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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyfluthrin
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Accession:CHEBI:4034 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation between 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid and (4-fluoro-3-phenoxyphenyl)(hydroxy)acetonitrile.
Synonyms:exact_synonym: cyano(4-fluoro-3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate
 related_synonym: (R,S)-alpha-Cyano-4-fluoro-3-phenoxybenzyl-(1R,S)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate;   Formula=C22H18Cl2FNO3;   InChI=1S/C22H18Cl2FNO3/c1-22(2)15(11-19(23)24)20(22)21(27)29-18(12-26)13-8-9-16(25)17(10-13)28-14-6-4-3-5-7-14/h3-11,15,18,20H,1-2H3;   InChIKey=QQODLKZGRKWIFG-UHFFFAOYSA-N;   SMILES=CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)c1ccc(F)c(Oc2ccccc2)c1
 xref: Beilstein:2788149;   CAS:68359-37-5;   Drug_Central:4407;   KEGG:C10982;   KEGG:D07761
 xref_mesh: MESH:C052570
 xref: PMID:17912691;   PMID:18383791;   PPDB:192;   Patent:DE2709264;   Patent:US4218469;   Patent:US4287208;   Reaxys:2788149


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cyfluthrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP cyfluthrin results in decreased activity of ACHE protein CTD PMID:26604153 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression		 ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of AKT1 mRNA] CTD PMID:31330490 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin decreases expression
multiple interactions		 EXP cyfluthrin results in decreased expression of ALB protein
basil oil inhibits the reaction [cyfluthrin results in decreased expression of ALB protein]; Oils, Volatile inhibits the reaction [cyfluthrin results in decreased expression of ALB protein]		 CTD PMID:35126122 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions
increases expression		 ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of AOX1 mRNA] CTD PMID:31330490 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO cyfluthrin results in increased expression of APAF1 mRNA CTD PMID:31330490 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor decreases activity
multiple interactions		 ISO cyfluthrin results in decreased activity of AR protein
cyfluthrin binds to and results in increased activity of AR protein; Dihydrotestosterone inhibits the reaction [cyfluthrin results in increased activity of AR protein]		 CTD PMID:15064155 PMID:20410157 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP cyfluthrin results in increased expression of ATF4 mRNA; cyfluthrin results in increased expression of ATF4 protein CTD PMID:36548566 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atox1 antioxidant 1 copper chaperone decreases expression ISO cyfluthrin results in decreased expression of ATOX1 mRNA CTD PMID:31330490 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO cyfluthrin results in increased expression of BAX mRNA
Melatonin inhibits the reaction [cyfluthrin results in increased expression of BAX mRNA]		 CTD PMID:31330490 PMID:32028016 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO cyfluthrin results in increased expression of BCL2 mRNA CTD PMID:31330490 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase increases expression ISO cyfluthrin results in increased expression of BCR protein CTD PMID:16790487 NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP cyfluthrin results in increased expression of BDNF mRNA CTD PMID:16166269 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions
increases expression		 ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of BNIP3 mRNA] CTD PMID:31330490 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO cyfluthrin results in increased expression of CAMK2A mRNA CTD PMID:32028016 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression ISO cyfluthrin results in increased expression of CAMK2B mRNA CTD PMID:32028016 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO cyfluthrin results in increased expression of CASP3 mRNA
Melatonin inhibits the reaction [cyfluthrin results in increased expression of CASP3 mRNA]		 CTD PMID:31330490 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression
affects binding		 ISO
EXP		 cyfluthrin results in decreased activity of CAT protein
[Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]; N-acetylserotonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
basil oil inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]; Oils, Volatile inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]; Selenium inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
cyfluthrin results in decreased expression of CAT protein
cyfluthrin binds to CAT protein
cyfluthrin results in decreased expression of CAT mRNA		 CTD PMID:19961921 PMID:23595963 PMID:26604153 PMID:31330490 PMID:32278787 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression		 ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of CCL5 mRNA] CTD PMID:31330490 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ces2e carboxylesterase 2E affects metabolic processing ISO CES2E protein affects the metabolism of cyfluthrin CTD PMID:15123619 NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856 		JBrowse link
