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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:731401 | 6480464 | Ethinyl Estradiol affects the expression of ADAM17 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:731401 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM17 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:731401 | 6480464 | Ethinyl Estradiol results in increased expression of ADAM17 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:731401 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM17 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:731401 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ADAM17 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731401 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ADAM17 mRNA | CTD | PMID:17942748 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ADAM17 mRNA | CTD | PMID:21346803 | 2-amino-2-deoxy-D-glucopyranose | multiple interactions | EXP | | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of ADAM17 mRNA]; more ... | CTD | PMID:17109745 | 2-amino-2-deoxy-D-glucopyranose | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of ADAM17 mRNA | CTD | PMID:17109745 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:731401 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ADAM17 mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:731401 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of ADAM17 mRNA | CTD | PMID:18648102 | 7alpha-hydroxycholesterol | decreases activity | EXP | | 6480464 | cholest-5-en-3 beta,7 alpha-diol results in decreased activity of ADAM17 protein | CTD | PMID:15591071 | acrolein | multiple interactions | ISO | RGD:731400 | 6480464 | ADAM17 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA] | CTD | PMID:15531749 | aldehydo-D-glucosamine | multiple interactions | EXP | | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of ADAM17 mRNA]; more ... | CTD | PMID:17109745 | aldehydo-D-glucosamine | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of ADAM17 mRNA | CTD | PMID:17109745 | all-trans-retinoic acid | affects localization | ISO | RGD:731400 | 6480464 | Tretinoin affects the localization of ADAM17 protein | CTD | PMID:19476501 | all-trans-retinoic acid | affects localization | ISO | RGD:731401 | 6480464 | Tretinoin affects the localization of ADAM17 protein | CTD | PMID:19476501 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ADAM17 mRNA | CTD | PMID:16483693 | arsenic atom | decreases expression | ISO | RGD:731400 | 6480464 | Arsenic results in decreased expression of ADAM17 mRNA | CTD | PMID:11134558 | beta-D-glucosamine | multiple interactions | EXP | | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of ADAM17 mRNA]; more ... | CTD | PMID:17109745 | beta-D-glucosamine | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of ADAM17 mRNA | CTD | PMID:17109745 | bisphenol A | increases expression | ISO | RGD:731401 | 6480464 | bisphenol A results in increased expression of ADAM17 mRNA | CTD | PMID:21932408 | bisphenol A | decreases expression | ISO | RGD:731400 | 6480464 | bisphenol A results in decreased expression of ADAM17 mRNA | CTD | PMID:20678512 | bleomycin A2 | multiple interactions | ISO | RGD:731401 | 6480464 | Bleomycin results in increased expression of and results in increased activity of ADAM17 protein | CTD | PMID:22687607 | butyric acid | increases expression | EXP | | 6480464 | Butyric Acid results in increased expression of ADAM17 mRNA | CTD | PMID:12800193 | calcium dichloride | increases expression | EXP | | 6480464 | Calcium Chloride results in increased expression of ADAM17 mRNA; more ... | CTD | PMID:20621845 | cobalt dichloride | decreases expression | ISO | RGD:731400 | 6480464 | cobaltous chloride results in decreased expression of ADAM17 mRNA | CTD | PMID:19376846 | copper atom | multiple interactions | ISO | RGD:731400 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of ADAM17 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:731400 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of ADAM17 mRNA | CTD | PMID:20971185 | copper(2+) sulfate | decreases expression | ISO | RGD:731400 | 6480464 | Copper Sulfate results in decreased expression of ADAM17 mRNA | CTD | PMID:20599845 | copper(2+) sulfate | increases expression | ISO | RGD:731400 | 6480464 | Copper Sulfate results in increased expression of ADAM17 mRNA | CTD | PMID:19549813 | curcumin | multiple interactions | ISO | RGD:731400 | 6480464 | Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] | CTD | PMID:17666914 | cyclosporin A | increases expression | ISO | RGD:731400 | 6480464 | Cyclosporine results in increased expression of ADAM17 mRNA | CTD | PMID:20106945 | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of ADAM17 mRNA | CTD | PMID:14618091 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of ADAM17 mRNA | CTD | PMID:17920746 | flufenamic acid | increases response to substance | ISO | RGD:731401 | 6480464 | ADAM17 results in increased susceptibility to Flufenamic Acid | CTD | PMID:12147693 | N-methyl-4-phenylpyridinium | multiple interactions | ISO | RGD:731400 | 6480464 | U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ADAM17 mRNA] | CTD | PMID:12710931 | nicotinic acid | increases expression | EXP | | 6480464 | Niacin results in increased expression of ADAM17 protein | CTD | PMID:19223914 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of ADAM17 mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | ISO | RGD:731400 | 6480464 | Phenobarbital affects the expression of ADAM17 mRNA | CTD | PMID:19159669 | phenylephrine | multiple interactions | EXP | | 6480464 | ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; more ... | CTD | PMID:16760267 | phorbol 13-acetate 12-myristate | increases response to substance | ISO | RGD:731401 | 6480464 | ADAM17 results in increased susceptibility to Tetradecanoylphorbol Acetate | CTD | PMID:12147693 | propiconazole | increases expression | ISO | RGD:731401 | 6480464 | propiconazole results in increased expression of ADAM17 mRNA | CTD | PMID:21278054 | tamoxifen | affects expression | ISO | RGD:731401 | 6480464 | Tamoxifen affects the expression of ADAM17 mRNA | CTD | PMID:17555576 | vanadium atom | increases expression | ISO | RGD:731400 | 6480464 | Vanadium results in increased expression of ADAM17 mRNA | CTD | PMID:19000753 | vanadium(0) | increases expression | ISO | RGD:731400 | 6480464 | Vanadium results in increased expression of ADAM17 mRNA | CTD | PMID:19000753 | zoledronic acid | increases expression | ISO | RGD:731400 | 6480464 | zoledronic acid results in increased expression of ADAM17 protein | CTD | PMID:14753746 | zoledronic acid | decreases activity | ISO | RGD:731400 | 6480464 | zoledronic acid results in decreased activity of ADAM17 protein | CTD | PMID:14753746 | zoledronic acid | multiple interactions | ISO | RGD:731400 | 6480464 | ADAM17 protein promotes the reaction [zoledronic acid results in decreased expression of TNFSF11 protein] | CTD | PMID:14753746 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Notch signaling pathway | |
