Creb3l4 (cAMP responsive element binding protein 3-like 4)

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Gene: Creb3l4 (cAMP responsive element binding protein 3-like 4) Rattus norvegicus

Analyze

Symbol:

Creb3l4

Name:

cAMP responsive element binding protein 3-like 4

RGD ID:

1359278

Description:

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to localize to several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleus. Orthologous to human CREB3L4 (cAMP responsive element binding protein 3 like 4); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Huntington's disease pathway; prostate cancer pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

AIbZIP; androgen-induced basic leucine zipper protein; androgen-induced bZIP protein; cAMP-responsive element-binding protein 3-like protein 4; cyclic AMP-responsive element-binding protein 3-like protein 4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	175,690,340 - 175,696,084 (-)	NCBI
Rnor_6.0 Ensembl	2	189,595,415 - 189,602,143 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	189,596,657 - 189,602,243 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	209,029,454 - 209,035,218 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	182,477,247 - 182,482,238 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	182,427,352 - 182,432,344 (-)	NCBI
Celera	2	169,626,107 - 169,631,098 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant non-syndromic intellectual disability 18 (ISO)

Neoplasm Recurrence, Local (ISO)

prostate adenocarcinoma (ISO)

prostate carcinoma in situ (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

5-azacytidine (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

atrazine (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

diclofenac (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (ISO)

hydrogen peroxide (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

nickel atom (ISO)

phenylmercury acetate (ISO)

Ptaquiloside (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (EXP)

titanium dioxide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

endoplasmic reticulum unfolded protein response (IEA)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IBA)

spermatogenesis (ISO)

Cellular Component

cellular_component (ND)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

Golgi apparatus (ISO)

integral component of membrane (IEA)

mitochondrion (IEA,ISO)

nuclear membrane (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA)

Molecular Function

cAMP response element binding (IEA)

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

molecular_function (ND)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endoplasmic reticulum stress - the unfolded protein response pathway (ISO)

Huntington's disease pathway (IEA)

prostate cancer pathway (IEA)

vasopressin signaling pathway via receptor type 2 (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Levesque MH, etal., Urology. 2007 Jan;69(1):196-201. doi: 10.1016/j.urology.2006.11.001.
3.	MGD data from the GO Consortium
4.	Nagamori I, etal., Genes Cells 2005 Jun;10(6):575-94.
5.	Pipeline to import KEGG annotations from KEGG into RGD
6.	Qi H, etal., Cancer Res. 2002 Feb 1;62(3):721-33.
7.	RGD automated import pipeline for gene-chemical interactions
8.	RGD comprehensive gene curation
9.	Stelzer G and Don J, Endocrinology 2002 May;143(5):1578-88.
10.	Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.

Additional References at PubMed

PMID:16107712	PMID:16236796	PMID:17933519

Genomics

Comparative Map Data

Creb3l4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	175,690,340 - 175,696,084 (-)	NCBI
Rnor_6.0 Ensembl	2	189,595,415 - 189,602,143 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	189,596,657 - 189,602,243 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	209,029,454 - 209,035,218 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	182,477,247 - 182,482,238 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	182,427,352 - 182,432,344 (-)	NCBI
Celera	2	169,626,107 - 169,631,098 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

CREB3L4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	153,967,534 - 153,974,361 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	153,967,487 - 153,974,364 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	153,940,378 - 153,946,835 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	1	153,940,315 - 153,946,840 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	152,207,021 - 152,213,456 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	150,753,469 - 150,759,905	NCBI
Celera	1	127,012,147 - 127,018,583 (+)	NCBI
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	125,302,901 - 125,309,202 (+)	NCBI		HuRef
CHM1_1	1	155,336,628 - 155,343,154 (+)	NCBI		CHM1_1