G Ces2h carboxylesterase 2H increases metabolic processing ISO CES2 protein results in increased metabolism of cyfluthrin CTD PMID:19249324 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chat choline O-acetyltransferase decreases expression EXP cyfluthrin results in decreased expression of CHAT protein CTD PMID:26604153 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Clip3 CAP-GLY domain containing linker protein 3 increases expression ISO cyfluthrin results in increased expression of CLIP3 protein CTD PMID:16790487 NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression		 ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of CYBB mRNA] CTD PMID:31330490 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cygb cytoglobin decreases expression ISO cyfluthrin results in decreased expression of CYGB mRNA CTD PMID:31330490 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity EXP cyfluthrin results in increased activity of CYP2E1 protein CTD PMID:23639246 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO cyfluthrin results in increased expression of CYP3A4 mRNA CTD PMID:19249324 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP cyfluthrin results in increased expression of DDIT3 mRNA; cyfluthrin results in increased expression of DDIT3 protein CTD PMID:36548566 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Duox1 dual oxidase 1 increases expression ISO cyfluthrin results in increased expression of DUOX1 mRNA CTD PMID:31330490 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 increases expression ISO cyfluthrin results in increased expression of DUOX2 mRNA CTD PMID:31330490 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
increases expression		 EXP cyfluthrin results in increased phosphorylation of EIF2AK3 protein
cyfluthrin results in increased expression of EIF2AK3 mRNA		 CTD PMID:36548566 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression
increases phosphorylation		 EXP cyfluthrin results in increased expression of EIF2S1 mRNA
cyfluthrin results in increased phosphorylation of EIF2S1 protein		 CTD PMID:36548566 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO cyfluthrin results in decreased expression of EPHX2 mRNA CTD PMID:31330490 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Esr1 estrogen receptor 1 increases activity
decreases activity
multiple interactions		 ISO
EXP		 cyfluthrin results in increased activity of ESR1 protein
cyfluthrin results in decreased activity of ESR1 protein
cyfluthrin binds to and results in increased activity of ESR1 protein		 CTD PMID:15064155 PMID:20410157 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP cyfluthrin results in increased expression of FLT1 protein CTD PMID:36548566 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO cyfluthrin results in decreased expression of FTH1 mRNA CTD PMID:31330490 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gap43 growth associated protein 43 increases expression ISO cyfluthrin results in increased expression of GAP43 mRNA CTD PMID:32028016 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gla galactosidase, alpha decreases expression ISO cyfluthrin results in decreased expression of GLA mRNA CTD PMID:31330490 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664 		JBrowse link
G Gpt glutamic--pyruvic transaminase affects activity
multiple interactions		 EXP cyfluthrin affects the activity of GPT protein
basil oil affects the reaction [cyfluthrin affects the activity of GPT protein]; Oils, Volatile affects the reaction [cyfluthrin affects the activity of GPT protein]		 CTD PMID:35126122 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO cyfluthrin results in decreased expression of GPX1 mRNA CTD PMID:31330490 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 decreases expression ISO cyfluthrin results in decreased expression of GPX2 mRNA CTD PMID:31330490 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO cyfluthrin results in decreased expression of GPX3 mRNA CTD PMID:31330490 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression		 EXP
ISO		 basil oil inhibits the reaction [cyfluthrin results in decreased activity of GSR protein]; Oils, Volatile inhibits the reaction [cyfluthrin results in decreased activity of GSR protein]; Selenium inhibits the reaction [cyfluthrin results in decreased activity of GSR protein]
cyfluthrin results in decreased expression of GSR mRNA		 CTD PMID:23595963 PMID:31330490 PMID:35126122 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases expression ISO cyfluthrin results in decreased expression of GSTZ1 mRNA CTD PMID:31330490 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO cyfluthrin results in increased expression of HSP90AA1 mRNA CTD PMID:31330490 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions		 ISO cyfluthrin results in increased expression of HSPA1A mRNA
