Symbol:
Arhgef9
Name:
Cdc42 guanine nucleotide exchange factor 9
RGD ID:
620719
Description:
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in receptor clustering. Located in cell cortex. Is active in GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
Cdc42 guanine nucleotide exchange factor (GEF) 9; collybistin I; LOC100912165; rac/Cdc42 guanine nucleotide exchange factor 9; rho guanine nucleotide exchange factor 9; rho guanine nucleotide exchange factor 9-like
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 X 63,929,168 - 64,087,267 (-) NCBI GRCr8 mRatBN7.2 X 59,919,560 - 60,077,538 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl X 59,920,870 - 60,077,513 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx X 61,390,247 - 61,547,577 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 X 64,890,769 - 65,048,097 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 X 62,468,985 - 62,626,907 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 X 64,249,576 - 64,428,444 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 64,248,278 - 64,428,592 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 65,150,714 - 65,329,116 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 82,594,347 - 82,754,179 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 X 82,667,647 - 82,827,471 (-) NCBI Celera X 60,352,255 - 60,508,707 (-) NCBI Celera Cytogenetic Map X q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,2-dichloroethane (ISO) 2,2',4,4'-Tetrabromodiphenyl ether (EXP) 2,3,7,8-tetrachlorodibenzodioxine (ISO) 3,4-methylenedioxymethamphetamine (EXP) 3-isobutyl-1-methyl-7H-xanthine (ISO) 6-propyl-2-thiouracil (EXP) acrolein (ISO) aflatoxin B1 (ISO) all-trans-retinoic acid (ISO) alpha-pinene (ISO) amiodarone (ISO) benzo[a]pyrene (EXP,ISO) bisphenol A (EXP,ISO) butanal (ISO) cadmium atom (ISO) cadmium dichloride (EXP,ISO) carbon nanotube (ISO) CGP 52608 (ISO) clozapine (ISO) cyclosporin A (ISO) dexamethasone (ISO) dorsomorphin (ISO) doxorubicin (ISO) ethanol (ISO) fulvestrant (ISO) furan (EXP) indole-3-methanol (EXP) indometacin (ISO) mercury dibromide (ISO) methylmercury chloride (ISO) nickel atom (EXP) nickel sulfate (EXP) ozone (ISO) p-chloromercuribenzoic acid (ISO) pentanal (ISO) perfluorohexanesulfonic acid (ISO) perfluorononanoic acid (ISO) perfluorooctane-1-sulfonic acid (ISO) perfluorooctanoic acid (ISO) phencyclidine (ISO) phenobarbital (EXP,ISO) phenylmercury acetate (ISO) phorbol 13-acetate 12-myristate (ISO) pirinixic acid (ISO) potassium chromate (ISO) propiconazole (EXP) SB 431542 (ISO) silicon dioxide (ISO) sodium arsenite (ISO) sulforaphane (ISO) thioacetamide (EXP) triphenyl phosphate (ISO) triptonide (ISO) troglitazone (ISO) valproic acid (ISO) venlafaxine hydrochloride (EXP) vinclozolin (EXP) zinc atom (ISO) zinc(0) (ISO)
1.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.
Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin.
Kins S, etal., Nat Neurosci 2000 Jan;3(1):22-9.
3.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
4.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
6.
Selective localization of collybistin at a subset of inhibitory synapses in brain circuits.
Patrizi A, etal., J Comp Neurol. 2012 Jan 1;520(1):130-41. doi: 10.1002/cne.22702.
