ASIP (agouti signaling protein) - Rat Genome Database

Name: ASIP
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: ASIP (agouti signaling protein) Chlorocebus sabaeus

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Symbol:

ASIP

Name:

agouti signaling protein

RGD ID:

18644075

Description:

ENCODES a protein that exhibits melanocortin receptor binding (ortholog); type 3 melanocortin receptor binding (ortholog); type 4 melanocortin receptor binding (ortholog); INVOLVED IN adult feeding behavior (ortholog); epigenetic programming in the zygotic pronuclei (ortholog); epigenetic regulation of gene expression (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; melanocortin system pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); coat/hair pigmentation trait (ortholog); dermatitis (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

agouti-signaling protein; LOC103248705

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ASIP (agouti signaling protein)	NCBI	Ortholog
Mus musculus (house mouse):	a (non-agouti)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Asip (agouti signaling protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Asip (agouti signaling protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ASIP (agouti signaling protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ASIP (agouti signaling protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Asip (agouti signaling protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ASIP (agouti signaling protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Asip (agouti signaling protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	38,479,328 - 38,568,756 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	88,288,816 - 88,382,787 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Experimental Data Annotations Click to see Annotation Detail View

Vertebrate Trait

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
ASIP	Green Monkey	coat/hair pigmentation trait		ISO	ASIP (Canis lupus familiaris)	9068941	Coat colour and agouti	OMIA	PMID:12692166 more ...
ASIP	Green Monkey	coat/hair pigmentation trait		ISO	ASIP (Canis lupus familiaris)	9068941	Coat colour and saddle tan vs black-and-tan	OMIA	PMID:23519866 more ...

Disease Annotations Click to see Annotation Detail View

basal cell carcinoma (ISO)

dermatitis (ISO)

diabetes mellitus (ISO)

Diabetic Nephropathies (ISO)

disease of cellular proliferation (ISO)

Edema (ISO)

Failure to Thrive (ISO)

Fibrosis (ISO)

Furunculosis (ISO)

glutathione synthetase deficiency (ISO)

hepatic veno-occlusive disease (ISO)

hyperglycemia (ISO)

hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (ISO)

Hyperplasia (ISO)

keratosis (ISO)

Liver Neoplasms (ISO)

long QT syndrome (ISO)

melanoma (ISO)

obesity (ISO)

Obesity and Hypopigmentation (ISO)

pigmentation disease (ISO)

Prenatal Exposure Delayed Effects (ISO)

Skin Neoplasms (ISO)

Sunburn (ISO)

type 2 diabetes mellitus (ISO)

Weight Gain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult feeding behavior (ISO)

epigenetic programming in the zygotic pronuclei (ISO)

epigenetic regulation of gene expression (ISO)

generation of precursor metabolites and energy (ISO)

melanin biosynthetic process (ISO)

melanosome organization (ISO)

melanosome transport (ISO)

pigmentation (ISO)

Cellular Component

extracellular space (ISO)

Molecular Function

melanocortin receptor binding (ISO)

protein binding (ISO)

type 3 melanocortin receptor binding (ISO)

type 4 melanocortin receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

melanocortin system pathway (ISO)

Experimental Data Annotations Click to see Annotation Detail View

Vertebrate Trait

coat/hair pigmentation trait (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ASIP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	38,479,328 - 38,568,756 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	88,288,816 - 88,382,787 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ASIP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	34,186,493 - 34,269,344 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	34,194,569 - 34,269,344 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	32,782,368 - 32,857,150 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	32,311,832 - 32,320,809 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	32,311,831 - 32,320,809	NCBI
Celera	20	29,597,653 - 29,606,630 (+)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	29,629,973 - 29,638,950 (+)	NCBI		HuRef
CHM1_1	20	32,749,256 - 32,758,241 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	35,912,881 - 35,992,459 (+)	NCBI		T2T-CHM13v2.0

a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	154,792,519 - 154,892,932 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	154,633,322 - 154,892,932 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	154,950,599 - 155,051,012 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	155,018,266 - 155,027,104 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	2	154,791,402 - 155,051,012 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	154,839,306 - 154,876,748 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	154,705,018 - 154,742,423 (+)	NCBI		MGSCv36	mm8
Celera	2	160,940,588 - 160,977,934 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	76.83	NCBI

Asip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	163,933,768 - 164,021,377 (+)	NCBI		GRCr8
mRatBN7.2	3	143,473,584 - 143,561,170 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,555,696 - 143,561,171 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	147,341,174 - 147,428,809 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	155,958,462 - 156,046,095 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	153,697,992 - 153,785,636 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	150,492,010 - 150,579,870 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,574,473 - 150,579,870 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	156,860,395 - 156,949,277 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	145,445,175 - 145,536,831 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	145,350,796 - 145,442,453 (+)	NCBI
Celera	3	142,203,571 - 142,291,520 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