Melatonin inhibits the reaction [cyfluthrin results in increased expression of HSPA1A mRNA]		 CTD PMID:31330490 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP cyfluthrin results in increased expression of HSPA5 mRNA; cyfluthrin results in increased expression of HSPA5 protein CTD PMID:36548566 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hydin Hydin, axonemal central pair apparatus protein decreases expression ISO cyfluthrin results in decreased expression of HYDIN protein CTD PMID:16790487 NCBI chr19:38,236,996...38,583,271
Ensembl chr19:38,236,464...38,583,264 		JBrowse link
G Ifng interferon gamma multiple interactions ISO cyfluthrin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IFNG protein] CTD PMID:12755381 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO cyfluthrin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL4 protein] CTD PMID:12755381 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 cyfluthrin results in increased expression of IL6 protein
cyfluthrin results in increased expression of IL6 mRNA; cyfluthrin results in increased expression of IL6 protein
basil oil inhibits the reaction [cyfluthrin results in increased expression of IL6 mRNA]; Oils, Volatile inhibits the reaction [cyfluthrin results in increased expression of IL6 mRNA]		 CTD PMID:16790487 PMID:35126122 PMID:36515635 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression EXP
ISO		 cyfluthrin results in increased expression of MAP1LC3A mRNA CTD PMID:36515635 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO cyfluthrin results in increased expression of MAPK1 protein CTD PMID:16790487 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO cyfluthrin results in increased expression of MAPK3 protein CTD PMID:16790487 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression
decreases expression		 ISO
EXP		 cyfluthrin results in increased expression of MTOR mRNA; cyfluthrin results in increased expression of MTOR protein
cyfluthrin results in decreased expression of MTOR protein modified form		 CTD PMID:36515635 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nefh neurofilament heavy chain increases expression ISO cyfluthrin results in increased expression of NEFH mRNA CTD PMID:32028016 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain decreases expression ISO cyfluthrin results in decreased expression of NEFL mRNA CTD PMID:32028016 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO cyfluthrin results in increased expression of NFE2L2 mRNA
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NFE2L2 mRNA]		 CTD PMID:31330490 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO cyfluthrin results in increased expression of NFKB1 mRNA CTD PMID:31330490 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO cyfluthrin results in increased expression of NOS2 mRNA
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NOS2 mRNA]		 CTD PMID:31330490 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
decreases activity		 ISO Melatonin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NQO1 mRNA]; Silybin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein] CTD PMID:31330490 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO cyfluthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 EXP
ISO		 cyfluthrin results in increased activity of NR1I2 protein
cyfluthrin binds to and results in increased activity of NR1I2 protein
cyfluthrin results in increased activity of NR1I2 protein; cyfluthrin results in increased activity of NR1I2 protein polymorphism		 CTD PMID:19249324 PMID:21115097 PMID:22206814 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP cyfluthrin results in decreased expression of PCNA protein CTD PMID:36548566 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pgf placental growth factor decreases expression EXP cyfluthrin results in decreased expression of PGF protein CTD PMID:36548566 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Pgr progesterone receptor affects binding ISO cyfluthrin binds to PGR protein CTD PMID:32278787 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO cyfluthrin results in increased expression of PIK3C3 mRNA CTD PMID:32028016 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO cyfluthrin binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta increases expression ISO cyfluthrin results in increased expression of PPP2R3B protein CTD PMID:16790487 NCBI chr14:88,507...95,750
Ensembl chr14:89,176...95,750 		JBrowse link
