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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:prostate cancer pathway
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Accession:PW:0000609 term browser browse the term
Definition:Prostate cancer is a frequent form of cancer in men over the age of fifty. It is usually asymptomatic but when in an advanced stage, it may spread to other parts of the body, causing symptoms others than those sometimes observed. Several susceptibility as well as defective genes have been identified.
Synonyms:exact_synonym: familial prostate cancer pathway;   hereditary prostate cancer pathway;   malignant tumor of the prostate pathway;   prostatic cancer pathway
 related_synonym: KEGG:05215;   prostate neoplasm pathway
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prostate cancer pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:05215 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:05215 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05215 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Ar androgen receptor ISO
IEA 		KEGG
RGD		 PMID:18008377 PMID:23759327 rno:05215, RGD:2326139, RGD:8693397 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Atf4 activating transcription factor 4 IEA KEGG rno:05215 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:05215 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEA KEGG rno:05215 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IEA KEGG rno:05215 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05215 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05215 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 IEA KEGG rno:05215 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Ccne2 cyclin E2 IEA KEGG rno:05215 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882 		JBrowse link
G Cdk2 cyclin dependent kinase 2 IEA KEGG rno:05215 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEA KEGG rno:05215 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEA KEGG rno:05215 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:05215 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IEA KEGG rno:05215 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 IEA KEGG rno:05215 NCBI chr 3:98,408,240...98,449,104
Ensembl chr 3:98,408,058...98,449,104 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 IEA KEGG rno:05215 NCBI chr 4:66,874,623...66,990,962
Ensembl chr 4:66,387,126...66,990,832 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 IEA KEGG rno:05215 NCBI chr 7:9,273,320...9,281,755
Ensembl chr 7:9,273,338...9,281,778 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 IEA KEGG rno:05215 NCBI chr 2:177,987,981...177,994,568
Ensembl chr 2:177,987,981...177,993,485 		JBrowse link
G Crebbp CREB binding lysine acetyltransferase IEA KEGG rno:05215 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Ctnnb1 catenin beta 1 IEA KEGG rno:05215 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G E2f1 E2F transcription factor 1 IEA KEGG rno:05215 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f3 E2F transcription factor 3 IEA KEGG rno:05215 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725 		JBrowse link
G Egf epidermal growth factor IEA KEGG rno:05215 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor IEA KEGG rno:05215 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Ep300 EP300 lysine acetyltransferase IEA KEGG rno:05215 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEA KEGG rno:05215 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEA KEGG rno:05215 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IEA KEGG rno:05215 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914 		JBrowse link
G Foxo1 forkhead box O1 IEA KEGG rno:05215 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG rno:05215 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:05215 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IEA KEGG rno:05215 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hras HRas proto-oncogene, GTPase IEA KEGG rno:05215 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 IEA KEGG rno:05215 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 IEA KEGG rno:05215 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 IEA KEGG rno:05215 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Igf1 insulin-like growth factor 1 IEA KEGG rno:05215 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEA KEGG rno:05215 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:05215 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:05215 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Ins1 insulin 1 IEA KEGG rno:05215 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 IEA KEGG rno:05215 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Insrr insulin receptor-related receptor IEA KEGG rno:05215 NCBI chr 2:175,553,244...175,572,676
Ensembl chr 2:175,553,293...175,572,676 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:05215 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA KEGG rno:05215 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:05215 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:05215 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:05215 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:05215 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mdm2 MDM2 proto-oncogene IEA KEGG rno:05215 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEA KEGG rno:05215 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:05215 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:05215 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nkx3-1 NK3 homeobox 1 IEA KEGG rno:05215 NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251 		JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:05215 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
G Pdgfa platelet derived growth factor subunit A IEA KEGG rno:05215 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEA KEGG rno:05215 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pdgfc platelet derived growth factor C IEA KEGG rno:05215 NCBI chr 2:168,613,409...168,791,575
Ensembl chr 2:168,614,353...168,791,573 		JBrowse link
G Pdgfd platelet derived growth factor D IEA KEGG rno:05215 NCBI chr 8:11,773,335...12,007,277
Ensembl chr 8:11,773,475...12,007,271 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEA KEGG rno:05215 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEA KEGG rno:05215 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IEA KEGG rno:05215 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA
ISO 		KEGG
RGD		 PMID:23759327 rno:05215, RGD:8693397 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05215 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05215 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05215 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05215 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05215 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05215 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Pten phosphatase and tensin homolog ISO
IEA 		KEGG
RGD		 PMID:18008377 PMID:23759327 rno:05215, RGD:2326139, RGD:8693397 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:05215 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rb1 RB transcriptional corepressor 1 IEA KEGG rno:05215 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:05215 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG rno:05215 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG rno:05215 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 IEA KEGG rno:05215 NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588 		JBrowse link
G Tcf3 transcription factor 3 IEA KEGG rno:05215 NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,928,685...9,953,044 		JBrowse link
G Tcf7 transcription factor 7 IEA KEGG rno:05215 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 IEA KEGG rno:05215 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
G Tgfa transforming growth factor alpha IEA KEGG rno:05215 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
G Tp53 tumor protein p53 IEA
ISO 		KEGG
RGD		 PMID:23759327 rno:05215, RGD:8693397 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      cancer pathway 369
        urogenital cancer pathway 159
          prostate cancer pathway 86
paths to the root