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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:62108 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN4 mRNA | CTD | PMID:17942748 | 2,2,2-tetramine | multiple interactions | EXP | | 6480464 | Trientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein] | CTD | PMID:19634143 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:62108 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62108 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ACTN4 mRNA | CTD | PMID:20702594 PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62108 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ACTN4 mRNA | CTD | PMID:20702594 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ACTN4 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | RGD:735302 | 6480464 | beta-methylcholine affects the expression of ACTN4 mRNA | CTD | PMID:21179406 | 2-nitrotoluene | decreases expression | EXP | | 6480464 | 2-nitrotoluene results in decreased expression of ACTN4 mRNA | CTD | PMID:16460773 | 4-hydroxynon-2-enal | affects binding | ISO | RGD:735302 | 6480464 | ACTN4 protein binds to 4-hydroxy-2-nonenal | CTD | PMID:20043646 | 7,12-dimethyltetraphene | increases expression | EXP | | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in increased expression of ACTN4 mRNA | CTD | PMID:12376462 | aflatoxin B1 | decreases expression | ISO | RGD:735302 | 6480464 | Aflatoxin B1 results in decreased expression of ACTN4 mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ACTN4 mRNA | CTD | PMID:16483693 | bromobenzene | decreases expression | EXP | | 6480464 | bromobenzene results in decreased expression of ACTN4 mRNA | CTD | PMID:15056800 | bromochloroacetic acid | decreases expression | EXP | | 6480464 | bromochloroacetic acid results in decreased expression of ACTN4 mRNA | CTD | PMID:16460773 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of ACTN4 mRNA | CTD | PMID:19167457 | carbonyl sulfide | increases expression | EXP | | 6480464 | carbonyl sulfide results in increased expression of ACTN4 mRNA | CTD | PMID:19395590 | carvedilol | decreases expression | EXP | | 6480464 | carvedilol results in decreased expression of ACTN4 protein | CTD | PMID:20403466 | cobalt dichloride | decreases expression | ISO | RGD:735302 | 6480464 | cobaltous chloride results in decreased expression of ACTN4 mRNA | CTD | PMID:19320972 | cyclosporin A | decreases expression | ISO | RGD:735302 | 6480464 | Cyclosporine results in decreased expression of ACTN4 mRNA | CTD | PMID:20106945 | dibutyl phthalate | increases expression | ISO | RGD:62108 | 6480464 | Dibutyl Phthalate results in increased expression of ACTN4 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:62108 | 6480464 | Dibutyl Phthalate results in increased expression of ACTN4 mRNA | CTD | PMID:17361019 PMID:21266533 | doxorubicin | affects localization | EXP | | 6480464 | Doxorubicin affects the localization of ACTN4 protein | CTD | PMID:16636307 | elemental selenium | increases expression | ISO | RGD:735302 | 6480464 | Selenium results in increased expression of ACTN4 mRNA | CTD | PMID:19244175 | hydrazine | increases expression | ISO | RGD:62108 | 6480464 | hydrazine results in increased expression of ACTN4 mRNA | CTD | PMID:15282401 | N-ethyl-N-nitrosourea | increases expression | EXP | | 6480464 | Ethylnitrosourea results in increased expression of ACTN4 mRNA | CTD | PMID:15954086 | paracetamol | affects expression | ISO | RGD:62108 | 6480464 | Acetaminophen affects the expression of ACTN4 mRNA | CTD | PMID:17562736 | prostaglandin A1 | increases metabolic processing | ISO | RGD:62108 | 6480464 | prostaglandin A1 analog results in increased metabolism of ACTN4 protein | CTD | PMID:19800325 | selenium atom | increases expression | ISO | RGD:735302 | 6480464 | Selenium results in increased expression of ACTN4 mRNA | CTD | PMID:19244175 | simvastatin | increases expression | ISO | RGD:735302 | 6480464 | Simvastatin results in increased expression of ACTN4 mRNA | CTD | PMID:16710349 | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of ACTN4 protein | CTD | PMID:19634143 | streptozocin | multiple interactions | EXP | | 6480464 | Trientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein] | CTD | PMID:19634143 | valproic acid | affects expression | ISO | RGD:62108 | 6480464 | Valproic Acid affects the expression of ACTN4 mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Adherens junction |
| Amoebiasis | |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |
| Focal adhesion | |
| Leukocyte transendothelial migration | |
| Regulation of actin cytoskeleton | |
| Systemic lupus erythematosus | |
| Tight junction | |
| Viral carcinogenesis | |
| Pathway Interaction Database | PDGFR-beta signaling pathway (PID:200149) |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Adherens junction |
| Amoebiasis | |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |
| Focal adhesion | |
| Leukocyte transendothelial migration | |
| Regulation of actin cytoskeleton | |
| Systemic lupus erythematosus | |
| Tight junction | |
| Viral carcinogenesis | |
| Pathway Interaction Database | PDGFR-beta signaling pathway (PID:200149) |
