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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | multiple interactions | EXP | | 6480464 | [Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA | CTD | PMID:16819974 | (+)-pilocarpine | decreases expression | EXP | | 6480464 | Pilocarpine results in decreased expression of GRIA2 mRNA | CTD | PMID:19222700 | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of GRIA2 protein | CTD | PMID:15857427 | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of GRIA2 3' UTR alternative form | CTD | PMID:19222700 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62154 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GRIA2 mRNA | CTD | PMID:16922920 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:62154 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRIA2 mRNA | CTD | PMID:19285098 | all-trans-retinoic acid | decreases expression | ISO | RGD:62154 | 6480464 | Tretinoin results in decreased expression of GRIA2 mRNA | CTD | PMID:16604517 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GRIA2 mRNA | CTD | PMID:16483693 | amphetamine | affects expression | EXP | | 6480464 | Amphetamine affects the expression of GRIA2 mRNA alternative form | CTD | PMID:15784965 | arsenic acid | decreases expression | EXP | | 6480464 | arsenic acid analog results in decreased expression of GRIA2 mRNA | CTD | PMID:19761793 | bicuculline | multiple interactions | EXP | | 6480464 | Bicuculline results in decreased expression of and results in decreased localization of GRIA2 protein | CTD | PMID:19674091 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GRIA2 mRNA | CTD | PMID:22504913 | bleomycin A2 | decreases expression | EXP | | 6480464 | Bleomycin results in decreased expression of GRIA2 mRNA | CTD | PMID:15808516 | celecoxib | multiple interactions | ISO | RGD:62154 | 6480464 | celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA] | CTD | PMID:21589914 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of GRIA2 mRNA | CTD | PMID:19440498 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of GRIA2 mRNA | CTD | PMID:18668222 PMID:19440498 | cocaine | increases expression | ISO | RGD:732446 | 6480464 | Cocaine results in increased expression of GRIA2 protein | CTD | PMID:16363995 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 protein | CTD | PMID:12511956 more ... | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 protein | CTD | PMID:15140200 more ... | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 protein | CTD | PMID:12787079 more ... | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 protein | CTD | PMID:19105975 more ... | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 protein | CTD | PMID:20534846 more ... | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 protein | CTD | PMID:20534846 more ... | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 mRNA | CTD | PMID:20187946 PMID:12511956 | cocaine | decreases response to substance | EXP | | 6480464 | GRIA2 results in decreased susceptibility to Cocaine | CTD | PMID:12511956 | cocaine | multiple interactions | EXP | | 6480464 | Cocaine results in increased phosphorylation of and affects the localization of GRIA2 protein | CTD | PMID:18945913 | cocaine | increases expression | ISO | RGD:62154 | 6480464 | Cocaine results in increased expression of GRIA2 mRNA | CTD | PMID:9886066 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 protein | CTD | PMID:19105975 more ... | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIA2 mRNA | CTD | PMID:12511956 PMID:20187946 | cytarabine | increases expression | ISO | RGD:732446 | 6480464 | Cytarabine results in increased expression of GRIA2 mRNA | CTD | PMID:21198554 | diazinon | decreases expression | EXP | | 6480464 | Diazinon results in decreased expression of GRIA2 mRNA | CTD | PMID:19440498 PMID:17452286 | diazinon | decreases expression | EXP | | 6480464 | Diazinon results in decreased expression of GRIA2 mRNA | CTD | PMID:17452286 PMID:19440498 | dieldrin | decreases expression | EXP | | 6480464 | Dieldrin results in decreased expression of GRIA2 mRNA | CTD | PMID:19440498 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of GRIA2 mRNA | CTD | PMID:22504913 | dopamine | increases localization | EXP | | 6480464 | Dopamine results in increased localization of GRIA2 protein | CTD | PMID:19674091 | elemental selenium | decreases expression | ISO | RGD:732446 | 6480464 | Selenium results in decreased expression of GRIA2 mRNA | CTD | PMID:19244175 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of GRIA2 mRNA | CTD | PMID:11772933 | ethanol | multiple interactions | EXP | | 6480464 | N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRIA2 mRNA] | CTD | PMID:20655511 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of GRIA2 mRNA | CTD | PMID:20655511 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of GRIA2 protein | CTD | PMID:20417256 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of GRIA2 mRNA | CTD | PMID:22504913 | kainic acid | multiple interactions | EXP | | 6480464 | Kainic Acid binds to and results in increased activity of GRIA2 protein; more ... | CTD | PMID:11812690 | kainic acid | decreases expression | ISO | RGD:62154 | 6480464 | Kainic Acid results in decreased expression of GRIA2 mRNA | CTD | PMID:21589914 | kainic acid | multiple interactions | ISO | RGD:62154 | 6480464 | celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA] | CTD | PMID:21589914 | kainic acid | decreases expression | EXP | | 6480464 | Kainic Acid results in decreased expression of GRIA2 mRNA | CTD | PMID:7529610 | kainic acid | affects response to substance | ISO | RGD:62154 | 6480464 | GRIA2 protein affects the susceptibility to Kainic Acid | CTD | PMID:10551584 | lactacystin | increases localization | EXP | | 6480464 | lactacystin results in increased localization of GRIA2 protein | CTD | PMID:19674091 | lithium atom | multiple interactions | EXP | | 6480464 | [Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA | CTD | PMID:16819974 | lithium atom | decreases expression | EXP | | 6480464 | Lithium results in decreased expression of GRIA2 protein | CTD | PMID:18171924 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of GRIA2 mRNA | CTD | PMID:18419818 | nickel atom | multiple interactions | ISO | RGD:732446 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of GRIA2 mRNA] | CTD | PMID:14575637 | nickel atom | affects expression | ISO | RGD:732446 | 6480464 | Nickel affects the expression of GRIA2 mRNA | CTD | PMID:14575637 | olanzapine | increases expression | EXP | | 6480464 | olanzapine results in increased expression of GRIA2 mRNA | CTD | PMID:11526992 | pentobarbital | affects response to substance | ISO | RGD:62154 | 6480464 | GRIA2 protein affects the susceptibility to Pentobarbital | CTD | PMID:10551584 | phenobarbital | affects response to substance | ISO | RGD:62154 | 6480464 | GRIA2 protein affects the susceptibility to Phenobarbital | CTD | PMID:10551584 | selenium atom | decreases expression | ISO | RGD:732446 | 6480464 | Selenium results in decreased expression of GRIA2 mRNA | CTD | PMID:19244175 | tetrodotoxin | increases localization | EXP | | 6480464 | Tetrodotoxin results in increased localization of GRIA2 protein | CTD | PMID:19674091 | thiopental | affects response to substance | ISO | RGD:62154 | 6480464 | GRIA2 protein affects the susceptibility to Thiopental | CTD | PMID:10551584 | tocopherol | increases expression | ISO | RGD:62154 | 6480464 | Tocopherols results in increased expression of GRIA2 mRNA | CTD | PMID:17654050 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of GRIA2 mRNA | CTD | PMID:21827849 | tributylstannane | decreases expression | EXP | | 6480464 | tributyltin results in decreased expression of GRIA2 protein; more ... | CTD | PMID:19591855 | trichostatin A | multiple interactions | ISO | RGD:732446 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of GRIA2 mRNA] | CTD | PMID:14575637 | urethane | multiple interactions | EXP | | 6480464 | Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein] | CTD | PMID:11812690 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of GRIA2 protein | CTD | PMID:18171924 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Amphetamine addiction |
| Amyotrophic lateral sclerosis (ALS) | |
| Circadian entrainment | |
| Cocaine addiction | |
| Dopaminergic synapse | |
| Glutamatergic synapse | |
