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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1349909 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PNP mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PNP mRNA | CTD | PMID:17557909 | 17beta-estradiol | increases expression | ISO | RGD:10999 | 6480464 | Estradiol results in increased expression of PNP mRNA | CTD | PMID:14664709 | 17beta-estradiol | affects expression | ISO | RGD:1349909 | 6480464 | Estradiol affects the expression of PNP mRNA | CTD | PMID:14699072 | 5-fluorouracil | affects response to substance | ISO | RGD:1349909 | 6480464 | PNP protein affects the susceptibility to Fluorouracil | CTD | PMID:15548681 | afimoxifene | multiple interactions | ISO | RGD:1349909 | 6480464 | 4-hydroxytamoxifen inhibits the reaction [Estrogens results in increased expression of PNP mRNA] | CTD | PMID:21233418 | aflatoxin B1 | affects expression | ISO | RGD:1349909 | 6480464 | Aflatoxin B1 affects the expression of PNP protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RGD:1349909 | 6480464 | Aflatoxin B1 results in increased expression of PNP mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | decreases expression | ISO | RGD:1349909 | 6480464 | Tretinoin results in decreased expression of PNP mRNA | CTD | PMID:16054129 | arsenic acid | increases reduction | ISO | RGD:1349909 | 6480464 | PNP protein results in increased reduction of arsenic acid | CTD | PMID:15929903 | arsenic acid | increases metabolic processing | ISO | RGD:1349909 | 6480464 | PNP protein results in increased metabolism of arsenic acid | CTD | PMID:12928150 | arsenic acid | multiple interactions | ISO | RGD:1349909 | 6480464 | [PNP protein results in increased metabolism of arsenic acid] which results in increased chemical synthesis of arsenite | CTD | PMID:12928150 | arsenic atom | multiple interactions | ISO | RGD:1349909 | 6480464 | GSTO2 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]; more ... | CTD | PMID:21605854 | arsenic atom | increases reduction | ISO | RGD:1349909 | 6480464 | PNP protein results in increased reduction of Arsenic | CTD | PMID:18414634 | arsenic atom | increases response to substance | ISO | RGD:1349909 | 6480464 | PNP gene polymorphism results in increased susceptibility to Arsenic | CTD | PMID:18414634 | arsenic atom | affects response to substance | ISO | RGD:1349909 | 6480464 | PNP gene polymorphism affects the susceptibility to Arsenic | CTD | PMID:21605854 | arsenite(3-) | increases chemical synthesis | ISO | RGD:1349909 | 6480464 | PNP protein results in increased chemical synthesis of arsenite | CTD | PMID:12928150 | arsenite(3-) | multiple interactions | ISO | RGD:1349909 | 6480464 | [PNP protein results in increased metabolism of arsenic acid] which results in increased chemical synthesis of arsenite | CTD | PMID:12928150 | benzo[a]pyrene | multiple interactions | ISO | RGD:10999 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of PNP mRNA | CTD | PMID:21715664 | ciguatoxin CTX1B | affects expression | ISO | RGD:10999 | 6480464 | Ciguatoxins affects the expression of PNP mRNA | CTD | PMID:18353800 | cisplatin | increases expression | ISO | RGD:10999 | 6480464 | Cisplatin results in increased expression of PNP mRNA | CTD | PMID:21151649 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of PNP protein | CTD | PMID:16470657 | clofibrate | decreases expression | ISO | RGD:10999 | 6480464 | Clofibrate results in decreased expression of PNP mRNA | CTD | PMID:17585979 | clofibrate | multiple interactions | ISO | RGD:10999 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of PNP mRNA; more ... | CTD | PMID:17585979 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PNP mRNA | CTD | PMID:17602206 | copper(2+) sulfate | increases expression | ISO | RGD:1349909 | 6480464 | Copper Sulfate results in increased expression of PNP mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1349909 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of PNP mRNA; more ... | CTD | PMID:19167446 | coumestrol | increases expression | ISO | RGD:1349909 | 6480464 | Coumestrol results in increased expression of PNP mRNA | CTD | PMID:19167446 | Delta(9)-tetrahydrocannabinol | affects expression | ISO | RGD:1349909 | 6480464 | Tetrahydrocannabinol affects the expression of PNP mRNA | CTD | PMID:18454173 | diarsenic trioxide | decreases expression | ISO | RGD:1349909 | 6480464 | arsenic trioxide results in decreased expression of PNP mRNA | CTD | PMID:19128835 | diazoxide | increases expression | ISO | RGD:10999 | 6480464 | Isoproterenol results in increased expression of PNP mRNA | CTD | PMID:20003209 | diazoxide | increases expression | ISO | RGD:10999 | 6480464 | Isoproterenol results in increased expression of PNP mRNA | CTD | PMID:20003209 PMID:21335049 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PNP mRNA | CTD | PMID:21266533 | disodium selenite | increases expression | ISO | RGD:1349909 | 6480464 | Sodium Selenite results in increased expression of PNP mRNA | CTD | PMID:18175754 | isoprenaline | increases expression | ISO | RGD:10999 | 6480464 | Isoproterenol results in increased expression of PNP mRNA | CTD | PMID:20003209 | isoprenaline | increases expression | ISO | RGD:10999 | 6480464 | Isoproterenol results in increased expression of PNP mRNA | CTD | PMID:20003209 PMID:21335049 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of PNP mRNA | CTD | PMID:20080153 | L-ascorbic acid | affects expression | ISO | RGD:10999 | 6480464 | Ascorbic Acid affects the expression of PNP protein | CTD | PMID:19224539 | menadione | affects expression | ISO | RGD:1349909 | 6480464 | Vitamin K 3 affects the expression of PNP mRNA | CTD | PMID:20044591 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PNP mRNA | CTD | PMID:17602206 | paracetamol | multiple interactions | ISO | RGD:10999 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of PNP mRNA; more ... | CTD | PMID:17585979 | paracetamol | multiple interactions | ISO | RGD:10999 | 6480464 | dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] | CTD | PMID:22939915 | paracetamol | decreases expression | ISO | RGD:10999 | 6480464 | Acetaminophen results in decreased expression of PNP protein | CTD | PMID:22939915 | paracetamol | increases expression | ISO | RGD:1349909 | 6480464 | Acetaminophen results in increased expression of PNP mRNA | CTD | PMID:21420995 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of PNP protein | CTD | PMID:16099942 | pirinixic acid | decreases expression | ISO | RGD:10999 | 6480464 | pirinixic acid results in decreased expression of PNP mRNA | CTD | PMID:17426115 PMID:18445702 | pirinixic acid | decreases expression | ISO | RGD:10999 | 6480464 | pirinixic acid results in decreased expression of PNP mRNA | CTD | PMID:18445702 PMID:17426115 | quercetin | increases expression | ISO | RGD:1349909 | 6480464 | Quercetin results in increased expression of PNP mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:1349909 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of PNP mRNA | CTD | PMID:19167446 | tamoxifen | affects expression | ISO | RGD:1349909 | 6480464 | Tamoxifen affects the expression of PNP mRNA | CTD | PMID:14699072 | tert-butyl hydroperoxide | increases expression | ISO | RGD:1349909 | 6480464 | tert-Butylhydroperoxide results in increased expression of PNP mRNA | CTD | PMID:15336504 | trans-resveratrol | multiple interactions | ISO | RGD:1349909 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of PNP mRNA | CTD | PMID:19167446 | valproic acid | increases expression | ISO | RGD:1349909 | 6480464 | Valproic Acid results in increased expression of PNP mRNA | CTD | PMID:19101580 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Nicotinate and nicotinamide metabolism | |
| Purine metabolism | |
| Pyrimidine metabolism | |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Nicotinate and nicotinamide metabolism | |
| Purine metabolism | |
| Pyrimidine metabolism | |
References - curated| 1. |
Castellano B, etal., J Histochem Cytochem. 1990 Nov;38(11):1535-9. |
| 2. |
RGD automated data pipeline |
| 3. |
RGD automated import pipeline for gene-chemical interactions |
| 4. |
RGD Automated Pipelines |
| 5. |
RGD, Sept. 2003 |
| 6. |
Silva RG, etal., Neurochem Res. 2004 Oct;29(10):1831-5. |
| 7. |
Williams SR, etal., J Biol Chem. 1987 Feb 15;262(5):2332-8. |
| 8. |
Wu G and Marliss EB, Clin Exp Immunol. 1991 Nov;86(2):260-5. |
RGD Disease Portals| Pnp has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pnp (Rattus norvegicus) |
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| PNP (Homo sapiens) |
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| Pnp (Mus musculus) |
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Position Markers| RH127813 |
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| RH140701 |
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| RH125524 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001106031 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06082825 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01082889 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474040 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001106031 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001099501 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001099501 | (Get FASTA) |
| GenBank Protein | EDL88429 | (Get FASTA) |
| EDL88430 | (Get FASTA) | |
| EDL88431 | (Get FASTA) | |
| P85973 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009982 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000013582 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000013582 | UniProtKB/TrEMBL |
| Entrez Gene | 290029 | ENTREZGENE |
| InterPro | InoGua/Xao_phosphorylase | UniProtKB/Swiss-Prot |
| Nucleoside_phosphorylase | UniProtKB/Swiss-Prot | |
| Pur_Nuc_Pase_Ino/Guo-sp | UniProtKB/Swiss-Prot | |
| Purine_phosphorylase-2 | UniProtKB/Swiss-Prot | |
| Purine_phosphorylase-2_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00870631 | UniProtKB/Swiss-Prot |
| IPI00950730 | UniProtKB/TrEMBL | |
| KEGG Report | rno:290029 | ENTREZGENE, UniProtKB/TrEMBL |
| PANTHER | Mtap_PNP | UniProtKB/Swiss-Prot |
| PTHR11904:SF9 | UniProtKB/Swiss-Prot | |
| Pfam | PNP_UDP_1 | UniProtKB/Swiss-Prot |
| PIRSF | PurNPase | UniProtKB/Swiss-Prot |
| PROSITE | PNP_MTAP_2 | UniProtKB/Swiss-Prot |
| TIGRFAMs | PNPH | UniProtKB/Swiss-Prot |
| PNPH-PUNA-XAPA | UniProtKB/Swiss-Prot | |
| UniGene | Rn.2738 | ENTREZGENE |
| UniProt | D3ZXK9_RAT | UniProtKB/TrEMBL |
| PNPH_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2011-08-02 | Pnp | purine nucleoside phosphorylase | Np | nucleoside phosphorylase | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2007-03-06 | Np | nucleoside phosphorylase (mapped) | Np_mapped | nucleoside phosphorylase (mapped) | Data Merged | 9333 | PROVISIONAL |
| 2006-11-20 | Np | nucleoside phosphorylase (mapped) | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2005-11-17 | Np_mapped | nucleoside phosphorylase (mapped) | Np | nucleoside phosphorylase | Symbol and Name updated | 14094 | APPROVED |
| 2002-11-06 | Np | nucleoside phosphorylase | Nucleoside phosphorylase | Name updated | 2225 | APPROVED | |
| 2002-06-10 | Np | Nucleoside phosphorylase | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_homology | mouse purine-nucleoside phosphorylase (Pnp) exhibits purine-nucleoside phosphorylase and glycosyl transferase activities | 704405 |
| More on Pnp | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1597189 |
| Created: | 2006-11-20 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