Creb3l4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	90,144,805 - 90,161,387 (-)	NCBI	GRCm39		mm39
GRCm38	3	90,237,498 - 90,244,582 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	90,237,500 - 90,243,512 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	90,041,422 - 90,047,434 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	90,323,427 - 90,329,439 (-)	NCBI			mm8
Celera	3	90,274,687 - 90,280,699 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI

Creb3l4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	564,193 - 568,942 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955545	563,710 - 569,224 (+)	NCBI	ChiLan1.0	ChiLan1.0

CREB3L4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	132,952,912 - 132,959,696 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	132,953,062 - 132,959,696 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	129,324,479 - 129,331,204 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CREB3L4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	7	43,161,816 - 43,165,641 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	7	43,161,814 - 43,166,149 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Creb3l4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936580	3,715,122 - 3,720,154 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CREB3L4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	95,716,537 - 95,722,947 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	95,716,530 - 95,723,959 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	104,617,839 - 104,624,693 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CREB3L4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	9,839,137 - 9,848,413 (-)	NCBI
ChlSab1.1 Ensembl	20	9,838,085 - 9,845,287 (-)	Ensembl

Creb3l4
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624885	3,249,747 - 3,255,210 (-)	NCBI

Position Markers

RH131369

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	189,596,859 - 189,597,075	NCBI	Rnor6.0
Rnor_5.0	2	209,029,656 - 209,029,872	UniSTS	Rnor5.0
RGSC_v3.4	2	182,477,201 - 182,477,417	UniSTS	RGSC3.4
Celera	2	169,626,061 - 169,626,277	UniSTS
RH 3.4 Map	2	1154.2	UniSTS
Cytogenetic Map	2	q34	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42776916	195645082	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	157914311	204022555	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	140566078	217498545	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	147522550	217498710	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46537589	217498710	Rat
61457	Niddm8	Non-insulin dependent diabetes mellitus QTL 8	4.1	0.01	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	2	188449158	189857032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43133606	217498545	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43133606	217498545	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	184730446	229730446	Rat
61473	Bp19	Blood pressure QTL 19	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	186611811	189857032	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	184730446	229730446	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	149114878	225501939	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	181990297	240020001	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56244671	217498710	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141583337	217498710	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828049	217498710	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147122993	240020001	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	147122993	240020001	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	183984665	228984665	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	142053350	204585731	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	157914409	217498545	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	116075644	228737869	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	186611811	198704485	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	169852800	217498545	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	254121739	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	237742948	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	161745602	206745602	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	181522444	226522444	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	172795683	189857032	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	116075644	228737869	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	175403337	239166203	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	118446646	227707979	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	138901276	217498710	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43149788	198704485	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	75687495	221880419	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	158159186	217498710	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83819608	239166203	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828236	243550655	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83819608	243901375	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	158159186	217498710	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	142053350	228984665	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	181987080	199696953	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	118446793	228582621	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	177680772	243901375	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	118446646	200453484	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	118446646	200453484	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	169852670	207612467	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	188838511	228984665	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78321410	217498710	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	159585731	204585731	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	149614623	198704357	Rat
7488904	Bp363	Blood pressure QTL 363		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	186889035	189857032	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	174160958	219160958	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	177339806	222339806	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	169852670	243026643	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83754907	237610852	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	149614466	205573168	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	149614466	205573168	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	172795683	189857032	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	172795683	199696953	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	16679272	245624402	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	172795683	199696953	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	172795683	189857032	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	172795683	199696953	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	172795683	199696953	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	172795683	189857032	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	172795683	189857032	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	172795683	199696953	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	172795683	189857032	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	85
Count of miRNA genes:	73
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000032062
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3										3
Low		8	9		16		1	2	5	18	29	11	1
Below cutoff		27	42	35	3	35	7	9	57	17	9		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY750875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY750876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000032062 ⟹ ENSRNOP00000033353

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	189,595,415 - 189,602,143 (-)	Ensembl

RefSeq Acc Id:

