Sv2b (synaptic vesicle glycoprotein 2b) - Rat Genome Database

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Gene: Sv2b (synaptic vesicle glycoprotein 2b) Rattus norvegicus
Analyze
Symbol: Sv2b
Name: synaptic vesicle glycoprotein 2b
RGD ID: 619716
Description: Predicted to enable transmembrane transporter activity. Predicted to be involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in glutamatergic synapse and synaptic vesicle membrane. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: synaptic vesicle glycoprotein 2 b; synaptic vesicle protein 2B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,388,268 - 138,562,635 (-)NCBIGRCr8
mRatBN7.21128,978,471 - 129,152,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1128,978,473 - 129,152,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1136,896,702 - 137,070,712 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,066,885 - 144,240,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01136,959,578 - 137,133,094 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01136,664,199 - 136,842,247 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,664,204 - 136,842,247 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01137,657,432 - 137,833,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,683,155 - 130,884,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,821,099 - 130,963,095 (-)NCBI
Celera1121,088,853 - 121,261,754 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Brain contains two forms of synaptic vesicle protein 2. Bajjalieh SM, etal., Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2150-4.
2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
3. Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals. Bragina L, etal., Front Cell Neurosci. 2012 Jan 10;5:32. doi: 10.3389/fncel.2011.00032. eCollection 2011.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Identification of a new synaptic vesicle protein 2B mRNA transcript which is up-regulated in neurons by amyloid beta peptide fragment (1-42). Heese K, etal., Biochem Biophys Res Commun 2001 Dec 21;289(5):924-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy. Tejero R, etal., Hum Mol Genet. 2016 Aug 29. pii: ddw297.
13. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:8889548   PMID:9648885   PMID:9801366   PMID:10625067   PMID:10747945   PMID:12060780   PMID:12687700   PMID:12754292   PMID:15866046   PMID:16306227   PMID:16543415   PMID:18524768  
PMID:22871113   PMID:23167466   PMID:29476059   PMID:34435329  


Genomics

Comparative Map Data
Sv2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,388,268 - 138,562,635 (-)NCBIGRCr8
mRatBN7.21128,978,471 - 129,152,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1128,978,473 - 129,152,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1136,896,702 - 137,070,712 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,066,885 - 144,240,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01136,959,578 - 137,133,094 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01136,664,199 - 136,842,247 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,664,204 - 136,842,247 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01137,657,432 - 137,833,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,683,155 - 130,884,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,821,099 - 130,963,095 (-)NCBI
Celera1121,088,853 - 121,261,754 (-)NCBICelera
Cytogenetic Map1q31NCBI
SV2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381591,099,588 - 91,302,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1591,099,950 - 91,302,565 (+)EnsemblGRCh38hg38GRCh38
GRCh371591,642,818 - 91,845,795 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,570,107 - 89,639,654 (+)NCBINCBI36Build 36hg18NCBI36
Build 341589,444,548 - 89,639,514NCBI
Celera1568,053,643 - 68,255,113 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,755,090 - 67,956,780 (+)NCBIHuRef
CHM1_11591,484,697 - 91,686,166 (+)NCBICHM1_1
T2T-CHM13v2.01588,860,310 - 89,063,343 (+)NCBIT2T-CHM13v2.0
Sv2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39774,764,642 - 74,959,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl774,764,642 - 74,959,010 (-)EnsemblGRCm39 Ensembl
GRCm38775,114,894 - 75,309,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl775,114,894 - 75,309,262 (-)EnsemblGRCm38mm10GRCm38
MGSCv37782,259,780 - 82,454,148 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36774,988,407 - 75,080,208 (-)NCBIMGSCv36mm8
Celera772,579,539 - 72,767,752 (-)NCBICelera
Cytogenetic Map7D1NCBI
cM Map743.62NCBI
Sv2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541619,577,275 - 19,651,295 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541619,456,414 - 19,650,782 (+)NCBIChiLan1.0ChiLan1.0
SV2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,654,440 - 80,849,933 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,352,822 - 84,550,591 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,793,642 - 69,989,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,989,560 - 89,184,370 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1589,114,744 - 89,184,370 (+)Ensemblpanpan1.1panPan2
SV2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1348,694,905 - 48,870,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl348,697,293 - 48,827,194 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha351,336,197 - 51,509,930 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0349,117,185 - 49,290,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl349,117,943 - 49,289,778 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1348,618,333 - 48,792,169 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0348,844,324 - 49,018,092 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0349,190,330 - 49,363,923 (-)NCBIUU_Cfam_GSD_1.0
Sv2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640134,786,121 - 134,957,039 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648311,377,442 - 11,450,830 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648311,377,375 - 11,450,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SV2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl787,568,026 - 87,766,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1787,564,380 - 87,767,247 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2793,628,605 - 93,828,482 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SV2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1299,691,421 - 9,875,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl299,806,570 - 9,872,782 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605936,826,711 - 37,003,073 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sv2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476812,425,890 - 12,509,901 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476812,426,232 - 12,621,852 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sv2b
648 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:408
Count of miRNA genes:235
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000015084
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat

Markers in Region
D1Rat349  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01136,742,822 - 136,742,994NCBIRnor6.0
Rnor_5.01137,735,464 - 137,735,636UniSTSRnor5.0
RGSC_v3.41130,788,605 - 130,788,777UniSTSRGSC3.4
RGSC_v3.41130,788,605 - 130,788,775RGDRGSC3.4
RGSC_v3.11130,866,948 - 130,867,118RGD
Celera1121,166,352 - 121,166,524UniSTS
RH 3.4 Map11012.3RGD
RH 3.4 Map11012.3UniSTS
RH 2.0 Map1660.7RGD
SHRSP x BN Map165.4199RGD
Cytogenetic Map1q31UniSTS
RH134242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21128,978,627 - 128,978,819 (+)MAPPERmRatBN7.2
Rnor_6.01136,664,354 - 136,664,545NCBIRnor6.0
Rnor_5.01137,657,585 - 137,657,776UniSTSRnor5.0
RGSC_v3.41130,683,308 - 130,683,499UniSTSRGSC3.4
Celera1121,089,006 - 121,089,197UniSTS
RH 3.4 Map11013.2UniSTS
Cytogenetic Map1q31UniSTS
BE119178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21128,980,188 - 128,980,338 (+)MAPPERmRatBN7.2
Rnor_6.01136,665,915 - 136,666,064NCBIRnor6.0
Rnor_5.01137,659,146 - 137,659,295UniSTSRnor5.0
RGSC_v3.41130,684,869 - 130,685,018UniSTSRGSC3.4
Celera1121,090,567 - 121,090,716UniSTS
RH 3.4 Map11010.1UniSTS
Cytogenetic Map1q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 52 10 2
Low 3 4 16 1 17 1 8 8 22 10 32 11 8
Below cutoff 31 18 17 2 17 3 14 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI716529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF285601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG671769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB609053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO402345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ819365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV721065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000015084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1128,978,473 - 129,152,479 (-)Ensembl
Rnor_6.0 Ensembl1136,664,204 - 136,842,247 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1136,699,202 - 136,841,608 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1136,665,741 - 136,691,163 (-)Ensembl
RefSeq Acc Id: NM_057207   ⟹   NP_476555
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,562,258 (-)NCBI
mRatBN7.21128,978,475 - 129,152,479 (-)NCBI
Rnor_6.01136,664,201 - 136,842,247 (-)NCBI
Rnor_5.01137,657,432 - 137,833,134 (-)NCBI
RGSC_v3.41130,683,155 - 130,884,752 (-)RGD
Celera1121,088,853 - 121,261,754 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759492   ⟹   XP_008757714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,532,662 (-)NCBI
mRatBN7.21128,978,471 - 129,122,829 (-)NCBI
Rnor_6.01136,664,199 - 136,808,316 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759493   ⟹   XP_008757715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,561,820 (-)NCBI
mRatBN7.21128,978,471 - 129,152,017 (-)NCBI
Rnor_6.01136,664,201 - 136,841,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588700   ⟹   XP_017444189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,561,444 (-)NCBI
mRatBN7.21128,978,471 - 129,151,665 (-)NCBI
Rnor_6.01136,664,199 - 136,841,433 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588701   ⟹   XP_017444190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,562,635 (-)NCBI
mRatBN7.21128,978,471 - 129,152,325 (-)NCBI
Rnor_6.01136,664,199 - 136,842,158 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080109   ⟹   XP_038936037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,561,206 (-)NCBI
mRatBN7.21128,978,471 - 129,151,446 (-)NCBI
RefSeq Acc Id: XM_063268635   ⟹   XP_063124705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,509,634 (-)NCBI
RefSeq Acc Id: XM_063268675   ⟹   XP_063124745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,388,268 - 138,520,568 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_476555   ⟸   NM_057207
- UniProtKB: Q63564 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757715   ⟸   XM_008759493
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWR6 (UniProtKB/TrEMBL),   A6JBZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757714   ⟸   XM_008759492
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWR6 (UniProtKB/TrEMBL),   A6JBZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444190   ⟸   XM_017588701
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWR6 (UniProtKB/TrEMBL),   A6JBZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444189   ⟸   XM_017588700
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWR6 (UniProtKB/TrEMBL),   A6JBZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038936037   ⟸   XM_039080109
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWR6 (UniProtKB/TrEMBL),   A6JBZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124745   ⟸   XM_063268675
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWR6 (UniProtKB/TrEMBL),   A6JBZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124705   ⟸   XM_063268635
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWR6 (UniProtKB/TrEMBL),   A6JBZ8 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63564-F1-model_v2 AlphaFold Q63564 1-683 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619716 AgrOrtholog
BioCyc Gene G2FUF-58865 BioCyc
Ensembl Genes ENSRNOG00000011160 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015084 ENTREZGENE
  ENSRNOT00000015084.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3 ubiquitin-protein ligase SopA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SV2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117556 UniProtKB/Swiss-Prot
NCBI Gene 117556 ENTREZGENE
PANTHER SYNAPTIC VESICLE GLYCOPROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTIC VESICLE GLYCOPROTEIN 2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sv2b PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011160 RatGTEx
Superfamily-SCOP Pentapeptide repeat-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZWR6 ENTREZGENE, UniProtKB/TrEMBL
  A6JBZ8 ENTREZGENE, UniProtKB/TrEMBL
  A6JC03_RAT UniProtKB/TrEMBL
  A6JC05_RAT UniProtKB/TrEMBL
  Q63564 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Sv2b  synaptic vesicle glycoprotein 2b    synaptic vesicle glycoprotein 2 b  Name updated 1299863 APPROVED
2002-08-07 Sv2b  synaptic vesicle glycoprotein 2 b      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization a synaptic vesicle protein 634183
gene_expression expressed in neural tissues 634183