Asip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	27,020,386 - 27,057,626 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	27,021,810 - 27,150,339 (-)	NCBI	ChiLan1.0	ChiLan1.0

ASIP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	39,987,569 - 39,997,795 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	39,980,671 - 39,990,897 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	30,583,038 - 30,592,726 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	31,718,169 - 31,727,217 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	31,718,169 - 31,727,217 (+)	Ensembl	panpan1.1		panPan2

ASIP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	23,338,757 - 23,393,913 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	23,354,888 - 23,393,896 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	22,999,470 - 23,041,722 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	24,041,356 - 24,084,629 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	24,041,485 - 24,084,612 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	23,334,340 - 23,373,386 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	23,428,191 - 23,467,532 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,865,404 - 23,906,575 (+)	NCBI		UU_Cfam_GSD_1.0

Asip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	172,298,779 - 172,407,882 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	6,341,623 - 6,346,458 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	6,341,667 - 6,346,440 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASIP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	37,545,474 - 37,718,779 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	37,542,615 - 37,718,787 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	42,538,122 - 42,686,968 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Asip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	5,079,499 - 5,084,933 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	5,079,499 - 5,084,933 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008021289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008021296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008021306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008021314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008021323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008021329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008021289 ⟹ XP_008019480

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	38,481,132 - 38,568,756 (+)	NCBI
Vero_WHO_p1.0	NW_023666050	88,288,816 - 88,382,787 (-)	NCBI

Sequence:

show sequence

TCTAGTGAGGGAAGAAGAAACTTCTTTTGCTTTCTGAGTGGGTGCTTTGGTACAGTACAATATC
TATGCTATAGTAATATATCTATAGGCTCGACTTCTCCTTCTCCTCTTTTTCCTTTCTCCAGCCC
CCTCCTTCCTCATCATCATCTTCTTTTGTTTTTTTATTTGCTTCTTCCATAGTAAAACTTTCTG
AAAGCCGATGTGCCTGGATGATTTTTGCCTGGTACGTTCCGCTAATTGGAGTTCCAGAATCACA
GTTTCTTGCTTGGGTGTAGAATTTTCAAAAGTGTTTAAGTGCCTAAATTATTGTAGTAGTGGCT
GGCCACTGCCCATGCCTTGTAGACAGGCAGCTGAGAAGATACCAAAAAAAAAAAAAAAAAAAAA
AAAAGGCTGCAGGTCTGTACCATTCACTGTACCAGAATGCAGAACCCTACTGGACTGCTCCTCA
TGGAAGGAGGAGCTATGTTGTACTGAGCTGACAACACGGGCAATCGAAAGAGCAAACCCGGGGC
ATAAATGGAACCAGGCCCTGGAAGCGTTTGGTTGGGAGTCTCCCTTTGATCAAGCCTTTCCTTT
GGTCAAGTGGCTCTGTGAAAATAAAGAAGAATCTGATCCAGATGAAGGCCTCCTGGGATGGATG
TCACCCGCCTACTCCTGGCCACCCTGCTGGTCTTCCTCTGCTTCTTCACTGCGTACAGCCACCT
GCCACCTGAGGAGAAGCTCCGAGATGACAGAAGCCTGAGAAGCAACTCCTCTGTGAACCTACTG
GACTTCCCTTCTGTCTCTATTGTGGCACTGAACAAGAAATCCAAACAGATCAGCAGAAAAGAAG
CAGAAAAGAAGAGATCTTCTAAGAAGGAGGCTTCGATGAAGAAAGTGGCGCGGCCCCGGACCCC
CCTCTCTGCGCCCTGCGTGGCCACCCGCGACAGCTGCAAGCCGCCTGCACCCGCCTGTTGCGAC
CCGTGCGCCTCCTGCCAGTGCCGCTTCTTCCGCAGCGCCTGCTCCTGCCGCGTGCTCAGCCTCA
ACTGCTGAGCGCGCCCTCTCCCGGCCGCGGGCGGGCAGGGCTTTGGGGACGCGGGGCGCTTTTC
GGGCGGGTGATCTCTAACTGGGCGGCTTCCCAGGACTGGGGGTGGGCGGAGGTTGCAGGAGGTG
GGAGTTCAGGGAGACCTGGCTTGGGCTAAACTCGAAATACAATATATATAGGCTGCTCTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008019480	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_008019480 ⟸ XM_008021289

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	ASIP	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-08-09	ASIP	agouti signaling protein	LOC103248705	agouti signaling protein	Symbol and/or name change	5135510	APPROVED
2020-12-08	LOC103248705	agouti signaling protein	ASIP	agouti signaling protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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