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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:piperidine
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Accession:CHEBI:18049 term browser browse the term
Definition:An azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine.
Synonyms:related_synonym: Azacyclohexane;   Formula=C5H11N;   Hexahydropyridine;   InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2;   InChIKey=NQRYJNQNLNOLGT-UHFFFAOYSA-N;   Piperidin;   SMILES=C1CCNCC1;   azinane;   cyclopentimine;   cypentil;   hexazane;   pentamethyleneamine;   pentamethyleneimine;   pentamethylenimine;   perhydropyridine;   pip
 alt_id: CHEBI:14841;   CHEBI:26146;   CHEBI:45123;   CHEBI:8238
 xref: CAS:110-89-4;   Chemspider:7791;   FooDB:FDB012644;   HMDB:HMDB0034301;   KEGG:C01746;   KNApSAcK:C00051876
 xref_mesh: MESH:C032727
 xref: MetaCyc:PIPERIDINE;   PDBeChem:PIP;   PMID:12355363;   PMID:15017096;   PMID:15412;   PMID:25897321;   PMID:32120931;   PMID:33021609;   PMID:5300194;   PMID:5308835;   PMID:799462;   Reaxys:102438;   Wikipedia:Piperidine
 cyclic_relationship: is_conjugate_base_of CHEBI:589779


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piperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]
piperidine analog results in decreased activity of ACHE protein		 CTD PMID:17681794 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]; piperidine analog inhibits the reaction [APP protein binds to APP protein] CTD PMID:17681794 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO piperidine analog results in decreased activity of BCHE protein CTD PMID:17681794 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] CTD PMID:17706638 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein] CTD PMID:17706638 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ifng interferon gamma multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IFNG protein] CTD PMID:17706638 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 ISO piperidine analog results in decreased expression of IL2 mRNA
piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IL2 protein]		 CTD PMID:11859000 PMID:17706638 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases activity ISO
EXP		 piperidine analog results in decreased activity of SRD5A1 protein CTD PMID:10896124 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO
EXP		 piperidine analog results in decreased activity of SRD5A2 protein CTD PMID:10896124 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
N-nitrosopiperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of and results in increased activity of N-nitrosopiperidine CTD PMID:11774366 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO N-nitrosopiperidine results in increased cleavage of PARP1 protein CTD PMID:17929238 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
phencyclidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor decreases expression ISO Phencyclidine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Ajuba ajuba LIM protein increases expression ISO Phencyclidine results in increased expression of AJUBA mRNA CTD PMID:12105081 NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Phencyclidine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Apod apolipoprotein D increases expression ISO Phencyclidine results in increased expression of APOD mRNA CTD PMID:17266109 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G Apol2 apolipoprotein L2 increases expression ISO Phencyclidine results in increased expression of APOL2 mRNA CTD PMID:17205118 NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558 		JBrowse link
G Arhgef9 Cdc42 guanine nucleotide exchange factor 9 decreases expression ISO Phencyclidine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:59,919,560...60,077,538
Ensembl chr  X:59,920,870...60,077,513 		JBrowse link
G Calm1 calmodulin 1 decreases expression ISO Phencyclidine results in decreased expression of CALM1 mRNA CTD PMID:17205118 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Phencyclidine results in decreased expression of CALM2 mRNA CTD PMID:17205118 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression
decreases expression		 ISO Phencyclidine results in increased expression of CAMK2A mRNA
Phencyclidine results in decreased expression of CAMK2A mRNA		 CTD PMID:17266109 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Phencyclidine results in decreased expression of CAMK2B mRNA CTD PMID:17205118 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Casp1 caspase 1 increases expression ISO Phencyclidine results in increased expression of CASP1 mRNA CTD PMID:12105081 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]; Cadmium Chloride inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; omega-agatoxin-Aa4b inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; staurosporine aglycone inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]] CTD PMID:24995437 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cckbr cholecystokinin B receptor increases expression ISO Phencyclidine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Phencyclidine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression		 ISO Phencyclidine results in decreased expression of CNP mRNA
