Morroniside - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Morroniside	go back to main search page
Accession:	CHEBI:80852	browse the term
Definition:	A glycoside that has formula C17H26O11.
Synonyms:	related_synonym:	Formula=C17H26O11; InChI=1S/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9+,10+,11+,12+,13-,14+,16-,17-/m0/s1; InChIKey=YTZSBJLNMIQROD-SFBCHFHNSA-N; SMILES=COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]2[C@H](C)O[C@@H](O)C[C@H]12
	xref:	CAS:25406-64-8; KEGG:C17000
	xref_mesh:	MESH:C488401

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Genes (87)

Morroniside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 protein]

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily G member 1

multiple interactions

morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 protein]

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

acid phosphatase 5, tartrate resistant

decreases expression

morroniside results in decreased expression of ACP5 mRNA

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

actin alpha 2, smooth muscle

multiple interactions

LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]

PMID:35279615 PMID:35679793

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adenosine A2a receptor

increases expression

morroniside results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

AKT serine/threonine kinase 1

multiple interactions

morroniside inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

morroniside inhibits the reaction [Glucose results in decreased expression of ALPL mRNA]
morroniside results in increased expression of ALPL mRNA

PMID:32643284 PMID:34638983 PMID:35848187

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

angiogenin

increases expression

morroniside results in increased expression of ANG protein

NCBI chr15:24,312,711...24,323,361

G

apolipoprotein E

multiple interactions

morroniside inhibits the reaction [Glucose results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of APOE protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE protein]

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

arginase 1

increases expression

morroniside results in increased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

agouti signaling protein

multiple interactions

morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SCD1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein]

NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171

G

autophagy related 13

multiple interactions
increases expression

MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein]

NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects expression

[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; morroniside inhibits the reaction [Glucose results in increased expression of BAX protein]
morroniside affects the expression of BAX protein

PMID:21963495 PMID:28106847

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
increases expression

[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; morroniside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
morroniside results in increased expression of BCL2 mRNA

PMID:20966881 PMID:28106847

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

multiple interactions
increases expression

MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein]
morroniside inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 protein]

PMID:32954801 PMID:35957534

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

multiple interactions

morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein]

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein 2

multiple interactions
increases expression

morroniside inhibits the reaction [Glucose results in decreased expression of BMP2 mRNA]
morroniside results in increased expression of BMP2 mRNA

PMID:32643284 PMID:35848187

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

caspase 1

affects expression
multiple interactions

morroniside affects the expression of CASP1
morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

decreases expression
multiple interactions

morroniside results in decreased expression of CASP3 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; morroniside inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]

PMID:20966881 PMID:28106847 PMID:32954801

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

decreases expression

morroniside results in decreased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

morroniside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

affects expression

morroniside affects the expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

increases expression

morroniside results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

increases expression

morroniside results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

collagen type I alpha 1 chain

multiple interactions

LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

multiple interactions

LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

catenin beta 1

increases expression

morroniside results in increased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin K

decreases expression

morroniside results in decreased expression of CTSK mRNA

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome b-245 alpha chain

affects expression

morroniside affects the expression of CYBA protein

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

Fas cell surface death receptor

multiple interactions

morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibroblast growth factor 2

increases expression

morroniside results in increased expression of FGF2 protein

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

GATA binding protein 3

multiple interactions
affects binding

morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA]
morroniside binds to GATA3 protein

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glyoxalase 1

multiple interactions

morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 protein]

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glucagon-like peptide 1 receptor

affects response to substance

GLP1R affects the susceptibility to morroniside

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

heme oxygenase 1

multiple interactions
affects expression

morroniside promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; morroniside results in increased expression of and results in increased phosphorylation of HMOX1 protein
morroniside affects the expression of HMOX1 protein

PMID:21963495 PMID:34029560

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

intercellular adhesion molecule 1

affects expression

morroniside affects the expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

multiple interactions
increases expression

SB 203580 inhibits the reaction [morroniside results in increased expression of IL10 mRNA]
morroniside results in increased expression of IL10 mRNA; morroniside results in increased expression of IL10 protein

PMID:32595037 PMID:34867417

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]]
morroniside inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:32643284 PMID:33022338 PMID:33804203 PMID:35279615

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

increases expression

morroniside results in increased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]]

PMID:32643284 PMID:35279615

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kinase insert domain receptor

multiple interactions

morroniside results in increased expression of and results in increased phosphorylation of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

lipase A, lysosomal acid type

multiple interactions

LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein]

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

lymphocyte antigen 96

affects binding

morroniside binds to [TLR4 protein binds to LY96 protein]

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

G

mitogen activated protein kinase 1

multiple interactions

morroniside results in increased expression of and results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

morroniside results in increased expression of and results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

matrix metallopeptidase 13

multiple interactions
affects expression

morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]
morroniside affects the expression of MMP13

PMID:33022338 PMID:33804203

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 3

multiple interactions

morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

decreases expression

morroniside results in decreased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mannose receptor, C type 1

increases expression

morroniside results in increased expression of MRC1 mRNA

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

mechanistic target of rapamycin kinase

multiple interactions
increases activity

MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein]; MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein]
morroniside results in increased activity of MTOR protein
morroniside inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MTOR protein]

