate that rs184003 might play a predominant role in the development of breast cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Breast Neoplasms  IAGP 8695984DNA:SNP and haplotype: :rs184003 (human)RGD 
Breast Neoplasms  ISOAGER (Homo sapiens)8695984; 8695984DNA:SNP and haplotype: :rs184003 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ager  (advanced glycosylation end product-specific receptor)

Genes (Mus musculus)
Ager  (advanced glycosylation end product-specific receptor)

Genes (Homo sapiens)
AGER  (advanced glycosylation end-product specific receptor)


Additional Information