CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pyridazinone
Accession: CHEBI:26414
browse the term
Synonyms: related_synonym: pyridazinones
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Alad
aminolevulinate dehydratase
decreases activity
ISO
Maleic Hydrazide results in decreased activity of ALAD protein
CTD
PMID:8687997
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA
CTD
PMID:25028461
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Impdh2
inosine monophosphate dehydrogenase 2
decreases activity
ISO
Maleic Hydrazide results in decreased activity of IMPDH2 protein
CTD
PMID:11370715
NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
[Maleic Hydrazide co-treated with Chlorpropham] results in increased activity of NR1I2 protein
CTD
PMID:25028461
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone
CTD
PMID:16608219
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone; CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to norflurazone
CTD
PMID:15853388 PMID:16608219
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions
ISO
[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone
CTD
PMID:16608219
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases methylation
ISO
CYP1A2 protein results in decreased methylation of pimobendan
CTD
PMID:10611143
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases methylation
ISO
CYP3A4 protein results in decreased methylation of pimobendan
CTD
PMID:10611143
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Il1b
interleukin 1 beta
multiple interactions decreases expression
ISO
pimobendan promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] pimobendan results in decreased expression of IL1B protein
CTD
PMID:9004165 PMID:10193745
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
decreases expression multiple interactions
ISO
pimobendan results in decreased expression of IL6 protein pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD
PMID:9004165 PMID:10193745
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ins1
insulin 1
multiple interactions
EXP
pimobendan promotes the reaction [Glucose results in increased secretion of INS1 protein]
CTD
PMID:9492047
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
pimobendan results in decreased activity of KCNH2 protein
CTD
PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Nos2
nitric oxide synthase 2
decreases expression multiple interactions
ISO
pimobendan results in decreased expression of NOS2 mRNA [pimobendan results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide
CTD
PMID:10193745
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Tnf
tumor necrosis factor
multiple interactions decreases expression
ISO
pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] pimobendan results in decreased expression of TNF protein
CTD
PMID:9004165 PMID:10193745
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Aco2
aconitase 2
decreases activity
EXP
pyridaben results in decreased activity of ACO2 protein
CTD
PMID:26141520
NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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Adam22
ADAM metallopeptidase domain 22
increases expression
ISO
pyridaben results in increased expression of ADAM22 mRNA
CTD
PMID:22563483
NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962
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Adcyap1
adenylate cyclase activating polypeptide 1
increases expression
ISO
pyridaben results in increased expression of ADCYAP1 mRNA
CTD
PMID:22563483
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
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Ago3
argonaute RISC catalytic component 3
increases expression
ISO
pyridaben results in increased expression of AGO3 mRNA
CTD
PMID:22563483
NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
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Amn
amnion associated transmembrane protein
decreases expression
ISO
pyridaben results in decreased expression of AMN mRNA
CTD
PMID:22563483
NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815
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Ar
androgen receptor
multiple interactions
ISO
pyridaben inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:30818834
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atoh7
atonal bHLH transcription factor 7
decreases expression
ISO
pyridaben results in decreased expression of ATOH7 mRNA
CTD
PMID:22563483
NCBI chr20:25,530,826...25,531,275
Ensembl chr20:25,530,826...25,531,275
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Atp8a2
ATPase phospholipid transporting 8A2
increases expression
ISO
pyridaben results in increased expression of ATP8A2 mRNA
CTD
PMID:22563483
NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223
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Bcl2
BCL2, apoptosis regulator
decreases response to substance multiple interactions
ISO
BCL2 protein results in decreased susceptibility to pyridaben PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to pyridaben]
CTD
PMID:12730627
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2a1