7.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
Arhgef9 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 X 63,929,168 - 64,087,267 (-) NCBI GRCr8 mRatBN7.2 X 59,919,560 - 60,077,538 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl X 59,920,870 - 60,077,513 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx X 61,390,247 - 61,547,577 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 X 64,890,769 - 65,048,097 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 X 62,468,985 - 62,626,907 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 X 64,249,576 - 64,428,444 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 64,248,278 - 64,428,592 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 65,150,714 - 65,329,116 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 82,594,347 - 82,754,179 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 X 82,667,647 - 82,827,471 (-) NCBI Celera X 60,352,255 - 60,508,707 (-) NCBI Celera Cytogenetic Map X q22 NCBI
ARHGEF9 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 X 63,634,967 - 63,785,214 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl X 63,634,967 - 63,809,274 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 X 62,854,847 - 63,005,094 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 X 62,771,573 - 62,891,718 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 X 62,637,868 - 62,758,014 NCBI Celera X 63,201,689 - 63,352,277 (-) NCBI Celera Cytogenetic Map X q11.1 NCBI HuRef X 56,681,875 - 56,830,928 (-) NCBI HuRef CHM1_1 X 62,747,364 - 62,897,940 (-) NCBI CHM1_1 T2T-CHM13v2.0 X 62,060,231 - 62,210,488 (-) NCBI T2T-CHM13v2.0
Arhgef9 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 X 94,092,536 - 94,240,801 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl X 94,092,541 - 94,240,462 (-) Ensembl GRCm39 Ensembl GRCm38 X 95,048,930 - 95,196,853 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl X 95,048,935 - 95,196,856 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 X 92,244,283 - 92,361,825 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 X 91,251,663 - 91,369,205 (-) NCBI MGSCv36 mm8 Celera X 82,072,839 - 82,190,049 (-) NCBI Celera Cytogenetic Map X C3 NCBI cM Map X 41.85 NCBI
Arhgef9 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955475 4,017,632 - 4,214,563 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955475 4,020,922 - 4,214,464 (-) NCBI ChiLan1.0 ChiLan1.0
ARHGEF9 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 X 63,187,432 - 63,354,672 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 X 63,191,038 - 63,358,277 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 X 52,779,238 - 52,946,480 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 X 62,862,115 - 63,010,088 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl X 62,862,115 - 63,010,512 (-) Ensembl panpan1.1 panPan2
ARHGEF9 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 X 49,101,034 - 49,312,797 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl X 49,101,985 - 49,313,136 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha X 39,935,940 - 40,147,896 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 X 49,423,808 - 49,636,405 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl X 49,423,811 - 49,635,946 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 X 48,080,874 - 48,292,865 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 X 49,379,468 - 49,591,390 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 X 48,833,236 - 49,045,287 (-) NCBI UU_Cfam_GSD_1.0
Arhgef9 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 X 53,051,180 - 53,194,392 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936635 3,816,606 - 3,960,190 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936635 3,817,034 - 3,956,928 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
ARHGEF9
ARHGEF9 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 X 54,029,085 - 54,214,760 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl X 54,029,084 - 54,153,172 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666083 1,255,104 - 1,436,620 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Arhgef9
.
Predicted Target Of
Count of predictions: 186 Count of miRNA genes: 141 Interacting mature miRNAs: 161 Transcripts: ENSRNOT00000042654, ENSRNOT00000063861 Prediction methods: Microtar, Miranda, Pita, Rnahybrid, Targetscan Result types: miRGate_prediction
61430 Cia18 Collagen induced arthritis QTL 18 3.1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) X 14843113 120568734 Rat 738035 Stresp1 Stress response QTL 1 4.96 0.000011 stress-related behavior trait (VT:0010451) defensive burying - coping X 41304447 112935181 Rat 70221 Bp56 Blood pressure QTL 56 4.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) X 57042141 65612192 Rat 71116 Niddm16 Non-insulin dependent diabetes mellitus QTL 16 7.81 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) X 15297802 60297802 Rat 1598837 Memor13 Memory QTL 13 3.2 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) X 41052407 146860749 Rat
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
59
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000042654