Phencyclidine results in increased expression of CNP mRNA		 CTD PMID:17266109 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO [Phencyclidine co-treated with Dronabinol] results in decreased expression of CNR1 protein CTD PMID:28648819 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cplx2 complexin 2 decreases expression ISO Phencyclidine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases activity		 ISO acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein] CTD PMID:29037473 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
affects oxidation
affects metabolic processing		 ISO Phencyclidine analog results in decreased activity of CYP2B6 protein; Phencyclidine results in decreased activity of CYP2B6 protein
CYP2B6 protein affects the oxidation of Phencyclidine
CYP2B6 protein affects the metabolism of Phencyclidine analog		 CTD PMID:16782764 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects oxidation
decreases activity		 ISO CYP2C19 protein affects the oxidation of Phencyclidine
Phencyclidine results in decreased activity of CYP2C19 protein		 CTD PMID:16782764 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Phencyclidine CTD PMID:16782764
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ddo D-aspartate oxidase multiple interactions
affects response to substance		 ISO [DDO protein affects the susceptibility to Phencyclidine] which affects the expression of DLG4 mRNA; [DDO protein affects the susceptibility to Phencyclidine] which affects the expression of HOMER1 mRNA; DDO protein affects the reaction [Phencyclidine results in decreased expression of HOMER1 mRNA]; DDO protein affects the reaction [Phencyclidine results in increased expression of DLG4 mRNA] CTD PMID:25979765 NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions
increases expression		 ISO [DDO protein affects the susceptibility to Phencyclidine] which affects the expression of DLG4 mRNA; DDO protein affects the reaction [Phencyclidine results in increased expression of DLG4 mRNA] CTD PMID:25979765 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 decreases expression ISO Phencyclidine results in decreased expression of DNAJC1 mRNA CTD PMID:12105081 NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988 		JBrowse link
G Drd1 dopamine receptor D1 decreases expression
multiple interactions		 ISO Phencyclidine results in decreased expression of DRD1 mRNA; Phencyclidine results in decreased expression of DRD1 protein
NTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein]		 CTD PMID:17266109 PMID:20659557 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression
affects binding		 ISO
EXP		 Phencyclidine results in decreased expression of DRD2 mRNA; Phencyclidine results in decreased expression of DRD2 protein
Phencyclidine binds to Drd2 protein		 CTD
RGD		 PMID:17266109 PMID:20659557 PMID:15852061 RGD:1581406 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Egf epidermal growth factor increases expression ISO Phencyclidine results in increased expression of EGF mRNA CTD PMID:12105081 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Phencyclidine results in increased expression of FDFT1 mRNA CTD PMID:17205118 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [FOS protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] results in increased expression of FOS protein; [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOS protein; Phencyclidine promotes the reaction [FOS protein binds to FOS promoter]; Phencyclidine promotes the reaction [SRF protein binds to FOS promoter]
Phencyclidine results in increased expression of FOS protein		 CTD PMID:12510024 PMID:16678866 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein
Phencyclidine results in increased expression of FOSB protein		 CTD PMID:16678866 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Phencyclidine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Phencyclidine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression ISO Phencyclidine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Phencyclidine results in increased expression of GAD2 mRNA CTD PMID:17266109 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Phencyclidine results in increased expression of GAP43 mRNA CTD PMID:11377751 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gcc1 GRIP and coiled-coil domain containing 1 increases expression ISO Phencyclidine results in increased expression of GCC1 mRNA CTD PMID:17205118 NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Phencyclidine results in increased expression of GFAP mRNA CTD PMID:17266109 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gnas GNAS complex locus increases expression ISO Phencyclidine results in increased expression of GNAS mRNA CTD PMID:12105081 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]; GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein] CTD PMID:29037473 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 increases expression ISO Phencyclidine results in increased expression of GRIA4 mRNA CTD PMID:17266109 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
multiple interactions		 ISO Phencyclidine results in decreased expression of GRIN1 mRNA; Phencyclidine results in decreased expression of GRIN1 protein