G Prdx2 peroxiredoxin 2 decreases expression ISO cyfluthrin results in decreased expression of PRDX2 mRNA CTD PMID:31330490 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx4 peroxiredoxin 4 decreases expression ISO cyfluthrin results in decreased expression of PRDX4 mRNA CTD PMID:31330490 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Prdx5 peroxiredoxin 5 decreases expression ISO cyfluthrin results in decreased expression of PRDX5 mRNA CTD PMID:31330490 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases expression ISO cyfluthrin results in decreased expression of PRKAA1 mRNA CTD PMID:36515635 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 decreases expression EXP cyfluthrin results in decreased expression of PRKAA2 mRNA CTD PMID:36515635 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO cyfluthrin results in decreased expression of PTGS1 mRNA CTD PMID:31330490 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO cyfluthrin results in increased expression of PTGS2 mRNA CTD PMID:31330490 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression
increases expression		 EXP
ISO		 cyfluthrin results in decreased expression of RPS6KB1 protein modified form
cyfluthrin results in increased expression of RPS6KB1 mRNA; cyfluthrin results in increased expression of RPS6KB1 protein		 CTD PMID:36515635 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions
affects activity		 EXP cyfluthrin affects the reaction [SCN10A protein results in increased transport of Sodium]
cyfluthrin affects the activity of SCN10A protein		 CTD PMID:16051293 PMID:19766671 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 multiple interactions EXP cyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 multiple interactions EXP cyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 multiple interactions EXP cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 multiple interactions EXP cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Slc6a14 solute carrier family 6 member 14 decreases expression ISO cyfluthrin results in decreased expression of SLC6A14 protein CTD PMID:16790487 NCBI chr  X:112,314,643...112,375,412
Ensembl chr  X:112,314,691...112,375,096 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO cyfluthrin results in decreased expression of SOD2 mRNA CTD PMID:31330490 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Melatonin inhibits the reaction [cyfluthrin results in increased expression of SQSTM1 mRNA]
cyfluthrin results in decreased expression of SQSTM1 mRNA; cyfluthrin results in decreased expression of SQSTM1 protein		 CTD PMID:31330490 PMID:36515635 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 decreases expression ISO cyfluthrin results in decreased expression of STAT6 protein CTD PMID:12755381 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 increases expression ISO
EXP		 cyfluthrin results in increased expression of STING1 mRNA; cyfluthrin results in increased expression of STING1 protein CTD PMID:36515635 NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
G Syn1 synapsin I decreases expression ISO cyfluthrin results in decreased expression of SYN1 mRNA CTD PMID:32028016 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO cyfluthrin binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO cyfluthrin results in decreased expression of TJP1 mRNA CTD PMID:36167171 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 cyfluthrin results in increased expression of TNF mRNA
cyfluthrin results in increased expression of TNF mRNA; cyfluthrin results in increased expression of TNF protein
basil oil inhibits the reaction [cyfluthrin results in increased expression of TNF mRNA]; Oils, Volatile inhibits the reaction [cyfluthrin results in increased expression of TNF mRNA]		 CTD PMID:31330490 PMID:35126122 PMID:36515635 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO cyfluthrin results in increased expression of TP53 mRNA CTD PMID:31330490 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trappc6a trafficking protein particle complex subunit 6A multiple interactions
decreases expression		 ISO Melatonin inhibits the reaction [cyfluthrin results in decreased expression of TRAPPC6A mRNA] CTD PMID:31330490 NCBI chr 1:79,158,587...79,165,502
Ensembl chr 1:79,158,529...79,165,493 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO cyfluthrin results in decreased expression of TXNRD1 mRNA CTD PMID:31330490 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP cyfluthrin results in decreased expression of VEGFA mRNA; cyfluthrin results in decreased expression of VEGFA protein CTD PMID:36548566 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt3a Wnt family member 3A increases expression ISO cyfluthrin results in increased expression of WNT3A mRNA CTD PMID:32028016 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO cyfluthrin results in increased expression of WNT5A mRNA CTD PMID:32028016 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Wnt7a Wnt family member 7A increases expression ISO cyfluthrin results in increased expression of WNT7A mRNA CTD PMID:32028016 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        agrochemical 16259
          cyfluthrin 97
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        cyclopropanecarboxylic acid 2223
                                          3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid 2084
                                            cyfluthrin 97
paths to the root