GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Bleomycin results in increased expression of TNF mRNA; Bleomycin results in increased expression of TNF protein | PMID:17035056 PMID:19362168 PMID:23523906 PMID:26093215 PMID:26768587 | Tnf | multiple interactions | EXP | | 6480464 | CTD | [Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of TNF protein; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; celastrol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Taurine inhibits the reaction [Bleomycin results in increased expression of TNF protein] | PMID:17035056 PMID:19362168 PMID:23523906 PMID:26093215 PMID:26768587 PMID:33516805 | Tnf | affects response to substance | ISO | Tnf (Mus musculus) | 6480464 | CTD | TNF protein affects the susceptibility to Bleomycin | PMID:33647319 | Tnf | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Bleomycin results in increased expression of TNF mRNA; Bleomycin results in increased expression of TNF protein | PMID:11350791 PMID:12003776 PMID:14609568 PMID:15541506 PMID:16317386 PMID:17118201 PMID:17177178 PMID:19080365 PMID:22687607 PMID:26520185 PMID:27704718 PMID:28850077 PMID:31901889 PMID:32032644 PMID:35187969 PMID:35716765 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Bleomycin results in increased expression of TNF mRNA | PMID:37898439 PMID:8473757 | Tnf | increases secretion | ISO | Tnf (Mus musculus) | 6480464 | CTD | Bleomycin results in increased secretion of TNF protein | PMID:22687607 PMID:26600069 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of TNF protein]; [SLCO2A1 gene mutant form results in increased susceptibility to Bleomycin] which results in increased expression of TNF mRNA; [TNF protein affects the susceptibility to Bleomycin] which affects the expression of SFTPB protein; [TNF protein affects the susceptibility to Bleomycin] which affects the expression of SFTPD protein; Calcitriol inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; honokiol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Oils, Volatile inhibits the reaction [Bleomycin results in increased expression of TNF protein]; pirinixic acid inhibits the reaction [Bleomycin results in increased expression of TNF protein]; PPARA protein affects the reaction [Bleomycin results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of TNF protein]; verlukast inhibits the reaction [Bleomycin results in increased expression of TNF protein]; zileuton inhibits the reaction [Bleomycin results in increased expression of TNF protein] | PMID:12003776 PMID:14609568 PMID:15541506 PMID:16317386 PMID:17118201 PMID:17177178 PMID:19080365 PMID:26520185 PMID:26600069 PMID:27704718 PMID:28850077 PMID:31901889 PMID:32032644 PMID:32828905 PMID:33647319 PMID:35187969 PMID:35716765 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [Bleomycin co-treated with SFTPA1 protein polymorphism] results in increased expression of TNF protein; [Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of TNF protein; Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]; calfactant inhibits the reaction [Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]]; Ozone inhibits the reaction [[Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of TNF protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of CAT protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; yupingfeng inhibits the reaction [Bleomycin results in increased expression of TNF mRNA] | PMID:14617519 PMID:37898439 PMID:8317554 | | ||||||||||||||||||||||
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