[Phencyclidine co-treated with Dronabinol] results in decreased expression of GRIN1 protein		 CTD PMID:17266109 PMID:28648819 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression ISO Phencyclidine results in decreased expression of GRIN2A mRNA; Phencyclidine results in decreased expression of GRIN2A protein CTD PMID:20659557 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP Phencyclidine results in increased expression of HMOX1 mRNA; Phencyclidine results in increased expression of HMOX1 protein
1,3-dimethylthiourea inhibits the reaction [Phencyclidine results in increased expression of HMOX1 protein]		 CTD PMID:9875361 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions
decreases expression		 ISO [DDO protein affects the susceptibility to Phencyclidine] which affects the expression of HOMER1 mRNA; DDO protein affects the reaction [Phencyclidine results in decreased expression of HOMER1 mRNA] CTD PMID:25979765 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Phencyclidine results in decreased expression of HOXB9 mRNA CTD PMID:12105081 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
decreases activity		 EXP [Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein] CTD PMID:15380371 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of JUND protein CTD PMID:16678866 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 decreases expression ISO Phencyclidine results in decreased expression of KCNH1 mRNA CTD PMID:12105081 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740 		JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 increases expression ISO Phencyclidine results in increased expression of KCNIP3 mRNA CTD PMID:17266109 NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556 		JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 increases expression ISO Phencyclidine results in increased expression of KCNJ4 mRNA CTD PMID:17266109 NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151 		JBrowse link
G Kitlg KIT ligand increases expression ISO Phencyclidine results in increased expression of KITL mRNA CTD PMID:12105081 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Lep leptin increases expression ISO Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO Phencyclidine results in increased expression of LPL mRNA CTD PMID:17266109 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO Phencyclidine results in decreased expression of MAL mRNA CTD PMID:17266109 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Maob monoamine oxidase B increases expression ISO Phencyclidine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO Phencyclidine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Mbp myelin basic protein increases expression ISO Phencyclidine results in increased expression of MBP mRNA CTD PMID:17266109 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein increases expression ISO Phencyclidine results in increased expression of MOBP mRNA CTD PMID:17266109 NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
multiple interactions		 ISO Phencyclidine affects the localization of NCF1 protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [Phencyclidine affects the localization of NCF1 protein]; GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]		 CTD PMID:29037473 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Phencyclidine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Ntsr1 neurotensin receptor 1 multiple interactions ISO NTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein] CTD PMID:20659557 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G P2ry1 purinergic receptor P2Y1 increases expression ISO Phencyclidine results in increased expression of P2RY1 mRNA CTD PMID:12105081 NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457 		JBrowse link
G Pde10a phosphodiesterase 10A increases expression ISO Phencyclidine results in increased expression of PDE10A mRNA CTD PMID:17266109 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Phencyclidine results in increased expression of PLP1 mRNA CTD PMID:17266109 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Prkcd protein kinase C, delta increases expression ISO Phencyclidine results in increased expression of PRKCD mRNA CTD PMID:12105081 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcg protein kinase C, gamma increases expression EXP Phencyclidine results in increased expression of PRKCG mRNA CTD PMID:11169168 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Ptgds prostaglandin D2 synthase increases expression ISO Phencyclidine results in increased expression of PTGDS mRNA CTD PMID:17266109 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein increases expression ISO Phencyclidine results in increased expression of PTPRCAP mRNA CTD PMID:12105081 NCBI chr 1:201,449,133...201,451,293
Ensembl chr 1:201,449,113...201,451,288 		JBrowse link
G Pvalb parvalbumin multiple interactions
decreases expression		 EXP Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]; Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561 		JBrowse link