BCL2-related protein A1
increases expression
ISO
pyridaben results in increased expression of BCL2A1 mRNA
CTD
PMID:22563483
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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Bicd1
BICD cargo adaptor 1
increases expression
ISO
pyridaben results in increased expression of BICD1 mRNA
CTD
PMID:22563483
NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
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C2cd4d
C2 calcium-dependent domain containing 4D
decreases expression
ISO
pyridaben results in decreased expression of C2CD4D mRNA
CTD
PMID:22563483
NCBI chr 2:181,999,778...182,001,941
Ensembl chr 2:181,997,078...182,002,087
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Cabyr
calcium binding tyrosine phosphorylation regulated
increases expression
ISO
pyridaben results in increased expression of CABYR mRNA
CTD
PMID:22563483
NCBI chr18:3,892,062...3,904,391
Ensembl chr18:3,892,132...3,903,840
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Cacna1e
calcium voltage-gated channel subunit alpha1 E
increases expression
ISO
pyridaben results in increased expression of CACNA1E mRNA
CTD
PMID:22563483
NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
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Camp
cathelicidin antimicrobial peptide
increases expression
ISO
pyridaben results in increased expression of CAMP mRNA
CTD
PMID:22563483
NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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Capn11
calpain 11
decreases expression
ISO
pyridaben results in decreased expression of CAPN11 mRNA
CTD
PMID:22563483
NCBI chr 9:15,344,059...15,365,604
Ensembl chr 9:15,344,089...15,365,601
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Casp3
caspase 3
increases expression
EXP
pyridaben results in increased expression of CASP3 mRNA; pyridaben results in increased expression of CASP3 protein
CTD
PMID:37357870
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccdc88a
coiled coil domain containing 88A
increases expression
ISO
pyridaben results in increased expression of CCDC88A mRNA
CTD
PMID:22563483
NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368
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Ccl19
C-C motif chemokine ligand 19
increases expression
ISO
pyridaben results in increased expression of CCL19 mRNA
CTD
PMID:22563483
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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Ccl21
C-C motif chemokine ligand 21
increases expression
ISO
pyridaben results in increased expression of CCL21A mRNA
CTD
PMID:22563483
NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
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Cdhr4
cadherin-related family member 4
decreases expression
ISO
pyridaben results in decreased expression of CDHR4 mRNA
CTD
PMID:22563483
NCBI chr 8:108,682,594...108,690,358
Ensembl chr 8:108,682,613...108,690,367
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Cebpd
CCAAT/enhancer binding protein delta
decreases expression
ISO
pyridaben results in decreased expression of CEBPD mRNA
CTD
PMID:22563483
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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Cep290
centrosomal protein 290
increases expression
ISO
pyridaben results in increased expression of CEP290 mRNA
CTD
PMID:22563483
NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392
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Cldn3
claudin 3
decreases expression
ISO
pyridaben results in decreased expression of CLDN3 mRNA
CTD
PMID:22563483
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
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Crlf2
cytokine receptor-like factor 2
decreases expression
ISO
pyridaben results in decreased expression of CRLF2 mRNA
CTD
PMID:22563483
NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642
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Dgki
diacylglycerol kinase, iota
increases expression
ISO
pyridaben results in increased expression of DGKI mRNA
CTD
PMID:22563483
NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733
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Dip2b
disco-interacting protein 2 homolog B
increases expression
ISO
pyridaben results in increased expression of DIP2B mRNA
CTD
PMID:22563483
NCBI chr 7:131,174,575...131,350,417
Ensembl chr 7:131,174,567...131,349,092
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Dmrta2
DMRT-like family A2
decreases expression
ISO
pyridaben results in decreased expression of DMRTA2 mRNA
CTD
PMID:22563483
NCBI chr 5:124,805,883...124,811,694
Ensembl chr 5:124,805,883...124,811,630
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Drd4
dopamine receptor D4
decreases expression
ISO
pyridaben results in decreased expression of DRD4 mRNA
CTD
PMID:22563483
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Egr4
early growth response 4
decreases expression
ISO
pyridaben results in decreased expression of EGR4 mRNA
CTD
PMID:22563483
NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
