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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NME2 protein | CTD | PMID:16548065 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1552274 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NME2 mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1552274 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of NME2 mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1346564 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of NME2 mRNA | CTD | PMID:12419474 | 5-aza-2'-deoxycytidine | affects methylation | ISO | RGD:1346564 | 6480464 | decitabine affects the methylation of NME2 gene | CTD | PMID:17630775 | 5-azacytidine | increases expression | EXP | | 6480464 | Azacitidine results in increased expression of NME2 protein | CTD | PMID:17105402 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of NME2 mRNA | CTD | PMID:19483382 | amiodarone | affects expression | EXP | | 6480464 | Amiodarone affects the expression of NME2 mRNA | CTD | PMID:19483382 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of NME2 mRNA | CTD | PMID:16483693 | astaxanthin | multiple interactions | ISO | RGD:1552274 | 6480464 | astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] | CTD | PMID:16964424 | benzbromarone | affects expression | EXP | | 6480464 | Benzbromarone affects the expression of NME2 mRNA | CTD | PMID:19483382 | calcitriol | decreases expression | ISO | RGD:1346564 | 6480464 | Calcitriol results in decreased expression of NME2 mRNA | CTD | PMID:16847355 PMID:15951637 | calcitriol | decreases expression | ISO | RGD:1346564 | 6480464 | Calcitriol results in decreased expression of NME2 mRNA | CTD | PMID:15951637 PMID:16847355 | capsaicin | increases expression | ISO | RGD:1346564 | 6480464 | Capsaicin results in increased expression of NME2 mRNA | CTD | PMID:21310942 | choline | multiple interactions | ISO | RGD:1552274 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NME2 gene | CTD | PMID:20938992 | clofibrate | affects expression | EXP | | 6480464 | Clofibrate affects the expression of NME2 mRNA | CTD | PMID:19483382 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NME2 mRNA | CTD | PMID:17602206 | cocaine | affects expression | ISO | RGD:1346564 | 6480464 | Cocaine affects the expression of NME2 protein | CTD | PMID:19393250 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of NME2 mRNA | CTD | PMID:21266533 | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of NME2 mRNA | CTD | PMID:18636392 | diethylstilbestrol | increases expression | ISO | RGD:1346564 | 6480464 | Diethylstilbestrol results in increased expression of NME2 mRNA | CTD | PMID:15766595 | disodium selenite | decreases expression | ISO | RGD:1346564 | 6480464 | Sodium Selenite results in decreased expression of NME2 mRNA | CTD | PMID:16705456 | doxorubicin | decreases expression | ISO | RGD:1552274 | 6480464 | Doxorubicin results in decreased expression of NME2 protein | CTD | PMID:16144979 | folic acid | multiple interactions | ISO | RGD:1552274 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NME2 gene | CTD | PMID:20938992 | hyaluronic acid | multiple interactions | EXP | | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NME2 protein] | CTD | PMID:23178681 | hyaluronic acid | decreases expression | EXP | | 6480464 | Hyaluronic Acid analog results in decreased expression of NME2 protein | CTD | PMID:23178681 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NME2 protein] | CTD | PMID:23178681 | hydrogen peroxide | decreases expression | EXP | | 6480464 | Hydrogen Peroxide results in decreased expression of NME2 protein | CTD | PMID:23178681 | L-ethionine | affects expression | EXP | | 6480464 | Ethionine affects the expression of NME2 mRNA | CTD | PMID:19483382 | L-methionine | multiple interactions | ISO | RGD:1552274 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NME2 gene | CTD | PMID:20938992 | lithium atom | increases expression | EXP | | 6480464 | Lithium results in increased expression of NME2 protein | CTD | PMID:18296634 | mifepristone | multiple interactions | ISO | RGD:1346564 | 6480464 | Mifepristone inhibits the reaction [Progesterone results in increased expression of NME2 mRNA] | CTD | PMID:15674352 | N-nitrosodiethylamine | increases expression | ISO | RGD:1552274 | 6480464 | Diethylnitrosamine results in increased expression of NME2 protein | CTD | PMID:15928304 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NME2 mRNA | CTD | PMID:17602206 | omeprazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of NME2 mRNA | CTD | PMID:19483382 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of NME2 mRNA | CTD | PMID:18636392 | paracetamol | affects expression | ISO | RGD:1552274 | 6480464 | Acetaminophen affects the expression of NME2 mRNA | CTD | PMID:17562736 | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of NME2 mRNA | CTD | PMID:19483382 | progesterone | increases expression | ISO | RGD:1346564 | 6480464 | Progesterone results in increased expression of NME2 mRNA | CTD | PMID:15674352 | progesterone | multiple interactions | ISO | RGD:1346564 | 6480464 | Mifepristone inhibits the reaction [Progesterone results in increased expression of NME2 mRNA] | CTD | PMID:15674352 | quinoline | increases expression | ISO | RGD:1346564 | 6480464 | quinoline analog results in increased expression of NME2 protein | CTD | PMID:18645022 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1346564 | 6480464 | tert-Butylhydroperoxide results in decreased expression of NME2 mRNA | CTD | PMID:12419474 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of NME2 mRNA | CTD | PMID:19483382 | zinc atom | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of NME2 mRNA | CTD | PMID:11717422 | zinc(0) | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of NME2 mRNA | CTD | PMID:11717422 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Purine metabolism | |
| Pyrimidine metabolism | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation (PID:200056) |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Purine metabolism | |
| Pyrimidine metabolism | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation (PID:200056) |
Phenotype AnnotationsReferences - curated| 1. |
Anciaux K, etal., FEBS Lett. 1997 Jan 2;400(1):75-9. |
| 2. |
Baillat G, etal., J Biol Chem 2002 May 24;277(21):18961-6. |
| 3. |
Beyea JA, etal., Dev Dyn. 2005 Oct;234(2):404-12. |
| 4. |
Brock TG Lipids. 2008 Feb;43(2):161-9. Epub 2007 Dec 15. |
| 5. |
Fukuchi T, etal., Biochim Biophys Acta. 1994 Mar 16;1205(1):113-22. |
| 6. |
Fukuda M, etal., Int J Cancer. 1996 Feb 8;65(4):531-7. |
| 7. |
Hemmerich S and Pecht I, Biochemistry. 1992 May 19;31(19):4580-7. |
| 8. |
Hemmerich S, etal., Biochemistry 1992 May 19;31(19):4574-9. |
| 9. |
Hippe HJ, etal., Circ Res. 2007 Apr 27;100(8):1191-9. Epub 2007 Mar 15. |
| 10. |
Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36. |
| 11. |
Ishijima Y, etal., FEBS Lett. 1999 Feb 19;445(1):155-9. |
| 12. |
Jovanovic S, etal., J Mol Biol. 2007 Aug 10;371(2):349-61. Epub 2007 Jun 2. |
| 13. |
Kanayama H, etal., Int J Urol. 1994 Dec;1(4):324-31. |
| 14. |
KEGG |
| 15. |
Kimura N, etal., J Biol Chem 1990 Sep 15;265(26):15744-9. |
| 16. |
Konishi N, etal., Jpn J Cancer Res. 1993 Oct;84(10):1050-4. |
| 17. |
Kowluru A, etal., Arch Biochem Biophys. 2002 Feb 15;398(2):160-9. |
| 18. |
Lacombe ML, etal., J Bioenerg Biomembr. 2000 Jun;32(3):247-58. |
| 19. |
Lutz S, etal., Cardiovasc Res. 2001 Jan;49(1):48-55. |
| 20. |
Mandai M, etal., Cancer Res. 1994 Apr 1;54(7):1825-30. |
| 21. |
Marone M, etal., Br J Cancer. 1996 Oct;74(7):1063-8. |
| 22. |
MGD data from the GO Consortium |
| 23. |
Murty VV, etal., Oncogene. 1994 Aug;9(8):2245-51. |
| 24. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 25. |
Ohkura N, etal., Biochem Biophys Res Commun. 2001 Apr 20;282(5):1206-10. |
| 26. |
Okabe-Kado J, etal., FEBS Lett. 1995 Apr 24;363(3):311-5. |
| 27. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 28. |
Rayner K, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R743-50. Epub 2006 Aug 3. |
| 29. |
RGD automated data pipeline |
| 30. |
RGD automated import pipeline for gene-chemical interactions |
| 31. |