G Reln reelin decreases expression ISO Phencyclidine results in decreased expression of RELN mRNA CTD PMID:17266109 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Phencyclidine results in increased expression of RGS4 mRNA CTD PMID:17266109 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rtn4 reticulon 4 increases expression ISO Phencyclidine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Phencyclidine results in increased expression of SCARB1 mRNA CTD PMID:17205118 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Selplg selectin P ligand increases expression ISO Phencyclidine results in increased expression of SELPLG mRNA CTD PMID:12105081 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Sema3b semaphorin 3B decreases expression ISO Phencyclidine results in decreased expression of SEMA3B mRNA CTD PMID:17205118 NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Phencyclidine results in increased expression of SGK1 mRNA CTD PMID:17266109 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Phencyclidine results in increased expression of SLC17A6 mRNA CTD PMID:17266109 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542 		JBrowse link
G Smad5 SMAD family member 5 decreases expression ISO Phencyclidine results in decreased expression of SMAD5 mRNA CTD PMID:12105081 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Sod1 superoxide dismutase 1 increases activity
multiple interactions		 ISO Phencyclidine results in increased activity of SOD1 protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]		 CTD PMID:29037473 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
multiple interactions		 ISO Phencyclidine results in decreased activity of SOD2 protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]		 CTD PMID:29037473 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression EXP Phencyclidine results in increased expression of SRC mRNA CTD PMID:11249956 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srf serum response factor multiple interactions EXP [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; Phencyclidine promotes the reaction [SRF protein binds to FOS promoter] CTD PMID:12510024 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Syn2 synapsin II decreases expression ISO Phencyclidine results in decreased expression of SYN2 mRNA CTD PMID:17266109 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192 		JBrowse link
G Syt2 synaptotagmin 2 increases expression ISO Phencyclidine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO Phencyclidine results in decreased expression of TAC1 mRNA CTD PMID:17266109 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tead4 TEA domain transcription factor 4 decreases expression ISO Phencyclidine results in decreased expression of TEAD4 mRNA CTD PMID:12105081 NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression		 ISO Phencyclidine inhibits the reaction [Methamphetamine results in decreased activity of TH protein]
Phencyclidine results in increased expression of TH mRNA		 CTD PMID:1381816 PMID:12105081 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression		 EXP Haloperidol affects the reaction [Phencyclidine affects the expression of TNF mRNA] CTD PMID:16478754 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ttr transthyretin decreases expression ISO Phencyclidine results in decreased expression of TTR mRNA CTD PMID:17266109 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta decreases expression ISO Phencyclidine results in decreased expression of YWHAB mRNA CTD PMID:17266109 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105 		JBrowse link
G Zrsr2-ps1 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1 decreases expression ISO Phencyclidine results in decreased expression of ZRSR2-PS1 mRNA CTD PMID:12105081 NCBI chr14:96,972,651...96,978,364
Ensembl chr14:96,972,580...96,978,891 		JBrowse link
pizotifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Pizotyline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      chemical role 19489
        base 17889
          piperidine 105
            N-[(Z)-11-methyldodec-2-enoyl]piperidine 0
            N-[(Z)-dodec-2-enoyl]piperidine 0
            N-nitrosopiperidine 2
            phencyclidine 94
            pizotifen 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    main group molecular entity 19806
                      s-block molecular entity 19641
                        hydrogen molecular entity 19622
                          hydrides 19150
                            inorganic hydride 18152
                              pnictogen hydride 18164
                                nitrogen hydride 18055
                                  azane 17882
                                    ammonia 17860
                                      organic amino compound 17860
                                        secondary amino compound 6962
                                          secondary amine 1847
                                            piperidine 105
                                              N-[(Z)-11-methyldodec-2-enoyl]piperidine 0
                                              N-[(Z)-dodec-2-enoyl]piperidine 0
                                              N-nitrosopiperidine 2
                                              phencyclidine 94
                                              pizotifen 1
paths to the root