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Elane
elastase, neutrophil expressed
increases expression
ISO
pyridaben results in increased expression of ELANE mRNA
CTD
PMID:22563483
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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Esr1
estrogen receptor 1
increases activity multiple interactions
ISO
pyridaben results in increased activity of ESR1 protein pyridaben binds to and results in increased activity of ESR1 protein; pyridaben inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
CTD
PMID:20143881 PMID:30818834 PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
pyridaben inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
CTD
PMID:30818834
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Esrra
estrogen related receptor, alpha
multiple interactions
ISO
pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; pyridaben inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]
CTD
PMID:30818834
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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Etl4
enhancer trap locus 4
increases expression
ISO
pyridaben results in increased expression of ETL4 mRNA
CTD
PMID:22563483
NCBI chr17:82,841,075...83,304,868
Ensembl chr17:82,495,041...83,304,715
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H2bc9
H2B clustered histone 9
decreases expression
ISO
pyridaben results in decreased expression of H2BC9 mRNA
CTD
PMID:22563483
NCBI chr17:42,470,593...42,478,590
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H3c1
H3 clustered histone 1
decreases expression
ISO
pyridaben results in decreased expression of H3C1 mRNA
CTD
PMID:22563483
NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856
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Hexb
hexosaminidase subunit beta
multiple interactions
EXP
zinc chloride inhibits the reaction [pyridaben results in increased secretion of HEXB protein]
CTD
PMID:15272608
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
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Hmx3
H6 family homeobox 3
decreases expression
ISO
pyridaben results in decreased expression of HMX3 mRNA
CTD
PMID:22563483
NCBI chr 1:186,313,237...186,315,201
Ensembl chr 1:186,313,063...186,315,201
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Hs3st6
heparan sulfate-glucosamine 3-sulfotransferase 6
decreases expression
ISO
pyridaben results in decreased expression of HS3ST6 mRNA
CTD
PMID:22563483
NCBI chr10:13,781,999...13,788,133
Ensembl chr10:13,781,993...13,788,133
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Idh3a
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
decreases expression
ISO
pyridaben results in decreased expression of IDH3A mRNA
CTD
PMID:30818834
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
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Il6
interleukin 6
increases expression
EXP
pyridaben results in increased expression of IL6 mRNA
CTD
PMID:37357870
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inhba
inhibin subunit beta A
increases expression
ISO
pyridaben results in increased expression of INHBA mRNA
CTD
PMID:22563483
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Insl3
insulin-like 3
decreases expression
ISO
pyridaben results in decreased expression of INSL3 mRNA
CTD
PMID:22563483
NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
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Itgb8
integrin subunit beta 8
increases expression
ISO
pyridaben results in increased expression of ITGB8 mRNA
CTD
PMID:22563483
NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
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Kcna2
potassium voltage-gated channel subfamily A member 2
increases expression
ISO
pyridaben results in increased expression of KCNA2 mRNA
CTD
PMID:22563483
NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400
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Kcnma1
potassium calcium-activated channel subfamily M alpha 1
increases expression
ISO
pyridaben results in increased expression of KCNMA1 mRNA
CTD
PMID:22563483
NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198
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Kif1b
kinesin family member 1B
increases expression
ISO
pyridaben results in increased expression of KIF1B mRNA
CTD
PMID:22563483
NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
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Klf2
KLF transcription factor 2
decreases expression
ISO
pyridaben results in decreased expression of KLF2 mRNA
CTD
PMID:22563483
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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Klhl15
kelch-like family member 15
increases expression
ISO
pyridaben results in increased expression of KLHL15 mRNA
CTD
PMID:22563483
NCBI chr X:58,994,726...59,050,207
Ensembl chr X:58,995,461...59,046,069
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Lamc2
laminin subunit gamma 2
increases expression
ISO
pyridaben results in increased expression of LAMC2 mRNA
CTD
PMID:22563483
