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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-artemisinic acid | decreases expression | ISO | RGD:734203 | 6480464 | artemisic acid results in decreased expression of MIF mRNA | CTD | PMID:23063590 | (+)-catechin | decreases expression | ISO | RGD:734203 | 6480464 | Catechin results in decreased expression of MIF mRNA | CTD | PMID:15465739 | 1,10-phenanthroline | increases expression | ISO | RGD:734203 | 6480464 | 1,10-phenanthroline results in increased expression of MIF mRNA | CTD | PMID:19502547 | 1,2,4-trimethylbenzene | decreases expression | EXP | | 6480464 | pseudocumene results in decreased expression of MIF protein | CTD | PMID:17337753 | 1-fluoro-2,4-dinitrobenzene | increases expression | ISO | RGD:734204 | 6480464 | Dinitrofluorobenzene results in increased expression of MIF mRNA | CTD | PMID:11244134 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:734204 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MIF mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of MIF mRNA | CTD | PMID:16174780 PMID:15576828 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of MIF mRNA | CTD | PMID:15576828 PMID:16174780 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:734204 | 6480464 | Ethinyl Estradiol affects the expression of MIF mRNA | CTD | PMID:17555576 | 17beta-estradiol | increases expression | ISO | RGD:734204 | 6480464 | Estradiol results in increased expression of MIF mRNA | CTD | PMID:11861973 | 17beta-estradiol | multiple interactions | ISO | RGD:734204 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of MIF mRNA] | CTD | PMID:11861973 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | RGD:734204 | 6480464 | Dihydrotestosterone results in increased expression of MIF protein | CTD | PMID:16751997 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:734204 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MIF mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:734204 | 6480464 | Tetrachlorodibenzodioxin affects the expression of MIF mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:734204 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of MIF mRNA] | CTD | PMID:11861973 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of MIF mRNA | CTD | PMID:21346803 | 3H-1,2-dithiole-3-thione | increases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in increased expression of MIF mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:734204 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of MIF mRNA | CTD | PMID:18648102 | 7,12-dimethyltetraphene | increases expression | EXP | | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in increased expression of MIF mRNA | CTD | PMID:12376462 | all-trans-retinoic acid | increases expression | ISO | RGD:734203 | 6480464 | Tretinoin results in increased expression of MIF mRNA | CTD | PMID:17218384 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MIF mRNA | CTD | PMID:16483693 | apocynin | multiple interactions | ISO | RGD:734203 | 6480464 | acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] | CTD | PMID:22414048 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:734204 | 6480464 | Mustard Gas results in increased expression of MIF mRNA | CTD | PMID:18955075 | bis(2-chloroethyl) sulfide | decreases expression | ISO | RGD:734203 | 6480464 | Mustard Gas results in decreased expression of MIF mRNA | CTD | PMID:12884408 | bromobenzene | affects binding | EXP | | 6480464 | bromobenzene metabolite binds to MIF protein | CTD | PMID:17305373 | cadmium atom | affects binding | ISO | RGD:734204 | 6480464 | Cadmium binds to MIF protein | CTD | PMID:23085580 | cadmium atom | decreases response to substance | ISO | RGD:734204 | 6480464 | MIF protein results in decreased susceptibility to Cadmium | CTD | PMID:23085580 | cadmium atom | multiple interactions | ISO | RGD:734204 | 6480464 | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cadmium results in increased expression of MIF mRNA] | CTD | PMID:23085580 | cadmium atom | increases expression | ISO | RGD:734204 | 6480464 | Cadmium results in increased expression of MIF mRNA | CTD | PMID:23085580 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of MIF promoter | CTD | PMID:22457795 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of MIF protein | CTD | PMID:22150557 | capsaicin | multiple interactions | EXP | | 6480464 | Naproxen inhibits the reaction [Capsaicin results in increased expression of MIF protein]; more ... | CTD | PMID:22150557 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MIF mRNA | CTD | PMID:17602206 | cobalt atom | multiple interactions | ISO | RGD:734203 | 6480464 | [tungsten carbide co-treated with Cobalt] results in increased expression of MIF mRNA | CTD | PMID:18078969 | cobalt dichloride | increases expression | ISO | RGD:734203 | 6480464 | cobaltous chloride results in increased expression of MIF mRNA | CTD | PMID:19502547 | cobalt(2+) sulfate | increases expression | ISO | RGD:734203 | 6480464 | cobalt sulfate results in increased expression of MIF mRNA | CTD | PMID:19502547 | copper(2+) sulfate | decreases expression | ISO | RGD:734203 | 6480464 | Copper Sulfate results in decreased expression of MIF mRNA | CTD | PMID:19549813 | cumene | multiple interactions | ISO | RGD:734204 | 6480464 | [cumene co-treated with KRAS gene mutant form] results in increased expression of MIF mRNA | CTD | PMID:18648096 | cyclophosphamide | multiple interactions | EXP | | 6480464 | Cyclophosphamide affects the localization of and affects the expression of MIF protein; more ... | CTD | PMID:19066630 | dexamethasone | decreases expression | ISO | RGD:734204 | 6480464 | Dexamethasone results in decreased expression of MIF mRNA | CTD | PMID:21041162 | diarsenic trioxide | decreases expression | ISO | RGD:734203 | 6480464 | arsenic trioxide results in decreased expression of MIF protein | CTD | PMID:19364129 | diazinon | increases expression | ISO | RGD:734204 | 6480464 | Diazinon results in increased expression of MIF protein | CTD | PMID:19647006 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of MIF mRNA | CTD | PMID:21266533 | dioxygen | increases expression | ISO | RGD:734203 | 6480464 | Oxygen deficiency results in increased expression of MIF mRNA | CTD | PMID:19502547 | dioxygen | multiple interactions | ISO | RGD:734204 | 6480464 | HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of MIF mRNA] | CTD | PMID:20880076 | dioxygen | increases expression | ISO | RGD:734204 | 6480464 | Oxygen deficiency results in increased expression of MIF mRNA | CTD | PMID:20880076 | dioxygen | increases expression | ISO | RGD:734204 | 6480464 | Oxygen results in increased expression of MIF mRNA | CTD | PMID:10781441 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of MIF mRNA | CTD | PMID:15353170 | fluoxetine | affects response to substance | EXP | | 6480464 | MIF affects the susceptibility to Fluoxetine | CTD | PMID:20177408 | folic acid | affects expression | ISO | RGD:734203 | 6480464 | Folic Acid affects the expression of MIF mRNA | CTD | PMID:17320366 | hydrogen chloride | increases expression | EXP | | 6480464 | Hydrochloric Acid results in increased expression of MIF mRNA; more ... | CTD | PMID:12853844 | iron atom | multiple interactions | EXP | | 6480464 | [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA | CTD | PMID:22198552 | kojic acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MIF mRNA; more ... | CTD | PMID:18544905 | L-methionine | increases expression | ISO | RGD:734204 | 6480464 | Methionine deficiency results in increased expression of MIF mRNA | CTD | PMID:15924568 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of MIF mRNA | CTD | PMID:19149911 | mycophenolic acid | increases expression | ISO | RGD:734204 | 6480464 | Mycophenolic Acid results in increased expression of MIF mRNA | CTD | PMID:19818335 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MIF mRNA | CTD | PMID:17602206 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MIF mRNA; more ... | CTD | PMID:18544905 | naproxen | multiple interactions | EXP | | 6480464 | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; more ... | CTD | PMID:22150557 | nickel atom | multiple interactions | EXP | | 6480464 | [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA | CTD | PMID:22198552 | nickel sulfate | increases expression | ISO | RGD:734204 | 6480464 | nickel sulfate results in increased expression of MIF mRNA | CTD | PMID:11751209 | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of MIF mRNA | CTD | PMID:23358140 | paraquat | decreases expression | ISO | RGD:734204 | 6480464 | Paraquat results in decreased expression of MIF mRNA | CTD | PMID:21371552 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of MIF mRNA | CTD | PMID:19162173 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of MIF mRNA | CTD | PMID:19162173 | pyrogallol | decreases expression | ISO | RGD:734204 | 6480464 | Pyrogallol results in decreased expression of MIF mRNA | CTD | PMID:20362636 | quercetin | increases expression | ISO | RGD:734203 | 6480464 | Quercetin results in increased expression of MIF mRNA | CTD | PMID:19729006 | silver atom | increases expression | ISO | RGD:734203 | 6480464 | Silver results in increased expression of MIF mRNA | CTD | PMID:22342292 | silver(0) | increases expression | ISO | RGD:734203 | 6480464 | Silver results in increased expression of MIF mRNA | CTD | PMID:22342292 | sterigmatocystin | increases expression | ISO | RGD:734204 | 6480464 | Sterigmatocystin results in increased expression of MIF mRNA | CTD | PMID:19818335 | sumatriptan | multiple interactions | EXP | | 6480464 | Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MIF protein]; more ... | CTD | PMID:22150557 | trimellitic anhydride | increases expression | ISO | RGD:734204 | 6480464 | trimellitic anhydride results in increased expression of MIF mRNA | CTD | PMID:19042947 | tungsten atom | multiple interactions | EXP | | 6480464 | [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA | CTD | PMID:22198552 | zinc dichloride | decreases expression | ISO | RGD:734203 | 6480464 | zinc chloride results in decreased expression of MIF mRNA | CTD | PMID:18947441 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Phenylalanine metabolism |
| Tyrosine metabolism | |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Phenylalanine metabolism |
| Tyrosine metabolism | |
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RGD Disease Portals| Mif has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Mif (Rattus norvegicus) |
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| MIF (Homo sapiens) |
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| Mif (Mus musculus) |
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Position Markers| RH94636 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031051 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06100301 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01100182 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC061545 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473988 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ210474 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213295 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ217414 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ218686 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222835 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ223656 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229019 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229084 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S73424 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U20999 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U62326 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031051 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_112313 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_112313 | (Get FASTA) |
| GenBank Protein | AAA62644 | (Get FASTA) |
| AAB04024 | (Get FASTA) | |
| AAB32392 | (Get FASTA) | |
| AAH61545 | (Get FASTA) | |
| EDL97178 | (Get FASTA) | |
| P30904 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000006589 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000008608 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000008608 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 81683 | ENTREZGENE |
| Germonline | ENSRNOG00000006589 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55655 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:6920605 | IMAGE-MGC_LOAD |
| InterPro | Macrophage_inhib_fac | UniProtKB/Swiss-Prot |
| Macrophage_inhib_fac_CS | UniProtKB/Swiss-Prot | |
| Tautomerase | UniProtKB/Swiss-Prot | |
| IPI | IPI00230907 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:81683 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72801 | IMAGE-MGC_LOAD |
| PANTHER | MIF | UniProtKB/Swiss-Prot |
| Pfam | MIF | UniProtKB/Swiss-Prot |
| ProDom | Macrophage_inhib_fac | UniProtKB/Swiss-Prot |
| PROSITE | MIF | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | SSF55331 | UniProtKB/Swiss-Prot |
| UniGene | Rn.2661 | ENTREZGENE |
| UniProt | MIF_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2013-02-27 | Mif | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Mif | macrophage migration inhibitory factor | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Mif | macrophage migration inhibitory factor | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Mif | macrophage migration inhibitory factor | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | serum levels increase dramatically in in acute pancreatitis | 727512 |
| gene_regulation | protein expression is increased by dexamethasone treatment of the adrenal gland after ablation of the hypothalamic-pituitary-adrenal axis | 729251 |
| More on Mif | |
![]() |
Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621163 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




