Gene: Adam17 (ADAM metallopeptidase domain 17) Rattus norvegicus
Symbol: Adam17
Name: ADAM metallopeptidase domain 17
Description: ENCODES a protein that exhibits metalloendopeptidase activity; metallopeptidase activity; integrin binding (ortholog); INVOLVED IN membrane protein ectodomain proteolysis; negative regulation of apoptotic process; B cell differentiation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; ASSOCIATED WITH Aortic Aneurysm, Thoracic; Encephalomyelitis, Autoimmune, Experimental; Blister (ortholog); FOUND IN cell surface; plasma membrane; actin cytoskeleton (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
Also known as: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM 17; disintegrin and metalloproteinase domain-containing protein 17; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
Homo sapiens (human) : ADAM17 (ADAM metallopeptidase domain 17)  HGNC  AGR
Mus musculus (house mouse) : Adam17 (a disintegrin and metallopeptidase domain 17)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Adam17 (ADAM metallopeptidase domain 17)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM17 (ADAM metallopeptidase domain 17)
Canis lupus familiaris (dog) : ADAM17 (ADAM metallopeptidase domain 17)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam17 (ADAM metallopeptidase domain 17)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adam17
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620404
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-12-12
Status: ACTIVE