Klhl42 (kelch-like family, member 42)

Gene: Klhl42 (kelch-like family, member 42) Rattus norvegicus

Analyze

Symbol:

Klhl42

Name:

kelch-like family, member 42

RGD ID:

1560924

Description:

Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL42 (kelch like family member 42); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

kelch domain containing 5; kelch domain-containing protein 5; kelch-like protein 42; Klhdc5; LOC500367; RGD1560924; similar to C230080I20Rik protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KLHL42 (kelch like family member 42)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Klhl42 (kelch-like 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Klhl42 (kelch like family member 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KLHL42 (kelch like family member 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KLHL42 (kelch like family member 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Klhl42 (kelch like family member 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KLHL42 (kelch like family member 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KLHL42 (kelch like family member 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Klhl42 (kelch like family member 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KLHL42 (kelch like family member 42)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Klhl42 (kelch-like 42)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	klhl42 (kelch-like family, member 42)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	181,730,343 - 181,760,899 (+)	NCBI		GRCr8
mRatBN7.2	4	179,999,655 - 180,027,283 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	180,004,580 - 180,027,283 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	186,289,206 - 186,311,270 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	182,073,713 - 182,095,779 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	180,694,163 - 180,716,223 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	181,481,147 - 181,502,916 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	181,481,147 - 181,502,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	245,631,025 - 245,652,794 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	184,688,926 - 184,709,859 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	168,498,092 - 168,519,056 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-deoxy-D-glucose (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

alpha-pinene (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bleomycin A2 (ISO)

butanal (ISO)

C60 fullerene (EXP)

camptothecin (ISO)

chloroprene (EXP)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

decabromodiphenyl ether (EXP)

dieldrin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

fluoranthene (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

HC toxin (ISO)

maneb (ISO)

melphalan (ISO)

methyl methanesulfonate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

PCB138 (EXP)

rotenone (ISO)

silicon dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein polyubiquitination (ISO)

regulation of microtubule-based process (ISO)

Cellular Component

Cul3-RING ubiquitin ligase complex (ISO)

Molecular Function

protein binding (ISO)

ubiquitin-protein transferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19261606

Genomics

Comparative Map Data

Klhl42
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	181,730,343 - 181,760,899 (+)	NCBI		GRCr8
mRatBN7.2	4	179,999,655 - 180,027,283 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	180,004,580 - 180,027,283 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	186,289,206 - 186,311,270 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	182,073,713 - 182,095,779 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	180,694,163 - 180,716,223 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	181,481,147 - 181,502,916 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	181,481,147 - 181,502,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	245,631,025 - 245,652,794 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	184,688,926 - 184,709,859 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	168,498,092 - 168,519,056 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

KLHL42
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	27,780,233 - 27,803,040 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	27,780,048 - 27,803,040 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	27,933,166 - 27,955,973 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	27,824,454 - 27,847,240 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	27,824,453 - 27,847,239	NCBI
Celera	12	33,078,741 - 33,101,539 (+)	NCBI		Celera
Cytogenetic Map	12	p11.22	NCBI
HuRef	12	27,702,261 - 27,724,953 (+)	NCBI		HuRef
CHM1_1	12	27,898,197 - 27,920,989 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	27,651,947 - 27,674,765 (+)	NCBI		T2T-CHM13v2.0

Klhl42
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	146,990,783 - 147,014,276 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	146,992,877 - 147,014,276 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	147,090,615 - 147,112,778 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	147,091,379 - 147,112,778 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	147,039,597 - 147,061,300 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	147,048,245 - 147,069,948 (+)	NCBI		MGSCv36	mm8
MGSCv36	6	147,813,510 - 147,836,215 (+)	NCBI		MGSCv36	mm8
Celera	6	150,124,798 - 150,146,756 (+)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	77.7	NCBI

Klhl42
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955505	7,043,000 - 7,077,062 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955505	7,046,274 - 7,078,175 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLHL42
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	69,011,497 - 69,034,332 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	69,007,894 - 69,030,754 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	58,509,031 - 58,531,891 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	61,127,167 - 61,149,122 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	61,127,167 - 61,149,126 (-)	Ensembl	panpan1.1		panPan2

KLHL42
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	19,945,465 - 19,962,742 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	19,947,481 - 19,962,924 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	26,437,528 - 26,457,701 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	20,136,377 - 20,156,288 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	20,136,883 - 20,156,255 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	19,942,906 - 19,963,022 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	19,969,802 - 19,989,679 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	26,594,868 - 26,614,758 (+)	NCBI		UU_Cfam_GSD_1.0

