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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zardaverine
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Accession:CHEBI:46548 term browser browse the term
Definition:A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.
Synonyms:exact_synonym: 6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one
 related_synonym: 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone;   6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE;   Formula=C12H10F2N2O3;   InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17);   InChIKey=HJMQDJPMQIHLPB-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1;   zardaverina;   zardaverinum
 xref: CAS:101975-10-4;   LINCS:LSM-2833
 xref_mesh: MESH:C066436
 xref: PDBeChem:ZAR;   PMID:12387865;   PMID:12952271;   PMID:1426207;   PMID:1648920;   PMID:1665311;   PMID:1700309;   PMID:1723951;   PMID:1787170;   PMID:7644776;   PMID:7684572;   PMID:7925141;   PMID:8035322;   PMID:8369979;   PMID:8381357;   PMID:8392340



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zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        anti-asthmatic agent 9286
          anti-asthmatic drug 8662
            zardaverine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteromonocyclic compound 17145
                                    diazines 12356
                                      pyridazines 123
                                        pyridazinone 120
                                          zardaverine 3
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