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 59,922,511 - 60,049,890 (-) Ensembl Rnor_6.0 Ensembl X 64,273,599 - 64,367,255 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000063861
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 59,920,870 - 60,077,513 (-) Ensembl Rnor_6.0 Ensembl X 64,272,705 - 64,428,444 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000076190
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source Rnor_6.0 Ensembl X 64,248,278 - 64,250,792 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000076965
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 59,920,870 - 60,016,832 (-) Ensembl Rnor_6.0 Ensembl X 64,272,705 - 64,428,444 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000084678
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 59,922,519 - 60,049,890 (-) Ensembl Rnor_6.0 Ensembl X 64,250,870 - 64,428,592 (-) Ensembl
RefSeq Acc Id:
NM_001393743 ⟹ NP_001380672
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,059,406 (-) NCBI mRatBN7.2 X 59,919,560 - 60,049,817 (-) NCBI
RefSeq Acc Id:
NM_023957 ⟹ NP_076447
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,087,104 (-) NCBI mRatBN7.2 X 59,919,560 - 60,077,513 (-) NCBI Rnor_6.0 X 64,249,576 - 64,428,444 (-) NCBI Rnor_5.0 X 65,150,714 - 65,329,116 (-) NCBI RGSC_v3.4 X 82,594,347 - 82,754,179 (-) RGD Celera X 60,352,255 - 60,508,707 (-) RGD
Sequence:
GGCAGGCAGGGGTGGCAGCTGCCTTACCCTTGGCGGAGGTTATTTCCCCTATATTTTCGCCTGCATCCAACCCCTCAATTTGCAANCCTTGGAGGAAGACAAAGGCAGCTCACTGGGACCCCCTCCCC
hide sequence
RefSeq Acc Id:
XM_039100035 ⟹ XP_038955963
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,087,267 (-) NCBI mRatBN7.2 X 59,919,560 - 60,077,538 (-) NCBI
RefSeq Acc Id:
XM_039100036 ⟹ XP_038955964
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,058,707 (-) NCBI mRatBN7.2 X 59,919,560 - 60,049,817 (-) NCBI
RefSeq Acc Id:
XM_039100037 ⟹ XP_038955965
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,058,714 (-) NCBI mRatBN7.2 X 59,919,560 - 60,049,817 (-) NCBI
RefSeq Acc Id:
XM_039100039 ⟹ XP_038955967
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,057,512 (-) NCBI mRatBN7.2 X 59,919,560 - 60,047,500 (-) NCBI
RefSeq Acc Id:
XM_039100040 ⟹ XP_038955968
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,932,127 - 64,087,134 (-) NCBI mRatBN7.2 X 59,919,560 - 60,077,538 (-) NCBI
RefSeq Acc Id:
XM_039100041 ⟹ XP_038955969
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,087,129 (-) NCBI mRatBN7.2 X 59,919,560 - 60,077,538 (-) NCBI
RefSeq Acc Id:
XM_063280288 ⟹ XP_063136358
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,057,679 (-) NCBI
RefSeq Acc Id:
XM_063280289 ⟹ XP_063136359
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,929,168 - 64,058,021 (-) NCBI
RefSeq Acc Id:
XM_063280290 ⟹ XP_063136360
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 63,932,127 - 64,057,679 (-) NCBI
RefSeq Acc Id:
NP_076447 ⟸ NM_023957
- Peptide Label:
isoform 1
- UniProtKB:
Q9QX73 (UniProtKB/Swiss-Prot), Q9ER22 (UniProtKB/Swiss-Prot), A0A8I5ZLM2 (UniProtKB/TrEMBL), A6IQ20 (UniProtKB/TrEMBL)
- Sequence:
MQWIRGGSGMLITGDSIVSAEAVWDHVTMANRGVAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKH
hide sequence
RefSeq Acc Id:
XP_038955969 ⟸ XM_039100041
- Peptide Label:
isoform X6
- UniProtKB:
A6IQ21 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038955963 ⟸ XM_039100035
- Peptide Label:
isoform X1
- UniProtKB:
A6IQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038955968 ⟸ XM_039100040
- Peptide Label:
isoform X5
- UniProtKB:
A6IQ22 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038955965 ⟸ XM_039100037
- Peptide Label:
isoform X3
- UniProtKB:
A6IQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038955964 ⟸ XM_039100036
- Peptide Label:
isoform X2
- UniProtKB:
A0A8I5ZMR8 (UniProtKB/TrEMBL), A6IQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038955967 ⟸ XM_039100039
- Peptide Label:
isoform X4
- UniProtKB:
A6IQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id:
NP_001380672 ⟸ NM_001393743
- Peptide Label:
isoform 2
- UniProtKB:
A6IQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063136359 ⟸ XM_063280289
- Peptide Label:
isoform X4
- UniProtKB:
A6IQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063136358 ⟸ XM_063280288
- Peptide Label:
isoform X4
- UniProtKB:
A6IQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063136360 ⟸ XM_063280290
- Peptide Label:
isoform X7
- UniProtKB:
A0A8I5ZZM9 (UniProtKB/TrEMBL)
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2021-03-09
Arhgef9
Cdc42 guanine nucleotide exchange factor 9
LOC100912165
rho guanine nucleotide exchange factor 9-like
Data merged from RGD:6488862
737654 PROVISIONAL
2015-11-19
Arhgef9
Cdc42 guanine nucleotide exchange factor 9
Arhgef9
Cdc42 guanine nucleotide exchange factor (GEF) 9
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2012-07-05
LOC100912165
rho guanine nucleotide exchange factor 9-like
Symbol and Name status set to provisional
70820 PROVISIONAL
2004-09-10
Arhgef9
Cdc42 guanine nucleotide exchange factor (GEF) 9
collybistin I
Name updated
1299863 APPROVED
2002-08-07
Arhgef9
collybistin I
Symbol and Name status set to provisional
70820 PROVISIONAL
Note Type
Note
Reference
gene_product
belongs to the family of dbl-like GDP/GTP exchange factors (GEFs)
632270