Klhl42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	81,906,209 - 81,928,294 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936760	5,043 - 27,134 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936760	5,049 - 27,134 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLHL42
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	45,933,928 - 45,954,881 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	45,929,854 - 45,954,887 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	49,503,613 - 49,522,985 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KLHL42
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	27,502,268 - 27,522,280 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	27,502,022 - 27,520,136 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	7,527,767 - 7,550,439 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Klhl42
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624935	186,464 - 254,951 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624935	181,511 - 254,738 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Klhl42
193 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	177
Count of miRNA genes:	124
Interacting mature miRNAs:	152
Transcripts:	ENSRNOT00000002523
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	4	135204660	180204660	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	135699135	180699135	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157710145	182687754	Rat

Markers in Region

RH141790

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	180,026,352 - 180,026,562 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	181,501,987 - 181,502,196	NCBI	Rnor6.0
Rnor_5.0	4	245,651,865 - 245,652,074	UniSTS	Rnor5.0
RGSC_v3.4	4	184,708,930 - 184,709,139	UniSTS	RGSC3.4
Celera	4	168,518,127 - 168,518,336	UniSTS
RH 3.4 Map	4	1089.0	UniSTS
Cytogenetic Map	4	q44	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		6	19	12	8	12			19	18	25	8
Low	3	36	38	29	11	29	8	11	55	17	13	3	8
Below cutoff		1									3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002523 ⟹ ENSRNOP00000002523

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	180,004,580 - 180,027,283 (+)	Ensembl
Rnor_6.0 Ensembl	4	181,481,147 - 181,502,916 (+)	Ensembl

RefSeq Acc Id:

NM_001109257 ⟹ NP_001102727

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,735,232 - 181,757,930 (+)	NCBI
mRatBN7.2	4	180,004,580 - 180,027,283 (+)	NCBI
Rnor_6.0	4	181,481,147 - 181,502,916 (+)	NCBI
Rnor_5.0	4	245,631,025 - 245,652,794 (+)	NCBI
RGSC_v3.4	4	184,688,926 - 184,709,859 (+)	RGD
Celera	4	168,498,092 - 168,519,056 (+)	RGD

Sequence:

show sequence

GGGGAGGAGCCTGAGCAGCCGGGCGGCGGGCGCAGCGGCCCAGCCATGTCGGCCGAGGAGATGG
TGCAGATCCGCCTGGAAGACCGCTGCTACCCGGTGAGCAAGAGCAAATTGATCGAACAGAGCGA
CTACTTCCGCGCTCTCTACCGCTCCGGCATGCGCGAGGCCGTGCGGCCCGAGGTGGGTCCGGAG
GTGCAGCAGCTGCGCGGCCTGAGCGCTCCGGGCCTGCGGCTGGTGCTGGACTTCATCAACGCGG
GCGGCGCGCGCGAGGGCTGGGGCCTGAGCGAGGACGAGTTGGCCGAGGCCAGCGTGCTGGCCGA
GATGGTGGAGGCCGCGTCCTTTCTGCAGGTCACGGCGCTGCTGCGCTTGCTGCTGTCGCATGTG
CGTCTGGGCAACTGCCTGGAGCTGTACCGCCTGGCGCAGGTGTACGGGCTGCCCGACCTGCAGG
ACGCCTGCCTGCGCTTCATGGTGCTGCGCTTCCACCAGGTGCTGTGCCAGCCGCAATTCCCGCT
ACTGCTGTCGCCGCCTCAGGCCCCCGGGGACTGCAGCCTGAAGCAGAGGTTGCGGGAGGCCCGC
ATGCGCGGGACCCCGGTCCTGGTGGCCCTGGGGGACTTCCTCGGGGGACCCCTGGCTCCGCACC
CGTATCAGGGGGAACCCCCGTCCATGCTTAGGTATGAGGAGACCACAGAGCGCTGGTTCCCCCT
GGCCAACAACCTGCCCCCCGACCTGGTGAACGTCAGGGGCTACGGCTCAGCCATCTTGGACAAC
TACCTCTTCATCGTGGGTGGTTACAGGATCACCAGCCAGGAGATCTCGGCCGCACACTCCTACA
ATCCCACCACCAACGAGTGGCTGCAGGTGGCTTCCATGAACCAGAAGCGATCTAACTTCAAACT
TGTGGCTGTCAATTCGAAGCTTTACGCCATCGGCGGGCAGGCCGTTTCTAACGTGGAGTGCTAT
AACCCCGAACAAGATGCGTGGAATTTTGTGGCTCCCCTGCCGAACCCTCTGGCTGAGTTCTCTG
CGTGCGAGTGCAAGGGGAAGATTTATGTCATCGGTGGATATACTACCCGAGATCGCAACATGAA
CATCCTGCAGTACTGCCCCTCCGCTGACCTCTGGACGCTGTTTGAGACCTGCGACGTCCATATC
CGCAAGCAGCAGATGGTGTCCGTGGAGGAGACCATCTACATCGTGGGCGGGTGTCTCCACGAAC
TGGGGTCCAACCGCAGGAGCAGTCAGAGCGAGGACATGCTCACCGTGCAGTCCTACAACACGGA
AACTCGGCAGTGGCTCTACCTGAAGGAGAACACGTCCAAATCAGGCCTGAACTTGACGTGCGCA
CTACACAATGACGGCATCTACATTATGAGCAGGGACGTCACCCTGTCCACCAGCTTGGAGCACC
GAGTGTTTCTCAAGTACAACATCTTTGCGGACAGCTGGGAAGCCTTCAGGCGGTTCCCAGCCTT
CGGACACAACTTGTTGATTTCCTCTCTCTATCTGCCCAATAAAGCAGAGACCTGACTGATTCAA
CAGTACTTAAAAGAAAAATCTGGTTCAAGGGGGGAAAAAAACGAAAGGCAAGCCTTTGAAATAT
GGACTCCTGAAGAGACAAAGTGGGCTAACGTAGGTCAAGTGGGGAGGACGGCTCTGCTGTAAAT
AAGCTTCCTTGAGCTAGTTACTTGAAAACGTGGGGTAAAGAGACCAACCGTATTCTTTCCAGAT
TGTTTTTTTGTACCATGGGAACAAATGTCACGAAAAGTATTCAACCAAACCGAAGCAGTCTTGG
GCCAACAACTAAAACCCACCCTTAAAAGTAGACTGCCGGGGTCTGCTTTGAACGGGTCGAGGTC
AGTAGCTAAGATCACAGTAGCAATGGCTTTCTTCTGTGTTTTTCCCGTTGGGAATGGAACCCAG
GGCCTCACGCGAGTCCCGAAAGGATGACTTTAAAGACACTTGCTTCAGGTCACCTGCGATCTCG
TCAGTATGGACTTTTCCTTTTGGTGATCAGCGTTTGACAAGCTTTAGGATCCGCCCACCTCTAG
TCTCCTGTTCCCTGTCACCCAGGCTCTCTGGGCAGACATTTTATCCTATATTTGCTTTCAGAAA
CCCCGACGGGCGTGTCCAACCTTTTGACATTTAGAAATTATCATTCTTTAACTTTGTGCACACT
TGAGTTACCTTAAAAAAAAACAAGCCTCTTAATGCTCTAAGTAAGTTCCTGACGCTGTGTTGGC
TGCTACATAGCTTTCCTTGGGGCCCACAAGCTGCAGTTGCCTTGCCTGCTACAGAGATAGAGCC
AGACAGAATCCACACAGGCAGCCCGTCCATCCAAAAACATGGAGAGACACCTCCTCAGCCTTTC
CAGTCTTTGTGCAATTGAGAATGCTGTGTAAGGCAGACTTACCTCTTATCTCGTGTGTGGCAGA
TGAGGGCTCTGTTCTTAGGAGAGTGCTATAAACATTTTATAAGCTGAGTCTTAAGGGAGAGGGA
GTACTGCGTAAGGAAAGATGCCTTTGTGAGTTACTTTTATTGAATATATGTGACTTAGTTCTTG
TTTCAAGACAAAAAAAAAAAAAACCCACCCCAACTTTTGCACATTTCCACCAAGTTTCCTCCTA
GCTTGGTCTTAGCCTTAGATACATAGCTGTGTTTTGCCTTTTTAAGGGAATGGTGACTTTAGCT
GATGTGGTGCTAGAAAGCAGGGGAGATGTTCTTTACAGACGTGGGATGGCCTCTGCTGGCATTT
CTGAATTGAAGTGAGGTGCTGGCCTCACAGCTCTCCTGCCAACTGCGGTGAGTAGCCTAAGGAC
CTGTCAATCATGGGCCTGTGTTTCTTAAAAGACTCAAGGGCCCACTTAGCGTGCACAAGAGGCC
CCTGGGTTTAATCTCCAGCACTTACAGCAACAGCAACAAGGTCCTCACCTACAGGGATTTTGAT
TGAAGAGCTGCTATCTTGTAGTGGAGTCAGCTAAAGGAACCACACCAGCTGCAGGCAGCCGCCT
TGCATATTTAAGTATGCTCCATAGAAAAATAATTAGAATTACAGGCAGATTTTCTCCCAGTTCC
TTGCACAGCTGCTCACCTGGTGGCTGGGTGTGGGGGAGGGAAGCTGACCCCGAGTAGGTCTTCA
GTGTCGATGAGGGAGTCACTTCAGGGTTTCTTTATAGCCATGCCTCTAATACAGCCTTAGAGCC
TAGTTATAAAACTCTTACTTGCACAACT

hide sequence

RefSeq Acc Id:

XM_063286600 ⟹ XP_063142670

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,730,343 - 181,753,492 (+)	NCBI

