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Gene: Asip (agouti signaling protein) Rattus norvegicus
Symbol: Asip
Name: agouti signaling protein
Description: Predicted to have neuropeptide hormone activity; type 3 melanocortin receptor binding activity; and type 4 melanocortin receptor binding activity. Predicted to be involved in several processes, including adult feeding behavior; melanosome transport; and positive regulation of melanin biosynthetic process. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human ASIP (agouti signaling protein); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; melanocortin system pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; agouti; agouti (coat color); agouti switch protein; agouti-signaling protein; ASP
Homo sapiens (human) : ASIP (agouti signaling protein)  HGNC  Alliance
Mus musculus (house mouse) : a (nonagouti)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Asip (agouti signaling protein)
Pan paniscus (bonobo/pygmy chimpanzee) : ASIP (agouti signaling protein)
Canis lupus familiaris (dog) : ASIP (agouti signaling protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Asip (agouti signaling protein)
Sus scrofa (pig) : ASIP (agouti signaling protein)
Chlorocebus sabaeus (African green monkey) : ASIP (agouti signaling protein)
Heterocephalus glaber (naked mole-rat) : Asip (agouti signaling protein)
more info ...
Allele / Splice: Asipem1Mcwi   Asipm1  
Genetic Models: DA-Asipm1 ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi-Asipem1Mcwi
Is Marker For: Strains:   BLK/N   F344-AsipATyrCKitH/Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03150,492,010 - 150,579,870 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,574,473 - 150,579,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,860,395 - 156,949,277 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,445,175 - 145,536,831 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13145,350,796 - 145,442,453 (+)NCBI
Celera3142,203,571 - 142,291,520 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Asip
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2003
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.