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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:Toll-like receptor signaling pathway
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Accession:PW:0000814 term browser browse the term
Definition:Toll-like receptors represent a large and the better understood family of pattern recognition receptors that sense an array of exogenous structures, and recent evidence shows they can also recognize defective endogenous molecules. The intracellular signaling cascades they set in motion lead to the expression of inflammatory mediators.
Synonyms:related_synonym: TLR signaling pathway;   Toll-Like Receptors Cascades
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show annotations for term's descendants           Sort by:
Toll-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:04620 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04620 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04620 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Casp8 caspase 8 IEA KEGG rno:04620 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 IEA KEGG rno:04620 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEA KEGG rno:04620 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Cd14 CD14 molecule IEA
ISO 		KEGG
RGD		 PMID:22119168 rno:04620, RGD:7247704 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd40 CD40 molecule IEA KEGG rno:04620 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd80 Cd80 molecule IEA KEGG rno:04620 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540 		JBrowse link
G Cd86 CD86 molecule IEA KEGG rno:04620 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:04620 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Ctsk cathepsin K IEA KEGG rno:04620 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEA KEGG rno:04620 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 IEA KEGG rno:04620 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 IEA KEGG rno:04620 NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299 		JBrowse link
G Fadd Fas associated via death domain IEA KEGG rno:04620 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:04620 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Ifna1 interferon, alpha 1 IEA KEGG rno:04620 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG rno:04620 NCBI chr 5:108,374,363...108,374,941
Ensembl chr 5:108,374,363...108,374,941 		JBrowse link
G Ifna4 interferon, alpha 4 IEA KEGG rno:04620 NCBI chr 5:108,115,064...108,116,010
Ensembl chr 5:108,115,064...108,116,010 		JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 IEA KEGG rno:04620 NCBI chr 5:108,640,546...108,641,115 JBrowse link
G Ifna5 interferon, alpha 5 IEA KEGG rno:04620 NCBI chr 5:108,233,736...108,234,314
Ensembl chr 5:108,233,736...108,234,314 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 IEA KEGG rno:04620 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205 		JBrowse link
G Ifnb1 interferon beta 1 IEA KEGG rno:04620 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:04620 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon IEA KEGG rno:04620 NCBI chr13:45,264,404...45,290,737
Ensembl chr13:45,264,412...45,289,396 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:04620 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Il12a interleukin 12A IEA KEGG rno:04620 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B IEA KEGG rno:04620 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il1b interleukin 1 beta IEA KEGG rno:04620 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 IEA KEGG rno:04620 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO RGD PMID:28954388 RGD:34888230 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Irf3 interferon regulatory factor 3 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401 		JBrowse link
G Irf5 interferon regulatory factor 5 IEA KEGG rno:04620 NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:59,081,357...59,112,552 		JBrowse link
G Irf7 interferon regulatory factor 7 IEA KEGG rno:04620 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:04620 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Lbp lipopolysaccharide binding protein IEA
ISO 		KEGG
RGD		 PMID:22119168 rno:04620, RGD:7247704 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Ly96 lymphocyte antigen 96 ISO
IEA 		KEGG
RGD		 PMID:21741580 PMID:22119168 rno:04620, RGD:5685019, RGD:7247704 NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:04620 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:04620 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 IEA KEGG rno:04620 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEA KEGG rno:04620 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IEA KEGG rno:04620 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 IEA KEGG rno:04620 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 IEA KEGG rno:04620 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:04620 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04620 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 IEA KEGG rno:04620 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04620 NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04620 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 IEA KEGG rno:04620 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:04620 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04620 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04620 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:04620 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:04620 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04620 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04620 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04620 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04620 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04620 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04620 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04620 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG rno:04620 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:04620 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167 		JBrowse link