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
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Lifr
LIF receptor subunit alpha
increases expression
ISO
pyridaben results in increased expression of LIFR mRNA
CTD
PMID:22563483
NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
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Lrp4
LDL receptor related protein 4
increases expression
ISO
pyridaben results in increased expression of LRP4 mRNA
CTD
PMID:22563483
NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593
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Lrrc63
leucine rich repeat containing 63
decreases expression
ISO
pyridaben results in decreased expression of LRRC63 mRNA
CTD
PMID:22563483
NCBI chr15:50,400,199...50,437,321
Ensembl chr15:50,400,200...50,437,321
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Ltb4r2
leukotriene B4 receptor 2
decreases expression
ISO
pyridaben results in decreased expression of LTB4R2 mRNA
CTD
PMID:22563483
NCBI chr15:29,258,712...29,260,531
Ensembl chr15:29,259,240...29,260,316
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Ltf
lactotransferrin
increases expression
ISO
pyridaben results in increased expression of LTF mRNA
CTD
PMID:22563483
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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Mapk15
mitogen-activated protein kinase 15
decreases expression
ISO
pyridaben results in decreased expression of MAPK15 mRNA
CTD
PMID:22563483
NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645
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Marchf9
membrane associated ring-CH-type finger 9
decreases expression
ISO
pyridaben results in decreased expression of MARCHF9 mRNA
CTD
PMID:22563483
NCBI chr 7:62,879,017...62,882,495
Ensembl chr 7:62,879,018...62,882,495
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Mboat2
membrane bound O-acyltransferase domain containing 2
increases expression
ISO
pyridaben results in increased expression of MBOAT2 mRNA
CTD
PMID:22563483
NCBI chr 6:41,471,135...41,597,599
Ensembl chr 6:41,471,161...41,593,485
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Mdfi
MyoD family inhibitor
decreases expression
ISO
pyridaben results in decreased expression of MDFI mRNA
CTD
PMID:22563483
NCBI chr 9:13,156,806...13,175,218
Ensembl chr 9:13,156,866...13,175,217
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Mpo
myeloperoxidase
increases expression
ISO
pyridaben results in increased expression of MPO mRNA
CTD
PMID:22563483
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mrtfb
myocardin related transcription factor B
increases expression
ISO
pyridaben results in increased expression of MRTFB mRNA
CTD
PMID:22563483
NCBI chr10:1,116,315...1,278,106
Ensembl chr10:1,116,310...1,277,897
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Muc6
mucin 6, oligomeric mucus/gel-forming
increases expression
ISO
pyridaben results in increased expression of MUC6 mRNA
CTD
PMID:22563483
NCBI chr 1:196,726,678...196,764,842
Ensembl chr 1:196,726,807...196,764,842
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Myoc
myocilin
increases expression
ISO
pyridaben results in increased expression of MYOC mRNA
CTD
PMID:22563483
NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
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Nfat5
nuclear factor of activated T-cells 5
increases expression
ISO
pyridaben results in increased expression of NFAT5 mRNA
CTD
PMID:22563483
NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
pyridaben results in increased activity of NFE2L2 protein
CTD
PMID:30818834
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfib
nuclear factor I/B
increases expression
ISO
pyridaben results in increased expression of NFIB mRNA
CTD
PMID:22563483
NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479
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Nipbl
NIPBL, cohesin loading factor
increases expression
ISO
pyridaben results in increased expression of NIPBL mRNA
CTD
PMID:22563483
NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899
G
Nmnat3
nicotinamide nucleotide adenylyltransferase 3
decreases response to substance
ISO
NMNAT3 protein results in decreased susceptibility to pyridaben
CTD
PMID:18463239
NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645
G
Nps
neuropeptide S
increases expression
ISO
pyridaben results in increased expression of NPS mRNA
CTD
PMID:22563483
NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
pyridaben binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
ISO
pyridaben results in decreased expression of NR4A1 mRNA
CTD
PMID:22563483
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
G
Odc1
ornithine decarboxylase 1
multiple interactions increases activity
ISO
pyridaben inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA] pyridaben results in increased activity of ODC1 protein
CTD
PMID:9834970
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
G
Oxt
oxytocin/neurophysin I prepropeptide
decreases expression
ISO
pyridaben results in decreased expression of OXT mRNA
CTD
PMID:22563483