NM_001007093 ⟹ NP_001007094

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	175,690,588 - 175,695,581 (-)	NCBI
Rnor_6.0	2	189,596,905 - 189,601,896 (-)	NCBI
Rnor_5.0	2	209,029,454 - 209,035,218 (-)	NCBI
RGSC_v3.4	2	182,477,247 - 182,482,238 (-)	RGD
Celera	2	169,626,107 - 169,631,098 (-)	RGD

Sequence:

show sequence

ATGGAGCTCGGGTGCCCTGAGTTGCTGGAACCCCCAGAAGATATCTTCTCGACAGGATCTTTCC
TGGAGCTGGGATTTAATGGTCCCCCGTCAAAGGTGCCGGGCCTTCAGAAGAGCGAGTCTGATGA
TTTCCTGAACCTCTTTATCGATCCCAATATGATACGCTGCTCAGAAACATCTCCTGGTAGTGAC
AGTGGGGTCTCTGAAGATCCTGGCTCCCCTGCCCCACAGGCACCCAGTTCCCCAGCCCTCTATG
AAGTTGTCTATGAGGCAGGAGCCCTACAGGGAACCCAGCGGGAAGCTGGGCCAACCTTCGGACT
CATCTCCATCCAGATAGATCAGTGGAGCCCTGCATTTATGGTACCTGGTGCCTGCACAGTCAGT
GATCTGCCCTCTGAAGCTCATAGACACATCCTGCCTAGAGTCAGCACCATAGCCCCACCACCTC
CTGCAGCCCTGCTGTCCTGCCAACGTCTGTTCCTGACAGATGAAGAAAAGCATCTGCTGGGACA
AGAAGGGGTTACTCTGCCCTCTCACCTGCCCCTCACCAAGGCAGAGGAGAGAATACTCAAGAAG
ATCAGGAGGAAAATCCGCAACAAGCAGTCAGCTCAGGACAGCCGGCGGAGGAAGAAAGAATACA
TAGATGGGCTGGAGAGCAGAGTGGCAGCCTGTTCTGAGCAGAACCAGAAACTGCAGAGAAAGGT
CCAGGAGCTGGAGAGGCAGAACATCTCGTTGGTGGCGCAGGTCCATCAGTTACAGAAGTTCACT
GCTCAGACCTCCAGCAGAGCTGCCCAGACCAGCACCTGTGTTCTGATTCTTCTTTTTTCGTTGG
CTCTCATCATCCTGCCCAGCTTCAGCCCCTTTCAGAGTCAACCAGAAGCTAGGTCTGAGGGTTA
TCAGCTTCATGGAGTCATTTCCAGAAATATCTTGACTCATGAGGACATGACAGAAAGCCCGGAG
AGTCCAGTGCTAAAGGCCAACCTGGAGGAGCTACCTCAAGTCCCAGCCACAAATGGCTCAACAA
AGATGGCTCATCTGAAGATGCGAGTGAAGGCCAGACCCACTGGGCCGATCAGGGGAATGGTGCA
TGCAGATGAGATGTAA

hide sequence

RefSeq Acc Id:

XM_006232627 ⟹ XP_006232689

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	189,596,657 - 189,602,057 (-)	NCBI
Rnor_5.0	2	209,029,454 - 209,035,218 (-)	NCBI

Sequence:

