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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ager
Name: advanced glycosylation end product-specific receptor
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agerincreases expressionEXP 6480464CTDZinc deficiency results in increased expression of AGER proteinPMID:19111725
Agermultiple interactionsEXP 6480464CTDZinc inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of AGER protein]PMID:19111725 PMID:31009641
Agermultiple interactionsISOAger (Mus musculus)6480464CTDPTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of AGER protein]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of AGER protein]]PMID:20857495
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