| Long-term depression | |
| Long-term potentiation | |
| Neuroactive ligand-receptor interaction | |
| Nicotine addiction | |
| Retrograde endocannabinoid signaling | |
| Pathway Interaction Database | N-cadherin signaling events (PID:200209) |
References - curated| 1. |
Aicher SA, etal., Brain Res 2002 Dec 27;958(2):454-8. |
| 2. |
Boulter J, etal., Science 1990 Aug 31;249(4972):1033-7. |
| 3. |
Brusa R, etal., Science 1995 Dec 8;270(5242):1677-80. |
| 4. |
Dixon RM, etal., J Biol Chem. 2009 May 22;284(21):14230-5. doi: 10.1074/jbc.M901203200. Epub 2009 Mar 25. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Huang Y, etal., J Neurosci 2002 Oct 1;22(19):8422-8. |
| 7. |
Keinanen K, etal., Science 1990 Aug 3;249(4968):556-60. |
| 8. |
Levy RB and Aoki C, J Neurosci. 2002 Jun 15;22(12):5001-15. |
| 9. |
Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78. |
| 10. |
MGD data from the GO Consortium |
| 11. |
Nakanishi N, etal., Neuron 1990 Nov;5(5):569-81. |
| 12. |
Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7. |
| 13. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 14. |
Nishizaki T and Matsumura T, Brain Res Mol Brain Res 2002 Jan 31;98(1-2):130-4. |
| 15. |
Peineau S, etal., Neuron. 2007 Mar 1;53(5):703-17. |
| 16. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 17. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 18. |
Radley JJ, etal., Brain Res. 2007 Feb 23;1134(1):87-94. Epub 2007 Jan 17. |
| 19. |
RGD automated import pipeline for gene-chemical interactions |
| 20. |
Schenk U, etal., EMBO J 2003 Feb 3;22(3):558-68. |
| 21. |
Sommer B, etal., Science 1990 Sep 28;249(4976):1580-5. |
| 22. |
Sutton MA, etal., Nature 2003 Jan 2;421(6918):70-5. |
| 23. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
References - uncurated| PubMed | 10027300 |
| 10340301 | |
| 10414981 | |
| 10558890 | |
| 10688364 | |
| 11100149 | |
| 11348590 | |
| 11836517 | |
| 11891216 | |
| 12050666 | |
| 12379442 | |
| 12603280 | |
| 12605900 | |
| 12665613 | |
| 12904794 | |
| 12909632 | |
| 12956708 | |
| 14534256 | |
| 14706873 | |
| 14730302 | |
| 14739560 | |
| 14976558 | |
| 15071096 | |
| 15260958 | |
| 15269270 | |
| 15331617 | |
| 15351509 | |
| 15458844 | |
| 15610164 | |
| 15750591 | |
| 15784965 | |
| 15924137 | |
| 15944123 | |
| 16037816 | |
| 16103115 | |
| 16186507 | |
| 16480690 | |
| 16483599 | |
| 16707783 | |
| 16990276 | |
| 17018279 | |
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| 17446041 | |
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| 17543993 | |
| 17804792 | |
| 17873364 | |
| 17969105 | |
| 18390190 | |
| 18403705 | |
| 18439999 | |
| 18500330 | |
| 18598260 | |
| 18679721 | |
| 18720514 | |
| 18722513 | |
| 18794522 | |
| 18795801 | |
| 18815255 | |
| 18817736 | |
| 18823129 | |
| 19020286 | |
| 19063943 | |
| 19071197 | |
| 19091980 | |
| 19105974 | |
| 19110036 | |
| 19176091 | |
| 19185395 | |
| 19200070 | |
| 19222700 | |
| 19265014 | |
| 19330849 | |
| 19439609 | |
| 19461580 | |
| 19508696 | |
| 19534762 | |
| 19558602 | |
| 19563786 | |
| 19644508 | |
| 19673491 | |
| 19774669 | |
| 19776277 | |
| 19908285 | |
| 19946266 | |
| 20110361 | |
| 20110365 | |
| 20155979 | |
| 20179884 | |
| 20403402 | |
| 20408958 | |
| 20417256 | |
| 20422983 | |
| 20534470 | |
| 20547835 | |
| 20869354 | |
| 21106836 | |
| 21141507 | |
| 21414928 | |
| 21425350 | |
| 21527319 | |
| 21895609 | |
| 22144581 | |
| 22219297 | |
| 22284903 | |
| 22573673 | |
| 22813734 | |
| 23076153 | |
| 23129617 | |
| 23141062 | |
| 23212166 | |
| 7545935 | |
| 7992055 | |
| 8848293 | |
| 9069286 | |
| 9351977 | |
| 9697854 | |
| 9697855 | |
| 9712644 | |
| 9768844 | |
| 9804426 |
RGD Disease Portals| Gria2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gria2 (Rattus norvegicus) |
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| GRIA2 (Homo sapiens) |
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| Gria2 (Mus musculus) |
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Position Markers| Gria2 |
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| L32372 |