show sequence

CTGAACCCAAAAGATAAGACCTGAAGTGTGTTCTCCTGCAAGGGGCTGCCTCGTAAGCATGGAG
CTCGGGTGCCCTGAGTTGCTGGAACCCCCAGAAGATATCTTCTCGACAGGATCTTTCCTGGAGC
TGGGATTTAATGGTCCCCCGTCAAAGGTGCCGGGCCTTCAGAAGAGCGAGTCTGATGATTTCCT
GAACCTCTTTATCGATCCCAATATGATACGCTGCTCAGAAACATCTCCTGGTAGTGACAGTGGG
GTCTCTGAAGATCCTGGCTCCCCTGCCCCACAGGCACCCAGTTCCCCAGCCCTCTATGAAGTTG
TCTATGAGGCAGGAGCCCTACAGGGAACCCAGCGGGAAGCTGGGCCAACCTTCGGACTCATCTC
CATCCAGATAGATCAGTGGAGCCCTGCATTTATGGTACCTGGTGCCTGCACAGTCAGTGATCTG
CCCTCTGAAGCTCATAGACACATCCTGCCTAGAGTCAGCACCATAGCCCCACCACCTCCTGCAG
CCCTGCTGTCCTGCCAACGTCTGTTCCTGACAGATGAAGAAAAGCATCTGCTGGGACAAGAAGG
GGTTACTCTGCCCTCTCACCTGCCCCTCACCAAGGCAGAGGAGAGAATACTCAAGAAGATCAGG
AGGAAAATCCGCAACAAGCAGTCAGCTCAGGACAGCCGGCGGAGGAAGAAAGAATACATAGATG
GGCTGGAGAGCAGAGTGGCAGCCTGTTCTGAGCAGAACCAGAAACTGCAGAGAAAGGTCCAGGA
GCTGGAGAGGCAGAACATCTCGTTGGTGGCGCAGGTCCATCAGTTACAGAAGTTCACTGCTCAG
ACCTCCAGCAGAGCTGCCCAGACCAGCACCTGTGTTCTGATTCTTCTTTTTTCGTTGGCTCTCA
TCATCCTGCCCAGCTTCAGCCCCTTTCAGAGTCAACCAGAAGCTAGGTCTGAGGGTTATCAGCT
TCATGGAGTCATTTCCAGAAATATCTTGACTCATGAGGACATGACAGAAAGCCCGGAGAGTCCA
GTGCTAAAGGCCAACCTGGAGGAGCTACCTCAAGTCCCAGCCACAAATGGCTCAACAAAGATGG
CTCATCTGAAGATGCGAGTGAAGGCCAGACCCACTGGGCCGATCAGGGGAATGGTGCATGCAGA
TGAGATGTAACTACACAAGAAGACACCCAGGCTTCCCTGTCACCTTTCATCAGGTTCCCATTGA
GGAGTCCACAGCCCTGGAGTTCTGACTTACTCAGAACACAACTGGAGACTTCTGTCCCCTAAGG
CCAGGCTGCCTATGTGGCAGGGTACCTCAAATACTTCTGTCATACATTTGTGATTTCATTTCTT
CTCTGTGGATAAGGTCAGGGGGAGAAAAGGTTTGACTTGGAAATAAACTTCCTAGCTCAAATTC
TA

hide sequence

RefSeq Acc Id:

XM_008761147 ⟹ XP_008759369

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	175,690,340 - 175,696,084 (-)	NCBI
Rnor_6.0	2	189,596,657 - 189,602,057 (-)	NCBI

Sequence:

