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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:50212 term browser browse the term
Definition:A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.
Synonyms:exact_synonym: 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
 related_synonym: Formula=C19H21NS;   InChI=1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3;   InChIKey=FIADGNVRKBPQEU-UHFFFAOYSA-N;   Pizotyline;   SMILES=CN1CCC(CC1)=C1c2ccccc2CCc2sccc12;   pizotifene;   pizotifeno;   pizotifenum
 xref: Beilstein:753534;   CAS:15574-96-6;   Drug_Central:2220;   KEGG:D05523;   LINCS:LSM-3695
 xref_mesh: MESH:D010918
 xref: Patent:BE636717;   Patent:US3272826;   Reaxys:753534;   Wikipedia:Pizotifen
 cyclic_relationship: is_conjugate_base_of CHEBI:50318

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pizotifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Pizotyline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      chemical role 19519
        base 17524
          piperidine 105
            pizotifen 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    main group molecular entity 19938
                      s-block molecular entity 19726
                        hydrogen molecular entity 19718
                          hydrides 19086
                            inorganic hydride 17892
                              pnictogen hydride 17875
                                nitrogen hydride 17766
                                  azane 17520
                                    ammonia 17519
                                      organic amino compound 17519
                                        secondary amino compound 6638
                                          secondary amine 1725
                                            piperidine 105
                                              pizotifen 1
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