RefSeq Acc Id:

XM_063286601 ⟹ XP_063142671

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,730,343 - 181,760,899 (+)	NCBI

RefSeq Acc Id:

XM_063286602 ⟹ XP_063142672

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,730,343 - 181,760,899 (+)	NCBI

RefSeq Acc Id:

XM_063286603 ⟹ XP_063142673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,753,510 - 181,760,899 (+)	NCBI

RefSeq Acc Id:

XM_063286604 ⟹ XP_063142674

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,753,510 - 181,760,899 (+)	NCBI

RefSeq Acc Id:

XM_063286605 ⟹ XP_063142675

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,752,212 - 181,760,899 (+)	NCBI

RefSeq Acc Id:

XM_063286606 ⟹ XP_063142676

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,753,849 - 181,760,899 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102727	(Get FASTA)	NCBI Sequence Viewer
	XP_063142670	(Get FASTA)	NCBI Sequence Viewer
	XP_063142671	(Get FASTA)	NCBI Sequence Viewer
	XP_063142672	(Get FASTA)	NCBI Sequence Viewer
	XP_063142673	(Get FASTA)	NCBI Sequence Viewer
	XP_063142674	(Get FASTA)	NCBI Sequence Viewer
	XP_063142675	(Get FASTA)	NCBI Sequence Viewer
	XP_063142676	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01398	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002523
	ENSRNOP00000002523.5

RefSeq Acc Id:

NP_001102727 ⟸ NM_001109257

- UniProtKB:

D4A9Z3 (UniProtKB/TrEMBL), A6IN41 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSAEEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVGPEVQQLRGLSAPGLRLV
LDFINAGGAREGWGLSEDELAEASVLAEMVEAASFLQVTALLRLLLSHVRLGNCLELYRLAQVY
GLPDLQDACLRFMVLRFHQVLCQPQFPLLLSPPQAPGDCSLKQRLREARMRGTPVLVALGDFLG
GPLAPHPYQGEPPSMLRYEETTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEI
SAAHSYNPTTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPN
PLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWTLFETCDVHIRKQQMVSVEETIYIV
GGCLHELGSNRRSSQSEDMLTVQSYNTETRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTL
STSLEHRVFLKYNIFADSWEAFRRFPAFGHNLLISSLYLPNKAET

hide sequence

RefSeq Acc Id:

ENSRNOP00000002523 ⟸ ENSRNOT00000002523

RefSeq Acc Id:	XP_063142671 ⟸ XM_063286601
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063142672 ⟸ XM_063286602
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063142670 ⟸ XM_063286600
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063142675 ⟸ XM_063286605
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063142673 ⟸ XM_063286603
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063142674 ⟸ XM_063286604
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063142676 ⟸ XM_063286606
- Peptide Label:	isoform X4

Protein Domains

BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A9Z3-F1-model_v2	AlphaFold	D4A9Z3	1-493	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693511

Promoter ID:

EPDNEW_R4036

Type:

multiple initiation site

Name:

Klhl42_1

Description:

kelch-like family, member 42

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	181,481,153 - 181,481,213	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560924	AgrOrtholog
BioCyc Gene	G2FUF-42417	BioCyc
Ensembl Genes	ENSRNOG00000001844	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002523	ENTREZGENE
	ENSRNOT00000002523.6	UniProtKB/TrEMBL
Gene3D-CATH	2.120.10.80	UniProtKB/TrEMBL
InterPro	BTB/POZ-like	UniProtKB/TrEMBL
	BTB/POZ_fold	UniProtKB/TrEMBL
	Kelch-typ_b-propeller	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
	KLHL42_BACK	UniProtKB/TrEMBL
KEGG Report	rno:500367	UniProtKB/TrEMBL
NCBI Gene	500367	ENTREZGENE
PANTHER	KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED	UniProtKB/TrEMBL
	KELCH-LIKE FAMILY, MEMBER 42	UniProtKB/TrEMBL
Pfam	Kelch_1	UniProtKB/TrEMBL
PhenoGen	Klhl42	PhenoGen
PROSITE	BTB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001844	RatGTEx
SMART	Kelch	UniProtKB/TrEMBL
Superfamily-SCOP	BTB/POZ_fold	UniProtKB/TrEMBL
	SSF117281	UniProtKB/TrEMBL
UniProt	A6IN41	ENTREZGENE, UniProtKB/TrEMBL
	D4A9Z3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-06	Klhl42	kelch-like family, member 42	Klhdc5	kelch domain containing 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-28	Klhdc5	kelch domain containing 5	RGD1560924_predicted	similar to C230080I20Rik protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1560924_predicted	similar to C230080I20Rik protein (predicted)	LOC500367	similar to C230080I20Rik protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500367	similar to C230080I20Rik protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar