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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases activityEXP 6480464CTDBleomycin results in decreased activity of SOD2 proteinPMID:26768587
Sod2multiple interactionsEXP 6480464CTDcelastrol inhibits the reaction [Bleomycin results in decreased activity of SOD2 protein]PMID:26768587
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDBleomycin results in increased expression of SOD2 proteinPMID:8317554
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDIL1A protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]PMID:8317554
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