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
G
Park7
Parkinsonism associated deglycase
decreases response to substance
ISO
PARK7 protein results in decreased susceptibility to pyridaben
CTD
PMID:21219333
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
pyridaben results in increased cleavage of PARP1 protein [pyridaben co-treated with Paraquat] results in increased cleavage of PARP1 protein
CTD
PMID:16237197
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pgr
progesterone receptor
multiple interactions
ISO
pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein]
CTD
PMID:30818834
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Phox2a
paired-like homeobox 2a
decreases expression
ISO
pyridaben results in decreased expression of PHOX2A mRNA
CTD
PMID:22563483
NCBI chr 1:156,178,754...156,183,118
Ensembl chr 1:156,178,754...156,183,118
G
Plce1
phospholipase C, epsilon 1
increases expression
ISO
pyridaben results in increased expression of PLCE1 mRNA
CTD
PMID:22563483
NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
pyridaben binds to and results in increased activity of PPARG protein; pyridaben inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]
CTD
PMID:30818834 PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppargc1a
PPARG coactivator 1 alpha
increases expression multiple interactions
ISO
pyridaben results in increased expression of PPARGC1A mRNA pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]
CTD
PMID:22563483 PMID:30818834
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
G
Prr7
proline rich 7 (synaptic)
decreases expression
ISO
pyridaben results in decreased expression of PRR7 mRNA
CTD
PMID:22563483
NCBI chr17:9,164,375...9,173,669
Ensembl chr17:9,165,269...9,172,536
G
Retnlb
resistin like beta
increases expression
ISO
pyridaben results in increased expression of RETNLB mRNA
CTD
PMID:22563483
NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368
G
Rock1
Rho-associated coiled-coil containing protein kinase 1
increases expression
ISO
pyridaben results in increased expression of ROCK1 mRNA
CTD
PMID:22563483
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
G
S100a8
S100 calcium binding protein A8
increases expression
ISO
pyridaben results in increased expression of S100A8 mRNA
CTD
PMID:22563483
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
G
S100a9
S100 calcium binding protein A9
increases expression
ISO
pyridaben results in increased expression of S100A9 mRNA
CTD
PMID:22563483
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
G
Shox2
SHOX homeobox 2
decreases expression
ISO
pyridaben results in decreased expression of SHOX2 mRNA
CTD
PMID:22563483
NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
G
Slc8a1
solute carrier family 8 member A1
increases expression
ISO
pyridaben results in increased expression of SLC8A1 mRNA
CTD
PMID:22563483
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
G
Smoc2
SPARC related modular calcium binding 2
increases expression
ISO
pyridaben results in increased expression of SMOC2 mRNA
CTD
PMID:22563483
NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
G
Snca
synuclein alpha
increases response to substance
ISO
SNCA protein results in increased susceptibility to pyridaben
CTD
PMID:16239214
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
G
Socs1
suppressor of cytokine signaling 1
decreases expression
ISO
pyridaben results in decreased expression of SOCS1 mRNA
CTD
PMID:22563483
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
G
Ston2
stonin 2
increases expression
ISO
pyridaben results in increased expression of STON2 mRNA
CTD
PMID:22563483
NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376
G
Strbp
spermatid perinuclear RNA binding protein
increases expression
ISO
pyridaben results in increased expression of STRBP mRNA
CTD
PMID:22563483
NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
G
Tbck
TBC1 domain containing kinase
increases expression
ISO
pyridaben results in increased expression of TBCK mRNA
CTD
PMID:22563483
NCBI chr 2:221,175,749...221,348,058
Ensembl chr 2:221,175,785...221,348,126
G
Tcf15
transcription factor 15
decreases expression
ISO
pyridaben results in decreased expression of TCF15 mRNA
CTD
PMID:22563483
NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
pyridaben binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Tmem42
transmembrane protein 42
decreases expression
ISO
pyridaben results in decreased expression of TMEM42 mRNA
CTD
PMID:22563483
NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276
G
Tnnt2
troponin T2, cardiac type
increases expression
ISO
pyridaben results in increased expression of TNNT2 mRNA
CTD
PMID:22563483
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
G
Trpm3
transient receptor potential cation channel, subfamily M, member 3
increases expression
ISO
pyridaben results in increased expression of TRPM3 mRNA
CTD
PMID:22563483
NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717
G
Tusc1
tumor suppressor candidate 1
decreases expression
ISO
pyridaben results in decreased expression of TUSC1 mRNA
CTD
PMID:22563483
NCBI chr 5:108,089,952...108,091,315