| Pathway Interaction Database | ErbB4 signaling events (PID:200011) |
| p75(NTR)-mediated signaling (PID:200122) | |
| TNF receptor signaling pathway (PID:200102) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Notch signaling pathway | |
| Pathway Interaction Database | ErbB4 signaling events (PID:200011) |
| p75(NTR)-mediated signaling (PID:200122) | |
| TNF receptor signaling pathway (PID:200102) | |
References - curated| 1. |
Bax DV, etal., J Biol Chem. 2004 May 21;279(21):22377-86. Epub 2004 Feb 16. |
| 2. |
Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43. |
| 3. |
Cardellini M, etal., Diabetes. 2009 Jul 6. |
| 4. |
Chalaris A, etal., Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. Epub 2010 Dec 8. |
| 5. |
Colon AL, etal., Cytokine 2001 Dec 21;16(6):220-6. |
| 6. |
Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74. |
| 7. |
Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26. |
| 8. |
GOA data from the GO Consortium |
| 9. |
Hurtado O, etal., J Cereb Blood Flow Metab 2002 May;22(5):576-85. |
| 10. |
Lizama C, etal., J Cell Physiol. 2012 Feb;227(2):829-38. doi: 10.1002/jcp.22795. |
| 11. |
MGD data from the GO Consortium |
| 12. |
Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340. |
| 13. |
Monroy A, etal., Diabetologia. 2009 Jul 25. |
| 14. |
Myhre GM, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1213-9. Epub 2004 Jul 29. |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Peschon JJ, etal., Science 1998 Nov 13;282(5392):1281-4. |
| 17. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 18. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 19. |
Plumb J, etal., J Neuroimmunol. 2005 Jul;164(1-2):1-9. |
| 20. |
RGD automated data pipeline |
| 21. |
RGD automated import pipeline for gene-chemical interactions |
| 22. |
Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65. |
References - uncurated| PubMed | 12849708 |
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| 19796498 | |
| 20087163 | |
| 20359533 | |
| 20501791 | |
| 21357274 | |
| 21411748 | |
| 21645559 | |
| 22230263 | |
| 22413019 |
RGD Disease Portals| Adam17 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Adam17 (Rattus norvegicus) |
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| ADAM17 (Homo sapiens) |
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| Adam17 (Mus musculus) |
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Position Markers| RH128637 |
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| RH70698 |
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| RH141932 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_020306 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06043295 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01042970 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ012603 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473947 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230426 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_020306 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_064702 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_064702 | (Get FASTA) |
| GenBank Protein | CAA10072 | (Get FASTA) |
| EDM03171 | (Get FASTA) | |
| EDM03172 | (Get FASTA) | |
| Q9Z1K9 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000007503 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000010648 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000010648 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 57027 | ENTREZGENE |
| Gene3D-CATH | Blood-coag_inhib_Disintegrin | UniProtKB/Swiss-Prot |
| G3DSA:3.40.390.10 | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000007503 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2395 | ENTREZGENE |
| InterPro | Blood-coag_inhib_Disintegrin | UniProtKB/Swiss-Prot |
| MetalloPept_cat_dom | UniProtKB/Swiss-Prot | |
| Peptidase_M12B | UniProtKB/Swiss-Prot | |
| Peptidase_M12B_N | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:57027 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Disintegrin | UniProtKB/Swiss-Prot |
| Pep_M12B_propep | UniProtKB/Swiss-Prot | |
| PROSITE | ADAM_MEPRO | UniProtKB/Swiss-Prot |
| CYSTEINE_SWITCH; FALSE_NEG | UniProtKB/Swiss-Prot | |
| DISINTEGRIN_1; FALSE_NEG | UniProtKB/Swiss-Prot | |
| DISINTEGRIN_2 | UniProtKB/Swiss-Prot | |
| ZINC_PROTEASE | UniProtKB/Swiss-Prot | |
| SMART | DISIN | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Disintegrin | UniProtKB/Swiss-Prot |
| UniGene | Rn.144585 | ENTREZGENE |
| UniProt | ADA17_RAT | UniProtKB/Swiss-Prot |
| G3V711_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-09-18 | Adam17 | ADAM metallopeptidase domain 17 | Adam17 | a disintegrin and metallopeptidase domain 17 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-25 | Adam17 | a disintegrin and metallopeptidase domain 17 | Adam17 | a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-09-10 | Adam17 | a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) | a disintegrin and metalloproteinase domain 17 | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Adam17 | a disintegrin and metalloproteinase domain 17 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_mutations_overexpression | increased expression induced by oxygen-glucose deprivation induces release of TNF-alpha, which inhibits apoptosis via activation of NFkappaB | 632021 |
| gene_process | release of TNF-alpha promotes apoptosis inhibition | 632021 |
| gene_regulation | upregulated in response to oxygen glucose deprivation | 632021 |
| More on Adam17 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620404 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.