References - curated| 1. |
Bijian K, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1313-23. Epub 2005 Jul 12. |
| 2. |
El-Husseini AE, etal., Biochem Biophys Res Commun 2000 Jan 27;267(3):906-11. |
| 3. |
Geisert EE Jr, etal., J Neurosci 1996 Sep 1;16(17):5478-87. |
| 4. |
Geisert EE Jr, etal., Neurosci Lett 1991 Dec 9;133(2):262-6. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Irwin MH and Geisert EE Jr, Neurosci Lett 1993 May 14;154(1-2):57-60. |
| 7. |
Kaplan JM, etal., Nat Genet. 2000 Mar;24(3):251-6. |
| 8. |
Lehtonen S, etal., Am J Pathol. 2004 Sep;165(3):923-36. |
| 9. |
MGD data from the GO Consortium |
| 10. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 11. |
Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7. |
| 12. |
Ooshio T, etal., J Biol Chem 2004 Jul 23;279(30):31365-73. Epub 2004 May 12. |
| 13. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 14. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 15. |
Poliakov LE, etal., Voen Med Zh 1978 Nov;(11):15-20. |
| 16. |
RGD automated data pipeline |
| 17. |
RGD automated import pipeline for gene-chemical interactions |
| 18. |
RGD Automated Pipelines |
| 19. |
Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38. |
| 20. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 21. |
Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63. |
References - uncurated
RGD Disease Portals| Actn4 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Actn4 (Rattus norvegicus) |
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| ACTN4 (Homo sapiens) |
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| Actn4 (Mus musculus) |
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Position Markers| BM385106 |
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| RH130124 |
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| MARC_12245-12246:1008698037:1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031675 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06004216 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01004467 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF190909 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF336827 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AI070095 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY724534 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC061788 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BQ206143 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB805703 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473979 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U19893 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031675 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_113863 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_113863 | (Get FASTA) |
| GenBank Protein | AAC53102 | (Get FASTA) |
| AAF20064 | (Get FASTA) | |
| AAH61788 | (Get FASTA) | |
| AAK21296 | (Get FASTA) | |
| EDM07862 | (Get FASTA) | |
| Q9QXQ0 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000020433 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000027773 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000027773 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 63836 | ENTREZGENE |
| Gene3D-CATH | Calponin-homology | UniProtKB/Swiss-Prot |
| EF-Hand_type | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000020433 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55857 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:5623735 | IMAGE-MGC_LOAD |
| InterPro | Actinin_actin-bd_CS | UniProtKB/Swiss-Prot |
| Alpha-actinin | UniProtKB/Swiss-Prot | |
| Calponin_act_bd | UniProtKB/Swiss-Prot | |
| EF-hand-like_dom | UniProtKB/Swiss-Prot | |
| EF-hand_Ca_insen | UniProtKB/Swiss-Prot | |
| EF_Hand_1_Ca_BS | UniProtKB/Swiss-Prot | |
| EF_hand_Ca_bd | UniProtKB/Swiss-Prot | |
| Spectrin/alpha-actinin | UniProtKB/Swiss-Prot | |
| Spectrin_repeat | UniProtKB/Swiss-Prot | |
| IPI | IPI00213463 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:63836 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72395 | IMAGE-MGC_LOAD |
| PANTHER | PTHR11915:SF47 | UniProtKB/Swiss-Prot |
| Pfam | EF_hand_4 | UniProtKB/Swiss-Prot |
| efhand_Ca_insen | UniProtKB/Swiss-Prot | |
| PF00307 | UniProtKB/Swiss-Prot | |
| Spectrin | UniProtKB/Swiss-Prot | |
| PROSITE | ACTININ_1 | UniProtKB/Swiss-Prot |
| ACTININ_2 | UniProtKB/Swiss-Prot | |
| EF_HAND_1 | UniProtKB/Swiss-Prot | |
| EF_HAND_2 | UniProtKB/Swiss-Prot | |
| PS50021 | UniProtKB/Swiss-Prot | |
| SMART | EFh | UniProtKB/Swiss-Prot |
| SM00033 | UniProtKB/Swiss-Prot | |
| SPEC | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Calponin-homology | UniProtKB/Swiss-Prot |
| UniGene | Rn.15777 | ENTREZGENE |
| UniProt | ACTN4_RAT | UniProtKB/Swiss-Prot |
| Q99MI8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Actn4 | actinin alpha 4 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_physical_interaction | binds to BERP (a novel RING finger protein belonging to the RBCC protein family), may colocalized in the cytoplasm | 61532 |
| More on Actn4 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61816 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