G Spp1 secreted phosphoprotein 1 IEA KEGG rno:04620 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 IEA KEGG rno:04620 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO RGD PMID:20940366 RGD:5685016 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:113,555,819...113,587,351 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO RGD PMID:20940366 RGD:5685016 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:4,195,400...4,245,485 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:20940366 RGD:5685016 NCBI chr  X:53,923,473...53,995,777
Ensembl chr  X:53,923,492...53,995,610 		JBrowse link
G Tbk1 TANK-binding kinase 1 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,172,963...1,196,892 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr18:41,481,057...41,498,065
Ensembl chr18:41,478,539...41,512,243 		JBrowse link
G Tirap TIR domain containing adaptor protein ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312 		JBrowse link
G Tlr1 toll-like receptor 1 IDA
ISO 		RGD PMID:16973131 PMID:21235323 RGD:1643119, RGD:5685014 NCBI chr14:43,737,761...43,750,389
Ensembl chr14:43,740,379...43,756,243 		JBrowse link
G Tlr2 toll-like receptor 2 IDA
IMP
ISO
IEA 		KEGG
RGD		 PMID:16973131 PMID:18353287 PMID:21235323 rno:04620, RGD:1643119, RGD:5684896, RGD:5685014 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr3 toll-like receptor 3 IDA
ISO
IEA 		KEGG
RGD		 PMID:16973131 PMID:21235323 rno:04620, RGD:1643119, RGD:5685014 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385 		JBrowse link
G Tlr4 toll-like receptor 4 IDA
ISO
IEA 		KEGG
RGD		 PMID:16973131 PMID:21235323 PMID:22119168 rno:04620, RGD:1643119, RGD:5685014, RGD:7247704 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tlr5 toll-like receptor 5 IDA
ISO
IEA 		KEGG
RGD		 PMID:16973131 PMID:21235323 rno:04620, RGD:1643119, RGD:5685014 NCBI chr13:97,166,430...97,190,642
Ensembl chr13:97,166,405...97,192,525 		JBrowse link
G Tlr6 toll-like receptor 6 IDA
IMP
ISO
IEA 		KEGG
RGD		 PMID:16973131 PMID:18353287 PMID:21235323 rno:04620, RGD:1643119, RGD:5684896, RGD:5685014 NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,698,751...43,740,462 		JBrowse link
G Tlr7 toll-like receptor 7 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr  X:30,644,324...30,670,796
Ensembl chr  X:30,644,355...30,672,151 		JBrowse link
G Tlr8 toll-like receptor 8 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr  X:30,708,714...30,733,104
Ensembl chr  X:30,708,033...30,737,079 		JBrowse link
G Tlr9 toll-like receptor 9 IDA
ISO
IEA 		KEGG
RGD		 PMID:16973131 PMID:21235323 rno:04620, RGD:1643119, RGD:5685014 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:115,742,889...115,750,148 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:04620 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tollip toll interacting protein IEA KEGG rno:04620 NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:206,380,308...206,411,988 		JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO RGD PMID:21235323 RGD:5685014 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:136,027,157...136,128,363 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO
IEA 		KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N ISO RGD PMID:21235323 RGD:5685014 NCBI chr 7:32,041,190...32,071,252 JBrowse link
G Ube2v1 ubiquitin conjugating enzyme E2 V1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 3:176,736,325...176,759,174
Ensembl chr 3:176,736,325...176,788,278 		JBrowse link
G Unc93b1 unc-93B1 regulator of TLR signaling ISO RGD PMID:21235323 RGD:5685014 NCBI chr 1:210,596,639...210,607,579
Ensembl chr 1:210,573,288...210,607,579 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway pertinent to immunity 793
        signaling pathway in the innate immune response 146
          pattern recognition receptor mediated signaling pathway 145
            Toll-like receptor signaling pathway 97
              Toll-like receptor 1 signaling pathway 0
              Toll-like receptor 10 signaling pathway 0
              Toll-like receptor 2 signaling pathway 0
              Toll-like receptor 3 signaling pathway 0
              Toll-like receptor 4 signaling pathway 0
              Toll-like receptor 5 signaling pathway 0
              Toll-like receptor 6 signaling pathway 0
              Toll-like receptor 7 signaling pathway 0
              Toll-like receptor 8 signaling pathway 0
              Toll-like receptor 9 signaling pathway 0
              Toll-like receptor TLR1:TLR2 signaling pathway 0
              Toll-like receptor TLR6:TLR2 signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      immune response pathway 539
        innate immune response pathway 296
          inflammatory response pathway 228
            pattern recognition receptor mediated signaling pathway 145
              Toll-like receptor signaling pathway 97
                Toll-like receptor 1 signaling pathway 0
                Toll-like receptor 10 signaling pathway 0
                Toll-like receptor 2 signaling pathway 0
                Toll-like receptor 3 signaling pathway 0
                Toll-like receptor 4 signaling pathway 0
                Toll-like receptor 5 signaling pathway 0
                Toll-like receptor 6 signaling pathway 0
                Toll-like receptor 7 signaling pathway 0
                Toll-like receptor 8 signaling pathway 0
                Toll-like receptor 9 signaling pathway 0
                Toll-like receptor TLR1:TLR2 signaling pathway 0
                Toll-like receptor TLR6:TLR2 signaling pathway 0
paths to the root