Rohl C, etal., Glia. 2008 Aug 1;56(10):1114-26. |
| 32. |
Roymans D, etal., Exp Cell Res. 2000 Nov 25;261(1):127-38. |
| 33. |
Schmidt B, etal., J Urol. 1997 Nov;158(5):2000-5. |
| 34. |
Tagashira H, etal., Int J Mol Med. 1998 Jul;2(1):65-8. |
| 35. |
Tan WL, etal., Cancer Biol Ther. 2011 Mar 15;11(6):599-608. Epub 2011 Mar 15. |
| 36. |
Veluthakal R, etal., Mol Cell Biochem. 2009 Sep;329(1-2):121-9. Epub 2009 Apr 15. |
| 37. |
Watanabe J, etal., Br J Cancer. 1995 Dec;72(6):1469-73. |
| 38. |
Wei SJ, etal., J Biol Chem. 2004 Feb 13;279(7):5993-6004. Epub 2003 Nov 17. |
References - uncuratedRGD Disease Portals| Nme2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Nme2 (Rattus norvegicus) |
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| NME2 (Homo sapiens) |
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| Nme2 (Mus musculus) |
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Position Markers| D10Mgh23 |
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| RH135179 |
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| PMC312758P3 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031833 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06065289 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01065640 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01065641 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC086599 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D89068 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ217120 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ217563 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ218179 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222529 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M55331 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M91597 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031833 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_114021 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_114021 | (Get FASTA) |
| GenBank Protein | AAA41684 | (Get FASTA) |
| AAA42017 | (Get FASTA) | |
| AAH86599 | (Get FASTA) | |
| BAA13756 | (Get FASTA) | |
| EDM05687 | (Get FASTA) | |
| EDM05688 | (Get FASTA) | |
| P19804 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| BIND | 129608 | |
| Ensembl Genes | ENSRNOG00000002671 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000003611 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000003611 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 83782 | ENTREZGENE |
| Gene3D-CATH | NDK | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000002671 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 39553 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7312852 | IMAGE-MGC_LOAD |
| InterPro | Nuc_diP_kinase_core | UniProtKB/Swiss-Prot |
| Nucleoside_diP_kinase_AS | UniProtKB/Swiss-Prot | |
| IPI | IPI00325189 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:83782 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105386 | IMAGE-MGC_LOAD |
| PANTHER | Nuc_diP_kinase_core | UniProtKB/Swiss-Prot |
| Pfam | NDK | UniProtKB/Swiss-Prot |
| PRINTS | NUCDPKINASE | UniProtKB/Swiss-Prot |
| PROSITE | NDP_KINASES | UniProtKB/Swiss-Prot |
| SMART | NDK | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | NDK | UniProtKB/Swiss-Prot |
| UniGene | Rn.927 | ENTREZGENE |
| UniProt | NDKB_RAT | UniProtKB/Swiss-Prot |
| Q9QWQ4_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-10-05 | Nme2 | NME/NM23 nucleoside diphosphate kinase 2 | Nme2 | non-metastatic cells 2, protein (NM23B) expressed in | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-05-15 | Nme2 | non-metastatic cells 2, protein (NM23B) expressed in | Nme2 | expressed in non-metastatic cells 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Nme2 | expressed in non-metastatic cells 2 | nucleoside diphosphate kinase | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Nme2 | nucleoside diphosphate kinase | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Nme2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 619877 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.