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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zardaverine
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Accession:CHEBI:46548 term browser browse the term
Definition:A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.
Synonyms:exact_synonym: 6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one
 related_synonym: 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone;   6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE;   Formula=C12H10F2N2O3;   InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17);   InChIKey=HJMQDJPMQIHLPB-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1;   zardaverina;   zardaverinum
 xref: CAS:101975-10-4;   LINCS:LSM-2833
 xref_mesh: MESH:C066436
 xref: PDBeChem:ZAR;   PMID:12387865;   PMID:12952271;   PMID:1426207;   PMID:1648920;   PMID:1665311;   PMID:1700309;   PMID:1723951;   PMID:1787170;   PMID:7644776;   PMID:7684572;   PMID:7925141;   PMID:8035322;   PMID:8369979;   PMID:8381357;   PMID:8392340


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zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      application 19403
        anti-asthmatic agent 9233
          anti-asthmatic drug 8605
            zardaverine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic heterocyclic compound 18544
                                  organic heteromonocyclic compound 16992
                                    diazines 12211
                                      pyridazines 121
                                        pyridazinone 118
                                          zardaverine 3
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