PMID:32954801 PMID:35957534

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYD88, innate immune signal transduction adaptor

multiple interactions

morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

neurogenin 2

increases expression

morroniside results in increased expression of NEUROG2 protein

NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154

G

nuclear factor of activated T-cells 1

decreases expression

morroniside results in decreased expression of NFATC1 mRNA

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects expression

morroniside promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and affects the localization of NFE2L2 protein]; morroniside results in increased expression of and results in increased phosphorylation of NFE2L2 protein
morroniside affects the expression of NFE2L2 protein

PMID:21963495 PMID:34029560

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NLR family, pyrin domain containing 3

multiple interactions
affects expression

morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]
morroniside affects the expression of NLRP3

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions
decreases expression
affects expression

morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
morroniside results in decreased expression of NOS2 protein
morroniside affects the expression of NOS2 protein

PMID:20487222 PMID:21963495 PMID:34029560

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 4

affects expression

morroniside affects the expression of NOX4 protein

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

nuclear receptor subfamily 1, group H, member 2

multiple interactions

morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 protein]

NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377

G

neuropilin 1

increases expression

morroniside results in increased expression of NRP1 protein

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

paired box 6

increases expression

morroniside results in increased expression of PAX6 protein

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

proliferating cell nuclear antigen

increases expression

morroniside results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

proopiomelanocortin

increases expression

morroniside results in increased expression of POMC mRNA alternative form

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

PPARG coactivator 1 alpha

multiple interactions

morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase methylesterase 1

multiple interactions

morroniside inhibits the reaction [Okadaic Acid results in increased expression of PPME1 protein]

NCBI chr 1:154,668,099...154,715,079
Ensembl chr 1:154,668,109...154,715,110

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein]

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein]

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein kinase C, delta

multiple interactions

morroniside results in increased expression of and results in increased phosphorylation of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression
affects expression

morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
morroniside results in decreased expression of PTGS2 protein
morroniside affects the expression of PTGS2 protein

PMID:20487222 PMID:21963495 PMID:33804203 PMID:34029560

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
affects expression

morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of RELA protein]
morroniside results in decreased expression of RELA protein
morroniside affects the expression of RELA protein
morroniside inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]

PMID:20487222 PMID:21963495 PMID:33804203 PMID:35279615 PMID:37769864

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RUNX family transcription factor 2

multiple interactions
increases expression
affects expression

morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]
morroniside results in increased expression of RUNX2 mRNA
morroniside affects the expression of RUNX2 protein

PMID:32643284 PMID:34638983 PMID:35848187

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

stearoyl-CoA desaturase

multiple interactions

morroniside inhibits the reaction [A mutant form results in increased expression of SCD1 protein]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of SCD protein]

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

Sp7 transcription factor

increases expression

morroniside results in increased expression of SP7 mRNA

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

secreted phosphoprotein 1

affects expression
multiple interactions

morroniside affects the expression of SPP1 protein
morroniside inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]

PMID:32643284 PMID:35848187

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

multiple interactions

morroniside inhibits the reaction [Hydrogen Peroxide results in decreased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

morroniside results in increased expression of and results in increased phosphorylation of SRC protein
morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of and results in increased activity of SRC protein]

PMID:26836014 PMID:31991140

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

sterol regulatory element binding transcription factor 1

affects expression
multiple interactions

morroniside affects the expression of SREBF1 protein
morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]

PMID:20487222 PMID:37769864

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

affects expression

morroniside affects the expression of SREBF2 protein

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

multiple interactions

morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT3 protein]
morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transcription factor 7 like 2

increases expression

morroniside results in increased expression of TCF7L2 protein

NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967

G

TEK receptor tyrosine kinase

increases expression

morroniside results in increased expression of TEK protein

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transforming growth factor, beta 1

multiple interactions

LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA]
morroniside inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]

PMID:35279615 PMID:35679793

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 4

multiple interactions
affects binding

morroniside inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
morroniside binds to [TLR4 protein binds to LY96 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]]
morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of TNF protein]

PMID:32643284 PMID:35279615 PMID:37769864

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

decreases expression

morroniside results in decreased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

vascular endothelial growth factor A

increases expression

morroniside results in increased expression of VEGFA protein

PMID:24979385 PMID:31991140

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

Wnt family member 3A

increases expression

morroniside results in increased expression of WNT3A protein

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19890
chemical entity	19867
atom	19888
nonmetal atom	19789
oxygen atom	19549
oxygen molecular entity	19529
organooxygen compound	19180
carbohydrates and carbohydrate derivatives	15283
carbohydrate derivative	14317
glycosyl compound	13080
glycoside	11832
Morroniside	87
Path 2
Term	Annotations
CHEBI ontology	19890
subatomic particle	19867
composite particle	19888
hadron	19888
baryon	19888
nucleon	19867
atomic nucleus	19888
atom	19888
main group element atom	19806
p-block element atom	19806
carbon group element atom	19746
carbon atom	19743
organic molecular entity	19743
heteroorganic entity	19502
organochalcogen compound	19264
organooxygen compound	19180
carbohydrates and carbohydrate derivatives	15283
carbohydrate	15304
carbohydrate derivative	14317
glycosyl compound	13080
glycoside	11832
Morroniside	87

paths to the root