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| PMC283538P1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001083811 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_017261 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06018497 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01018237 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01018238 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01018239 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01018240 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF025917 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF164344 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF201344 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473976 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CO400088 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M36419 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M38061 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M85035 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X54655 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017261 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058957 | ||||||||||||||||||||
| Peptide Label: | isoform 1 precursor | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001083811 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001077280 | ||||||||||||||||||||
| Peptide Label: | isoform 2 precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001077280 | (Get FASTA) |
| NP_058957 | (Get FASTA) | |
| GenBank Protein | AAA41240 | (Get FASTA) |
| AAA41244 | (Get FASTA) | |
| AAC34260 | (Get FASTA) | |
| AAC37652 | (Get FASTA) | |
| AAD51284 | (Get FASTA) | |
| AAF23956 | (Get FASTA) | |
| CAA38465 | (Get FASTA) | |
| EDM00859 | (Get FASTA) | |
| EDM00860 | (Get FASTA) | |
| P19491 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000028589 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000032937 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000062152 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000039587 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000067113 | ENTREZGENE, UniProtKB/TrEMBL | |
| Entrez Gene | 29627 | ENTREZGENE |
| Germonline | ENSRNOG00000028589 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20225 | ENTREZGENE |
| InterPro | ANF_lig_bd_rcpt | UniProtKB/Swiss-Prot |
| Glu_rcpt_Glu/Gly-bd | UniProtKB/Swiss-Prot | |
| Iontro_glu_rcpt | UniProtKB/Swiss-Prot | |
| NMDA_rcpt | UniProtKB/Swiss-Prot | |
| IPI | IPI00231061 | UniProtKB/Swiss-Prot |
| IPI00324625 | UniProtKB/Swiss-Prot | |
| IPI00876626 | UniProtKB/Swiss-Prot | |
| IPI00952011 | UniProtKB/TrEMBL | |
| KEGG Report | rno:29627 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | ANF_receptor | UniProtKB/Swiss-Prot |
| Lig_chan | UniProtKB/Swiss-Prot | |
| Lig_chan-Glu_bd | UniProtKB/Swiss-Prot | |
| PRINTS | NMDARECEPTOR | UniProtKB/Swiss-Prot |
| SMART | Lig_chan-Glu_bd | UniProtKB/Swiss-Prot |
| PBPe | UniProtKB/Swiss-Prot | |
| TIGR | TC204985 | |
| UniGene | Rn.91361 | ENTREZGENE |
| UniProt | F1LNE4_RAT | UniProtKB/TrEMBL |
| G3V914_RAT | UniProtKB/TrEMBL | |
| GRIA2_RAT | UniProtKB/Swiss-Prot | |
| Q9QXM5_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-07-11 | Gria2 | glutamate receptor, ionotropic, AMPA 2 | Gria2 | glutamate receptor, ionotropic, AMPA 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-07-10 | Gria2 | glutamate receptor, ionotropic, AMPA 2 | Gria2 | glutamate receptor, ionotropic, AMPA2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Gria2 | glutamate receptor, ionotropic, AMPA2 | glutamate receptor, ionotropic, 2 | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Gria2 | glutamate receptor, ionotropic, 2 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | deacetylation of promoter-bound histones also occurs after transient global ischemia | 628432 |
| gene_process | may play a role in seizure-induced pathological events in the hippocampus | 628432 |
| gene_regulation | histones (e.g. H4) associated with the promoters in hippocampal CA3 neurons after seizures, are rapidly deacetylated, and a histone deacetylase inhibitor, trichostatin A, inhibits and quickly reverses deacetylation | 628432 |
| More on Gria2 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61862 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




