Mir18a (microRNA 18a) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mir18a (microRNA 18a) Rattus norvegicus
Analyze
Symbol: Mir18a
Name: microRNA 18a
RGD ID: 2325396
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated gene silencing by mRNA destabilization; negative regulation of cell differentiation; and regulation of cellular response to transforming growth factor beta stimulus. Predicted to act upstream of or within several processes, including cellular response to estrogen stimulus; cellular response to forskolin; and regulation of gene expression. Predicted to be located in axon. Biomarker of hepatocellular carcinoma. Orthologous to human MIR18A (microRNA 18a); INTERACTS WITH 2-acetamidofluorene; 2-methoxyethanol; aflatoxin B1.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-18a; rno-mir-18a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,587,984 - 98,588,079 (+)NCBIGRCr8
mRatBN7.21592,180,765 - 92,180,860 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,765 - 92,180,860 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,554 - 96,087,649 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,420 - 97,220,515 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,826 - 94,127,921 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,015 - 100,180,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,015 - 100,180,110 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,038 - 103,641,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,445 - 91,045,540 (+)NCBICelera
Cytogenetic Map15q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma. Li CL, etal., Int J Cancer. 2015 Feb 15;136(4):761-70. doi: 10.1002/ijc.29052. Epub 2014 Jul 7.
2. MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells. Liu WH, etal., Gastroenterology. 2009 Feb;136(2):683-93. doi: 10.1053/j.gastro.2008.10.029. Epub 2008 Nov 1.
3. Serum miRNA-27a and miRNA-18b as potential predictive biomarkers of hepatitis C virus-associated hepatocellular carcinoma. Rashad NM, etal., Mol Cell Biochem. 2018 Oct;447(1-2):125-136. doi: 10.1007/s11010-018-3298-8. Epub 2018 Feb 17.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. Sanchez-Mejias A, etal., Int J Cancer. 2019 Jan 15;144(2):311-321. doi: 10.1002/ijc.31857. Epub 2018 Nov 9.
6. MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10. Wang X, etal., Onco Targets Ther. 2018 Nov 9;11:7919-7934. doi: 10.2147/OTT.S180971. eCollection 2018.
Additional References at PubMed
PMID:12007417   PMID:14691248   PMID:16381832   PMID:17604727   PMID:17656374   PMID:18329372   PMID:18791161   PMID:20403161   PMID:20439489   PMID:21338882   PMID:21501375   PMID:21993888  
PMID:23152446   PMID:24205035   PMID:32815784   PMID:34077824   PMID:34505723   PMID:36499183   PMID:36935174  


Genomics

Comparative Map Data
Mir18a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,587,984 - 98,588,079 (+)NCBIGRCr8
mRatBN7.21592,180,765 - 92,180,860 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,765 - 92,180,860 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,554 - 96,087,649 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,420 - 97,220,515 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,826 - 94,127,921 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,015 - 100,180,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,015 - 100,180,110 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,038 - 103,641,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,445 - 91,045,540 (+)NCBICelera
Cytogenetic Map15q23NCBI
MIR18A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,350,751 - 91,350,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,350,751 - 91,350,821 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,003,005 - 92,003,075 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,801,005 - 90,801,075 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,849,976 - 72,850,046 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,598,840 - 72,598,910 (+)NCBIHuRef
CHM1_11391,971,645 - 91,971,715 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,327 - 90,553,397 (+)NCBIT2T-CHM13v2.0
Mir18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,283 - 115,281,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,283 - 115,281,378 (+)EnsemblGRCm39 Ensembl
GRCm3814115,043,851 - 115,043,946 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,043,851 - 115,043,946 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,443,073 - 115,443,168 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,419 - 113,634,514 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
MIR18A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12242,478,138 - 42,478,229 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2242,478,138 - 42,478,229 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2242,333,826 - 42,333,917 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02242,879,387 - 42,879,478 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2242,879,387 - 42,879,478 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12242,561,860 - 42,561,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02242,616,239 - 42,616,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02242,617,302 - 42,617,393 (+)NCBIUU_Cfam_GSD_1.0
MIR18A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,734,791 - 60,734,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11160,734,791 - 60,734,882 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,610,195 - 66,610,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mycrno-miR-18a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19167416

Predicted Targets
Summary Value
Count of predictions:14750
Count of gene targets:8473
Count of transcripts:9205
Interacting mature miRNAs:rno-miR-18a-3p, rno-miR-18a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)158885347095840528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 1 12 1 2 1
Low 8 17 7 4 7 7 7 11 8 14 7 7
Below cutoff 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1592,180,765 - 92,180,860 (+)Ensembl
Rnor_6.0 Ensembl15100,180,015 - 100,180,110 (+)Ensembl
RefSeq Acc Id: NR_031819
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81598,587,984 - 98,588,079 (+)NCBI
mRatBN7.21592,180,765 - 92,180,860 (+)NCBI
Rnor_6.015100,180,015 - 100,180,110 (+)NCBI
Rnor_5.015103,641,038 - 103,641,133 (+)NCBI
Celera1591,045,445 - 91,045,540 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325396 AgrOrtholog
BioCyc Gene G2FUF-12495 BioCyc
Ensembl Genes ENSRNOG00000035645 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053768 ENTREZGENE
miRBase MI0000846 ENTREZGENE
NCBI Gene 100314227 ENTREZGENE
PhenoGen Mir18a PhenoGen
RatGTEx ENSRNOG00000035645 RatGTEx
RNAcentral URS00000A2DB9 RNACentral
  URS000035CC3E RNACentral
  URS000075CBC1 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir18a  microRNA 18a  Mir18a  microRNA mir-18a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir18a  microRNA mir-18a      Symbol and Name status set to provisional 70820 PROVISIONAL