show sequence

CTGAACCCAAAAGATAAGACCTGAAGTGTGTTCTCCTGCAAGGGGCTGCCTCGTGTAAGCAGAG
GAAAGGAGTAACGGAGAGAATGCAGAGGAACCAGTAGCTTCCGAGGGCAGCCACCACCTTCCTT
CTATAACTTTCCTTCTCATCTTCCGGCAGAAGCATGGAGCTCGGGTGCCCTGAGTTGCTGGAAC
CCCCAGAAGATATCTTCTCGACAGGATCTTTCCTGGAGCTGGGATTTAATGGTCCCCCGTCAAA
GGGCCTTCAGAAGAGCGAGTCTGATGATTTCCTGAACCTCTTTATCGATCCCAATATGATACGC
TGCTCAGAAACATCTCCTGGTAGTGACAGTGGGGTCTCTGAAGATCCTGGCTCCCCTGCCCCAC
AGGCACCCAGTTCCCCAGCCCTCTATGAAGTTGTCTATGAGGCAGGAGCCCTACAGGGAACCCA
GCGGGAAGCTGGGCCAACCTTCGGACTCATCTCCATCCAGATAGATCAGTGGAGCCCTGCATTT
ATGGTACCTGGTGCCTGCACAGTCAGTGATCTGCCCTCTGAAGCTCATAGACACATCCTGCCTA
GAGTCAGCACCATAGCCCCACCACCTCCTGCAGCCCTGCTGTCCTGCCAACGTCTGTTCCTGAC
AGATGAAGAAAAGCATCTGCTGGGACAAGAAGGGGTTACTCTGCCCTCTCACCTGCCCCTCACC
AAGGCAGAGGAGAGAATACTCAAGAAGATCAGGAGGAAAATCCGCAACAAGCAGTCAGCTCAGG
ACAGCCGGCGGAGGAAGAAAGAATACATAGATGGGCTGGAGAGCAGAGTGGCAGCCTGTTCTGA
GCAGAACCAGAAACTGCAGAGAAAGGTCCAGGAGCTGGAGAGGCAGAACATCTCGTTGGTGGCG
CAGGTCCATCAGTTACAGAAGTTCACTGCTCAGACCTCCAGCAGAGCTGCCCAGACCAGCACCT
GTGTTCTGATTCTTCTTTTTTCGTTGGCTCTCATCATCCTGCCCAGCTTCAGCCCCTTTCAGAG
TCAACCAGAAGCTAGGTCTGAGGGTTATCAGCTTCATGGAGTCATTTCCAGAAATATCTTGACT
CATGAGGACATGACAGAAAGCCCGGAGAGTCCAGTGCTAAAGGCCAACCTGGAGGAGCTACCTC
AAGTCCCAGCCACAAATGGCTCAACAAAGATGGCTCATCTGAAGATGCGAGTGAAGGCCAGACC
CACTGGGCCGATCAGGGGAATGGTGCATGCAGATGAGATGTAACTACACAAGAAGACACCCAGG
CTTCCCTGTCACCTTTCATCAGGTTCCCATTGAGGAGTCCACAGCCCTGGAGTTCTGACTTACT
CAGAACACAACTGGAGACTTCTGTCCCCTAAGGCCAGGCTGCCTATGTGGCAGGGTACCTCAAA
TACTTCTGTCATACATTTGTGATTTCATTTCTTCTCTGTGGATAAGGTCAGGGGGAGAAAAGGT
TTGACTTGGAAATAAACTTCCTAGCTCAAATTCTA

hide sequence

RefSeq Acc Id:

XM_017590878 ⟹ XP_017446367

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	189,596,657 - 189,602,243 (-)	NCBI

Sequence:

show sequence

CACTAAACTCCATGAACAGCATAGGCAGGCGGGGCTTGACTGGGCAGGACCAGGATACAAGATC
CTGGTGGAAAGAAAAGGTGTAGTGTTTGGGGCTTCAGCGGGCTAGGCTGGTTTGGCAGGACAAA
GCTCTCTCAATAACAATTAAAAAAAAAAAAAAAGAAGCATGGAGCTCGGGTGCCCTGAGTTGCT
GGAACCCCCAGAAGATATCTTCTCGACAGGATCTTTCCTGGAGCTGGGATTTAATGGTCCCCCG
TCAAAGGTGCCGGGCCTTCAGAAGAGCGAGTCTGATGATTTCCTGAACCTCTTTATCGATCCCA
ATATGATACGCTGCTCAGAAACATCTCCTGGTAGTGACAGTGGGGTCTCTGAAGATCCTGGCTC
CCCTGCCCCACAGGCACCCAGTTCCCCAGCCCTCTATGAAGTTGTCTATGAGGCAGGAGCCCTA
CAGGGAACCCAGCGGGAAGCTGGGCCAACCTTCGGACTCATCTCCATCCAGATAGATCAGTGGA
GCCCTGCATTTATGGTACCTGGTGCCTGCACAGTCAGTGATCTGCCCTCTGAAGCTCATAGACA
CATCCTGCCTAGAGTCAGCACCATAGCCCCACCACCTCCTGCAGCCCTGCTGTCCTGCCAACGT
CTGTTCCTGACAGATGAAGAAAAGCATCTGCTGGGACAAGAAGGGGTTACTCTGCCCTCTCACC
TGCCCCTCACCAAGGCAGAGGAGAGAATACTCAAGAAGATCAGGAGGAAAATCCGCAACAAGCA
GTCAGCTCAGGACAGCCGGCGGAGGAAGAAAGAATACATAGATGGGCTGGAGAGCAGAGTGGCA
GCCTGTTCTGAGCAGAACCAGAAACTGCAGAGAAAGGTCCAGGAGCTGGAGAGGCAGAACATCT
CGTTGGTGGCGCAGGTCCATCAGTTACAGAAGTTCACTGCTCAGACCTCCAGCAGAGCTGCCCA
GACCAGCACCTGTGTTCTGATTCTTCTTTTTTCGTTGGCTCTCATCATCCTGCCCAGCTTCAGC
CCCTTTCAGAGTCAACCAGAAGCTAGGTCTGAGGGTTATCAGCTTCATGGAGTCATTTCCAGAA
ATATCTTGACTCATGAGGACATGACAGAAAGCCCGGAGAGTCCAGTGCTAAAGGCCAACCTGGA
GGAGCTACCTCAAGTCCCAGCCACAAATGGCTCAACAAAGATGGCTCATCTGAAGATGCGAGTG
AAGGCCAGACCCACTGGGCCGATCAGGGGAATGGTGCATGCAGATGAGATGTAACTACACAAGA
AGACACCCAGGCTTCCCTGTCACCTTTCATCAGGTTCCCATTGAGGAGTCCACAGCCCTGGAGT
TCTGACTTACTCAGAACACAACTGGAGACTTCTGTCCCCTAAGGCCAGGCTGCCTATGTGGCAG
GGTACCTCAAATACTTCTGTCATACATTTGTGATTTCATTTCTTCTCTGTGGATAAGGTCAGGG
GGAGAAAAGGTTTGACTTGGAAATAAACTTCCTAGCTCAAATTCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007094	(Get FASTA)	NCBI Sequence Viewer
	XP_008759369	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAV29942	(Get FASTA)	NCBI Sequence Viewer
	AAV29943	(Get FASTA)	NCBI Sequence Viewer
	EDM00576	(Get FASTA)	NCBI Sequence Viewer
	EDM00577	(Get FASTA)	NCBI Sequence Viewer
	Q5UEM7	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001007094 ⟸ NM_001007093

- UniProtKB:

Q5UEM7 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MELGCPELLEPPEDIFSTGSFLELGFNGPPSKVPGLQKSESDDFLNLFIDPNMIRCSETSPGSD
SGVSEDPGSPAPQAPSSPALYEVVYEAGALQGTQREAGPTFGLISIQIDQWSPAFMVPGACTVS
DLPSEAHRHILPRVSTIAPPPPAALLSCQRLFLTDEEKHLLGQEGVTLPSHLPLTKAEERILKK
IRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSEQNQKLQRKVQELERQNISLVAQVHQLQKFT
AQTSSRAAQTSTCVLILLFSLALIILPSFSPFQSQPEARSEGYQLHGVISRNILTHEDMTESPE
SPVLKANLEELPQVPATNGSTKMAHLKMRVKARPTGPIRGMVHADEM

hide sequence

RefSeq Acc Id:

XP_006232689 ⟸ XM_006232627

- Peptide Label:

isoform X1

- Sequence:

show sequence

MELGCPELLEPPEDIFSTGSFLELGFNGPPSKVPGLQKSESDDFLNLFIDPNMIRCSETSPGSD
SGVSEDPGSPAPQAPSSPALYEVVYEAGALQGTQREAGPTFGLISIQIDQWSPAFMVPGACTVS
DLPSEAHRHILPRVSTIAPPPPAALLSCQRLFLTDEEKHLLGQEGVTLPSHLPLTKAEERILKK
IRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSEQNQKLQRKVQELERQNISLVAQVHQLQKFT
AQTSSRAAQTSTCVLILLFSLALIILPSFSPFQSQPEARSEGYQLHGVISRNILTHEDMTESPE
SPVLKANLEELPQVPATNGSTKMAHLKMRVKARPTGPIRGMVHADEM

hide sequence

RefSeq Acc Id:	XP_008759369 ⟸ XM_008761147
- Peptide Label:	isoform X1
- UniProtKB:	Q5UEM7 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MELGCPELLEPPEDIFSTGSFLELGFNGPPSKGLQKSESDDFLNLFIDPNMIRCSETSPGSDSG VSEDPGSPAPQAPSSPALYEVVYEAGALQGTQREAGPTFGLISIQIDQWSPAFMVPGACTVSDL PSEAHRHILPRVSTIAPPPPAALLSCQRLFLTDEEKHLLGQEGVTLPSHLPLTKAEERILKKIR RKIRNKQSAQDSRRRKKEYIDGLESRVAACSEQNQKLQRKVQELERQNISLVAQVHQLQKFTAQ TSSRAAQTSTCVLILLFSLALIILPSFSPFQSQPEARSEGYQLHGVISRNILTHEDMTESPESP VLKANLEELPQVPATNGSTKMAHLKMRVKARPTGPIRGMVHADEM hide sequence

RefSeq Acc Id:

XP_017446367 ⟸ XM_017590878

- Peptide Label:

isoform X1

- Sequence:

show sequence

MELGCPELLEPPEDIFSTGSFLELGFNGPPSKVPGLQKSESDDFLNLFIDPNMIRCSETSPGSD
SGVSEDPGSPAPQAPSSPALYEVVYEAGALQGTQREAGPTFGLISIQIDQWSPAFMVPGACTVS
DLPSEAHRHILPRVSTIAPPPPAALLSCQRLFLTDEEKHLLGQEGVTLPSHLPLTKAEERILKK
IRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSEQNQKLQRKVQELERQNISLVAQVHQLQKFT
AQTSSRAAQTSTCVLILLFSLALIILPSFSPFQSQPEARSEGYQLHGVISRNILTHEDMTESPE
SPVLKANLEELPQVPATNGSTKMAHLKMRVKARPTGPIRGMVHADEM

hide sequence

RefSeq Acc Id:

ENSRNOP00000033353 ⟸ ENSRNOT00000032062

Protein Domains

bZIP

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691496

Promoter ID:

EPDNEW_R2021

Type:

single initiation site

Name:

Creb3l4_1

Description:

cAMP responsive element binding protein 3-like 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	189,602,161 - 189,602,221	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359278	AgrOrtholog
Ensembl Genes	ENSRNOG00000023493	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000033353	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000032062	UniProtKB/Swiss-Prot
InterPro	bZIP	UniProtKB/Swiss-Prot
	CREB4	UniProtKB/Swiss-Prot
KEGG Report	rno:310616	UniProtKB/Swiss-Prot
NCBI Gene	310616	ENTREZGENE
PANTHER	PTHR45996:SF2	UniProtKB/Swiss-Prot
Pfam	bZIP_1	UniProtKB/Swiss-Prot
PhenoGen	Creb3l4	PhenoGen
PROSITE	BZIP	UniProtKB/Swiss-Prot
SMART	BRLZ	UniProtKB/Swiss-Prot
UniProt	CR3L4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q5UEM6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Creb3l4	cAMP responsive element binding protein 3-like 4			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Creb3l4	cAMP responsive element binding protein 3-like 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)