RGD Reference Report - The relationship between receptor for advanced glycation end products expression and the severity of periodontal disease in the gingiva of diabetic and non diabetic periodontitis patients.

General

The relationship between receptor for advanced glycation end products expression and the severity of periodontal disease in the gingiva of diabetic and non diabetic periodontitis patients.
Authors:	Abbass, MM Korany, NS Salama, AH Dmytryk, JJ Safiejko-Mroczka, B
Citation:	Abbass MM, etal., Arch Oral Biol. 2012 Jul 12.
RGD ID:	6784499
Pubmed:	PMID:22795565 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.archoralbio.2012.06.007 (Journal Full-text)
OBJECTIVE: Activation of receptor for advanced glycation end products (RAGE) has been implicated in many chronic diseases, including diabetic complications. In this study we examined the relationship between RAGE expression and the morphological changes seen in the gingiva of diabetic and periodontitis patients. DESIGN: Gingival biopsies from 15 diabetic patients with periodontitis, 25 non diabetic patients with periodontitis and 10 healthy individuals were collected. Sections were stained with haematoxylin and eosin, and immunohistochemically to detect RAGE. Samples were examined in light and fluorescence microscopes and histomorphometric analysis was performed. RESULTS: Increased number of inflammatory cells and changes in collagen and vasculature were observed in diabetic and non diabetic patients with periodontitis. RAGE was weakly expressed in healthy gingiva. The strongest reaction with anti-RAGE antibody was found in the gingiva of diabetic patients with periodontitis followed by the severe periodontitis patients. RAGE expression in inflammatory cells was stronger than in the epithelium. The number of inflammatory cells in the gingiva was higher in the diabetic periodontitis patients than in the non diabetic severe periodontitis patients. CONCLUSIONS: RAGE is strongly expressed in the gingiva of diabetic patients with periodontitis and with severe periodontitis alone, the latter indicating RAGE activation even in the absence of hyperglycemia. However our findings are based on relatively small sample size. With a larger patient population, some of our other findings may have reached statistical significance.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
periodontitis		IEP		6784499		RGD
periodontitis		ISO	AGER (Homo sapiens)	6784499; 6784499		RGD

Objects Annotated

Genes (Rattus norvegicus)

Ager (advanced glycosylation end product-specific receptor)

Genes (Mus musculus)

Ager (advanced glycosylation end product-specific receptor)

Genes (Homo sapiens)

AGER (advanced glycosylation end-product specific receptor)

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The relationship between receptor for advanced glycation end products expression and the severity of periodontal disease in the gingiva of diabetic and non diabetic periodontitis patients.