Ensembl chr 5:108,090,613...108,091,224
G
Ubxn7
UBX domain protein 7
increases expression
ISO
pyridaben results in increased expression of UBXN7 mRNA
CTD
PMID:22563483
NCBI chr11:68,427,896...68,460,100
G
Ucn
urocortin
decreases expression
ISO
pyridaben results in decreased expression of UCN mRNA
CTD
PMID:22563483
NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
G
Unc13c
unc-13 homolog C
increases expression
ISO
pyridaben results in increased expression of UNC13C mRNA
CTD
PMID:22563483
NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223
G
Vdr
vitamin D receptor
increases activity
ISO
pyridaben results in increased activity of VDR protein
CTD
PMID:20143881
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
G
Zbtb44
zinc finger and BTB domain containing 44
increases expression
ISO
pyridaben results in increased expression of ZBTB44 mRNA
CTD
PMID:22563483
NCBI chr 8:29,466,055...29,524,027
Ensembl chr 8:29,466,352...29,518,163
G
Zfp580
zinc finger protein 580
decreases expression
ISO
pyridaben results in decreased expression of ZFP580 mRNA
CTD
PMID:22563483
NCBI chr 1:68,787,118...68,789,286
Ensembl chr 1:68,787,118...68,789,286
G
Zhx3
zinc fingers and homeoboxes 3
increases expression
ISO
pyridaben results in increased expression of ZHX3 mRNA
CTD
PMID:22563483
NCBI chr 3:149,417,787...149,548,671
Ensembl chr 3:149,417,818...149,527,079
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
pyridafenthion binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Cdh2
cadherin 2
decreases localization
EXP
zardaverine results in decreased localization of CDH2 protein
CTD
PMID:15082077
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
G
Gja1
gap junction protein, alpha 1
decreases localization
EXP
zardaverine results in decreased localization of GJA1 protein
CTD
PMID:15082077
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Tjp1
tight junction protein 1
decreases localization
EXP
zardaverine results in decreased localization of TJP1 protein
CTD
PMID:15082077
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19808
chemical entity
19806
atom
19806
nonmetal atom
19744
nitrogen atom
18933
nitrogen molecular entity
18933
organonitrogen compound
18783
organonitrogen heterocyclic compound
18126
diazines
13204
pyridazines
137
pyridazinone
122
(5R)-6-(4-\{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino\}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
0
1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine
0
2,6-Dimethyl-2,3,4,5-tetrahydropyridazin-3-one
0
2-(4-Chlorobenzyl)-6-methyl-2,3-dihydropyridazin-3-one
0
3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester
0
4,5-Dichloro-2-methyl-3(2H)-pyridazinone
0
4-chloro-5-[2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-phenyl-3-pyridazinone
0
4-phenyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-one
0
5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one
0
5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one
0
5-chloro-4-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
0
6-Methyl-2-(4-methylbenzyl)-2,3-dihydropyridazin-3-one
0
6-Methyl-2-phenyl-2,3,4,5-tetrahydropyridazin-3-one
0
6-hydroxy-2-phenylpyridazin-3-one +
1
6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one
0
Maleic hydrazide
4
Y 23684
0
chloridazon
0
chloridazone-methyl-desphenyl
0
clofencet
0
diclomezine
0
flufenpyr +
0
flufenpyr-ethyl
0
levosimendan
0
norflurazon
3
pimobendan
8
pyridaben
107
pyridaphenthion
1
zardaverine
3
Path 2
CHEBI ontology
19808
subatomic particle
19806
composite particle
19806
hadron
19806
baryon
19806
nucleon
19806
atomic nucleus
19806
atom
19806
main group element atom
19756
p-block element atom
19756
carbon group element atom
19705
carbon atom
19702
organic molecular entity
19702
organic molecule
19655
organic cyclic compound
19468
organic heterocyclic compound
18848
organic heteromonocyclic compound
17773
diazines
13204
pyridazines
137
pyridazinone
122
(5R)-6-(4-\{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino\}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
0
1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine
0
2,6-Dimethyl-2,3,4,5-tetrahydropyridazin-3-one
0
2-(4-Chlorobenzyl)-6-methyl-2,3-dihydropyridazin-3-one
0
3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester
0
4,5-Dichloro-2-methyl-3(2H)-pyridazinone
0
4-chloro-5-[2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-phenyl-3-pyridazinone
0
4-phenyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-one
0
5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one
0
5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one
0
5-chloro-4-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
0
6-Methyl-2-(4-methylbenzyl)-2,3-dihydropyridazin-3-one
0
6-Methyl-2-phenyl-2,3,4,5-tetrahydropyridazin-3-one
0
6-hydroxy-2-phenylpyridazin-3-one +
1
6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one
0
Maleic hydrazide
4
Y 23684
0
chloridazon
0
chloridazone-methyl-desphenyl
0
clofencet
0
diclomezine
0
flufenpyr +
0
flufenpyr-ethyl
0
levosimendan
0
norflurazon
3
pimobendan
8
pyridaben
107
pyridaphenthion
1
zardaverine
3