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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one | multiple interactions | ISO | RGD:733704 | 6480464 | cyclopiazonic acid inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] | CTD | PMID:11804840 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:733704 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of F2RL1 mRNA | CTD | PMID:20106945 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:733704 | 6480464 | Cyclic AMP promotes the reaction [F2RL1 protein results in increased transport of Chlorides] | CTD | PMID:11804840 | 5-aza-2'-deoxycytidine | affects expression | ISO | RGD:733704 | 6480464 | decitabine affects the expression of F2RL1 mRNA | CTD | PMID:17145863 | all-trans-retinoic acid | increases expression | ISO | RGD:733704 | 6480464 | Tretinoin results in increased expression of F2RL1 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of F2RL1 mRNA | CTD | PMID:16483693 | barium(0) | multiple interactions | ISO | RGD:733704 | 6480464 | Barium inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] | CTD | PMID:11804840 | barium(0) | multiple interactions | ISO | RGD:733704 | 6480464 | F2RL1 protein affects the reaction [1-oleoyl-2-acetoyl-sn-glycerol results in increased transport of Barium] | CTD | PMID:16123040 | benzo[a]pyrene | multiple interactions | ISO | RGD:1553673 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of F2RL1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:733704 | 6480464 | Benzo(a)pyrene results in increased expression of F2RL1 mRNA | CTD | PMID:21632981 PMID:21871943 | benzo[a]pyrene | decreases expression | ISO | RGD:1553673 | 6480464 | Benzo(a)pyrene results in decreased expression of F2RL1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:733704 | 6480464 | Benzo(a)pyrene results in increased expression of F2RL1 mRNA | CTD | PMID:21871943 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of F2RL1 mRNA | CTD | PMID:15620428 | bumetanide | multiple interactions | ISO | RGD:733704 | 6480464 | Bumetanide inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] | CTD | PMID:11804840 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of F2RL1 mRNA | CTD | PMID:19167457 | calcium atom | multiple interactions | ISO | RGD:733704 | 6480464 | F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:16793902 | calcium(0) | multiple interactions | ISO | RGD:733704 | 6480464 | F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:16793902 | capsaicin | multiple interactions | ISO | RGD:733704 | 6480464 | PRKCE protein affects the reaction [F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]] | CTD | PMID:16793902 | clotrimazole | multiple interactions | ISO | RGD:733704 | 6480464 | Clotrimazole inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] | CTD | PMID:11804840 | copper atom | multiple interactions | ISO | RGD:733704 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of F2RL1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:733704 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of F2RL1 mRNA | CTD | PMID:20971185 | coumestrol | multiple interactions | ISO | RGD:733704 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of F2RL1 mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | RGD:733704 | 6480464 | Coumestrol results in decreased expression of F2RL1 mRNA | CTD | PMID:19167446 | cyclophosphamide | increases expression | EXP | | 6480464 | Cyclophosphamide results in increased expression of F2RL1 protein | CTD | PMID:15643279 | cyclosporin A | decreases expression | ISO | RGD:733704 | 6480464 | Cyclosporine results in decreased expression of F2RL1 mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:733704 | 6480464 | Cyclosporine results in increased expression of F2RL1 mRNA | CTD | PMID:21632981 | diarsenic trioxide | decreases response to substance | ISO | RGD:733704 | 6480464 | F2RL1 protein results in decreased susceptibility to arsenic trioxide | CTD | PMID:20707922 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of F2RL1 mRNA | CTD | PMID:15620428 | indomethacin | multiple interactions | ISO | RGD:733704 | 6480464 | Indomethacin inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] | CTD | PMID:11804840 | methotrexate | increases expression | ISO | RGD:733704 | 6480464 | Methotrexate results in increased expression of F2RL1 mRNA | CTD | PMID:17400583 | nickel dichloride | increases expression | ISO | RGD:733704 | 6480464 | nickel chloride results in increased expression of F2RL1 mRNA | CTD | PMID:17312168 | pirinixic acid | multiple interactions | ISO | RGD:733704 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of F2RL1 mRNA | CTD | PMID:19710929 | quercetin | increases expression | ISO | RGD:733704 | 6480464 | Quercetin results in increased expression of F2RL1 mRNA | CTD | PMID:21632981 | valproic acid | increases expression | ISO | RGD:733704 | 6480464 | Valproic Acid results in increased expression of F2RL1 mRNA | CTD | PMID:19101580 | valproic acid | decreases expression | ISO | RGD:1553673 | 6480464 | Valproic Acid results in decreased expression of F2RL1 mRNA | CTD | PMID:21427059 | vancomycin | decreases expression | ISO | RGD:1553673 | 6480464 | Vancomycin results in decreased expression of F2RL1 mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | African trypanosomiasis |
| Neuroactive ligand-receptor interaction | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | African trypanosomiasis |
| Neuroactive ligand-receptor interaction | |
References - curated| 1. |
Cho HJ, etal., J Cell Biochem. 2010 Apr 15;109(6):1254-63. |
| 2. |
Ferrell WR, etal., J Clin Invest 2003 Jan;111(1):35-41. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Hidaka S, etal., J Surg Res. 2011 Jan;165(1):142-50. Epub 2009 Jun 25. |
| 5. |
Kawabata A, etal., Life Sci 2002 Oct 4;71(20):2435-46. |
| 6. |
Kawabata A, etal., Neurosci Lett 2002 Sep 6;329(3):349-53. |
| 7. |
Lee HM, etal., Ann Otol Rhinol Laryngol. 2007 Jul;116(7):554-8. |
| 8. |
Li J, etal., Environ Health Perspect. 2011 Jan 18. |
| 9. |
Matsuwaki Y, etal., J Immunol. 2009 Nov 15;183(10):6708-16. Epub 2009 Oct 28. |
| 10. |
MGD data from the GO Consortium |
| 11. |
Napoli C, etal., Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H2004-10. |
| 12. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 13. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 14. |
RGD automated data pipeline |
| 15. |
RGD automated import pipeline for gene-chemical interactions |
| 16. |
Riek-Burchardt M, etal., Neurosci Lett 2002 Aug 30;329(2):181-4. |
| 17. |
Rohatgi T, etal., J Neurosci Res 2003 Jul 15;73(2):246-54. |
| 18. |
Saifeddine M, etal., Br J Pharmacol 1996 Jun;118(3):521-30. |
| 19. |
Stenton GR, etal., J Pharmacol Exp Ther 2002 Aug;302(2):466-74. |
| 20. |
Trottier G, etal., Am J Physiol Renal Physiol 2002 May;282(5):F891-7. |
References - uncurated| PubMed | 11867180 |
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| 17102904 | |
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| 19683949 | |
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| 20118742 | |
| 20128384 | |
| 20347884 | |
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| 22028393 | |
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| 22200983 | |
| 22227167 | |
| 22244874 | |
| 22461388 | |
| 22505524 | |
| 22541444 | |
| 22616675 | |
| 22849826 | |
| 23238933 | |
| 23288842 |
RGD Disease Portals| F2rl1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| F2rl1 (Rattus norvegicus) |
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| F2RL1 (Homo sapiens) |
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| F2rl1 (Mus musculus) |
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Position Markers| D2Wox44 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053897 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06012118 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01012253 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC099765 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473955 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U61373 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053897 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_446349 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_446349 | (Get FASTA) |
| GenBank Protein | AAC52703 | (Get FASTA) |
| AAH99765 | (Get FASTA) | |
| EDM10102 | (Get FASTA) | |
| Q63645 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018003 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000058298 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000061580 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 116677 | ENTREZGENE |
| Germonline | ENSRNOG00000018003 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 21087 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7930573 | IMAGE-MGC_LOAD |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| Pro_rcpt_2 | UniProtKB/Swiss-Prot | |
| Protea_act_rcpt | UniProtKB/Swiss-Prot | |
| IPI | IPI00211046 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:116677 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:124581 | IMAGE-MGC_LOAD |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | GPCRRHODOPSN | UniProtKB/Swiss-Prot |
| PROTEASEAR | UniProtKB/Swiss-Prot | |
| PROTEASEAR2 | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1; FALSE_NEG | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.10543 | ENTREZGENE |
| UniProt | PAR2_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | F2rl1 | coagulation factor II (thrombin) receptor-like 1 | Proteinase-activated receptor-2, G protein-coupled receptor 11 | Name updated | 10779 | APPROVED | |
| 2002-08-07 | F2rl1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on F2rl1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620866 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




